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Statistical Distributions
by Catherine Forbes Merran Evans Nicholas Hastings Brian PeacockA new edition of the trusted guide on commonly used statistical distributions Fully updated to reflect the latest developments on the topic, Statistical Distributions, Fourth Edition continues to serve as an authoritative guide on the application of statistical methods to research across various disciplines. The book provides a concise presentation of popular statistical distributions along with the necessary knowledge for their successful use in data modeling and analysis. Following a basic introduction, forty popular distributions are outlined in individual chapters that are complete with related facts and formulas. Reflecting the latest changes and trends in statistical distribution theory, the Fourth Edition features: A new chapter on queuing formulas that discusses standard formulas that often arise from simple queuing systems Methods for extending independent modeling schemes to the dependent case, covering techniques for generating complex distributions from simple distributions New coverage of conditional probability, including conditional expectations and joint and marginal distributions Commonly used tables associated with the normal (Gaussian), student-t, F and chi-square distributions Additional reviewing methods for the estimation of unknown parameters, such as the method of percentiles, the method of moments, maximum likelihood inference, and Bayesian inference Statistical Distributions, Fourth Edition is an excellent supplement for upper-undergraduate and graduate level courses on the topic. It is also a valuable reference for researchers and practitioners in the fields of engineering, economics, operations research, and the social sciences who conduct statistical analyses.
Statistical DNA Forensics: Theory, Methods and Computation (Statistics in Practice)
by Wing Kam Fung Yue-Qing HuStatistical methodology plays a key role in ensuring that DNA evidence is collected, interpreted, analyzed and presented correctly. With the recent advances in computer technology, this methodology is more complex than ever before. There are a growing number of books in the area but none are devoted to the computational analysis of evidence. This book presents the methodology of statistical DNA forensics with an emphasis on the use of computational techniques to analyze and interpret forensic evidence.
Statistical Estimation of Epidemiological Risk (Statistics in Practice)
by Kung-Jong LuiStatistical Estimation of Epidemiological Risk provides coverage of the most important epidemiological indices, and includes recent developments in the field. A useful reference source for biostatisticians and epidemiologists working in disease prevention, as the chapters are self-contained and feature numerous real examples. It has been written at a level suitable for public health professionals with a limited knowledge of statistics. Other key features include: Provides comprehensive coverage of the key epidemiological indices. Includes coverage of various sampling methods, and pointers to where each should be used. Includes up-to-date references and recent developments in the field. Features many real examples, emphasising the practical nature of the book. Each chapter is self-contained, allowing the book to be used as a useful reference source. Includes exercises, enabling use as a course text.
Statistical Factor Analysis and Related Methods: Theory and Applications (Wiley Series in Probability and Statistics #418)
by Alexander T. BasilevskyStatistical Factor Analysis and Related Methods Theory andApplications In bridging the gap between the mathematical andstatistical theory of factor analysis, this new work represents thefirst unified treatment of the theory and practice of factoranalysis and latent variable models. It focuses on such areasas: * The classical principal components model and sample-populationinference * Several extensions and modifications of principal components,including Q and three-mode analysis and principal components in thecomplex domain * Maximum likelihood and weighted factor models, factoridentification, factor rotation, and the estimation of factorscores * The use of factor models in conjunction with various types ofdata including time series, spatial data, rank orders, and nominalvariable * Applications of factor models to the estimation of functionalforms and to least squares of regression estimators
Statistical Framework for Recreational Water Quality Criteria and Monitoring (Statistics in Practice #65)
by Larry J. WymerWith increasing rates of pollution to both land and aquatic environments, regulations for the quality of our waters are necessarily becoming more stringent. In the light of recent epidemiological studies new criteria are being established for the safety of our recreational waters. In order for such criteria to be developed an established statistical framework needs to be in place. Statistical Framework for Recreational Water Quality Criteria and Monitoring offers a practical guide to the statistical methods used for assessing health effects and monitoring and modelling water quality Both traditional and novel sampling designs are discussed. Written by a team of international experts in the field, this book sets out to provide an essential structure for the monitoring of water quality. · Proposes a much-needed framework for the monitoring of water quality, and provides practical guidance on the statistical methods involved. · Covers risk characterization, empirical modelling, sensitivity analysis and measures of robustness. · Details sampling methods and quality control approaches. · Presents crucial, real-life results from recent large-scale studies of water quality, central to the development of the area. · Accompanied by a supplementary website hosting data sets and tools for data analysis. The book is primarily aimed at public health officials, staff of regulatory bodies and students and faculty members of environmental and statistical science courses. There is also much to benefit readers from environmental research and risk analysis.
