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Molecular Biology of Membranes: Structure and Function

This text attempts to introduce the molecular biology of cell membranes to students and professionals of diverse backgrounds. Although several membrane biology books are available, they do not integrate recent knowledge gained using modern molecular tools with more traditional membrane topics. Molecular techniques, such as cDNA cloning and x-ray diffraction, have provided fresh insights into cell membrane structure and function. The great excitement today, which I attempt to convey in this book, is that molecular details are beginning to merge with physiological responses. In other words, we are beginning to understand precisely how membranes work. This textbook is appropriate for upper-level undergraduate or beginning graduate students. Readers should have previous or concurrent coursework in biochemistry; prior studies in elementary physiology would be helpful. I have found that the presentation of topics in this book is appropriate for students of biology, biochemistry, biophysics and physiology, chemistry, and medicine. This book will be useful in courses focusing on membranes and as a supplementary text in biochemistry courses. Professionals will also find this to be a useful resource book for their personal libraries.

Molecular Chaperones

Currently one of the hottest topics in biochemistry, the concept of molecular chaperones has challenged the paradigm of protein self-assembly. Key figures in many disciplines review all aspects of molecular chaperones in this volume, which arises from a Royal Society discussion meeting. Overview chapters discuss the significance of chaperones in biochemistry, molecular genetics and cell biology. Each chapter is well referenced providing access to the literature.

Molecular Methods for Microbial Identification and Typing

The accurate identification and typing of microbes is essential for workers active in all fields of microbiology. Many examples of modern molecular methods have been concealed in scientific and medical literature but this introductory text considers the possible applications of such methods and compares their advantages and disadvantages.

Morphogenesis in Plants: Molecular Approaches (Nato Science Series A: #253)

Proceedings of a NATO ASI held in Crete, Greece, September 5-17, 1992.

Mosquito Ecology: Field sampling methods

Numerous methods have been devised to catch mosquitoes and many approaches employed to study their ecology and behaviour but until the first edition of this book in 1976 there was no comprehensive guide to mosquito ecology. New work on the topic has meant that this completely revised and updated second edition was required.

Mycoplasma Cell Membranes (Subcellular Biochemistry #20)

The mycoplasmas, a trivial name used to denote organisms included in the class Mollicutes, are a group of prokaryotic organisms comprising more than 120 species distinguished from ordinary bacteria by their small size and the total lack of cell walls. The absence of a cell wall in mycoplasmas is a characteristic of outstanding importance to which the mycoplasmas owe many of their pecu­ liarities, for example, their morphological instability, osmotic sensitivity, unique ion pumping systems, resistance to antibiotics that interfere with cell wall bio­ synthesis, and susceptibility to lysis by detergents and alcohols. The fact that the mycoplasma cells contain only one membrane type, the plasma membrane, constitutes one of their most useful properties for membrane studies; once the membrane is isolated, it is uncontaminated with other mem­ brane types. Another advantage in using mycoplasmas as models for membrane studies stems from the fact that their membrane lipid composition can be altered in a controlled manner. This characteristic results from the partial or total inabili­ ty of the mycoplasmas to synthesize long-chain fatty acids and cholesterol, making mycoplasmas dependent on the supply of fatty acids from the growth medium. The ability to introduce controlled alterations in the fatty acid composi­ tion and cholesterol content of mycoplasma membranes has been utilized in studying the molecular organization and physical properties of biological mem­ branes.

Neurobiology and Cell Physiology of Chemoreception (Advances in Experimental Medicine and Biology #337)

This volume records the papers presented in Chieti, Italy, at the 1991 meeting of the International Society for Arterial Chemoreception (ISAC). This was the eleventh of a series of assemblies held since 1959. This field of research, which examines the critical function and mechanisms of O and pHIPC0 sensitive cells in 2 2 the body, is unique in that it encompasses diverse biological and medical areas. The reader of this book will note chapters concerning modem techniques like in situ hybridization; analysis of cell membrane channels and intracellular ion movements; immunohistochemistry of peptides, hormones, and the corresponding receptors of chemoreceptor cells; and systemic analysis of reflex pathways involving chemoreceptor cells and their meaning in health and disease. This broad spectrum will appeal to readers interested in the chemoreceptor field, as well as young scientists seeking a scientific field where not only structural analysis but also a sense for functional connections is required. In recognition of the importance of the contribution of a new scientific generation to this field, ISAC awarded the prestigious F. de Castro-C. Heymans­ E. Neil prize to A. G6rlach, a young scientist. Also at this meeting, the Ferdinando Data Foundation Award, for helping scientists from non-developed countries to pursue their interest in chemoreception, was initiated. ISAC held plenary lectures in honor of C. Eyzaguirre and R. Forster, both of whom have contributed greatly to research in the chemoreceptor field.

