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Endothelial Dysfunctions in Vascular Disease
by Peter Libby Raffaele De CaterinaBridging the gap between the laboratory and the bedside, this timely volume illuminates the connection between endothelial dysfunction and vascular disease. This comprehensive survey of atherosclerotic disease begins with biology – incorporating the latest breakthroughs in the field – then elucidates risk factors and diagnostic tools and markers. A major section on endothelium-directed prevention and therapy shows you how to apply cutting-edge research to clinical care. Under the careful editorial guidance of Drs. De Caterina and Libby, the highly-regarded contributors address: endothelial activation and the initiation of atherosclerosis mechanisms of plaque progression and complications the role of LDL in the origin and progression of atherosclerosis advanced glycation endproducts and the accelerated atherosclerosis in diabetes oxidative stress and vascular disease soluble adhesion molecules as markers of vascular disease hormone-replacement therapy and cardiovascular risk anti-oxidants and endothelial protection and more. The first book dedicated to the central role of endothelial dysfunction in vascular disease, this concise volume gathers all the latest information on the subject into one convenient and cohesive text. Make sure your patients are benefiting from current knowledge by keeping a copy of Enothelial Dysfunctions in Vascular Disease close at hand for frequent consultation. IntroductionEvery book has a history, this one not excepted, having emerged from intersections in professional lives of the Editors. This book bears the fruits of a collaboration between the “pupil” (RDC) and the “mentor” (PL). During an extended sabbatical of the pupil in Boston in 1994, we probed together the concept that endothelial dysfunction served as a common denominator of vascular disease, with the balance between inflammation and its inhibition as a fulcrum of the regulation of the behavior of endothelial cells. As practicing cardiologists in our clinical lives, we sought to link to endothelial function the mechanisms of action of risk factors and of pharmacologic agents used to treat and prevent vascular disease. The pupil therefore authored a few reviews on the mechanism of action of risk factors and included them in a small book, published in Italian, for which the mentor wrote a preface. The book was greeted with favor from the Italian cardiological community, and provided the nidus for the present, more ambitious endeavor, which includes updated reviews on the pathogenesis of vascular disease and on the most novel aspects of vascular biology. This enterprise was enabled by the contributions of many of our former or present collaborators and colleagues, without whose enthusiasm and engagement this work could never have seen light. We largely underestimated the devotion necessary on our own side at the beginning, but it ultimately yielded a product that we feel achieves our original goals. We are aware that we confront a continuously evolving topic, where frequent updates would be desirable - if not necessary. Yet, we believe in the value of books - such as the current one - that attempt to organize in a snapshot of time, the vast amount of literature available in a coherent and comprehensive scheme. We are aware of existing gaps, of emerging material not paid its due, and of the rapid evolution of some of the concepts highlighted within. The links between the laboratory and the clinic have never afforded more opportunity for new understanding and advances in diagnosis and treatment than today We hope that our colleagues, vascular biologists cardiologists, internists, and other physicians alike will find this compendium a useful guide to this most exciting time in vascular biology and medicine—Raffaele De Caterina and Peter Libby
New Arrhythmia Technologies
by Paul J. Wang Gerald V. Naccarelli Michael R. Rosen N. A. Mark Estes David L. Hayes David E. HainesNew Arrhythmia Technologies provides a complete discussion of recent, emerging, and future arrhythmia technologies. This forward-thinking book details successful trials and investigates areas of research that have not yet reached the trial phase. The elite panel of authors have explored fresh information on: advances in antiarrhythmic pharmacologis therapy advances in monitoring, risk assessment, and noninvasive mapping advances in pacing therapy advances in implantable defibrillators advances in catheter and surgical ablation advances in antiarrhythmic biological therapy vision for the future of arrhythmia technologies web-based defibrillation monitoring. New Arrhythmia Technologies presents a unique view of the latest in arrhythmia innovations through the eyes of the experts in the field.
