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Three Shots at Prevention: The HPV Vaccine and the Politics of Medicine's Simple Solutions

In 2007, Texas governor Rick Perry issued an executive order requiring that all females entering sixth grade be vaccinated against the human papillomavirus (HPV), igniting national debate that echoed arguments heard across the globe over public policy, sexual health, and the politics of vaccination. Three Shots at Prevention explores the contentious disputes surrounding the controversial vaccine intended to protect against HPV, the most common sexually transmitted infection. When the HPV vaccine first came to the market in 2006, religious conservatives decried the government's approval of the vaccine as implicitly sanctioning teen sex and encouraging promiscuity while advocates applauded its potential to prevent 4,000 cervical cancer deaths in the United States each year. Families worried that laws requiring vaccination reached too far into their private lives. Public health officials wrestled with concerns over whether the drug was too new to be required and whether opposition to it could endanger support for other, widely accepted vaccinations. Many people questioned the aggressive marketing campaigns of the vaccine's creator, Merck & Co. And, since HPV causes cancers of the cervix, vulva, vagina, penis, and anus, why was the vaccine recommended only for females? What did this reveal about gender and sexual politics in the United States? With hundreds of thousands of HPV-related cancer deaths worldwide, how did similar national debates in Europe and the developing world shape the global possibilities of cancer prevention?This volume provides insight into the deep moral, ethical, and scientific questions that must be addressed when sexual and social politics confront public health initiatives in the United States and around the world.

The Three-Pound Enigma: The Human Brain and the Quest to Unlock Its Mysteries

The average human brain weighs three pounds—80 percent of which is water—and yet it's capable of outstripping the computational and storage capacities of the most complex computer. But how the mind works remains one of humankind's greatest mysteries. With boundless curiosity and enthusiasm, Shannon Moffett, a Stanford medical student, takes us down the halls of neuroscience to the front lines of cutting-edge research and medicine to meet some of today's most extraordinary scientists and thinkers, all grappling with provocative questions: Why do we dream? How does memory work? How do we see? What happens when we think? Each chapter delves into a different aspect of the brain, following the experts as they chart new ground. Moffett takes us to a lab where fMRI scans reveal the multitude of stimuli that our brains unconsciously take in; inside an operating room where a neurosurgeon removes a bullet from a patient's skull; to the lab of Christof Koch, a neuroscientist tracking individual neurons in order to crack the code of consciousness; and to a research lab where scientists are investigating the relationship between dreams and waking life. She also takes us beyond the scientific world—to a Zen monk's zendo, where she explores the effects of meditation on the brain; inside the home of a woman suffering from dissociative identity disorder; to a conference with the philosopher Daniel Dennett, who uses illusions, magic, tricks, and logic to challenge our assumptions about the mind; and to the home of the late Nobel Laureate Francis Crick, co-discoverer with James Watson of DNA's double-helix structure. Filled with fascinating case studies and featuring a timeline that tracks the development of the brain from conception to death, The Three Pound Enigma is a remarkable exploration of what it means to be human.

Three Patients: International Perspective on Intensive Care at the End of Life

This volume explores how the scarce resources of intensive care units should be distributed. Three hypothetical patients, each with a different chance of survival, desire intensive care. A multinational panel of experienced critical care physicians offers assessments of the patients' conditions and outlines approaches to treatment. These approaches are then examined by academic medical experts and a medical ethicist, as well as from a legal perspective. The result is a well-rounded and introspective look at care for critically ill patients at or near the end of life.

Three Letter Plague: A Young Man’s Journey Through a Great Epidemic

At the end of a steep gravel road in one of the remotest corners of South Africa's Eastern Cape lies the village of Ithanga. Home to a few hundred villagers, the majority of them unemployed, it is inconceivably poor. It is to here that award-winning author Jonny Steinberg travels to explore the lives of a community caught up in a battle to survive the ravages of the greatest plague of our times, the African AIDS epidemic. He befriends Sizwe, a young local man who refuses to be tested for AIDS despite the existence of a well-run testing and anti-retroviral programme. It is Sizwe's deep ambivalence, rooted in his deep sense of the cultural divide, that becomes the key to understanding the dynamics that thread their way through a terrified community. As Steinberg grapples to get closer to finding answers that remain just out of reach, he realizes that he must look within himself to unlock the paradoxes at the heart of his country.