Neuropeptide Analogs, Conjugates, and Fragments: Methods in Neurosciences, Vol. 13

Methods in Neurosciences, Volume 13: Neuropeptide Analogs, Conjugates, and Fragments covers the synthesis and characterization of peptide analogs, conjugates, and fragments, their use as ligands for receptors, and their role in the development and use of antisera. The book discusses techniques such as novel synthetic approaches; biotinylation; purification and characterization; radioligand techniques and assay development; use of agonists and antagonists; distinguishing receptor subtypes; conjugation to carrier proteins; antiidiotypic antibody development; and radiolabeling. Neuroscientists, biochemists, neurochemists, and pharmacologists will find the book useful.

New Concepts in the Pathogenesis of NIDDM (Advances in Experimental Medicine and Biology #334)

The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, "New Concepts in the Pathogenesis of NIDDM," organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia­ betes research, hoping that this type of interaction may result in new concepts and treat­ ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in diabetes research to share new ideas and findings presented at the meeting. Claes-G6ran Ostenson Suad Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G. Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 WJ. Malaisse 2 Regulation of Cytoplasmic Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

New Developments in Lipid-Protein Interactions and Receptor Function (Nato Science Series A: #246)

A NATO Advanced Study Institute on "New Developments in Lipid-Protein Interactions and Receptor Function" was held on the Island of Spetsai, Greece, from August 16-27, 1992. This Institute was organized to bring together researchers in the field of membrane organization and dynamics with those actively involved in studies on receptor function, signal transduction mechanisms and gene regulation. 2 Presentations and discussions focussed on the regulation of intracellular Ca +-levels, on the second messengers derived from inositol lipids and on the specific phospholipase C isozymes involved in these processes. A major focus was on G-proteins and the effect of lipid anchors on their function. These principles of regulation were further discussed in the context of receptors for acetylcholine, lysophosphatidic acid and low-density lipoproteins. In addition, various aspects of the genomic regulation of cell growth and differentiation by transcription factors were presented. These topics were put into perspective by discussing the most recent developments in lipid-protein interactions, protein insertion into membranes, membrane lipid organization and lipid dynamics as mediated by phospholipid transfer proteins. This book presents the content of the major lectures and a selection of the most relevant of the most important topics posters. These proceedings offer a comprehensive account presented during the course of the Institute. The book is intended to make these proceedings accessible to a large audience.

New Generation Vaccines: The Role of Basic Immunology (Nato Science Series A: #261)

Proceedings of a NATO ASI held at Cape Sounion Beach, Greece, June 24-July 5, 1992.

North American Psocoptera

North American Psocoptera provides a complete review of the 28 families, 78 genera and 287 species of the order Psocoptera found in the United States and Canada.This comprehensive book contains keys to all of the known taxa of Psocoptera which have been found in the study area, including three genera named as new. Not only are the native and established species included, but also those which have been taken at ports of entry in human commerce. The book contains differential diagnoses of the taxa above species level. For each named species there is an account consisting of synonymy, recognition features, relationships, distribution, and habitat. Included are 119 pages of illustrations, glossary, bibliography and index.

North American Psocoptera

North American Psocoptera provides a complete review of the 28 families, 78 genera and 287 species of the order Psocoptera found in the United States and Canada.This comprehensive book contains keys to all of the known taxa of Psocoptera which have been found in the study area, including three genera named as new. Not only are the native and established species included, but also those which have been taken at ports of entry in human commerce. The book contains differential diagnoses of the taxa above species level. For each named species there is an account consisting of synonymy, recognition features, relationships, distribution, and habitat. Included are 119 pages of illustrations, glossary, bibliography and index.

Novel Approaches to Selective Treatments of Human Solid Tumors: Laboratory and Clinical Correlation (Advances in Experimental Medicine and Biology #339)

Palaeontology of Invertebrates

How could life have started on Earth and how did it proceed? After a short discussion on the origin of life on Earth and the origin of the major body plans the invertebrates are presented in the order of increasing complexity by the most significant fossil representatives. In each case, the adaptive significance of the respective forms and/or structures which more or less profoundly changed the original body plan is treated in detail. In the closing chapter, some general aspects of invertebrates in evolution and palaeoecology, palaeobiogeography and biochronology are outlined.

Paradigms for the Study of Behavior

Methods in Neurosciences, Volume 14: Paradigms for the Study of Behavior is a collection of articles that describes the methods for measuring a wide range of behavior. This volume covers the means for measuring different behaviors, such as reproductive, maternal, sexual, aggression, social interactions, feeding behavior, memory analysis, and classical conditioning. The opening papers outline the proper conditions and practical considerations in which the researcher can study the sexual and reproductive behavior of animals in the laboratory. Another paper describes how to assess aggressiveness in rodents including ethical issues involved in such study. The book then discusses the effects of intracerebral administration of neuropeptides in rats using surgical and stereotaxic methods. Another paper presents the measurement of behavioral thermoregulatory reflexes to show acuity of temperature sensation and thermoregulatory control. This volume also discusses the measurement of song-learning behavior in birds through ""sensorimotor,"" ""action-based,"" and ""sensory"" methods of learning. This book will be helpful for students, scientists, technicians, and laboratory workers whose work involves experiments that need to be accurately measured.