Evidence-Based Sports Medicine (Evidence-Based Medicine)
by Domhnall MacAuley Thomas BestThis second edition of the popular book Evidence-based Sports Medicine builds on the features that made the first edition such a valuable text and provides a completely up-to-date tool for sports medicine physicians, family practitioners and orthopedic surgeons. Updated to take into account new evidence from systematic reviews and controlled trials, Evidence-based Sports Medicine is a unique reference book on the optimum management of sports-related conditions. This second edition: contains sections on acute injury, chronic conditions, and injuries to the upper limb, groin and knee and to the lower leg pays increased attention to the important and emerging area of injury prevention features thoroughly revised methodology sections within each chapter, reflecting changes in technique and application MCQs and essay questions that allow readers to continually assess their knowledge and understanding of the topics covered
Haemoglobinopathy Diagnosis
by Barbara J. BainThis unique book is written by Barbara Bain, a leading haematologist with a reputation for her educational prowess in the field. It provides a concise overview of the haemoglobinopathies and focuses on the selection, performance, and interpretation of relevant laboratory tests. The tests dealt with are mainly those done regularly in diagnostic haematology laboratories. Where more specialist tests are required, the reader is given an overview of what the specialist centre will do, with guidance on what the result will imply. This book is extremely practical in orientation and is an essential reference volume in the haematology laboratory. Haemoglobinopathy Diagnosis is ideal for: Trainees and residents in haematology Hematologists in practice Laboratory scientists Why Buy This Book? New Edition - Fully updated, with 43 new pictures and 37 pages of illustrated clinical cases to use for teaching and self-evaluation Essential reference volume for the haematology laboratory Focuses on diagnosis Very practical in its approach In addition to the self-assessment case studies, contains "test your knowledge" sections at the end of every chapter Remarkably comprehensive for a compact book
Cardiovascular Regeneration and Stem Cell Therapy
by Annarosa Leri Piero Anversa William H. FrishmanThis book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.
Advanced Endovascular Therapy of Aortic Disease
by Alan B. Lumsden Peter H. Lin Changyi Chen Juan ParodiAt last, years of clinical experience and the latest clinical evidence comes together in one comprehensive collection by world-renown experts at the Baylor College of Medicine. A complete and focused examination of all aspects of endovascular therapy of aortic disease, Advanced Endovascular Therapy provides you with all of the information you need on: Natural history and preoperative planning Thoracic aortic aneurysm Aortic dissection and traumatic aortic injury Techniques, new devices, and surveillance With 26 chapters skilfully organized into four main sections, this book helps you obtain the best results when using endovascular treatments for patients with aortic disease. Keep Advanced Endovascular Therapy close at hand for frequent reference.
40 Years of Academic Public Psychiatry
by Selby Jacobs Ezra GriffithsDescribes an outstanding training programme in public psychiatry developed by the Connecticut Mental Health Center A worthwhile and valuable contribution to the field that has no current equivalent in the market The book suggests a plan for the future of public sector psychiatry and serves as a model to centers throughout North America and further afield Describes the impact of the Connecticut Mental Health Center on psychiatric service models in the public sector
Pregnancy and Childbirth: A Cochrane Pocketbook (Wiley Cochrane Series)
by G. Justus Hofmeyr James P. Neilson Zarko Alfirevic Caroline A. Crowther Lelia Duley Metin Gulmezoglu Gillian M. Gyte Ellen D. HodnettPregnancy and Childbirth presents the best evidence for the care of pregnant women to doctors, midwives, students and parents. The logical sequence of chapters and the index give quick access to the abstracts of over four hundred Cochrane systematic reviews. The book serves both as a stand-alone reference, and as a companion to locating full reviews on the Cochrane Library. The Cochrane Library is published by John Wiley on behalf of The Cochrane Collaboration. www.thecochranelibrary.com
From Patient Data to Medical Knowledge: The Principles and Practice of Health Informatics
by Paul TaylorHow can you make the best use of patient data to improve health outcomes? More and more information about patients' health is stored on increasingly interconnected computer systems. But is it shared in ways that help clinicians care for patients? Could it be better used as a resource for researchers? This book is aimed at all those who want to learn about how IT is transforming the way we think about medicine and medical research. The ideas explored here are taken from research carried out around the world, and are presented by a leading authority in Health Informatics based at University College London. This comprehensive guide to the field is split into three sections: What is health informatics? – an introduction Techniques for representing and analysing patient data and medical knowledge Implementation in the clinical setting: changing practice to improve health care outcomes Whether you are a health professional, NHS manager or IT specialist, this book will help you understand how data can be managed to provide the information you and your colleagues want in the most helpful and accessible way for both you and your patients.
