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Causal Inference in Pharmaceutical Statistics (Chapman & Hall/CRC Biostatistics Series)

Causal Inference in Pharmaceutical Statistics introduces the basic concepts and fundamental methods of causal inference relevant to pharmaceutical statistics. This book covers causal thinking for different types of commonly used study designs in the pharmaceutical industry, including but not limited to randomized controlled clinical trials, longitudinal studies, singlearm clinical trials with external controls, and real-world evidence studies. The book starts with the central questions in drug development and licensing, takes the reader through the basic concepts and methods via different study types and through different stages, and concludes with a roadmap to conduct causal inference in clinical studies. The book is intended for clinical statisticians and epidemiologists working in the pharmaceutical industry. It will also be useful to graduate students in statistics, biostatistics, and data science looking to pursue a career in the pharmaceutical industry.Key Features: Causal inference book for clinical statisticians in the pharmaceutical industry Introductory level on the most important concepts and methods Align with FDA and ICH guidance documents Across different stages of clinical studies: plan, design, conduct, analysis, and interpretation Cover a variety of commonly used study designs

Intelligent Computing for Sustainable Development: First International Conference, ICICSD 2023, Hyderabad, India, August 25–26, 2023, Revised Selected Papers, Part II (Communications in Computer and Information Science #2122)

The two-volume proceedings set CCIS 2121 and 2122 constitutes the refereed proceedings of the First International Conference on Intelligent Computing for Sustainable Development, ICICSD 2023, which took place in Hyderabad, India, during August 25–26, 2023. The 46 papers included in these proceedings were carefully reviewed and selected from 138 submissions. They focus on digital healthcare, renewable energy, smart cities, digital farming, and autonomous systems.

Integrated Computer Technologies in Mechanical Engineering - 2023: Synergetic Engineering, Volume 2 (Lecture Notes in Networks and Systems #996)

The International Scientific and Technical Conference “Integrated Computer Technologies in Mechanical Engineering” – Synergetic Engineering (ICTM) was established by National Aerospace University “Kharkiv Aviation Institute”. The Conference ICTM’2023 was held in Kharkiv, Ukraine, during December, 2023. During this conference, technical exchanges between the research community were carried out in the forms of keynote speeches, panel discussions, as well as special session. In addition, participants were treated to a series of receptions, which forge collaborations among fellow researchers. ICTM’2023 received 202 papers submissions from different countries. All of these offer us plenty of valuable information and would be of great benefit to the experience exchange among scientists in modeling and simulation. The organizers of ICTM’2023 made great efforts to ensure the success of this conference. We hereby would like to thank all the members of ICTM’2023 Advisory Committee for their guidance and advice, the members of program committee and organizing committee, and the referees for their effort in reviewing and soliciting the papers, and all authors for their contribution to the formation of a common intellectual environment for solving relevant scientific problems. Also, we grateful to Springer - Janusz Kacprzyk and Thomas Ditzinger as the editor responsible for the series “Lecture Notes in Networks and Systems” for their great support in publishing these selected papers.

Understanding and Managing Socioeconomic Systems Behaviour: Applications of Qualitative and Quantitative System Dynamics and Agent-Based Modelling in Healthcare and Pharmaceuticals, Finance, Arts and Culture, Sociology and Education Systems (Contributions to Management Science)

This book illustrates effective decision-making in complex socio-economic systems utilising system dynamics and agent-based simulation modelling approaches. It provides practical guidance on the application of conceptual and numerical modelling and simulation for analysing economic, strategic, regulatory, sociological and ethical questions from a complex systems perspective. Its theoretical, methodological and practical illustrations will enhance readers’ understanding of the application of simulation modelling for effective systems management. By virtually experimenting with alternative management scenarios, it will help them improve decision-making and control mechanisms. The book explores practical examples from the fields of pharmaceuticals, healthcare, finance, sociology, education and culture from a strategic, regulatory and ethics perspective. As such, it offers a valuable resource for managers, both at for-profit corporations and non-profit organisations, public policymakers and regulators alike.

Intelligent Computing for Sustainable Development: First International Conference, ICICSD 2023, Hyderabad, India, August 25–26, 2023, Revised Selected Papers, Part I (Communications in Computer and Information Science #2121)

The two-volume proceedings set CCIS 2121 and 2122 constitutes the refereed proceedings of the First International Conference on Intelligent Computing for Sustainable Development, ICICSD 2023, which took place in Hyderabad, India, during August 25–26, 2023. The 46 papers included in these proceedings were carefully reviewed and selected from 138 submissions. They focus on digital healthcare, renewable energy, smart cities, digital farming, and autonomous systems.

