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Studies on Hepatic Disorders (Oxidative Stress in Applied Basic Research and Clinical Practice)

This volume examines the current state of free radical biology as it impacts on hepatic disorders. It takes a thorough look at the relationship of oxidative stress in acute and chronic disease and takes into account factors like: redox biomarkers; antioxidant defense and protection; cell signaling, mutations; oxidative damage involving lipids, proteins and nucleic acids; membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function and toxicology and hypoxia. Studies on Hepatic Disorders, the latest volume in the Oxidative Stress in Basic Research and Clinical Practice series, provides a comprehensive look at liver topics. It is organized into four sections, each one thoroughly covering its topic and consisting of chapters written by recognized field leaders. Section One, covers basic principles including redox signaling, antioxidant defenses, nitric oxide, oxidative mechanisms in senescence and regeneration and the detection of oxidative stress. Section Two, explores Pathophysiology. It ranges from cell damage to fibrogenic response as broken out in chapters on hepatocellular injury, mitochondrial damage, unfolded protein response and autophagy, inflammation, ischemia-reperfusion injury and finally, fibrogenesis. Sections Three and Four cover specific diseases and cancer, respectively. Most of the chapters focus on diseases including acute failure, alcoholic disease, viral hepatitis, iron overload, autoimmune disease, Wilson’s disease and more, while the chapters on cancer round out the book.

Contemporary Bioethics: Islamic Perspective

This book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). Biomedical topics are presented and ethical issues related to topics such as genetic testing, assisted reproduction and organ transplantation are discussed.Whereas these natural sources are God’s special gifts to human beings, God’s revelation as given to the prophets is the supernatural source of divine guidance through which human communities have been guided at all times through history. The second part of the book concentrates on the objectives of Islamic religious practice – the maqa' sid – which include: Preservation of Faith, Preservation of Life, Preservation of Mind (intellect and reason), Preservation of Progeny (al-nasl) and Preservation of Property. Lastly, the third part of the book discusses selected topical issues, including abortion, assisted reproduction devices, genetics, organ transplantation, brain death and end-of-life aspects. For each topic, the current medical evidence is followed by a detailed discussion of the ethical issues involved.

Chest Pain: Advanced Assesment and Management Skills

Chest Pain: Advanced Assessment and Management promotes a systematic approach to the assessment and management of patients presenting with chest pain and related undifferentiated symptoms. Specifically, it equips practitioners with the knowledge and clinical skills needed to effectively differentiate and respond to clinical presentations where the primary symptom for seeking healthcare advice involves chest pain. Introductory chapters in section one explore the principles of physical assessment, history taking and differential diagnosis to provide the framework for subsequent chapters, which explore cardiac and non-cardiac causes of chest pain. Section two examines the advanced assessment and overall management of patients with pain in the chest. A range of clinical conditions that trigger chest pain and other related symptoms are covered, including: angina, acute coronary syndromes, pericarditis and myocarditis, aortic dissection, pulmonary embolism, oesophago-gastric disorders, musculoskeletal causes, pulmonary and respiratory causes, coronary heart disease, myocardial infarction, chest pain caused by trauma or cardiac syndrome X, cocaine misuse and Herpes zoster.

Using Whole Body Vibration in Physical Therapy and Sport E-Book: Clinical practice and treatment exercises

This innovative new manual demonstrates the application of vibration technology to the treatment of pathologies such as osteoporosis, osteopenia, stroke and different musculoskeletal disorders. It covers pathology on the upper and lower extremities as well as the whole spine. New treatment strategies are practically and logically presented with recommended exercises and accompanying instructions that can be applied using the vibration platforms. Rationale is given for selected vibration frequencies, amplitudes and modes for the duration and frequency of the exercise session. The manual is grounded in evidence underpinned by a thorough literature review (including a balanced view of both pros and cons) and clinical cases. The authors present clinical treatment parameters that are evidence-based and have supportive physiological rationale that is consistent with the nature of the pathology being treated.First book of its kind applying evidence-based vibration technology to physical (physiotherapy) and sport therapy practice Exercise recommendations accompanied by over 70 four-colour illustrations Indications and contra-indications in clinical practice Comprehensive literature review of evidence base and principles Written and supported by experts actively applying this technology to their practice