Cancer and the Adolescent
by Tim Eden Ronald Barr Archie Bleyer Myrna WhitesonYoung people with cancer have suffered from not being recognized as either children or adult patients. The lack of an adequate number of centres, properly equipped for teenage cancer care, is acknowledged worldwide. Yet their needs, both physically and psychologically, are perhaps the most acute of all. Now, this book, based on an international conference hosted by the Teenage Cancer Trust, addresses the issues surrounding care of the adolescent with cancer more completely than ever before. Some chapters provide practical information from leading specialists on managing and treating the specific tumours affecting this group whilst others present discussions by psychologists, nurses and other healthcare professionals on the many lifestyle issues that confront teenagers with cancer. Finally and maybe, most importantly, contributions from patients and carers give an insight into what it feels like to have the disease while growing into adulthood. With its insight into the problems, and guidance on best practice, this book will be welcomed by all professionals and carers who work with young people with cancer.
Myocardial Laser Revascularization
by Charles Bridges Keith Horvath Ray Chu-Jeng ChiuFinally, there is a dependable guide to transmyocardial laser revasculariztion (TMR). In this groundbreaking volume, clinicians who pioneered the use of this innovative treatment share their insights on the indications, results, mechanisms, and limitations of the technique. Under the careful editorial guidance of Drs. Bridges, Horvath, and Chiu, contributing authors explain: the evolution, science, rationale, and limitations for TMR how to select suitable candidates anesthetic considerations and the role of transesophageal echo TMR as a sole or combination therapy Whether you are already practicing TMR or contemplating its addition to your therapeutic armamentarium, this concise reference will answer all your questions about this important new procedure.
Cardiac Surgery in Chronic Renal Failure
by Mark S. Slaughter MD“The work focuses on a phenomenon that is occurring with increasing frequency in the practice of cardiac surgery, namely the need to address cardiac surgical issues in patients with end-stage renal disease (ESRD). . . . this book will serve to stimulate trials of competing and complementary therapies so that the outcomes for these unfortunate patients can be improved.” -- from the Foreword by R. Morton Boltman, III, MD Professor of Surgery, Harvard Medical School Chief, Cardiac Surgery, Brigham and Women’s Hospital, Boston Cardiovascular disease remains the most common cause of death for patients with chronic renal failure, and although cardiac surgery can frequently relieve symptoms and prolong survival, it is still associated with significant complications. This concise volume draws on the expertise of leading specialists to help practitioners and trainees understand the full range of current treatment options and their outcomes. Noted authorities such as Charles A. Herzog and William Cohn share both their insights and their technical tips, developed through years of experience. Cardiac Surgery in Chronic Renal Failure includes chapters on: • the impact of ESRD in society • percutaneous coronary revascularization in ESRD patients • cardiopulmonary bypass in patients with chronic renal failure • coronary bypass grafting in ESRD patients requiring dialysis • surgical treatment of valvular heart disease in ESRD patients • surgical evaluation and treatment of uremic pericarditis Practicing nephrologists and cardiologists, as well as residents and fellows, will find this important volume serves as a guide to achieving the best possible outcomes and a call to reduce the impact of cardiovascular disease in ESRD.
Heart Disease in Pregnancy
by Celia Oakley Carole A. WarnesThe new edition of this practical guide draws on the clinical skills of a wide range of international experts to help you recognize and manage heart disease in pregnancy. Designed for on-the-spot use, this convenient and concise text helps you identify a cardiac problem, understand its pathophysiology, and respond appropriately. Under the careful editorial direction of Drs. Oakley and Warnes, the Second Edition introduces new contributors from North America and Europe as well as new chapters on: pulmonary hypertension rheumatic heart disease artificial heart valves Marfan syndrome auto-immune diseases hypertrophic cardiomyopathy rhythm disorders hypertension cardiac intervention The entire book is scrupulously updated to reflect the most current standards of care. The contributors – all recognized leaders in their respective fields – outline the pathway to diagnosis and appropriate management by a multi-disciplinary team. Although heart disease is the leading medical cause of maternal death, clinical trials in this population are few and the evidence base is small. The expert recommendations in Heart Disease in Pregnancy, Second Edition, are a welcome source of information for cardiologists, obstetricians, general practitioners, and all members of the patient care team.
