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Gene Expression Studies Using Affymetrix Microarrays
by Hinrich Gohlmann Willem TalloenThe Affymetrix GeneChip system is one of the most widely adapted microarray platforms. However, due to the overwhelming amount of information available, many Affymetrix users tend to stick to the default analysis settings and may end up drawing sub-optimal conclusions. Written by a molecular biologist and a biostatistician with a combined decade of
Introduction to Data Technologies
by Paul MurrellProviding key information on how to work with research data, Introduction to Data Technologies presents ideas and techniques for performing critical, behind-the-scenes tasks that take up so much time and effort yet typically receive little attention in formal education. With a focus on computational tools, the book shows readers how to improve thei
Introduction to Probability with R (Chapman And Hall/crc Texts In Statistical Science Ser.)
by Kenneth BaclawskiBased on a popular course taught by the late Gian-Carlo Rota of MIT, with many new topics covered as well, Introduction to Probability with R presents R programs and animations to provide an intuitive yet rigorous understanding of how to model natural phenomena from a probabilistic point of view. Although the R programs are small in length, they ar
Immunological Computation: Theory and Applications
by Dipankar Dasgupta Fernando NinoClearly, nature has been very effective in creating organisms that are capable of protecting themselves against a wide variety of pathogens such as bacteria, fungi, and parasites. The powerful information-processing capabilities of the immune system, such as feature extraction, pattern recognition, learning, memory, and its distributive nature prov
Java Programming Fundamentals: Problem Solving Through Object Oriented Analysis and Design
by Premchand S. NairWhile Java texts are plentiful, it's difficult to find one that takes a real-world approach, and encourages novice programmers to build on their Java skills through practical exercise. Written by an expert with 19 experience teaching computer programming, Java Programming Fundamentals presents object-oriented programming by employing examples taken
Applied Statistical Inference with MINITAB
by Sally A. LesikThrough clear, step-by-step mathematical calculations, Applied Statistical Inference with MINITAB enables students to gain a solid understanding of how to apply statistical techniques using a statistical software program. It focuses on the concepts of confidence intervals, hypothesis testing, validating model assumptions, and power analysis.Illustr
Design and Analysis of Clinical Trials with Time-to-Event Endpoints
by Karl E. PeaceUsing time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or "noninformativeness" of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with Time-to-Event Endpoints provides a thorough presentation o
Fundamental Number Theory with Applications (Discrete Mathematics And Its Applications Ser.)
by Richard A. MollinAn update of the most accessible introductory number theory text available, Fundamental Number Theory with Applications, Second Edition presents a mathematically rigorous yet easy-to-follow treatment of the fundamentals and applications of the subject. The substantial amount of reorganizing makes this edition clearer and more elementary in i
Machine Learning: An Algorithmic Perspective
by Stephen MarslandTraditional books on machine learning can be divided into two groups- those aimed at advanced undergraduates or early postgraduates with reasonable mathematical knowledge and those that are primers on how to code algorithms. The field is ready for a text that not only demonstrates how to use the algorithms that make up machine learning methods, but
DNA Methylation Microarrays: Experimental Design and Statistical Analysis
by Sun-Chong Wang Art PetronisProviding an interface between dry-bench bioinformaticians and wet-lab biologists, DNA Methylation Microarrays: Experimental Design and Statistical Analysis presents the statistical methods and tools to analyze high-throughput epigenomic data, in particular, DNA methylation microarray data. Since these microarrays share the same under
Grid Computing: Infrastructure, Service, and Applications
by Lizhe Wang Wei Jie Jinjun ChenIdentifies Recent Technological Developments Worldwide The field of grid computing has made rapid progress in the past few years, evolving and developing in almost all areas, including concepts, philosophy, methodology, and usages. Grid Computing: Infrastructure, Service, and Applications reflects the recent advances in this field, covering the research aspects that involve infrastructure, middleware, architecture, services, and applications. Grid Systems Across the Globe The first section of the book focuses on infrastructure and middleware and presents several national and international grid systems. The text highlights China Research and Development environment Over Wide-area Network (CROWN), several ongoing cyberinfrastructure efforts in New York State, and Enabling Grids for E-sciencE (EGEE), which is co-funded by the European Commission and the world’s largest multidisciplinary grid infrastructure today. The second part of the book discusses recent grid service advances. The authors examine the UK National Grid Service (NGS), the concept of resource allocation in a grid environment, OMIIBPEL, and the possibility of treating scientific workflow issues using techniques from the data stream community. The book describes an SLA model, reviews portal and workflow technologies, presents an overview of PKIs and their limitations, and introduces PIndex, a peer-to-peer model for grid information services. New Projects and Initiatives The third section includes an analysis of innovative grid applications. Topics covered include the WISDOM initiative, incorporating flow-level networking models into grid simulators, system-level virtualization, grid usage in the high-energy physics environment in the LHC project, and the Service Oriented HLA RTI (SOHR) framework. With a comprehensive summary of past advances, this text is a window into the future of this nascent technology, forging a path for the next generation of cyberinfrastructure developers.