The Pesticide Question: Environment, Economics and Ethics

Pesticides have contributed impressively to our present-day agricultural productivity, but at the same time they are at the center of serious concerns about safety, health, and the environment. Increasingly, the public wonders whether the benefits of pesticides - `the perfect red apple' - outweigh the costs of environmental pollution, human illness, and the destruction of animals and our habitat. Scientists and government officials are suspected of promoting commercial interests rather than protecting human welfare.

Phospholipids and Signal Transmission (NATO ASI Series #70)

Once Nietzsche said that human beings may be divided into two categories: Apollonians and Dionysians*. By this the philosopher meant that there are human beings a) who know what they are going to do in the long-term future (what we now call the grant application for the next 5 years), i. e. , Apollonians, and b) who barely know what they are going to do tomorrow morning before breakfast, i. e. , Dionysians. ** To organize a symposium, this symposium in particular, a committee had to be formed either of individuals sharing both Nietzschean characteristics or of individuals possessing either characteristic. Considering the rarity of the former type of subject, this organizing committee was spontaneously formed by a typical sample of both types of individuals. We first met in Perugia in 1988. Those of us who were Apollonians had thus a chance to organize a programme. The Dionysians knew what was going to happen to them, but, of course, did not know yet how to cope with it. They duly did so every day of the meeting, after breakfast. The organizers decided that it would be a useful exercise to assemble experts having different perspectives but all pursuing a very rapidly developing aspect of cell biology. They also hoped that these selected Apollonians and Dionysians would not merely recount their results but try to project the future through active interchanges of ideas and opinions with other attendees.

POLES AND GRIDWORK

This illustrated guide provides straightforward advice on using poles and gridwork in order to improve a horse's suppleness, balance, strength and agility. It covers riding over poles, lungeing over poles, simple grids, exercises with bounces, jumping at an angle and turning exercises.

Primate Laterality: Current Behavioral Evidence of Primate Asymmetries (Recent Research in Psychology)

This book arrays recent research on the neural and behavioral lateralization of the brain relying heavily on animal modes. The authors employ the comparative method to enhance our understanding of behavior, specifically through hand use and "handedness" by drawing comparisons with studies involving primates. Topics discussed include Patterns of Lateralized Behavior in Prosimians; Behavioral Lateralization in Language-Trained Chimpanzees; Patterns of Handedness: Comparative Study of Nursery School Children and Captive Gorillas; and Rotational Behavior in Children and Adults. It is the first book of its kind devoted entirely to the question of behavioral asymmetries in all primates and thus presents a milestone as it recognizes the accumulating evidence of asymmetry and lateralized behavior in the non-human nervous system.

Primates and Their Relatives in Phylogenetic Perspective (Advances in Primatology)

Pseudomonas aeruginosa as an Opportunistic Pathogen (Infectious Agents and Pathogenesis)

Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It will provide a deeper understanding of the pathogen to physicians and surgeons caring for patients infected, or at risk of becoming infected, with Pseudomonas Aeruginosa.

Rapid Diagnosis of Mycoplasmas (F.E.M.S. Symposium Series #62)

This compendium is the result of the FEMS Workshop on "Rapid Diagnosis of Mycoplasmas" which I organized and which took place in Jerusalem, Israel, August 11-23, 1991. The first week's sessions were held at a resort on the outskirts of Jerusalem and consisted of lectures and discussions. This part was modelled along the lines of the Gordon Conference in the USA, i.e., in an intimate atmo­ sphere in which everyone could mix and exchange ideas, and was very benefi­ cial. About 100 scientists from around the world attended the first week. Dur­ ing the first week, the biology, molecular biology and pathophysiology of myco­ plasmas, as well as all the main diagnostic methods were covered, including both conventional and the newer technologies. The session on mycoplasmas in the human urogenital tracts was held in conjunction with the Israel Society for the Study and Prevention of Sexually Transmitted Disease. The second week was a laboratory session and was held at the Hebrew University-Hadassah Medical School campus in Ein Karem, Jerusalem. All ex­ periments were conducted by eminent specialists in their field. The lab session had 36 participants from 19 countries who used the most modern techniques for the diagnosis of mycoplasmas in medicine, veterinary medicine and agri­ culture. The efficacy of several commercial kits were also tested at this time. I want to again thank everyone who helped and supported this work­ shop, as well as the authors of the various chapters.

Read and Wonder: Think of an Eel

Join one young eel as it makes a long journey in this fun, informative, award-winning picture book and CD, part of the new Nature Storybooks series

Read and Wonder: Think of an Eel (PDF)

Join one young eel as it makes a long journey in this fun, informative, award-winning picture book and CD, part of the new Nature Storybooks series