Poisson Hyperplane Tessellations (Springer Monographs in Mathematics)

This book is the first comprehensive presentation of a central topic of stochastic geometry: random mosaics that are generated by Poisson processes of hyperplanes. It thus connects a basic notion from probability theory, Poisson processes, with a fundamental object of geometry. The independence properties of Poisson processes and the long-range influence of hyperplanes lead to a wide range of phenomena which are of interest from both a geometric and a probabilistic point of view. A Poisson hyperplane tessellation generates many random polytopes, also a much-studied object of stochastic geometry. The book offers a variety of different perspectives and covers in detail all aspects studied in the original literature. The work will be useful to graduate students (advanced students in a Master program, PhD students), and professional mathematicians. The book can also serve as a reference for researchers in fields of physics, computer science, economics or engineering.

Android Malware Detection and Adversarial Methods

The rise of Android malware poses a significant threat to users’ information security and privacy. Malicious software can inflict severe harm on users by employing various tactics, including deception, personal information theft, and device control. To address this issue, both academia and industry are continually engaged in research and development efforts focused on detecting and countering Android malware. This book is a comprehensive academic monograph crafted against this backdrop. The publication meticulously explores the background, methods, adversarial approaches, and future trends related to Android malware. It is organized into four parts: the overview of Android malware detection, the general Android malware detection method, the adversarial method for Android malware detection, and the future trends of Android malware detection. Within these sections, the book elucidates associated issues, principles, and highlights notable research. By engaging with this book, readers will gain not only a global perspective on Android malware detection and adversarial methods but also a detailed understanding of the taxonomy and general methods outlined in each part. The publication illustrates both the overarching model and representative academic work, facilitating a profound comprehension of Android malware detection.

Real Analysis: An Undergraduate Problem Book for Mathematicians, Applied Scientists, and Engineers

Real Analysis: An Undergraduate Problem Book for Mathematicians, Applied Scientists, and Engineers is a classical Real Analysis/Calculus problem book. This topic has been a compulsory subject for every undergraduate studying mathematics or engineering for a very long time. This volume contains a huge number of engaging problems and solutions, as well as detailed explanations of how to achieve these solutions. This latter quality is something that many problem books lack, and it is hoped that this feature will be useful to students and instructors alike. Features Hundreds of problems and solutions Can be used as a stand-alone problem book, or in conjunction with the author’s textbook, Real Analysis: An Undergraduate Textbook for Mathematicians, Applied Scientists, and Engineers, ISBN 9781032481487 Perfect resource for undergraduate students studying a first course in Calculus or Real Analysis Contains explanatory figures, detailed techniques, tricks, hints, and “recipes” on how to proceed once we have a calculus problem in front of us.

Real Analysis: An Undergraduate Problem Book for Mathematicians, Applied Scientists, and Engineers

Real Analysis: An Undergraduate Problem Book for Mathematicians, Applied Scientists, and Engineers is a classical Real Analysis/Calculus problem book. This topic has been a compulsory subject for every undergraduate studying mathematics or engineering for a very long time. This volume contains a huge number of engaging problems and solutions, as well as detailed explanations of how to achieve these solutions. This latter quality is something that many problem books lack, and it is hoped that this feature will be useful to students and instructors alike. Features Hundreds of problems and solutions Can be used as a stand-alone problem book, or in conjunction with the author’s textbook, Real Analysis: An Undergraduate Textbook for Mathematicians, Applied Scientists, and Engineers, ISBN 9781032481487 Perfect resource for undergraduate students studying a first course in Calculus or Real Analysis Contains explanatory figures, detailed techniques, tricks, hints, and “recipes” on how to proceed once we have a calculus problem in front of us.

Mathematical Sciences and Applications: Proceedings of the International Conference on Mathematical Sciences and Applications (ICMSA 2023)

The papers appearing in these proceedings are part of talks, oral presentations and poster presentations given at the International Conference on Mathematical Sciences and Applications held in the Department of Mathematics, Dr. Bhimrao Ambedkar University, Agra (India) from March 24-26, 2023. The Conference was held under the auspices of the Mathematics Department which is recognized and founded by the U.P. State Govt. as a Centre of Excellence in Mathematics. The aim of the conference was to have a gathering of experts from the different field of Mathematical sciences and its applications in physical and biological sciences.