Practical Intracardiac Echocardiography in Electrophysiology
by Jian-Fang Ren Francis E. Marchlinski David J. Callans David SchwartsmanTremendous advances in intracardiac echocardiography (ICE) have coincided with the evolution of interventional electrophysiology. This book is designed to provide both the electrophysiologist and echocardiographer with an in-depth view of the role and value of ICE during electrophysiologic procedures. A guide to techniques used for optimal ICE imaging in cardiac electrophysiology is provided. In addition, new and less-recognized uses of ICE in electrophysiological procedures are described and their clinical applications are presented. Illustrated with over 500 images, many of which are in color, the book can also be used as a practical atlas. Readers need not be experts in the field of echocardiography to benefit from this practical approach to intracardiac imaging in electrophysiology.
Variants of Ventricular Preexcitation: Recognition and Treatment
by Eduardo Back Sternick Hein J. Wellens“Variants of Ventricular Preexcitation: Recognition and Treatment provides a unique opportunity for general cardiologists and electrophysiologists to find in one text the intricacies of recognizing and treating a group of disorders that has intrigued physicians for more than 100 years.” --from the Foreword by Mark E. Josephson, MD, Chief, Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, USA Drs Sternick and Wellens combine their expertise in the diagnosis and treatment of cardiac arrhythmias to bring you this complete overview of decrementally conducting accessory pathways and their role in cardiac arrhythmias. This is the first book dedicated to these special types of accessory pathways, their recognition and management. By covering the uncommon varieties of ventricular preexcitation, this book supports you in improving patient care by: Helping you to identify decrementally conducting AV fibers- which comprise 3-5 % of all accessory AV pathways Explaining exactly what information can be obtained from the 12-lead ECG Showing how to identify and localize these pathways during an electrophysiologic study Detailing the proper treatment and how to treat these patients By explaining the fundamental pathophysiology as well as the diverse clinical presentation of arrhythmias, Drs Sternick and Wellens demystify the subject of the different variants of decrementally conducting accessory pathways leading to ventricular pre-excitation and their role in cardiac arrhythmias.
Syncope Cases
by Roberto García-Civera Angel Moya I Mitjans Gonzalo Barón-Esquivias Jean-Jacques Blanc Michele Brignole Ricardo Ruiz-Granell Wouter WielingThis book presents a unique collection of clinical cases to help combat the difficulty of diagnosis and treatment of Syncope. Medical professionals using this book are provided with a reference to a large array of succinctly described and illustrated clinical scenarios. Each case is presented with the results of appropriate tests and critical comments about the evaluation, diagnosis and treatment according to guidelines. Syncope is considered a difficult diagnostic and treatment problem for all who work in the field. Regardless of your prior knowledge, you will find the case studies easy to digest, enlightening, and immediately pertinent to improving the care patients – giving you confidence in your diagnosis and your advice. The editors have developed a lively and easy-to-read book with a focused expert editorial commentary, offering the reader a broader and easily understood context for each case, as well as key citations from the literature. Syncope Cases is a valuable contribution to your collection; edited by seven prominent authorities on the management of syncope from four countries, with more than 130 contributors, this book provides a unique additional step in the fostering of a better understanding of the many factors that can cause syncope, with the ultimate goal of facilitating the delivery of more precise and cost-effective care for syncope patients. It is a contribution that should be widely read, and one that offers the possibility of distinctly enhancing medical care of the syncope patient.
Living with Hearing Difficulties: The process of enablement
by Dafydd StephensLiving with Hearing Difficulties is a source-book for professionals who encounter and support individuals with hearing difficulties. It will also be of interest to people with hearing difficulties themselves and those close to them. The book highlights the concept of audiological enablement as being an interactive process requiring the active involvement of both clinician and patient. The thirteen chapters encompass four sections which broadly follow the categories of the World Health Organization's ICF (2001): Section 1 addresses types of hearing disorders, the impairments they cause and also the process of help seeking. Section 2 deals with the effects of hearing impairment on communication and psychosocial functioning. Section 3 considers the individual in their environment; their family, work, and leisure. Section 4 elaborates on the process of enablement in a non-prescriptive manner. The authors approach the problems and needs from the standpoint of what the patient/client is seeking. Enablement is seen as a team effort between the professionals, the patient and their family in an ever-changing environment. This entails using any relevant techniques to ensure the well-being of the individual with hearing impairment; that end remains very much their goal. The book also has a companion website www.wiley.com/go/stephens which hosts additional downloadable documents as well as a demonstration of the concept of the signal-to-noise ratio.
