Current Topics in Microbiology and Immunology: Ergebnisse der Mikrobiologie und Immunitätsforschung Volume 59 (1972) (Current Topics in Microbiology and Immunology #59)
By: and and and and and and and and and and and and and and
Sign Up Now!
Already a Member? Log In
You must be logged into UK education collection to access this title.
Learn about membership options,
or view our freely available titles.
- Synopsis
- Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve chan ges in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune popula tion of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRAN CIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hem agglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism.
- Copyright:
- 1972
Book Details
- Book Quality:
- Publisher Quality
- ISBN-13:
- 9783642654442
- Related ISBNs:
- 9783540059431
- Publisher:
- Springer Berlin Heidelberg
- Date of Addition:
- 06/30/22
- Copyrighted By:
- N/A
- Adult content:
- No
- Language:
- English
- Has Image Descriptions:
- No
- Categories:
- Nonfiction, Science, Medicine
- Submitted By:
- Bookshare Staff
- Usage Restrictions:
- This is a copyrighted book.
Reviews
Other Books
- by W. Henle
- by P. H. Hofschneider
- by H. Koprowski
- by R. Rott
- by H. G. Schweiger
- by P. K. Vogt
- by R. Haas
- by W. Arber
- by W. Braun
- by N. K. Jerne
- by O. Maaløe
- by M. Sela
- by E. Wecker
- by P. Koldovský
- by L. Svru?ek
- in Nonfiction
- in Science
- in Medicine