Mathematical Sciences and Applications: Proceedings of the International Conference on Mathematical Sciences and Applications (ICMSA 2023)

The papers appearing in these proceedings are part of talks, oral presentations and poster presentations given at the International Conference on Mathematical Sciences and Applications held in the Department of Mathematics, Dr. Bhimrao Ambedkar University, Agra (India) from March 24-26, 2023. The Conference was held under the auspices of the Mathematics Department which is recognized and founded by the U.P. State Govt. as a Centre of Excellence in Mathematics. The aim of the conference was to have a gathering of experts from the different field of Mathematical sciences and its applications in physical and biological sciences.

Large-Scale Scientific Computations: 14th International Conference, LSSC 2023, Sozopol, Bulgaria, June 5–9, 2023, Revised Selected Papers (Lecture Notes in Computer Science #13952)

This book constitutes the refereed proceedings of the 14th International Conference on Large-Scale Scientific Computations, LSSC 2023, held in Sozopol, Bulgaria, during June 5–9, 2023. The 49 full papers included in this book were carefully reviewed and selected from 61 submissions. They were organized in topical sections as follows: preconditioning and multilevel methods; fractures and mixed dimensional modeling: discretizations, solvers, and methodology; machine learning and model order reduction for large scale predictive simulations; fractional differential problems: theoretical aspects, algorithms and applications; variational analysis and optimal control; stochastic optimal control and numerical methods in economics and finance; tensor methods for big data analytics and low-rank approximations of PDEs solutions; applications of metaheuristics to large-scale problems; large-scale models: numerical methods, parallel computations and applications; HPC and HPDA: algorithms and applications.

Conversations on Optimal Transport

This work is closely tied to the renowned mathematics textbook series known as UNITEXT, tailored for university students pursuing bachelor’s or master’s degrees. What sets this particular book apart in the Springer collection is its unique origin: it has been crafted through a meticulous process involving interviews handled with and by world-class mathematicians. The content featured in this book revolve around a highly relevant and engaging topic: Optimal Transport. These conversations involve not only authors from the UNITEXT series, but also members of the series’ Editorial Board. Additionally, they feature prominent figures in the field, including a Field Medalist. This work provides readers with a snapshot of remarkable vitality and freshness, guaranteed to captivate and engage anyone with an interest in mathematics. It’s important to note that these interviews were initially shared as podcasts and originally broadcasted as online events on the Cassyni platform. Subsequently, advanced AI tools were employed under human supervision to transcribe the audios and edit them for better readability. A human copy-editor was involved during the whole process, and the authors revised the final copy-edited texts before publication. The content in each format – the interviews, the PODCASTS and the book – is self-contained and not a mere adaptation from one medium to another. Instead, it represents an independent exploration of the subject matter.

Topics of Thought: The Logic of Knowledge, Belief, Imagination

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. When one thinks--knows, believes, imagines--that something is the case, one's thought has a topic: it is about something, towards which one's mind is directed. What is the logic of thought, so understood? This book begins to explore the idea that, to answer the question, we should take topics seriously. It proposes a hyperintensional account of the propositional contents of thought, arguing that these are individuated not only by the set of possible worlds at which they are true, but also by their topic: what they are about. The book then builds epistemic, doxastic, probabilistic, and conditional logics based on this view. It applies them to issues ranging from dogmatism, scepticism, and epistemic fallibilism, to imagination and suppositional reasoning, belief revision, framing effects, and the acceptability of indicative conditionals.

Ordinary Differential Equations with Applications (Texts in Applied Mathematics #34)

This book, developed during 20 years of the author teaching differential equations courses at his home university, is designed to serve as a text for a graduate level course focused on the central theory of the subject with attention paid to applications and connections to other advanced topics in mathematics. Core theory includes local existence and uniqueness, the phase plane, Poincaré-Bendixson theory, Lyapunov and linearized stability, linear systems, Floquet theory, the Grobman–Hartman theorem, persistence of rest points and periodic orbits, the stable and center manifold theorems, and bifurcation theory. This edition includes expanded treatment of deterministic chaos, perturbation theory for periodic solutions, boundary value problems, optimization, and a wide range of their applications. In addition, it contains a formulation and new proof of a theorem on instability of rest points in the presence of an eigenvalue with positive real part, and new proofs of differential inequalities and Lyapunov’s center theorem. New sections present discussions of global bifurcation, the Crandall–Rabinowitz theorem, and Alekseev’s formula. Of particular note is a new chapter on basic control theory, a discussion of optimal control, and a proof of a useful special case of the maximum principle. A key feature of earlier editions, a wide selection of original exercises, is respected in this edition with the inclusion of a wealth of new exercises. Reviews of the first edition:“As an applied mathematics text on linear and nonlinear equations, the book by Chicone is written with stimulating enthusiasm. It will certainly appeal to many students and researchers.”—F. Verhulst, SIAM Review “The author writes lucidly and in an engaging conversational style. His book is wide-ranging in its subject matter, thorough in its presentation, and written at a generally high level of generality, detail, and rigor.”—D. S. Shafer, Mathematical Reviews