Three-Letter Plague: A Young Man's Journey Through A Great Epidemic

At the age of 29, Sizwe Magadia is among the most handsome, well-educated, and richest of the men in his poverty-striken village in rural Transkei. Dr Hermann Reuter, a son of old South West African stock, wants to prove to the world that if you provide decent treatment, people will come and get it, no matter their circumstances. Already, Sizwe has watched several neighbours grow ill and die, yet he remains reluctant to establish his own HIV status. When Hermann establishes an antiretroviral treatment programme in Sizwe's village, these figures from two different worlds collide - one afraid that people will turn their backs on medical care, the other fearful of the advent of a world in which respect for traditional ways has been lost and privacy has been obliterated. The resulting antagonism mirrors a continent-wide battle against an epidemic that has corrupted souls as much as bodies. In this eye-opening, compassionate, searing and beautifully written account, Steinberg seeks to understand the AIDS crisis in South Africa. As he grapples to get closer to answers that remain maddeningly just out of reach, he realises that he must look within to unravel some of the enigma surronding the greatest African disaster of our times.

Three Generations, No Imbeciles: Eugenics, the Supreme Court, and <I>Buck v. Bell</I>

"Three generations of imbeciles are enough." Few lines from Supreme Court opinions are as memorable as this declaration by Justice Oliver Wendell Holmes Jr. in the landmark 1927 case Buck v. Bell. The ruling allowed states to forcibly sterilize residents in order to prevent "feebleminded and socially inadequate" people from having children. It is the only time the Supreme Court endorsed surgery as a tool of government policy. Paul Lombardo’s startling narrative exposes the Buck case’s fraudulent roots.In 1924 Carrie Buck—involuntarily institutionalized by the State of Virginia after she was raped and impregnated—challenged the state’s plan to sterilize her. Having already judged her mother and daughter mentally deficient, Virginia wanted to make Buck the first person sterilized under a new law designed to prevent hereditarily "defective" people from reproducing. Lombardo’s more than twenty-five years of research and his own interview with Buck before she died demonstrate conclusively that she was destined to lose the case before it had even begun. Neither Carrie Buck nor her mother and daughter were the "imbeciles" condemned in the Holmes opinion. Her lawyer—a founder of the institution where she was held—never challenged Virginia’s arguments and called no witnesses on Buck’s behalf. And judges who heard her case, from state courts up to the U.S. Supreme Court, sympathized with the eugenics movement. Virginia had Carrie Buck sterilized shortly after the 1927 decision.Though Buck set the stage for more than sixty thousand involuntary sterilizations in the United States and was cited at the Nuremberg trials in defense of Nazi sterilization experiments, it has never been overturned. Three Generations, No Imbeciles tracks the notorious case through its history, revealing that it remains a potent symbol of government control of reproduction and a troubling precedent for the human genome era.

