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Thymus Gland Pathology: Clinical, Diagnostic and Therapeutic Features

The thymus is a gland that over the last two centuries has generated great awareness not only from the anatomical perspective but also for the physiological and pat- logical roles it plays in many disease processes. Prior to the early studies on its th anatomy and physiology in the 18 century, the thymus was believed to perform - usual and curious functions such as purification of the nervous system, providing a protective cushion for the vasculature of the superior mediastinum, fetal nouri- ment, or more spiritual roles such as being the seat of the soul, among others. D- th ing the 19 century important anatomical/physiological studies took place focusing on the role of the thymus in pathological conditions. However, it was not until the th middle of the 19 century that a more comprehensive analysis of the role of the thymic gland and its role in pathogenesis began to emerge. Currently, while the knowledge gained on the diverse aspects of the thymic gland has furthered our understanding of its role in a gamut of processes, more knowledge is still being sought, and by no means is a full understanding of the gland’s physi- ogy and pathology complete. Different aspects, including its purported endocrine function, its association with other autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and lupus erythematosus, among others, are under evaluation and research.

The Thymus Gland: Diagnosis and Surgical Management

This book, written by selected experts who outline the surgical procedure, provides an up-to-date and concise review of the thymus gland for both the surgeon and the physician. The critical role of the thymus in the immune system is becoming increasingly well understood. Much of this knowledge is widely dispersed throughout the literature. Although thymectomy is well established as a surgical procedure, these advances need to be made available to the surgeon. This book offers neurologists and physicians a better understanding of the surgical aspects of the thymus.

The Thymus: Diagnostic Imaging, Functions, and Pathologic Anatomy (Medical Radiology)

Until the middle of the present century, the morphology and function of the thymus were primarily of interest to those working in the fields of pathologic anatomy, endo­ crinology, and pediatrics. However, during recent decades careful and refined histo­ logic studies of the organ have expanded our knowledge. It now seems certain that the thymus plays a central role in the immune system, and some of the substances pro­ duced by this organ are considered together under the collective term of "thymic hor­ mones". In clinical medicine (in particular endocrinology and pediatrics, as well as surgery and radiologic oncology), the startling advances that have taken place in radiologic diagnostics with the advent of new imaging procedures such as computed tomography and magnetic resonance imaging have provided fresh impetus in the search for effec­ tive treatments for hyperplasia, tumors, and tumor-like changes of the thymus. Normal variants of the thymus, which lies concealed within the anterior superior mediastinum, have been recorded, and pathologic changes such as primary or secondary tumors can now be analyzed and correctly diagnosed.

The Thymus: Its Role in Immune Responses, Leukaemia Development and Carcinogenesis (Recent Results in Cancer Research #5)

The sudden burst of interest in the thymus during the last five years more than justifies the appearance of a monograph on those aspects of its function which bear particularly on immunity and the processes associated with the development of malignant disease. Of those who are actively working in the field I believe that Dr. DONALD METCALF is uniquely suited to produce such a work. His demonstration of a lymphocytosis stimulating factor from thymic tissue in 1956 was almost the first evidence of physiological activity by the thymus. He has played an important part in the analysis of the leukaemogenic process in mice and his recent work on thymic grafting has been almost disconcertingly productive of new ideas. I feel confident that this monograph will be of great value to a wide range of investigators and teachers interested in obtaining a clear summary of the present posi­ tion. Incidentally, Dr. METCALF has provided a well chosen sample of factual material from which others who may wish to question some of his speculations, can draw their own conclusions. He has been careful to keep the observational and experimental facts clearly distinct from theoretical matters but has not shirked from making his con­ tribution to the current ferment of immunological theory.

The Thymus: Experimental and Clinical Studies (Novartis Foundation Symposia #971)

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Thymic Development and Selection of T Lymphocytes (Current Topics in Microbiology and Immunology #373)

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Thumbnail Sketch of Theatre Nursing

The Thumb: A Guide to Surgical Management

In this book, globally renowned orthopedic, plastic, and hand surgeons provide the knowledge required in order to understand and resolve the full range of problems associated with diseases, anomalies, deformities, and trauma of the thumb. The opening section describes the history of “making a thumb” and covers the fundamentals of anatomy, embryology, and functional dynamics. After careful presentation of the surgical procedures for various developmental anomalies of the thumb, subsequent sections focus on the treatment of bone and joint, tendon, and nerve problems encountered in patients with different diseases and injuries. All aspects of the surgical management of benign and malignant tumors of the thumb are then described. The final section is devoted to current and emerging treatments for trauma, including amputation and microsurgical and non-microsurgical reconstruction. The text is supported by superb clinical photographs as well as high-quality schematic drawings and video clips. The book will be of value not only to practicing surgeons but also to residents and medical students.