Functions of Least Gradient (Monographs in Mathematics #110)

This book is devoted to the least gradient problem and its variants. The least gradient problem concerns minimization of the total variation of a function with prescribed values on the boundary of a Lipschitz domain. It is the model problem for studying minimization problems involving functionals with linear growth. Functions which solve the least gradient problem for their own boundary data, which arise naturally in the study of minimal surfaces, are called functions of least gradient. The main part of the book is dedicated to presenting the recent advances in this theory. Among others are presented an Euler–Lagrange characterization of least gradient functions, an anisotropic counterpart of the least gradient problem motivated by an inverse problem in medical imaging, and state-of-the-art results concerning existence, regularity, and structure of solutions. Moreover, the authors present a surprising connection between the least gradient problem and the Monge–Kantorovich optimal transport problem and some of its consequences, and discuss formulations of the least gradient problem in the nonlocal and metric settings. Each chapter is followed by a discussion section concerning other research directions, generalizations of presented results, and presentation of some open problems. The book is intended as an introduction to the theory of least gradient functions and a reference tool for a general audience in analysis and PDEs. The readers are assumed to have a basic understanding of functional analysis and partial differential equations. Apart from this, the text is self-contained, and the book ends with five appendices on functions of bounded variation, geometric measure theory, convex analysis, optimal transport, and analysis in metric spaces.

Adaptive Instructional Systems: 6th International Conference, AIS 2024, Held as Part of the 26th HCI International Conference, HCII 2024, Washington, DC, USA, June 29–July 4, 2024, Proceedings (Lecture Notes in Computer Science #14727)

This book constitutes the refereed proceedings of 6th International Conference on Adaptive Instructional Systems, AIS 2024, held as part of the 26th International Conference, HCI International 2024, which took place in Washington, DC, USA, during June 29-July 4, 2024. The total of 1271 papers and 309 posters included in the HCII 2024 proceedings was carefully reviewed and selected from 5108 submissions. The HCII-AIS 2024 contributions have been organized in the following topical sections: Designing and developing adaptive instructional systems; adaptive learning experiences; AI in adaptive learning.

Stochastic Programming in Supply Chain Risk Management: Resilience, Viability, and Cybersecurity (International Series in Operations Research & Management Science #359)

This book offers a novel multi-portfolio approach and stochastic programming formulations for modeling and solving contemporary supply chain risk management problems. The focus of the book is on supply chain resilience under propagated disruptions, supply chain viability under severe crises, and supply chain cybersecurity under direct and indirect cyber risks. The content is illustrated with numerous computational examples, some of which are modeled on real-world supply chains subject to severe multi-regional or global crises, such as pandemics. In the computational examples, the proposed stochastic programming models are solved using an advanced algebraic modeling language AMPL and GUROBI solver. The book seamlessly continues the journey begun in the author’s previously published book “Supply Chain Disruption Management: Using Stochastic Mixed Integer Programming.” It equips readers with the knowledge, tools, and managerial insights needed to effectively model and address modern supply chain risk management challenges. As such, the book is designed for practitioners and researchers who are interested in supply chain risk management. Master’s and Ph.D. students in disciplines like supply chain management, operations research, industrial engineering, applied mathematics, and computer science will also find the book a valuable resource.

Science for Humans: Mind, Life, The Formal-&-Natural Sciences, and A New Concept of Nature

This book presents and defends an original and paradigm-shifting conception of formal science, natural science, and the natural universe alike, that’s fully pro-science, but at the same time neither theological or God-centered, nor solipsistic or self-centered, nor communitarian or social-institution-centered, nor scientistic or science-valorizing, nor materialist/physicalist or reductive, nor—above all—mechanistic. It does this by presenting and defending what Robert Hanna calls the neo-organicist turn, including manifest realism and the three sub-parts of metaphysical organicism: liberal naturalism, mind-life continuity, and explanatory inversion, whereby mechanical systems are explained by grounding them in organic systems, and not the other way around. Or more briefly and simply put, the purpose of this book is to present and defend science for humans. As such, it will be highly interesting and profoundly relevant to graduate students and specialist researchers in philosophy and the formal-&-natural sciences.