Three Generations, No Imbeciles: Eugenics, the Supreme Court, and Buck v. Bell

This updated edition includes a new afterword that identifies the role the Buck story plays in the Supreme Court's review of emerging state laws that seek to limit access to abortion."Three generations of imbeciles are enough." Few lines from U.S. Supreme Court opinions are as memorable as this declaration by Justice Oliver Wendell Holmes Jr. in the landmark 1927 case Buck v. Bell. The ruling allowed states to forcibly sterilize residents in order to prevent "feebleminded and socially inadequate" people from having children. It is the only time the Supreme Court endorsed surgery as a tool of government policy. Though Buck set the stage for more than sixty thousand involuntary sterilizations in the United States and was cited at the Nuremberg trials in defense of Nazi sterilization experiments, it has never been overturned. It has been more than a decade since Paul A. Lombardo's classic Three Generations, No Imbeciles first exposed the Buck case's fraudulent roots. During that time, several of the remaining twentieth-century eugenic sterilization statutes have finally been repealed, and reparations to sterilization survivors have been paid in two states. Discussion of the Buck case has once again engendered controversy in the courts. The Wisconsin Supreme Court invoked Buck most recently in a debate over the power of the state to enact restrictions on citizens and businesses during the COVID-19 crisis, and the US Supreme Court cited Three Generations, No Imbeciles in arguments over the newest state laws seeking to limit access to abortion. This updated edition collects and analyzes information related to events and trends discussed in the earlier volume and includes a completely new afterword, "Looking Back at Buck," that explains how the case remains a key feature of public discourse about disability, government power, and reproductive rights. It also presents restored copies of the letters of Carrie Buck and points readers to an online archive of legal documents, images, and other material relevant to the case. The book remains a key resource for law school faculties, legal and medical historians, and anyone with an interest in the history of reproduction in the United States."Startling."—Reason"Compelling and well-researched... Three Generations, No Imbeciles gives Carrie Buck's long-untold story the attention it deserves."—Harvard Law Review"Three Generations provides valuable, new, and timely revelations for students and professional scholars across many disciplines."—Disability Studies Quarterly"For almost 30 years, Lombardo has tried to uncover the full story of the wrongs."—USA Today"Meticulously detailed and researched history... this book is enjoyable, thought provoking, and troubling in equal measure. I highly recommend it."—Psychiatric Services

Three Generations, No Imbeciles: Eugenics, the Supreme Court, and Buck v. Bell

This updated edition includes a new afterword that identifies the role the Buck story plays in the Supreme Court's review of emerging state laws that seek to limit access to abortion."Three generations of imbeciles are enough." Few lines from U.S. Supreme Court opinions are as memorable as this declaration by Justice Oliver Wendell Holmes Jr. in the landmark 1927 case Buck v. Bell. The ruling allowed states to forcibly sterilize residents in order to prevent "feebleminded and socially inadequate" people from having children. It is the only time the Supreme Court endorsed surgery as a tool of government policy. Though Buck set the stage for more than sixty thousand involuntary sterilizations in the United States and was cited at the Nuremberg trials in defense of Nazi sterilization experiments, it has never been overturned. It has been more than a decade since Paul A. Lombardo's classic Three Generations, No Imbeciles first exposed the Buck case's fraudulent roots. During that time, several of the remaining twentieth-century eugenic sterilization statutes have finally been repealed, and reparations to sterilization survivors have been paid in two states. Discussion of the Buck case has once again engendered controversy in the courts. The Wisconsin Supreme Court invoked Buck most recently in a debate over the power of the state to enact restrictions on citizens and businesses during the COVID-19 crisis, and the US Supreme Court cited Three Generations, No Imbeciles in arguments over the newest state laws seeking to limit access to abortion. This updated edition collects and analyzes information related to events and trends discussed in the earlier volume and includes a completely new afterword, "Looking Back at Buck," that explains how the case remains a key feature of public discourse about disability, government power, and reproductive rights. It also presents restored copies of the letters of Carrie Buck and points readers to an online archive of legal documents, images, and other material relevant to the case. The book remains a key resource for law school faculties, legal and medical historians, and anyone with an interest in the history of reproduction in the United States."Startling."—Reason"Compelling and well-researched... Three Generations, No Imbeciles gives Carrie Buck's long-untold story the attention it deserves."—Harvard Law Review"Three Generations provides valuable, new, and timely revelations for students and professional scholars across many disciplines."—Disability Studies Quarterly"For almost 30 years, Lombardo has tried to uncover the full story of the wrongs."—USA Today"Meticulously detailed and researched history... this book is enjoyable, thought provoking, and troubling in equal measure. I highly recommend it."—Psychiatric Services

