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LUNGEING

This practical and accessible guide to lungeing covers equipment and various training methods. It offers advice on the correction of many faults, particularly in the young horse, and gives instruction on the use of such training aids as the Lauffer rein, the Chambon and side-reins.

Lupo and the Curse at Buckingham Palace: Book 2 (Lupo)

Film rights have been optioned to a major UK film company in this series about the palaces and the animals who share them with the ever-popular royals.It's the Queen's birthday, and the palace is ready to celebrate. But the discovery of an ancient curse threatenes to spoil the plans - for ever. Can Lupo and his friends get to the bottom of a mysterious curse which was brought to Buckingham Palace from ancient Egypt? That is ... before Vulcan gets his paws on it! And this time, brave Lupo faces another opponent in the form of a sleek and formidable queen cat called Ebony who has designs on becoming the next queen of England. Full of animal mayhem and adventure, Lupo's second book will delight all fans of the royal family - especially Prince George - and anyone who enjoys classic animal stories.

Lupo and the Lost Pirate of Kensington Palace: Book 4 (Lupo #4)

Film rights have been optioned to a major UK film company in this series about the palaces and the animals who share them with the ever-popular royals.This fourth book in Aby King's exciting series is set at the royal residences of Balmoral and Hampton Court. Lupo and his friends untangle a Tudor riddle of the lost Golden Hind. A legendary monster of the deep will help lead the way to a lost palace and treasure galore. Lupo will have to hurry though or else he may miss the Coronation! A treasure trove of a story with excitement, danger and heroics.

Lupo and the Thief at the Tower of London: Book 3 (Lupo)

The royal family are disturbed by the shocking news that there has been a break-in at the Tower of London - everything has been stolen, including the crown jewels. The adults say it's a human matter, but Lupo has an especially bad feeling about this particular crime. He and Kitty take matters into their own hands. Meanwhile, something is stirring in the Thames - a creature who has been hiding in the sewers for hundreds of years. A creature with revenge on its mind ...

Lyme Borreliosis (Nato Science Series A: #260)

Lyme Borreliosis is a worldwide infectious disease causing a multisystem illness with considerable morbidity, particularly in North America and Europe. The causative agent is the spirochaete Borrelia burgdorferi, which is usually transmitted by the ixodid tick from animal reservoirs. This book is formed by contributions from the Second European Symposium on Lyme Borreliosis, held at St George's Hospital Medical School, London in 1993, which reviewed the current state of knowledge of the condition with regard to clinical manifestations, diagnosis, treatment, ecology, epidemiology, biology and immunopathogenesis. In this book, important data is reviewed concerning the clinical manifestations of Lyme Borreliosis. It seems that strain variation of the spirochaete is the main cause of regional differences seen in the clinical presentation of patients. One striking example of this, is the relatively high incidence of Lyme arthritis in the USA and apparent rarity of this manifestion in some areas of Europe. These important studies open the way for exciting new research that focuses on the immunological and molecular mechanisms that result in disease. A full insight into the ecology of Borrelia burgdorferi is essential to a balanced understanding of the disease and a number of excellent reviews on this subject are included. Significant advances with regard to the biology of Borrelia burgdorjeri and the immunopathogenic mechanisms that result in disease have been made, enabling the role of the Band T lymphocytes in disease to be established and the development of sophisticated phenotyping methods, improved diagnostic tests and effective vaccines.