Consensus on Menopause Research: A Summary of International Opinion

This book contains a consensus on menopause research, a consensus reached during the First International Congress on the Menopause in June, 1976. The Congress brought together about 165 people, most of whom are engaged in research in this field, in the resort town of La Grande Motte, near Montpellier, France. It was planned so that the main emphasis would be on the exchange of information in small Workshop sessions. Workshop Chairmen were asked to present summaries of their deliberations at the closing session. It is these summaries that form the essence of this text. The Congress also included six Free Communications sessions. They are represented in this book by a small number of papers printed in full (selected from some 40 contributions in all) that in the opinion of the editors, contain data that particularly complement the Workshop summaries. All other papers are mentioned in these Pro­ ceedings by titles and by the name, affiliation and address of the first author. Organizing this Congress was a stimulating and heart-warming experience. It was done by the staff of the International Health Foundation in Brussels and Geneva, under the considerate auspices of the American Geriatric Society and the Medical Faculty of the University of Montpellier. We are deeply grateful to these two bodies.

HNO Praxis Heute (HNO Praxis heute #1)

Anthropological Perspectives on Care: Work, Kinship, and the Life-Course

In the course of last two decades, the notion of care has become prominent in the social and cultural sciences. As a result of this proliferation of care in several disciplinary fields, we are observing not only the expansion of its conceptual meaning, but also an increasing imprecision in its usage. A growing amount of literature focuses on the intersection between work, gender, ethnicity, affect, and mobility regimes. In view of this growing field of literature, Anthropological Perspectives on Care looks at the notion of care from an anthropological perspective. Complementing earlier approaches, Alber and Drotbohm argue that an interpretation of care in relation to three different concepts, namely work, kinship and the life-course, will facilitate empirical and conceptual distinctions between the different activities that are labeled as care.

Physiotherapie auf der Intensivstation: Atemtherapie, Mobilisation und Lagerung

Dieses Praxisbuch liefert Physiotherapeuten wesentliche Grundlagen für die Arbeit mit Intensivpatienten. Was beinhaltet der atemtherapeutische Befund bei sedierten Patienten? Wie sichere ich den Tubus während der Mobilisation der Halsfaszien? Welche Technik eignet sich für die Behandlung eines kranialisierten Diaphragmas? Hier finden Sie die Antworten!Aus dem Inhalt:• Strukturen einer Intensivstation inkl. Patientenzentrierung, Dokumentation und Hygiene• Mentale Funktionen und Erhebungsinstrumente• Physiologie und Pathologie von Atmung, Formen der Beatmung, Weaning und Atemtherapie• Sensomotorik, normale Bewegung, Lagerung und MobilisationPlus: Befundbögen zum Download! Mit beeindruckenden Erfahrungsberichten eines ehemaligen Patienten und realen Bildern von der Intensivstation.

Cellular Aspects of Hypertension

In the last two decades, investigations at the cellular level have progressively gained ground in the context of hypertension research. This choice of approach is due to some extent to the build up of know-how that molecular and cellular biology have been producing at a continuous rate. As the contents list of this volume shows, a large mass of work has been directed to gaining some insight into pathogenetic mechanisms. The pathogenesis of primary hypertension has been progressively categorized as a distinct biological problem, not amenable to the theoretical models that proved successful in understanding the nature of secondary forms of hypertension. At the same time, great efforts have been made to simplify this problem by sorting out, if possible, a few crucial mechanisms from the network of contributory factors in the regulation of blood pressure. The idea that what is to be sought is a primary structural and/or functional fault in arterial muscle has met with widespread acceptance. The strength of this argument lies in the fact that peripheral vascular resistance is increased in all forms of hypertension and, in turn, the diameter of resistance vessels is the dominant factor in the computation of total per­ ipheral resistance. On the basis of this, cardiovascular structural adaptation was proposed as a positive feedback mechanism tending to maintain hypertension, once begun, whatever the initiating factor is.

Implementation Science 3.0

This textbook presents a much-needed overview of the recent developments in implementation science — a discipline that is young, has gained increasing attention in recent years, and has experienced substantial and rapid growth in knowledgeproduction and debate. It captures the latest developments in research and pushes the reader toward the next phase for implementation science: bridging the science-to-practice divide. Drawing from multidisciplinary, international research by top scholars in the field, this book provides a critical but friendly approach to understanding what implementation science is, what it isn’t, and where it’s going.Topics include:• Factors associated with effective implementation• Organizational context and readiness for change• Implementation theories, models, and frameworks• Enhancing implementation measurement• Bringing interventions to scale• Closing the science-practice gap in implementationImplementation Science 3.0 is a timely, important resource for researchers, students, and others with an interest in implementation working across the fields of social welfare,public health, education, and psychology.The chapter “Making sense of implementation theories, models and frameworks”,in which some modifications to the text were made, is available open access under a Creative Commons Attribution 4.0 International License in Nilsen, P. (2015). Implementation Science, 10(53), via link.springer.com.