Statistical Group Comparison (Wiley Series in Probability and Statistics #367)
by Tim Futing LiaoAn incomparably useful examination of statistical methods for comparison The nature of doing science, be it natural or social, inevitably calls for comparison. Statistical methods are at the heart of such comparison, for they not only help us gain understanding of the world around us but often define how our research is to be carried out. The need to compare between groups is best exemplified by experiments, which have clearly defined statistical methods. However, true experiments are not always possible. What complicates the matter more is a great deal of diversity in factors that are not independent of the outcome. Statistical Group Comparison brings together a broad range of statistical methods for comparison developed over recent years. The book covers a wide spectrum of topics from the simplest comparison of two means or rates to more recently developed statistics including double generalized linear models and Bayesian as well as hierarchical methods. Coverage includes: * Testing parameter equality in linear regression and other generalized linear models (GLMs), in order of increasing complexity * Likelihood ratio, Wald, and Lagrange multiplier statistics examined where applicable * Group comparisons involving latent variables in structural equation modeling * Models of comparison for categorical latent variables Examples are drawn from the social, political, economic, and biomedical sciences; many can be implemented using widely available software. Because of the range and the generality of the statistical methods covered, researchers across many disciplines-beyond the social, political, economic, and biomedical sciences-will find the book a convenient reference for many a research situation where comparisons may come naturally.
Statistical Hypothesis Testing with SAS and R
by Dirk Taeger Sonja KuhntA comprehensive guide to statistical hypothesis testing with examples in SAS and R When analyzing datasets the following questions often arise: Is there a short hand procedure for a statistical test available in SAS or R? If so, how do I use it? If not, how do I program the test myself? This book answers these questions and provides an overview of the most common statistical test problems in a comprehensive way, making it easy to find and perform an appropriate statistical test. A general summary of statistical test theory is presented, along with a basic description for each test, including the necessary prerequisites, assumptions, the formal test problem and the test statistic. Examples in both SAS and R are provided, along with program code to perform the test, resulting output and remarks explaining the necessary program parameters. Key features: • Provides examples in both SAS and R for each test presented. • Looks at the most common statistical tests, displayed in a clear and easy to follow way. • Supported by a supplementary website http://www.d-taeger.de featuring example program code. Academics, practitioners and SAS and R programmers will find this book a valuable resource. Students using SAS and R will also find it an excellent choice for reference and data analysis.
Statistical Hypothesis Testing with SAS and R
by Dirk Taeger Sonja KuhntA comprehensive guide to statistical hypothesis testing with examples in SAS and R When analyzing datasets the following questions often arise: Is there a short hand procedure for a statistical test available in SAS or R? If so, how do I use it? If not, how do I program the test myself? This book answers these questions and provides an overview of the most common statistical test problems in a comprehensive way, making it easy to find and perform an appropriate statistical test. A general summary of statistical test theory is presented, along with a basic description for each test, including the necessary prerequisites, assumptions, the formal test problem and the test statistic. Examples in both SAS and R are provided, along with program code to perform the test, resulting output and remarks explaining the necessary program parameters. Key features: • Provides examples in both SAS and R for each test presented. • Looks at the most common statistical tests, displayed in a clear and easy to follow way. • Supported by a supplementary website http://www.d-taeger.de featuring example program code. Academics, practitioners and SAS and R programmers will find this book a valuable resource. Students using SAS and R will also find it an excellent choice for reference and data analysis.