Three-dimensional Kinematics of the Eye, Head and Limb Movements

The 19th-century pioneers of motor physiology — Helmholtz, Hering, Fick and others — used the mathematics of motion, known as kinematics, to describe the laws of human movement and to deduce the neural control principles underlying these laws. After long neglect — partly due to limitations in stimulation and recording techniques — the kinematic approach is now resurging, fortified with modern computers and electrophysiology. New developments in recording techniques, as well as an improved understanding of the complex control properties of three-dimensional movements, have led to a flood of new research in this area. The classical laws of Donders and Listing have been confirmed and generalized, and computer simulations of the neural control of three-dimensional movement have been developed and tested. In this book, some of the world's leading scientists of motor control discuss how the brain represents and transforms the kinematic variables of movement. Background chapters explain the basic concepts — non-commutativity, redundancy and the classical laws — and their application to normal function and motor disorders, and shorter articles describe current research. The contributions are based on presentations at a symposium held in Tubingen in August 1995. The wide scope of the book should enable researchers to gain an overview of current research, but should also help newcomers to the field to get a good understanding of the questions and problems involved in three-dimensional movement control.

Three-dimensional Kinematics of the Eye, Head and Limb Movements

The 19th-century pioneers of motor physiology — Helmholtz, Hering, Fick and others — used the mathematics of motion, known as kinematics, to describe the laws of human movement and to deduce the neural control principles underlying these laws. After long neglect — partly due to limitations in stimulation and recording techniques — the kinematic approach is now resurging, fortified with modern computers and electrophysiology. New developments in recording techniques, as well as an improved understanding of the complex control properties of three-dimensional movements, have led to a flood of new research in this area. The classical laws of Donders and Listing have been confirmed and generalized, and computer simulations of the neural control of three-dimensional movement have been developed and tested. In this book, some of the world's leading scientists of motor control discuss how the brain represents and transforms the kinematic variables of movement. Background chapters explain the basic concepts — non-commutativity, redundancy and the classical laws — and their application to normal function and motor disorders, and shorter articles describe current research. The contributions are based on presentations at a symposium held in Tubingen in August 1995. The wide scope of the book should enable researchers to gain an overview of current research, but should also help newcomers to the field to get a good understanding of the questions and problems involved in three-dimensional movement control.

Three-Dimensional Imaging for Orthodontics and Maxillofacial Surgery

Three Dimensional Imaging for Orthodontics and Maxillofacial Surgery is a major new specialist resource that identifies and applies the principles of three dimensional imaging to orthodontic practice. Readers are introduced to three-dimensional imaging, comparing it with the traditional two-dimensional assessments and exploring the benefits and drawbacks of these imaging modalities. Three Dimensional Imaging for Orthodontics and Maxillofacial Surgery centers on the appropriate application of three-dimensional imaging in the various practices related to orthodontic delivery and craniofacial surgery. The book guides the reader through detailed and illustrated examples of three-dimensional patient management in the context of daily practice. Both three-dimensional static and motion analyses are explored. The book also addresses growth, orthodontic treatment and surgical prediction, both static and dynamic and explores the use of morphing and finite element analyses with particular focus on surgical intervention. A key resource for specialist working in the fields of orthodontics and cranio-maxillofacial surgery. KEY FEATURES · Applies principles of 3D imaging to orthodontic practice · Surveys and analyzes current technologies and modalities, relating them to clinical usage · Companion website with motion images ( www.wiley.com/go/kau) · Richly illustrated in full color throughout · Brings together expert contributors for an international perspective

Three-Dimensional Imaging for Orthodontics and Maxillofacial Surgery

Three Dimensional Imaging for Orthodontics and Maxillofacial Surgery is a major new specialist resource that identifies and applies the principles of three dimensional imaging to orthodontic practice. Readers are introduced to three-dimensional imaging, comparing it with the traditional two-dimensional assessments and exploring the benefits and drawbacks of these imaging modalities. Three Dimensional Imaging for Orthodontics and Maxillofacial Surgery centers on the appropriate application of three-dimensional imaging in the various practices related to orthodontic delivery and craniofacial surgery. The book guides the reader through detailed and illustrated examples of three-dimensional patient management in the context of daily practice. Both three-dimensional static and motion analyses are explored. The book also addresses growth, orthodontic treatment and surgical prediction, both static and dynamic and explores the use of morphing and finite element analyses with particular focus on surgical intervention. A key resource for specialist working in the fields of orthodontics and cranio-maxillofacial surgery. KEY FEATURES · Applies principles of 3D imaging to orthodontic practice · Surveys and analyzes current technologies and modalities, relating them to clinical usage · Companion website with motion images ( www.wiley.com/go/kau) · Richly illustrated in full color throughout · Brings together expert contributors for an international perspective

Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine (Computational Imaging and Vision #4)

This book contains a selection of communications presented at the Third International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, held 4-6 July 1995 at Domaine d' Aix-Marlioz, Aix-Ies-Bains, France. This nice resort provided an inspiring environment to hold discussions and presentations on new and developing issues. Roentgen discovered X-ray radiation in 1895 and Becquerel found natural radioactivity in 1896 : a hundred years later, this conference was focused on the applications of such radiations to explore the human body. If the physics is now fully understood, 3D imaging techniques based on ionising radiations are still progressing. These techniques include 3D Radiology, 3D X-ray Computed Tomography (3D-CT), Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET). Radiology is dedicated to morphological imaging, using transmitted radiations from an external X-ray source, and nuclear medicine to functional imaging, using radiations emitted from an internal radioactive tracer. In both cases, new 3D tomographic systems will tend to use 2D detectors in order to improve the radiation detection efficiency. Taking a set of 2D acquisitions around the patient, 3D acquisitions are obtained. Then, fully 3D image reconstruction algorithms are required to recover the 3D image of the body from these projection measurements.

Three Dimensional Human Organotypic Models for Biomedical Research (Current Topics in Microbiology and Immunology #430)

This edited volume discusses the application of very diverse human organotypic models in major areas of biomedical research. The authors lay a main focus on infectious diseases, cancer, allergies, as well as drug/vaccine discovery and toxicology studies. Representing a valid alternative to laboratory animals, these models are relevant for most areas of translational research. As the contemporary research shows, many human tissues can today be cultivated in vitro and used for several research objectives. This book provides an unprecedented overview of recent developments in an exciting field of research methodology. It is a reference guide for scientists in both academia and industry. Readers can update their knowledge and get hands-on recommendations on how to set up an organotypic model in their lab. Chapters 'Progress on Reconstructed Human Skin Models for Allergy Research and Identifying Contact Sensitizers' and 'Human Organotypic Models for Anti-infective Research' of this book are available open access under a CC BY 4.0 license at link.springer.com.

Three Dimensional Ethics: Implementing Workplace Values

Ethics is not just about morality; it is a complex dimension of personal and corporate life that can lead to higher performance by both business and society. Customers, employees and business partners seek predictable corporate behaviour that is aligned with stated personal, workplace and democratic values. Ethics training can help to achieve this. This business ethics primer is a valuable tool for raising ethical awareness in your organisation. Reflecting on employees' personal values and world views, it then examines their impact on the development and application of your organisation's mission, vision and values and finally, your organisation's impact on the societies and environment in which it operates. Three Dimensional Ethics: Implementing Workplace Values concludes with a unique chapter on ethics and doing business in China, illuminating roles in corporate stakeholder responsibility that align with principles in the Confucian Analects. Lagan and Moran provide a practical perspective on business ethics training that is lively, relevant and useful with insights into managing corporate values such as: Ethical frameworks Ladder of escalation options Ethical dilemmas Ethical decision making models Ethics audits Codes of ethics and Codes of conduct Vision and values models Stakeholder commitment steps Governance checklists Addressing values gaps Knowing your values The four virtues Stages of moral development Reflection and action Training tools include Australian and global case studies, definitions, tips, snapshots of ethical approaches, models, quotes, checklists, discussion panels, workshops, scenarios and exercises.