Pulmonary Arterial Hypertension: Diagnosis and Evidence-Based Treatment
by Robyn BarstFirst book dedicated to this disease, previously thought to be incurable, but with the advent of new drugs, now amenable to management and a much improved prognosis for patients From the PAH Association, the leading experts in field Incorporates the latest AACP management guidelines Includes evidence-based treatment algorithms based on the recently updated ACCP Guidelines for Medical Treatment Aimed at specialists in pulmonology and cardiovascular disease, this volume provides the clinician with the most up to date information on the effective management of PAH
Fetal Anomalies: Ultrasound Diagnosis and Postnatal Management
by Max Maizels Bettina F. Cuneo Rudy E. SabbaghaFETAL ANOMALIES Advances in ultrasound technology are reshaping the field of health care for obstetricians and pediatric specialists. Detailed fetal imaging has enabled medical professionals to detect fetal structural anomalies and research practical guidelines for prenatal diagnosis and postnatal management. Fetal Anomalies: Ultrasound Diagnosis and Postnatal Management is a practical sourcebook with images of structural fetal malformations on a continuum that begins at the stage of ultrasonographic identification, progressing to characterization in the newborn period, and culminating in repair and postoperative follow up. This comprehensive text correlates pre- and post-natal images with the type of treatment appropriate to structural anomalies of the different organ systems. Numerous examples from each organ system are included and the material is clinically oriented. Fetal Anomalies: Ultrasound Diagnosis and Postnatal Management reviews such topics as: Externally visible defects Skeletal dysplasia Central nervous, gastrointestinal, urinary, and genital systems Umbilical cord anomalies Abnormalities specific to multiple pregnancies Abnormalities of amniotic fluid volume Abnormalities that elude prenatal detection Incorporating the pictorial strengths of an atlas with the didactic utility of a reference work, Fetal Anomalies: Ultrasound Diagnosis and Postnatal Management is a unique book bridging various specialties that comprise maternal-fetal medicine, such as obstetrics, diagnostic imaging, neonatology, perinatology, surgery, and urology.
Statistical Methods for Rates and Proportions (Wiley Series in Probability and Statistics #477)
by Joseph L. Fleiss Bruce Levin Myunghee Cho Paik* Includes a new chapter on logistic regression. * Discusses the design and analysis of random trials. * Explores the latest applications of sample size tables. * Contains a new section on binomial distribution.
Culture of Epithelial Cells (Culture of Specialized Cells #10)
by R. Ian Freshney Mary G. Freshney"...a wonderful compendium of current in vitro approaches that will be a useful resource to those just starting to work with an epithelial cell system as well as those that have been working with them for years and years." --Pharmaceutical Research This completely revised and expanded new edition provides detailed descriptions of fundamental and practical aspects relating to the in vitro cultivation of disparate types of epithelia. In recent years, the use of epithelial cell culture in cell biology and tissue engineering has increased dramatically. This revision reflects those advances by including new chapters on the culture of animal and human hepatocytes, kidney epithelium, and bladder epithelium. Each chapter provides an introductory review of the principles and advantages of the particular method, followed by detailed protocols, practical tips, alternate methods, and a useful list of materials and suppliers.
Genomic Imprinting and Uniparental Disomy in Medicine: Clinical and Molecular Aspects
by Eric Engel Stylianos E. AntonarakisEric Engel and Stylianos Antonarakis have written the most authoritative and vital reference on molecular and clinical aspects of uniparental disomy (UPD) and genomic imprinting to date. Genomic Imprinting and Uniparental Disomy in Medicine features comprehensive overviews of a multitude of genetic disorders linked to UPD, with a strong emphasis on clinical consequences. This book will provide readers with the tools necessary to identify and treat diseases associated with nontraditional chromosomal inheritance.Genomic Imprinting and Uniparental Disomy in Medicine features handy tables summarizing clinical phenotypes and chromosomal involvement in UPD, as well as clear illustrations on imprinting mechanisms and diagnostic testing. This authoritative, completely up-to-date practical reference will be useful for any clinical geneticist, genetic counselor, physician, or researcher encountering patients with such disorders or studying complex disease mechanisms.