Thuisloosheid bij jongeren en volwassenen (Werken in SPH)

Dit cahier gaat over jonge en volwassen thuislozen. De auteurs bespreken wie deze thuislozen zijn en hoe ze in die situatie zijn terechtgekomen. In de afgelopen decennia zijn allerlei voorzieningen voor thuislozen geïnitieerd. De huidige trend is om het gefragmentariseerde aanbod meer op elkaar af te stemmen en organisatorisch onder één noemer te brengen. Tegelijkertijd zijn er veranderingen aan de gang in de methodieken voor jongeren en volwassenen. Deze veranderingen zijn onder meer terug te vinden in de opleidingen voor hulpverleners en in de professionalisering van de zorg. Dit cahier biedt een beknopt overzicht van de stand van zaken.

The Thrust Plate Hip Prosthesis

As is probably the case with all successful innovations, the unique design of the thrust plate prosthesis (TPP) was not born of a sudden fancy for a radically different hip joint replacement, but emerged from elaborate biomechanical investigations on the loosening of conventional, intramedullarly anchored hip prosthesis shafts. In the 1970s, hip revisions due to loosening of the prostheses became a burden to patients not only physically and psychologically but also economically. This meant that it also became a matter of daily concern to the orthopaedic surgeon, who then had to cope with new, previously unknown problems. Loosening processes were de­ tected within 5 years of implantation in up to 25% of cases. While implant loosenings were considered to be the result of incorrect handling of materials, we felt that a number of details still had to be considered in regard to the behavior of the entire bone-prosthesis complex and the action of mechanical forces.

Through the Valley of Shadows: Living Wills, Intensive Care, and Making Medicine Human

Hospital intensive care units have changed when and how we die--and not always for the better. The ICU is a new world, one in which once-fatal diseases can be cured and medical treatments greatly enhance our chances of full recovery. But, paradoxically, these places of physical healing can exact a terrible toll, and by focusing on technology rather than humanity, they too often rob the dying of their dignity. By some accounts, the expensive medical treatments provided in ICUs also threaten to bankrupt the nation. In an attempt to give patients a voice in the ICU when they might not otherwise have one, the living will was introduced in 1969, in response to several notorious cases. These documents were meant to keep physicians from ignoring patients' and families' wishes in stressful situations. Unfortunately, despite their aspirations, living wills contain static statements about hypothetical preferences that rarely apply in practice. And they created a process that isn't faithful to who we are as human beings. Further confusing difficult and painful situations, living wills leave patients with the impression that actual communication with their physicians has taken place, when in fact their deepest desires and values remain unaddressed. In this provocative and empathetic book, medical researcher and ICU physician Samuel Morris Brown uses stories from his clinical practice to outline a new way of thinking about life-threatening illness. Brown's approach acknowledges the conflicting emotions we have when talking about the possibility of death and proposes strategies by which patients, their families, and medical practitioners can better address human needs before, during, and after serious illness. Arguing that any solution to the problems of the inhumanity of intensive care must take advantage of new research on the ways human beings process information and make choices, Brown imagines a truly humane ICU. His manifesto for reform advocates wholeness and healing for people facing life-threatening illness.

Through the Valley of Shadows: Living Wills, Intensive Care, and Making Medicine Human