IoT/AI Control of VRF Distributed Building Air-Conditioners

This book describes new energy service controls of VRF (Variable Refrigerant Flow) air-conditioners, i.e., distributed-type air-conditioners for commercial buildings in the near future, in the context of the energy savings for CO2 reduction and the reform of the electric power system. In other words, this book introduces the state-of-the-art technology of the next-generation distributed building air-conditioning energy service system, from IoT cloud control to AI optimal control, as well as standards for the smart grid supply and demand adjustment market. Rather than simple saving energy by On Off operations or shifting set- temperatures, the author proposes technology that sends numerical commands for the air-conditioner inverters directly from the cloud. By using this innovative IoT method, this book describes how to realizes the AI optimal cloud control as a cluster of air-conditioners while machine-learning of each air conditioner's situation.

Handbook of Digital Resources in Mathematics Education (Springer International Handbooks Of Education Ser.)

Intelligent Systems of Computing and Informatics

Since 2011, the Fourth Industrial Revolution (IR4.0) has played a significant role in education, research, and industry. Data technologies have also evolved rapidly to cater to the rapidly growing size of the data as well as to enhance the security of the shared data through multiple resources and platforms.Intelligent Systems of Computing and Informatics aims to develop a new Intelligent Systems of Computing and Informatics (ISCI) to cater to the needs of industries in line with the United Nations’ Sustainable Development Goals (SDGs) of affordable and clean energy and sustainable cities and communities.Comprising 20 chapters by experts from all over the world, this book covers such topics as data technologies, machine learning, signal and image processing, software systems efficiency, computer networking, Internet of Things, and computational intelligence for real-life problems.Key Features: Develops a new system for computing and informatics Provides the state of the art of current research and studies in intelligence systems Written by experts in the field of computing and informatics This book is aimed at postgraduate students, researchers working in various research and development (R&D) agencies, and practitioners, as well as scientists that have an interest in ISCI.

Intelligent Systems of Computing and Informatics

Since 2011, the Fourth Industrial Revolution (IR4.0) has played a significant role in education, research, and industry. Data technologies have also evolved rapidly to cater to the rapidly growing size of the data as well as to enhance the security of the shared data through multiple resources and platforms.Intelligent Systems of Computing and Informatics aims to develop a new Intelligent Systems of Computing and Informatics (ISCI) to cater to the needs of industries in line with the United Nations’ Sustainable Development Goals (SDGs) of affordable and clean energy and sustainable cities and communities.Comprising 20 chapters by experts from all over the world, this book covers such topics as data technologies, machine learning, signal and image processing, software systems efficiency, computer networking, Internet of Things, and computational intelligence for real-life problems.Key Features: Develops a new system for computing and informatics Provides the state of the art of current research and studies in intelligence systems Written by experts in the field of computing and informatics This book is aimed at postgraduate students, researchers working in various research and development (R&D) agencies, and practitioners, as well as scientists that have an interest in ISCI.

New Trends in Information and Communications Technology Applications: 7th National Conference, NTICT 2023, Baghdad, Iraq, December 20–21, 2023, Proceedings (Communications in Computer and Information Science #2096)

This book constitutes the refereed proceedings of the 7th National Conference on New Trends in Information and Communications Technology Applications, NTICT 2023, held in Baghdad, Iraq, during December 20–21, 2023. The 28 full papers included in this book were carefully reviewed and selected from 92 submissions. They were organized in topical sections as follows: artificial intelligence and machine learning; and computer networks.

Advances in Multimodal Information Retrieval and Generation (Synthesis Lectures on Computer Vision)

This book provides an extensive examination of state-of-the-art methods in multimodal retrieval, generation, and the pioneering field of retrieval-augmented generation. The work is rooted in the domain of Transformer-based models, exploring the complexities of blending and interpreting the intricate connections between text and images. The authors present cutting-edge theories, methodologies, and frameworks dedicated to multimodal retrieval and generation, aiming to furnish readers with a comprehensive understanding of the current state and future prospects of multimodal AI. As such, the book is a crucial resource for anyone interested in delving into the intricacies of multimodal retrieval and generation. Serving as a bridge to mastering and leveraging advanced AI technologies in this field, the book is designed for students, researchers, practitioners, and AI aficionados alike, offering the tools needed to expand the horizons of what can be achieved in multimodal artificial intelligence.