Statistical Implications of Turing's Formula
by Zhiyi ZhangFeatures a broad introduction to recent research on Turing’s formula and presents modern applications in statistics, probability, information theory, and other areas of modern data science Turing's formula is, perhaps, the only known method for estimating the underlying distributional characteristics beyond the range of observed data without making any parametric or semiparametric assumptions. This book presents a clear introduction to Turing’s formula and its connections to statistics. Topics with relevance to a variety of different fields of study are included such as information theory; statistics; probability; computer science inclusive of artificial intelligence and machine learning; big data; biology; ecology; and genetics. The author provides examinations of many core statistical issues within modern data science from Turing's perspective. A systematic approach to long-standing problems such as entropy and mutual information estimation, diversity index estimation, domains of attraction on general alphabets, and tail probability estimation is presented in light of the most up-to-date understanding of Turing's formula. Featuring numerous exercises and examples throughout, the author provides a summary of the known properties of Turing's formula and explains how and when it works well; discusses the approach derived from Turing's formula in order to estimate a variety of quantities, all of which mainly come from information theory, but are also important for machine learning and for ecological applications; and uses Turing's formula to estimate certain heavy-tailed distributions. In summary, this book: • Features a unified and broad presentation of Turing’s formula, including its connections to statistics, probability, information theory, and other areas of modern data science • Provides a presentation on the statistical estimation of information theoretic quantities • Demonstrates the estimation problems of several statistical functions from Turing's perspective such as Simpson's indices, Shannon's entropy, general diversity indices, mutual information, and Kullback–Leibler divergence • Includes numerous exercises and examples throughout with a fundamental perspective on the key results of Turing’s formula Statistical Implications of Turing's Formula is an ideal reference for researchers and practitioners who need a review of the many critical statistical issues of modern data science. This book is also an appropriate learning resource for biologists, ecologists, and geneticists who are involved with the concept of diversity and its estimation and can be used as a textbook for graduate courses in mathematics, probability, statistics, computer science, artificial intelligence, machine learning, big data, and information theory. Zhiyi Zhang, PhD, is Professor of Mathematics and Statistics at The University of North Carolina at Charlotte. He is an active consultant in both industry and government on a wide range of statistical issues, and his current research interests include Turing's formula and its statistical implications; probability and statistics on countable alphabets; nonparametric estimation of entropy and mutual information; tail probability and biodiversity indices; and applications involving extracting statistical information from low-frequency data space. He earned his PhD in Statistics from Rutgers University.
Statistical Implications of Turing's Formula
by Zhiyi ZhangFeatures a broad introduction to recent research on Turing’s formula and presents modern applications in statistics, probability, information theory, and other areas of modern data science Turing's formula is, perhaps, the only known method for estimating the underlying distributional characteristics beyond the range of observed data without making any parametric or semiparametric assumptions. This book presents a clear introduction to Turing’s formula and its connections to statistics. Topics with relevance to a variety of different fields of study are included such as information theory; statistics; probability; computer science inclusive of artificial intelligence and machine learning; big data; biology; ecology; and genetics. The author provides examinations of many core statistical issues within modern data science from Turing's perspective. A systematic approach to long-standing problems such as entropy and mutual information estimation, diversity index estimation, domains of attraction on general alphabets, and tail probability estimation is presented in light of the most up-to-date understanding of Turing's formula. Featuring numerous exercises and examples throughout, the author provides a summary of the known properties of Turing's formula and explains how and when it works well; discusses the approach derived from Turing's formula in order to estimate a variety of quantities, all of which mainly come from information theory, but are also important for machine learning and for ecological applications; and uses Turing's formula to estimate certain heavy-tailed distributions. In summary, this book: • Features a unified and broad presentation of Turing’s formula, including its connections to statistics, probability, information theory, and other areas of modern data science • Provides a presentation on the statistical estimation of information theoretic quantities • Demonstrates the estimation problems of several statistical functions from Turing's perspective such as Simpson's indices, Shannon's entropy, general diversity indices, mutual information, and Kullback–Leibler divergence • Includes numerous exercises and examples throughout with a fundamental perspective on the key results of Turing’s formula Statistical Implications of Turing's Formula is an ideal reference for researchers and practitioners who need a review of the many critical statistical issues of modern data science. This book is also an appropriate learning resource for biologists, ecologists, and geneticists who are involved with the concept of diversity and its estimation and can be used as a textbook for graduate courses in mathematics, probability, statistics, computer science, artificial intelligence, machine learning, big data, and information theory. Zhiyi Zhang, PhD, is Professor of Mathematics and Statistics at The University of North Carolina at Charlotte. He is an active consultant in both industry and government on a wide range of statistical issues, and his current research interests include Turing's formula and its statistical implications; probability and statistics on countable alphabets; nonparametric estimation of entropy and mutual information; tail probability and biodiversity indices; and applications involving extracting statistical information from low-frequency data space. He earned his PhD in Statistics from Rutgers University.