Game Equilibrium Models III: Strategic Bargaining

The four volumes of Game Equilibrium Models present applications of non-cooperative game theory. Problems of strategic interaction arising in biology, economics, political science and the social sciences in general are treated in 42 papers on a wide variety of subjects. Internationally known authors with backgrounds in various disciplines have contributed original research. The reader finds innovative modelling combined with advanced methods of analysis. The four volumes are the outcome of a research year at the Center for Interdisciplinary Studies of the University of Bielefeld. The close interaction of an international interdisciplinary group of researchers has produced an unusual collection of remarkable results of great interest for everybody who wants to be informed on the scope, potential, and future direction of work in applied game theory. Volume III Strategic Bargaining contains ten papers on game equilibrium models of bargaining. All these contributions look at bargaining situations as non-cooperative games. General models of two-person and n-person bargaining are explored.

Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products (Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products #37)

Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progrès dans la Chimie des Substances Organiques Naturelles (Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products #11)

The properties of proteins are determined not only by the sequence of amino-acid residues in the polypeptide chains, but also by the con­ figuration of the chains-the way in which the chains are coiled or folded. It is probable that denaturation, the loss of some of the specific properties of a native protein, may in many cases be the result simply of a change in configuration of the polypeptide chains, without any change whatever in the sequence of amino-acid residues. During the past few years great progress has been made in the attack on the determination of the sequence of amino-acid residues in the poly­ peptide chains of proteins, through the work of SANGER and his collabora­ tors (Io9, IIO) and of other investigators. There has also been significant progress in the attack on the problem of the configuration of polypeptide chains, largely through the application of the X-ray diffraction technique.

Selective Toxicity: The physico-chemical basis of therapy

Selective Toxicity: The physico-chemical basis of therapy

Operative Techniques in Coronary Artery Bypass Surgery: An Illustrated Guide to Personalized Therapy

This book provides an invaluable practically applicable and comprehensive manual to coronary artery bypass grafting (CABG) surgery. Critical concepts and techniques are discussed in an easy-to-follow and understand step-by-step guide, featuring a wealth of intraoperative photos and illustrations with concise and instructive descriptions. Topics covered include classical sternotomy, variants of arterial revascularization, off-pump and minimally invasive techniques (MICS-CABG). Operative Techniques in Coronary Artery Bypass Surgery provides invaluable assistance to residents, fellows and trainee surgeons by explaining theoretical and technical aspects of the latest advances in procedural techniques and therapy personalization to optimize CABG surgical outcome. Considering that any heart team depends entirely on the participants’ knowledge and their willingness to cooperate, this work allows cardiologists and the other participants of a heart team to better understand the strengths and limitations of state-of-the-art surgical coronary revascularization. The concepts synthesized within the checklists and decision algorithms provided also enable the reader to develop their knowledge of which technique is the most appropriate for a particular patient.

The Uterus: Pathology, Diagnosis, and Management (Clinical Perspectives in Obstetrics and Gynecology)

Handbook of Antimicrobial Resistance

Systems Neuroscience (Advances in Neurobiology #21)

This edition of Advances in Neurobiology brings together experts in the emerging field of Systems Neuroscience to present an overview of this area of research. Topics covered include: how different neural circuits analyze sensory information, form perceptions of the external world, make decisions, and execute movements; how nerve cells behave when connected together to form neural networks; the relationship between molecular and cellular approaches to understanding brain structure and function; the study of high-level mental functions; and studying brain pathologies and diseases with Systems Neuroscience. A hierarchy of biological complexity arises from the genome, transcriptome, proteome, organelles, cells, synapses, circuits, brain regions, the whole brain, and behaviour. The best way to study the brain, the most complex organ in the body composed of 100 billion cells with trillions of interconnections, is with a Systems Biology approach. Systems biology is an inter-disciplinary field that focuses on complex interactions within biological systems to reveal 'emergent properties' - properties of cells and groups of cells functioning as a system whose actual and theoretical description is only possible using Systems Biology techniques.