The Practical Guide to the Genetic Family History
by Robin L. BennettThe Practical Guide to The Genetic Family History Robin L. Bennett Compiling the most recent genetic developments in medical specialties, The Practical Guide to the Genetic Family History is a valuable resource which outlines the proper methods for taking and recording a patient's family medical history, allowing primary care physicians to be more efficient in diagnosing conditions with potential genetic components. With genetic screening forms, an overview of directed questions, pedigree nomenclature, and outlining common approaches used, genetic counselor Robin L. Bennett provides readers with the basic foundation in human genetics necessary to recognize inherited disorders and familial disease susceptibility in patients. As the only guide which is geared for the physician in this field, The Practical Guide to the Genetic Family History includes remarks by renowned medical geneticist Arno Motulsky, as well as information on structuring an accurate pedigree and its components, including: * Using a pedigree to identify individuals with an increased susceptibility to cancer * Family history, adoption, and their challenges * The connection between the pedigree and assisted reproductive technologies * Making referrals for genetic services * Neurological and neuromuscular conditions * Tables covering hearing loss, mental retardation, dementia, and seizures * Five case studies of genetics in practice An essential reference for genetics clinics, medical geneticists, and counselors, The Practical Guide to the Genetic Family History is also an invaluable aid for both primary care and specialist physicians who need an up-to-date reference that emphasizes both the science and art of modern clinical genetics.
Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins (Methods of Biochemical Analysis #43)
by Andreas D. Baxevanis B. F. Ouellette"In this book, Andy Baxevanis and Francis Ouellette . . . have undertaken the difficult task of organizing the knowledge in this field in a logical progression and presenting it in a digestible form. And they have done an excellent job. This fine text will make a major impact on biological research and, in turn, on progress in biomedicine. We are all in their debt." —Eric Lander from the Foreword Reviews from the First Edition "...provides a broad overview of the basic tools for sequence analysis ... For biologists approaching this subject for the first time, it will be a very useful handbook to keep on the shelf after the first reading, close to the computer." —Nature Structural Biology "...should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data." —Science "...a wonderful primer designed to navigate the novice through the intricacies of in scripto analysis ... The accomplished gene searcher will also find this book a useful addition to their library ... an excellent reference to the principles of bioinformatics." —Trends in Biochemical Sciences This new edition of the highly successful Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins provides a sound foundation of basic concepts, with practical discussions and comparisons of both computational tools and databases relevant to biological research. Equipping biologists with the modern tools necessary to solve practical problems in sequence data analysis, the Second Edition covers the broad spectrum of topics in bioinformatics, ranging from Internet concepts to predictive algorithms used on sequence, structure, and expression data. With chapters written by experts in the field, this up-to-date reference thoroughly covers vital concepts and is appropriate for both the novice and the experienced practitioner. Written in clear, simple language, the book is accessible to users without an advanced mathematical or computer science background. This new edition includes: All new end-of-chapter Web resources, bibliographies, and problem sets Accompanying Web site containing the answers to the problems, as well as links to relevant Web resources New coverage of comparative genomics, large-scale genome analysis, sequence assembly, and expressed sequence tags A glossary of commonly used terms in bioinformatics and genomics Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, Second Edition is essential reading for researchers, instructors, and students of all levels in molecular biology and bioinformatics, as well as for investigators involved in genomics, positional cloning, clinical research, and computational biology.
Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects
by Peter M. Royce Beat SteinmannThe Second Edition of Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects is the definitive reference text in its field, with over 40% more pages on the nature, diagnosis, and treatment of disease than its predecessor. Collecting new research on disorders detailed in the first edition as well as on those previously excluded, editors Peter Royce and Beat Steinmann provide the most up-to-date clinical and scientific information for medical specialists treating affected individuals. Features of this revised and updated volume include detailed reviews of the clinical diagnosis, mode of inheritance, risk of recurrence, and prenatal diagnosis of each inherited connective tissue disorder; a thorough description of the morphology of connective tissues; a completely updated and revised section on the biology of the extracellular matrix; and the addition of syndromes such as craniosyntosis, and disorders of sulfate metabolism.