Statistical Inference: A Short Course
by Michael J. PanikA concise, easily accessible introduction to descriptive and inferential techniques Statistical Inference: A Short Course offers a concise presentation of the essentials of basic statistics for readers seeking to acquire a working knowledge of statistical concepts, measures, and procedures. The author conducts tests on the assumption of randomness and normality, provides nonparametric methods when parametric approaches might not work. The book also explores how to determine a confidence interval for a population median while also providing coverage of ratio estimation, randomness, and causality. To ensure a thorough understanding of all key concepts, Statistical Inference provides numerous examples and solutions along with complete and precise answers to many fundamental questions, including: How do we determine that a given dataset is actually a random sample? With what level of precision and reliability can a population sample be estimated? How are probabilities determined and are they the same thing as odds? How can we predict the level of one variable from that of another? What is the strength of the relationship between two variables? The book is organized to present fundamental statistical concepts first, with later chapters exploring more advanced topics and additional statistical tests such as Distributional Hypotheses, Multinomial Chi-Square Statistics, and the Chi-Square Distribution. Each chapter includes appendices and exercises, allowing readers to test their comprehension of the presented material. Statistical Inference: A Short Course is an excellent book for courses on probability, mathematical statistics, and statistical inference at the upper-undergraduate and graduate levels. The book also serves as a valuable reference for researchers and practitioners who would like to develop further insights into essential statistical tools.
Statistical Inference: A Short Course
by Michael J. PanikA concise, easily accessible introduction to descriptive and inferential techniques Statistical Inference: A Short Course offers a concise presentation of the essentials of basic statistics for readers seeking to acquire a working knowledge of statistical concepts, measures, and procedures. The author conducts tests on the assumption of randomness and normality, provides nonparametric methods when parametric approaches might not work. The book also explores how to determine a confidence interval for a population median while also providing coverage of ratio estimation, randomness, and causality. To ensure a thorough understanding of all key concepts, Statistical Inference provides numerous examples and solutions along with complete and precise answers to many fundamental questions, including: How do we determine that a given dataset is actually a random sample? With what level of precision and reliability can a population sample be estimated? How are probabilities determined and are they the same thing as odds? How can we predict the level of one variable from that of another? What is the strength of the relationship between two variables? The book is organized to present fundamental statistical concepts first, with later chapters exploring more advanced topics and additional statistical tests such as Distributional Hypotheses, Multinomial Chi-Square Statistics, and the Chi-Square Distribution. Each chapter includes appendices and exercises, allowing readers to test their comprehension of the presented material. Statistical Inference: A Short Course is an excellent book for courses on probability, mathematical statistics, and statistical inference at the upper-undergraduate and graduate levels. The book also serves as a valuable reference for researchers and practitioners who would like to develop further insights into essential statistical tools.