Three Dimensional Ethics: Implementing Workplace Values

Ethics is not just about morality; it is a complex dimension of personal and corporate life that can lead to higher performance by both business and society. Customers, employees and business partners seek predictable corporate behaviour that is aligned with stated personal, workplace and democratic values. Ethics training can help to achieve this. This business ethics primer is a valuable tool for raising ethical awareness in your organisation. Reflecting on employees' personal values and world views, it then examines their impact on the development and application of your organisation's mission, vision and values and finally, your organisation's impact on the societies and environment in which it operates. Three Dimensional Ethics: Implementing Workplace Values concludes with a unique chapter on ethics and doing business in China, illuminating roles in corporate stakeholder responsibility that align with principles in the Confucian Analects. Lagan and Moran provide a practical perspective on business ethics training that is lively, relevant and useful with insights into managing corporate values such as: Ethical frameworks Ladder of escalation options Ethical dilemmas Ethical decision making models Ethics audits Codes of ethics and Codes of conduct Vision and values models Stakeholder commitment steps Governance checklists Addressing values gaps Knowing your values The four virtues Stages of moral development Reflection and action Training tools include Australian and global case studies, definitions, tips, snapshots of ethical approaches, models, quotes, checklists, discussion panels, workshops, scenarios and exercises.

Three-dimensional Echocardiography

Three-dimensional echocardiography is the most recent fundamental advancement in echocardiography with a strong impact on almost all clinical and research applications of echocardiography.After a very successful 1st edition, this book presents the fully revised 2nd edition. Accounting for the marked progress of real-time 3D echocardiography since the 1st edition it covers all clinically important aspects of this fascinating new technology, including a comprehensive explanation of its basic principles, practical aspects of clinical application, new recommendations in recent guidelines and detailed descriptions of specific uses in the broad spectrum of clinically important heart disease.The book was written by a group of well-recognized international experts in the field, who have not only been involved in scientific and clinical evolution of 3D echocardiography since its beginnings but are also intensely involved in expert training courses. As a result, the clear focus of this book is on the practical application of 3D echocardiography in daily clinical routine with tips and tricks for both beginners and experts, all accompanied by more than 150 case examples comprehensively illustrated with more than 850 images and more than 500 videos available on a DVD.In concert with an in-depth review and comprehensive update of the most recent literature on real-time 3D echocardiography, this book continues to represent an invaluable reference on 3D echocardiography for beginners and expert users.

Three-dimensional Echocardiography

Three-dimensional echocardiography is the most recent fundamental advancement in echocardiography. Since real-time 3D echocardiography became commercially available in 2002, it has rapidly been accepted in echo labs worldwide. This book covers all clinically relevant aspects of this fascinating new technology, including a comprehensive explanation of its basic principles, practical aspects of clinical application, and detailed descriptions of specific uses in the broad spectrum of clinically important heart disease. The book was written by a group of well-recognized international experts in the field, who have not only been involved in the scientific and clinical evolution of 3D echocardiography since its inception but are also intensively involved in expert training courses. As a result, the clear focus of this book is on the practical application of 3D echocardiography in daily clinical routine with tips and tricks for both beginners and experts, accompanied by more than 150 case examples comprehensively illustrated in more than 800 images and more than 500 videos provided on a DVD. In addition to an in-depth review of the most recent literature on real-time 3D echocardiography, this book represents an invaluable reference work for beginners and expert users of 3D echocardiography.

Three-Dimensional Cephalometry: A Color Atlas and Manual

Three Daughters, Three Journeys: Quest for Cancer Cure

Cancer threatens the lives of people around the world. Women, in particular, are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60, these inheritable cancers threaten women’s lives, health and fertility even when they are young, before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters, Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena, a Polish oncology nurse, has spent her life treating child patients with cancer. Then, she confronts it in her own family and her own body. Kamola, a rural Indian girl, knows she has symptoms of the same disease that took her mother, but feels afraid to discuss it with her father and brothers, knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra, a doctor testing a new treatment called Neelazin, using a bacterial anticancer protein in food, to destroy cancer cells. Selena, a wealthy woman of color in Chicago, finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment, Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional, the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs, as these drugs can enter both normal and cancer cells, though preferably cancer cells, causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets, thereby becoming resistant to the drugs, as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation, thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food, and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer, rather than removing the healthy tissue of the breasts and ovaries. Hopefully, they would not have to choose between fertility and survival, as is the implied message in this book, fictional as it is at this time.