Hospital intensive care units have changed when and how we die--and not always for the better. The ICU is a new world, one in which once-fatal diseases can be cured and medical treatments greatly enhance our chances of full recovery. But, paradoxically, these places of physical healing can exact a terrible toll, and by focusing on technology rather than humanity, they too often rob the dying of their dignity. By some accounts, the expensive medical treatments provided in ICUs also threaten to bankrupt the nation. In an attempt to give patients a voice in the ICU when they might not otherwise have one, the living will was introduced in 1969, in response to several notorious cases. These documents were meant to keep physicians from ignoring patients' and families' wishes in stressful situations. Unfortunately, despite their aspirations, living wills contain static statements about hypothetical preferences that rarely apply in practice. And they created a process that isn't faithful to who we are as human beings. Further confusing difficult and painful situations, living wills leave patients with the impression that actual communication with their physicians has taken place, when in fact their deepest desires and values remain unaddressed. In this provocative and empathetic book, medical researcher and ICU physician Samuel Morris Brown uses stories from his clinical practice to outline a new way of thinking about life-threatening illness. Brown's approach acknowledges the conflicting emotions we have when talking about the possibility of death and proposes strategies by which patients, their families, and medical practitioners can better address human needs before, during, and after serious illness. Arguing that any solution to the problems of the inhumanity of intensive care must take advantage of new research on the ways human beings process information and make choices, Brown imagines a truly humane ICU. His manifesto for reform advocates wholeness and healing for people facing life-threatening illness.

Through the Seasons: Activities for Memory-Challenged Adults and Their Caregivers (Second Edition)

Dementia and related disorders impact the lives of those affected in countless ways, making it difficult to remain independent at work, at home, and in the wider world. But recent studies have shown that structured activities can make a significant, positive difference by stimulating mental engagement while improving interactions between caregivers and memory-challenged adults. Fun and easy to use, this large-format, full-color picture book is divided into themes representing the four seasons. Each section describes several multisensory experiences―such as walking on the beach, making ice cream, or planting flowers―along with related topics for discussion and activities to elicit memories and encourage new positive associations. The topics and activities incorporate all five senses to facilitate connections and conversations. The book adopts a compassionate, person-centered approach and is designed so that two people can easily look together while sitting side by side.

Through Her Eyes: A New History of Ireland in 21 Women

Told through the prism of the lives of 21 extraordinary women, this remarkable book offers an alternative vision of Irish history – one that puts the spotlight on women whose contributions have been forgotten or overlooked.Author Clodagh Finn travels through the ages to ‘meet’, among others, Macha, the Celtic horse goddess of Ulster; St Dahalin, an early Irish saint and miracle worker; Jo Hiffernan, painter and muse to the artists Whistler and Courbet; Jennie Hodgers, a woman who fought as a male soldier in the American Civil War; Sr Concepta Lynch, businesswoman, Dominican sister and painter of a unique Celtic shrine; the Overend sisters, farmers, charity workers and motoring enthusiasts; and Rosemary Gibb, athlete, social worker, clown and accomplished magician.From a Stone Age farmer who lived in Co. Clare more than 5,000 years ago to the modern-day founder of a 3D printing company, this book opens a fascinating window onto the life and times of some amazing women whose stories were shaped by the centuries in which they lived.

Thrombus and Stroke

Providing a clear foundation as to what a clot is, how it forms, and the most recent approaches to treatment, Thrombus and Stroke is an all-inclusive resource covering:The fundamental science of clot formation and the pharmacokinetics of thrombolysis The clinical impact of thrombus as it pertains to stroke and the most recent clinical and minimally

Thrombozytenszintigraphie bei zerebrovaskulären Erkrankungen: Methodik · Ergebnisse · Indikationen

Thrombozytenfunktion bei neurologischen Erkrankungen: Laborchemische und klinische Untersuchungen

The Thrombotic Process in Atherogenesis (Advances in Experimental Medicine and Biology #104)

Two infonnal meetings of consultants expert in hemostatic phenomena and in atherogenesis were held in Bethesda, Maryland, in December 1975 and February 1976 by the National Heart, Lung, and Blood Institute. Their purpose was to discuss the current status of knowledge concerning the thrombotic process in the pathogenesis of atherosclerosis. It was readily agreed that thrombosis often played a major role in plaque building and in plaque complication. It was also commented, however, that the data were qualitative in nature and that quantitative infonnation was remarkably sparse. The term thromboatherogenesis was thought to be appropriate for those phenomena in which the full expression of the thrombotic process is manifest. At the same time, recent research was noted in which what appears to be an important pathway for the initiation of atherogenesis arises from the reaction of platelets with injured arterial endothelium and'Subendothelium without necessarily involving the complete classical thrombotic process. A name was not coined for this circumstance, but it was held that thromboatherogenesis was not a fully appropriate one.

