Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene (2015) (SpringerBriefs in Applied Sciences and Technology)

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Synopsis
Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies.This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.
Copyright:
2015

Book Details

Book Quality:
Publisher Quality
ISBN-13:
9789814585088
Related ISBNs:
9789814585071
Publisher:
Springer Singapore, Singapore
Date of Addition:
Copyrighted By:
N/A
Adult content:
No
Language:
English
Has Image Descriptions:
No
Categories:
Nonfiction, Science, Computers and Internet, Technology, Medicine
Submitted By:
Bookshare Staff
Usage Restrictions:
This is a copyrighted book.

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