Three Daughters, Three Journeys: Quest for Cancer Cure

Cancer threatens the lives of people around the world. Women, in particular, are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60, these inheritable cancers threaten women’s lives, health and fertility even when they are young, before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters, Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena, a Polish oncology nurse, has spent her life treating child patients with cancer. Then, she confronts it in her own family and her own body. Kamola, a rural Indian girl, knows she has symptoms of the same disease that took her mother, but feels afraid to discuss it with her father and brothers, knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra, a doctor testing a new treatment called Neelazin, using a bacterial anticancer protein in food, to destroy cancer cells. Selena, a wealthy woman of color in Chicago, finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment, Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional, the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs, as these drugs can enter both normal and cancer cells, though preferably cancer cells, causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets, thereby becoming resistant to the drugs, as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation, thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food, and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer, rather than removing the healthy tissue of the breasts and ovaries. Hopefully, they would not have to choose between fertility and survival, as is the implied message in this book, fictional as it is at this time.

Three-Book Edition: A Place of Greater Safety; Beyond Black; The Giant O’Brien

From the twice Man Booker Prize-winning author of Wolf Hall and Bring Up the Bodies, a collection of three novels: A Place of Greater Safety, Beyond Black and The Giant, O’Brien.

Threats to Food and Water Chain Infrastructure (NATO Science for Peace and Security Series C: Environmental Security)

vi of a large number of people due to the enormous quantities of radioactive material that would be required to reach high levels of contamination in mass-produced or distributed supplies. Although, based on data presented at the Workshop concerning the more than 30,000 missing radioactive sources all over the word, the radioactive contamination of food or water is also a scenario that must be taken seriously into consideration. During the last two decades there have been several emerging hazards linked to animal diseases or originating in animal products for example: Avian Influenza (AI), Bovine Spongiform Encephalopathy (BSE), West Nile Fever, Severe Acute Respiratory Syndrome (SARS), and Ebola virus. All these diseases or events directly or indirectly affect food security and/or food safety. Approximately 75% of all emerging diseases are zoonotic by either an association with animal populations or an evolution of the disease in a- mals making it possible to move from animal species to humans. Participants were presented the primary results of the ongoing NATO- SPS Pilot Study on “Food Chain Security”. These results focused mainly on (i) an overview of the food system; (ii) prevention, surveillance and detection systems and (iii) response system. The importance of issues such as: vuln- ability assessments, risk communication in risk analysis, risk perception, traceability, preparedness – awareness, communication, have to be cons- ered when working on food chain security.

Threat Talk: The Comparative Politics of Internet Addiction

'Threat Talk' exposes how US and Chinese scientists and policy-makers have understood and responded to the problem of internet addiction in their societies. Is the internet good or bad for society? American analysts like Lessig and Zittrain suggest that the internet is inherently liberating and positive for society, while Morozov and Sageman warn that the internet poses risks to citizens and societies. Using a comparative framework to illustrate how the two states differ in their assessments of the risks to citizens posed by the introduction of new technology, Mary Manjikian compellingly argues that both 'risk' and 'disease' are ideas which are understood differently at different historic periods and in different cultures. Her culturalist approach claims that the internet is neither inherently helpful, nor inherently threatening. Rather, its role and the dangers it poses may be understood differently by different societies. Is the internet good or bad for society? The answer, it appears, is 'it depends'.

Threat Talk: The Comparative Politics of Internet Addiction

'Threat Talk' exposes how US and Chinese scientists and policy-makers have understood and responded to the problem of internet addiction in their societies. Is the internet good or bad for society? American analysts like Lessig and Zittrain suggest that the internet is inherently liberating and positive for society, while Morozov and Sageman warn that the internet poses risks to citizens and societies. Using a comparative framework to illustrate how the two states differ in their assessments of the risks to citizens posed by the introduction of new technology, Mary Manjikian compellingly argues that both 'risk' and 'disease' are ideas which are understood differently at different historic periods and in different cultures. Her culturalist approach claims that the internet is neither inherently helpful, nor inherently threatening. Rather, its role and the dangers it poses may be understood differently by different societies. Is the internet good or bad for society? The answer, it appears, is 'it depends'.