Thrombosis and Hemostasis in Cancer (Cancer Treatment and Research #179)

In this book, leaders in the field explore our current understanding of thrombosis and hemostasis in cancer and address key questions on the subject. Among the topics discussed are the mechanisms that cancers use to activate the coagulation system, and those by means of which an activated coagulation system can lead to more aggressive cancer growth. Clinical chapters examine the role of thrombosis prophylaxis and treatment, central line-associated thrombosis, and cancer-associated hemorrhage. Subsequent chapters deal with the management of chemotherapy-induced thrombocytopenia, anticoagulation in the presence of brain metastases, and other unique challenges in the interaction of thrombosis and hemostasis in cancer. It has been 150 years since Armand Trousseau first described the well-known association between cancer and an increased risk of thrombosis, which may be considered the first paraneoplastic syndrome ever identified. More recently, numerous studies have indicated that activation of the coagulation system by cancer not only increases the likelihood of thrombosis, but is also associated with a more aggressive cancer phenotype. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists and clinicians alike.

Thrombosis and Embolism: Volume 1 (Advances in Experimental Medicine and Biology #906)

This unique publication explores diverse themes relating to thrombosis and embolism, from basic research at cell and molecular level to the actual care, prevention, and treatment of diverse categories of patients suffering from such diseases. Chapters cover a variety of topics including thrombosis and embolism in surgical patients, cancer patients, pregnant women and children and adolescents, as well as treatment of the conditions by traditional anticoagulants, novel oral anticoagulants, thrombolytic therapy, endovascular treatment and embolectomy. Readers may explore cutting edge research, recommendations from major societies, contemporary guidelines, areas of controversy and directions for ongoing and future research.The book features comprehensive information ranging from molecular mechanisms of diseases to the clinical features, diagnosis, and therapeutic regimens for treating a variety of clinical conditions. It has a broad appeal to scientists and research students as well as busy clinicians engaged in patient care, who will all find something important and useful amongst these carefully selected chapters.

Thrombosis and Cardiovascular Diseases (Advances in Experimental Medicine and Biology #164)

Four years ago when the first European Symposium on the re­ lationship between alterations of blood clotting mechanisms and atherosclerosis was organized, we asked ourselves which would be the best way to obtain both scientific and practical contributions. We have been interested in cardiovascular diseases for several years now and have therefore focused our attention on the "container" (Le. the blood vessel) rather than on the "contents" (Le. the various components of blood) as considered only from a haemodynamic point of view. In recent years correlations were found between alterations of vascular wall and alteration of coagulative, fibrinolytic, and plate­ let factors as well as of haemorheological phenomena in the thrombo­ genic evolution of atherosclerotic lesions. A close cooperation between cardiologists and workers interested in atherosclerosis and thrombosis is therefore necessary. We think that the most appropriate approach to the various problems concerning correlations between thrombogenic and atherosclerotic lesions is co-operation between experts in these different fields of research. We thus decided to organize the 2nd Symposium taking into account the great progress achieved in this field during the past few years, and hope that discussions on diagnostic and therapeutical perspec'­ tives will yield useful elements both for the cardiologist and for the cardiologist and for the general practitioner.

Thrombosis and Cancer

It is common knowledge that thromboembolic disease is often the earliest manifestation and almost the most frequent complication of cancer. Recent studies have investigated the mechanisms by which cancer causes thrombosis and have emphasized the importance of the coagulation system in angiogenesis and tumor metastasis. Thrombosis and Cancer offers

Thrombosis and Cancer

It is common knowledge that thromboembolic disease is often the earliest manifestation and almost the most frequent complication of cancer. Recent studies have investigated the mechanisms by which cancer causes thrombosis and have emphasized the importance of the coagulation system in angiogenesis and tumor metastasis. Thrombosis and Cancer offers

Thrombosis: Animal and Clinical Models (Advances in Experimental Medicine and Biology #102)

Thromboseprophylaxe Klinische und ökonomische Effekte von Prophylaxestrümpfen

Mehr als 80.000 Menschen erkranken jedes Jahr in Deutschland an einer tiefen Venenthrombose und 25.000 bis 40.000 Patienten versterben an den Folgen einer Lungenembolie. Wie sieht aber eine effektive Thromboseprophylaxe aus, die für die Anwendung im klinischen Alltag empfohlen werden kann und welche Thromboseprophylaxestrümpfe sollten angewendet werden? Der vorliegende Band beleuchtet die erheblichen Qualitätsunterschiede unter klinischen, ökonomischen und rechtlichen Aspekten.