Statistical Inference for Fractional Diffusion Processes (Wiley Series In Probability And Statistics Ser. #901)
by B. L. RaoStochastic processes are widely used for model building in the social, physical, engineering and life sciences as well as in financial economics. In model building, statistical inference for stochastic processes is of great importance from both a theoretical and an applications point of view. This book deals with Fractional Diffusion Processes and statistical inference for such stochastic processes. The main focus of the book is to consider parametric and nonparametric inference problems for fractional diffusion processes when a complete path of the process over a finite interval is observable. Key features: Introduces self-similar processes, fractional Brownian motion and stochastic integration with respect to fractional Brownian motion. Provides a comprehensive review of statistical inference for processes driven by fractional Brownian motion for modelling long range dependence. Presents a study of parametric and nonparametric inference problems for the fractional diffusion process. Discusses the fractional Brownian sheet and infinite dimensional fractional Brownian motion. Includes recent results and developments in the area of statistical inference of fractional diffusion processes. Researchers and students working on the statistics of fractional diffusion processes and applied mathematicians and statisticians involved in stochastic process modelling will benefit from this book.
Statistical Inference for Fractional Diffusion Processes (Wiley Series in Probability and Statistics #870)
by B. L. RaoStochastic processes are widely used for model building in the social, physical, engineering and life sciences as well as in financial economics. In model building, statistical inference for stochastic processes is of great importance from both a theoretical and an applications point of view. This book deals with Fractional Diffusion Processes and statistical inference for such stochastic processes. The main focus of the book is to consider parametric and nonparametric inference problems for fractional diffusion processes when a complete path of the process over a finite interval is observable. Key features: Introduces self-similar processes, fractional Brownian motion and stochastic integration with respect to fractional Brownian motion. Provides a comprehensive review of statistical inference for processes driven by fractional Brownian motion for modelling long range dependence. Presents a study of parametric and nonparametric inference problems for the fractional diffusion process. Discusses the fractional Brownian sheet and infinite dimensional fractional Brownian motion. Includes recent results and developments in the area of statistical inference of fractional diffusion processes. Researchers and students working on the statistics of fractional diffusion processes and applied mathematicians and statisticians involved in stochastic process modelling will benefit from this book.
Statistical Inference for Models with Multivariate t-Distributed Errors
by A. K. Saleh Mohammad Arashi S M TabatabaeyThis book summarizes the results of various models under normal theory with a brief review of the literature. Statistical Inference for Models with Multivariate t-Distributed Errors: Includes a wide array of applications for the analysis of multivariate observations Emphasizes the development of linear statistical models with applications to engineering, the physical sciences, and mathematics Contains an up-to-date bibliography featuring the latest trends and advances in the field to provide a collective source for research on the topic Addresses linear regression models with non-normal errors with practical real-world examples Uniquely addresses regression models in Student's t-distributed errors and t-models Supplemented with an Instructor's Solutions Manual, which is available via written request by the Publisher
Statistical Inference for Models with Multivariate t-Distributed Errors
by A. K. Saleh Mohammad Arashi S M TabatabaeyThis book summarizes the results of various models under normal theory with a brief review of the literature. Statistical Inference for Models with Multivariate t-Distributed Errors: Includes a wide array of applications for the analysis of multivariate observations Emphasizes the development of linear statistical models with applications to engineering, the physical sciences, and mathematics Contains an up-to-date bibliography featuring the latest trends and advances in the field to provide a collective source for research on the topic Addresses linear regression models with non-normal errors with practical real-world examples Uniquely addresses regression models in Student's t-distributed errors and t-models Supplemented with an Instructor's Solutions Manual, which is available via written request by the Publisher
Statistical Inference for Piecewise-deterministic Markov Processes
by Romain Azaïs Florian BouguetPiecewise-deterministic Markov processes form a class of stochastic models with a sizeable scope of applications: biology, insurance, neuroscience, networks, finance... Such processes are defined by a deterministic motion punctuated by random jumps at random times, and offer simple yet challenging models to study. Nevertheless, the issue of statistical estimation of the parameters ruling the jump mechanism is far from trivial. Responding to new developments in the field as well as to current research interests and needs, Statistical inference for piecewise-deterministic Markov processes offers a detailed and comprehensive survey of state-of-the-art results. It covers a wide range of general processes as well as applied models. The present book also dwells on statistics in the context of Markov chains, since piecewise-deterministic Markov processes are characterized by an embedded Markov chain corresponding to the position of the process right after the jumps.