Physiology And Pharmacology of Cardio-Respiratory Control

On 15 November 1997, the first international symposium "Neural and Chemical Control of Breathing: Pharmacological and Clinical Aspects" was held at Leiden University Medical Center on the occasion of the retirement of one of the members of the Control of Breathing Research Group of the Departments of Physiology and Anesthesiology, Dr. Aad Berkenbosch. Among others, Dr. Berkenbosch, played an important role in this research group, which made a large and significant contribution to scientific research on the regulation of breathing. This book presents the proceedings of that meeting together with papers of several authors who have strong bonds with the Leiden Departments of Physiology and Anesthesiology. All studies represent state of the art work on the subject of respiratory control and cardiovascular medicine, with emphasis on the physiological, pharmacological and anesthesiological aspects of both fields. The book is divided in several sections: Oxygen Physiology. Prof. John Severinghaus presents among other things his ideas on oxygen sensing and high altitude related diseases. Prof. Honda gives results from studies in a unique set of subjects without carotid bodies. The findings of Honda's group support the idea that an intact hypoxic drive from the carotid bodies is necessary for the generation of central hypoxic depression. Dr. Hans van Beek discusses the effects of hypoxia and hypercapnia on cardiac contractility in animal models. Prof. Oeseburg demonstrates the feasibility of Near Infra Red Oximetry for monitoring tissue oxygenation in patients. Central Chemoreception.

Dates in Ophthalmology

The development of ophthalmology to its present level of sophisticated practice is an extraordinary story of research, experiment, and achievement. Dates in Ophthalmology: A Chronological Record of Progress in Ophthalmology over the Last Millennium charts the progress of that achievement over the last millennium, highlighting and describing the key dates of advancement. It presents a concise listing of the chief personages, periods, publications, and events in the history of ophthalmology from ancient times to the present.The book demonstrates how ideas, discoveries, and technologies cross borders and oceans. It illustrates the interplay of subspecialties, the changing pre-eminence of countries and cities, and the explosions of creativity and generations of dormancy in various areas. The author highlights the numerous and diverse events and people responsible for shaping this specialty.There are many ways of looking at history: from the standpoint of the lives of major figures, of society and impact, of subspecialties, of countries, of institutions, and of books. By presenting its information chronologically, Dates in Ophthalmology explores the how these areas intersect, influence, and impact each other.

Dates in Ophthalmology

The development of ophthalmology to its present level of sophisticated practice is an extraordinary story of research, experiment, and achievement. Dates in Ophthalmology: A Chronological Record of Progress in Ophthalmology over the Last Millennium charts the progress of that achievement over the last millennium, highlighting and describing the key dates of advancement. It presents a concise listing of the chief personages, periods, publications, and events in the history of ophthalmology from ancient times to the present.The book demonstrates how ideas, discoveries, and technologies cross borders and oceans. It illustrates the interplay of subspecialties, the changing pre-eminence of countries and cities, and the explosions of creativity and generations of dormancy in various areas. The author highlights the numerous and diverse events and people responsible for shaping this specialty.There are many ways of looking at history: from the standpoint of the lives of major figures, of society and impact, of subspecialties, of countries, of institutions, and of books. By presenting its information chronologically, Dates in Ophthalmology explores the how these areas intersect, influence, and impact each other.

Clinical Atlas of Procedures in Ophthalmic and Oculofacial Surgery (Oxford Atlases in Ophthalmology)

The second edition of Clinical Atlas of Procedures in Ophthalmic and Oculofacial Surgery provides an overview of a broad range of contemporary, well-established, and accepted ophthalmic surgical procedures with clear illustrations of surgical fundamentals that cover key intraoperative and postoperative points. This new edition of the Atlas includes streamlined, more uniform chapters, bookended by detailed and instructive tables of indications and complications. More than 2,500 detailed, professionally-rendered line drawings and full-color photographs supplement succinct information on surgical procedures. The high-quality illustrations and images are laid out in a fluid design to help the reader quickly pinpoint the fundamentals of each procedure. With innovations and techniques frequently evolving ophthalmic surgery, the second edition of Clinical Atlas of Procedures in Ophthalmic and Oculofacial Surgery provides the clear and comprehensive platform needed to navigate the fast-moving field of surgical ophthalmology, and will surely continue to prove useful to the trainee, the ophthalmologist, the teacher, and, most importantly, to the patients whom they ultimately serve.

Ocular Oncology

Survival rates in cases of uveal melanoma and retinoblastoma - the leading intraocular malignancies in adults and children - may be high, but means of earlier diagnosis and improved treatment options are needed to preserve vision and prevent metastasis. This reference deals principally with the molecular biology and genetic factors which trigger an

The Major Histocompatibility System in Man and Animals