Environmental Chemometrics: Principles and Modern Applications (Analytical Chemistry Ser.)
by Grady HanrahanMultivariate, heterogeneous data has been traditionally analyzed using the "one at a time" variable approach, often missing the main objective of discovering the relationships among multiple variables and samples. Enter chemometrics, with its powerful tools for design, analysis, and data interpretation of complex environmental systems. Delineating
Methods in Algorithmic Analysis (Chapman & Hall/CRC Computer and Information Science Series)
by Vladimir A. DobrushkinExplores the Impact of the Analysis of Algorithms on Many Areas within and beyond Computer ScienceA flexible, interactive teaching format enhanced by a large selection of examples and exercises Developed from the author’s own graduate-level course, Methods in Algorithmic Analysis presents numerous theories, techniques, and methods used for analyzing algorithms. It exposes students to mathematical techniques and methods that are practical and relevant to theoretical aspects of computer science. After introducing basic mathematical and combinatorial methods, the text focuses on various aspects of probability, including finite sets, random variables, distributions, Bayes’ theorem, and Chebyshev inequality. It explores the role of recurrences in computer science, numerical analysis, engineering, and discrete mathematics applications. The author then describes the powerful tool of generating functions, which is demonstrated in enumeration problems, such as probabilistic algorithms, compositions and partitions of integers, and shuffling. He also discusses the symbolic method, the principle of inclusion and exclusion, and its applications. The book goes on to show how strings can be manipulated and counted, how the finite state machine and Markov chains can help solve probabilistic and combinatorial problems, how to derive asymptotic results, and how convergence and singularities play leading roles in deducing asymptotic information from generating functions. The final chapter presents the definitions and properties of the mathematical infrastructure needed to accommodate generating functions. Accompanied by more than 1,000 examples and exercises, this comprehensive, classroom-tested text develops students’ understanding of the mathematical methodology behind the analysis of algorithms. It emphasizes the important relation between continuous (classical) mathematics and discrete mathematics, which is the basis of computer science.
Grid Computing: Techniques and Applications (Chapman And Hall/crc Computational Science Ser.)
by Barry WilkinsonDesigned for senior undergraduate and first-year graduate students, Grid Computing: Techniques and Applications shows professors how to teach this subject in a practical way. Extensively classroom-tested, it covers job submission and scheduling, Grid security, Grid computing services and software tools, graphical user interfaces, workflow editors,
Introduction to Mathematical Proofs: A Transition (Textbooks In Mathematics Ser.)
by Charles RobertsShows How to Read & Write Mathematical ProofsIdeal Foundation for More Advanced Mathematics CoursesIntroduction to Mathematical Proofs: A Transition facilitates a smooth transition from courses designed to develop computational skills and problem solving abilities to courses that emphasize theorem proving. It helps students develop the skills n
Algorithmic Cryptanalysis
by Antoine JouxIllustrating the power of algorithms, Algorithmic Cryptanalysis describes algorithmic methods with cryptographically relevant examples. Focusing on both private- and public-key cryptographic algorithms, it presents each algorithm either as a textual description, in pseudo-code, or in a C code program.Divided into three parts, the book begins with a
Bayesian Modeling in Bioinformatics
by Dipak K. Dey Samiran Ghosh Bani K. MallickBayesian Modeling in Bioinformatics discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research, such as cancer. It presents a broad overview of statistical inference, clustering, and c
Algorithms in Bioinformatics: A Practical Introduction (Chapman And Hall/crc Mathematical And Computational Biology Ser.)
by Wing-Kin SungThoroughly Describes Biological Applications, Computational Problems, and Various Algorithmic Solutions Developed from the author's own teaching material, Algorithms in Bioinformatics: A Practical Introduction provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the bi
Complex Analysis with Applications to Flows and Fields
by Luis Manuel Braga da Costa CamposComplex Analysis with Applications to Flows and Fields presents the theory of functions of a complex variable, from the complex plane to the calculus of residues to power series to conformal mapping. The book explores numerous physical and engineering applications concerning potential flows, the gravity field, electro- and magnetostatics, steady he
Introduction to Concurrency in Programming Languages (Chapman And Hall/crc Computational Science Ser.)
by Matthew J. SottileExploring how concurrent programming can be assisted by language-level techniques, Introduction to Concurrency in Programming Languages presents high-level language techniques for dealing with concurrency in a general context. It provides an understanding of programming languages that offer concurrency features as part of the language definition.Th
Statistics in Human Genetics and Molecular Biology (Chapman And Hall/crc Texts In Statistical Science Ser.)
by Cavan ReillyFocusing on the roles of different segments of DNA, Statistics in Human Genetics and Molecular Biology provides a basic understanding of problems arising in the analysis of genetics and genomics. It presents statistical applications in genetic mapping, DNA/protein sequence alignment, and analyses of gene expression data from microarray experiments.
Mathematical and Experimental Modeling of Physical and Biological Processes (Textbooks In Mathematics Ser.)
by H. T. BanksThrough several case study problems from industrial and scientific research laboratory applications, Mathematical and Experimental Modeling of Physical and Biological Processes provides students with a fundamental understanding of how mathematics is applied to problems in science and engineering. For each case study problem, the authors discuss why
Statistical Physics of Biomolecules: An Introduction
by Daniel M. ZuckermanFrom the hydrophobic effect to protein-ligand binding, statistical physics is relevant in almost all areas of molecular biophysics and biochemistry, making it essential for modern students of molecular behavior. But traditional presentations of this material are often difficult to penetrate. Statistical Physics of Biomolecules: An Introduction brin
Mixed Effects Models for Complex Data
by Lang WuAlthough standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors,
Pharmaceutical Statistics: Practical and Clinical Applications, Fifth Edition
by Sanford Bolton Charles BonThrough the use of practical examples and solutions, Pharmaceutical Statistics: Practical and Clinical Applications, Fifth Edition provides the most complete and comprehensive guide to the various statistical applications and research issues in the pharmaceutical industry, particularly in clinical trials and bioequivalence studies.