Statistical Inference for Piecewise-deterministic Markov Processes
by Romain Azais Florian BouguetPiecewise-deterministic Markov processes form a class of stochastic models with a sizeable scope of applications: biology, insurance, neuroscience, networks, finance... Such processes are defined by a deterministic motion punctuated by random jumps at random times, and offer simple yet challenging models to study. Nevertheless, the issue of statistical estimation of the parameters ruling the jump mechanism is far from trivial. Responding to new developments in the field as well as to current research interests and needs, Statistical inference for piecewise-deterministic Markov processes offers a detailed and comprehensive survey of state-of-the-art results. It covers a wide range of general processes as well as applied models. The present book also dwells on statistics in the context of Markov chains, since piecewise-deterministic Markov processes are characterized by an embedded Markov chain corresponding to the position of the process right after the jumps.
Statistical Intervals: A Guide for Practitioners and Researchers (Wiley Series in Probability and Statistics #541)
by William Q. Meeker Gerald J. Hahn Luis A. EscobarDescribes statistical intervals to quantify sampling uncertainty,focusing on key application needs and recently developed methodology in an easy-to-apply format Statistical intervals provide invaluable tools for quantifying sampling uncertainty. The widely hailed first edition, published in 1991, described the use and construction of the most important statistical intervals. Particular emphasis was given to intervals—such as prediction intervals, tolerance intervals and confidence intervals on distribution quantiles—frequently needed in practice, but often neglected in introductory courses. Vastly improved computer capabilities over the past 25 years have resulted in an explosion of the tools readily available to analysts. This second edition—more than double the size of the first—adds these new methods in an easy-to-apply format. In addition to extensive updating of the original chapters, the second edition includes new chapters on: Likelihood-based statistical intervals Nonparametric bootstrap intervals Parametric bootstrap and other simulation-based intervals An introduction to Bayesian intervals Bayesian intervals for the popular binomial, Poisson and normal distributions Statistical intervals for Bayesian hierarchical models Advanced case studies, further illustrating the use of the newly described methods New technical appendices provide justification of the methods and pathways to extensions and further applications. A webpage directs readers to current readily accessible computer software and other useful information. Statistical Intervals: A Guide for Practitioners and Researchers, Second Edition is an up-to-date working guide and reference for all who analyze data, allowing them to quantify the uncertainty in their results using statistical intervals.
Statistical Intervals: A Guide for Practitioners and Researchers (Wiley Series in Probability and Statistics #541)
by William Q. Meeker Gerald J. Hahn Luis A. EscobarDescribes statistical intervals to quantify sampling uncertainty,focusing on key application needs and recently developed methodology in an easy-to-apply format Statistical intervals provide invaluable tools for quantifying sampling uncertainty. The widely hailed first edition, published in 1991, described the use and construction of the most important statistical intervals. Particular emphasis was given to intervals—such as prediction intervals, tolerance intervals and confidence intervals on distribution quantiles—frequently needed in practice, but often neglected in introductory courses. Vastly improved computer capabilities over the past 25 years have resulted in an explosion of the tools readily available to analysts. This second edition—more than double the size of the first—adds these new methods in an easy-to-apply format. In addition to extensive updating of the original chapters, the second edition includes new chapters on: Likelihood-based statistical intervals Nonparametric bootstrap intervals Parametric bootstrap and other simulation-based intervals An introduction to Bayesian intervals Bayesian intervals for the popular binomial, Poisson and normal distributions Statistical intervals for Bayesian hierarchical models Advanced case studies, further illustrating the use of the newly described methods New technical appendices provide justification of the methods and pathways to extensions and further applications. A webpage directs readers to current readily accessible computer software and other useful information. Statistical Intervals: A Guide for Practitioners and Researchers, Second Edition is an up-to-date working guide and reference for all who analyze data, allowing them to quantify the uncertainty in their results using statistical intervals.
Statistical Issues in Drug Development (Statistics in Practice #69)
by Stephen S. SennDrug development is the process of finding and producing therapeutically useful pharmaceuticals, turning them into safe and effective medicine, and producing reliable information regarding the appropriate dosage and dosing intervals. With regulatory authorities demanding increasingly higher standards in such developments, statistics has become an intrinsic and critical element in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development. This highly readable second edition has been updated to include: Comprehensive coverage of the design and interpretation of clinical trials. Expanded sections on missing data, equivalence, meta-analysis and dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage of pharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9, Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue between statisticians and life scientists working within the pharmaceutical industry. The accessible and wide-ranging coverage make it essential reading for both statisticians and non-statisticians working in the pharmaceutical industry, regulatory bodies and medical research institutes. There is also much to benefit undergraduate and postgraduate students whose courses include a medical statistics component.
Statistical Issues in Drug Development (Statistics in Practice)
by Stephen S. SennStatistical Issues in Drug Development The revised third edition of Statistical Issues in Drug Development delivers an insightful treatment of the intersection between statistics and the life sciences. The book offers readers new discussions of crucial topics, including cluster randomization, historical controls, responder analysis, studies in children, post-hoc tests, estimands, publication bias, the replication crisis, and many more.This work presents the major statistical issues in drug development in a way that is accessible and comprehensible to life scientists working in the field, and takes pains not to gloss over significant disagreements in the field of statistics, while encouraging communication between the statistical and life sciences disciplines. In addition to new material on topics like invalid inversion, severity, random effects in network meta-analysis, and explained variation, readers will benefit from the inclusion of:A thorough introduction to basic topics in drug development and statistics, including the role played by statistics in drug developmentAn exploration of the four views of statistics in drug development, including the historical, methodological, technical, and professionalAn examination of debatable and controversial topics in drug development, including the allocation of treatments to patients in clinical trials, baselines and covariate information, and the measurement of treatment effectsPerfect for life scientists and other professionals working in the field of drug development, Statistical Issues in Drug Development is the ideal resource for anyone seeking a one-stop reference to enhance their understanding of the use of statistics during drug development.
Statistical Issues in Drug Development (Statistics in Practice)
by Stephen S. SennStatistical Issues in Drug Development The revised third edition of Statistical Issues in Drug Development delivers an insightful treatment of the intersection between statistics and the life sciences. The book offers readers new discussions of crucial topics, including cluster randomization, historical controls, responder analysis, studies in children, post-hoc tests, estimands, publication bias, the replication crisis, and many more.This work presents the major statistical issues in drug development in a way that is accessible and comprehensible to life scientists working in the field, and takes pains not to gloss over significant disagreements in the field of statistics, while encouraging communication between the statistical and life sciences disciplines. In addition to new material on topics like invalid inversion, severity, random effects in network meta-analysis, and explained variation, readers will benefit from the inclusion of:A thorough introduction to basic topics in drug development and statistics, including the role played by statistics in drug developmentAn exploration of the four views of statistics in drug development, including the historical, methodological, technical, and professionalAn examination of debatable and controversial topics in drug development, including the allocation of treatments to patients in clinical trials, baselines and covariate information, and the measurement of treatment effectsPerfect for life scientists and other professionals working in the field of drug development, Statistical Issues in Drug Development is the ideal resource for anyone seeking a one-stop reference to enhance their understanding of the use of statistics during drug development.
Statistical Learning for Big Dependent Data (Wiley Series in Probability and Statistics)
by Daniel Peña Ruey S. TsayMaster advanced topics in the analysis of large, dynamically dependent datasets with this insightful resource Statistical Learning with Big Dependent Data delivers a comprehensive presentation of the statistical and machine learning methods useful for analyzing and forecasting large and dynamically dependent data sets. The book presents automatic procedures for modelling and forecasting large sets of time series data. Beginning with some visualization tools, the book discusses procedures and methods for finding outliers, clusters, and other types of heterogeneity in big dependent data. It then introduces various dimension reduction methods, including regularization and factor models such as regularized Lasso in the presence of dynamical dependence and dynamic factor models. The book also covers other forecasting procedures, including index models, partial least squares, boosting, and now-casting. It further presents machine-learning methods, including neural network, deep learning, classification and regression trees and random forests. Finally, procedures for modelling and forecasting spatio-temporal dependent data are also presented. Throughout the book, the advantages and disadvantages of the methods discussed are given. The book uses real-world examples to demonstrate applications, including use of many R packages. Finally, an R package associated with the book is available to assist readers in reproducing the analyses of examples and to facilitate real applications. Analysis of Big Dependent Data includes a wide variety of topics for modeling and understanding big dependent data, like: New ways to plot large sets of time series An automatic procedure to build univariate ARMA models for individual components of a large data set Powerful outlier detection procedures for large sets of related time series New methods for finding the number of clusters of time series and discrimination methods , including vector support machines, for time series Broad coverage of dynamic factor models including new representations and estimation methods for generalized dynamic factor models Discussion on the usefulness of lasso with time series and an evaluation of several machine learning procedure for forecasting large sets of time series Forecasting large sets of time series with exogenous variables, including discussions of index models, partial least squares, and boosting. Introduction of modern procedures for modeling and forecasting spatio-temporal data Perfect for PhD students and researchers in business, economics, engineering, and science: Statistical Learning with Big Dependent Data also belongs to the bookshelves of practitioners in these fields who hope to improve their understanding of statistical and machine learning methods for analyzing and forecasting big dependent data.
Statistical Learning for Big Dependent Data (Wiley Series in Probability and Statistics)
by Daniel Peña Ruey S. TsayMaster advanced topics in the analysis of large, dynamically dependent datasets with this insightful resource Statistical Learning with Big Dependent Data delivers a comprehensive presentation of the statistical and machine learning methods useful for analyzing and forecasting large and dynamically dependent data sets. The book presents automatic procedures for modelling and forecasting large sets of time series data. Beginning with some visualization tools, the book discusses procedures and methods for finding outliers, clusters, and other types of heterogeneity in big dependent data. It then introduces various dimension reduction methods, including regularization and factor models such as regularized Lasso in the presence of dynamical dependence and dynamic factor models. The book also covers other forecasting procedures, including index models, partial least squares, boosting, and now-casting. It further presents machine-learning methods, including neural network, deep learning, classification and regression trees and random forests. Finally, procedures for modelling and forecasting spatio-temporal dependent data are also presented. Throughout the book, the advantages and disadvantages of the methods discussed are given. The book uses real-world examples to demonstrate applications, including use of many R packages. Finally, an R package associated with the book is available to assist readers in reproducing the analyses of examples and to facilitate real applications. Analysis of Big Dependent Data includes a wide variety of topics for modeling and understanding big dependent data, like: New ways to plot large sets of time series An automatic procedure to build univariate ARMA models for individual components of a large data set Powerful outlier detection procedures for large sets of related time series New methods for finding the number of clusters of time series and discrimination methods , including vector support machines, for time series Broad coverage of dynamic factor models including new representations and estimation methods for generalized dynamic factor models Discussion on the usefulness of lasso with time series and an evaluation of several machine learning procedure for forecasting large sets of time series Forecasting large sets of time series with exogenous variables, including discussions of index models, partial least squares, and boosting. Introduction of modern procedures for modeling and forecasting spatio-temporal data Perfect for PhD students and researchers in business, economics, engineering, and science: Statistical Learning with Big Dependent Data also belongs to the bookshelves of practitioners in these fields who hope to improve their understanding of statistical and machine learning methods for analyzing and forecasting big dependent data.