The Lymnaeidae: A Handbook on Their Natural History and Parasitological Significance (Zoological Monographs #7)

The Lymnaeidae (also known as ‘pond snails’) are a species-rich and globally distributed family of freshwater snails, many species of which are known to be hosts of parasitic trematodes (such as the liver fluke, Fasciola hepatica). Written by world-leading experts in the field, this book covers a wealth of topics ranging from the phylogeny and taxonomy of lymnaeid snails to their relationships with helminths and their impact on public and veterinary health. It provides an overview of the species richness, evolution, ecology, biogeography and fossil record of the family. A considerable number of chapters are devoted to the economic and medical importance of lymnaeids, their involvement in the transmission of fascioliasis and other zoonotic diseases. Special chapters deal with the molecular and morphological identification of the Lymnaeidae, their rearing in the laboratory and experimental approaches to their study. This contributed volume is aimed at experts and practitioners in various disciplines: Invertebrate zoology, evolutionary biology, biogeography, aquatic ecology, parasitology, epidemiology and public health. It is also useful for university lecturers, undergraduate and postgraduate students.

Lysosomes (Cellular Organelles)

In 1976 I wrote a monograph on lysosomes (Lysosomes: A Survey, Springer­ Verlag, Vienna) that was intended as an up-to-date, comprehensive survey. Whatever success I may have achieved then in fulfilling that intention, even the effort now would be foolhardy. The literature has grown so rapidly in the past decade that I certainly could not even read all of the essential papers, let alone understand and analyze them. My goal here, therefore, is simply to introduce the major features of lysosomes at a level I hope will be useful both to I;ldvanced students and to researchers interested in obtaining a broad background. This is in keeping with the design of the Cellular Organelles series: the series is more a set of advanced texts than of review monographs. This design carries with it the decision not to support each point by refer­ ences to the original literature. I apologize for the injustice involved in such a decision but feel that in any event it would be impossibly unwieldy to cite, adequately and in a balanced manner, the contributions of the vast network of researchers responsible for the information upon which I draw.

Mabel and the Mountain: a story about believing in yourself

Mabel may be a small fly but she has BIG plans . . .1. Climb a mountain2. Host a dinner party3. Make friends with a sharkMabel's friends are not very helpful . . . But Mabel knows the truth about Big Plans: do not listen to those who say you cannot. Listen to those who say you can! The perfect book to guide young readers through an adventure filled with confidence, self-belief and the power of believing in yourself. From exciting new picture-book author and illustrator Kim Hillyard, this positive picture book will inspire readers big and small to follow their hearts and face new challenges.

The Macaque Connection: Cooperation and Conflict between Humans and Macaques (Developments in Primatology: Progress and Prospects #43)

The concept of this book arises from a symposium entitled “Human-Macaque Interactions: Traditional and Modern Perspectives on Cooperation and Conflict ” organized at the 23rd Congress of the International Primatological Society, that was held in Kyoto in September 2010. The symposium highlighted the many aspects of human-macaque relations and some of the participants were invited to contribute to this volume. The volume will include about 11 chapters by a variety of international authors and some excerpts from published literature that illustrate cultural notions of macaques. Contributions from invited authors will engage with four main perspectives – traditional views of macaques, cooperative relationships between humans and macaques, current scenarios of human-macaque conflict, and how living with and beside humans has affected macaques. Authors will address these concerns through their research findings and reviews of their work on the Asian, and the lone African, macaques. ​

Macavity: Fixed Format Layout With Audio (Old Possum's Cats)

'Macavity' (the mystery cat!) is one of the best-loved poems from T. S. Eliot's Old Possum's Book of Practical Cats - the inspiration for Cats: The Musical - beloved by generations of children and their parents. Now, Macavity is given a new life in this stunning picture book with illustrations from Arthur Robins that perfectly convey all the wit and humour of Eliot's creation.

Machine Learning in Aquaculture: Hunger Classification of Lates calcarifer (SpringerBriefs in Applied Sciences and Technology)

This book highlights the fundamental association between aquaculture and engineering in classifying fish hunger behaviour by means of machine learning techniques. Understanding the underlying factors that affect fish growth is essential, since they have implications for higher productivity in fish farms. Computer vision and machine learning techniques make it possible to quantify the subjective perception of hunger behaviour and so allow food to be provided as necessary. The book analyses the conceptual framework of motion tracking, feeding schedule and prediction classifiers in order to classify the hunger state, and proposes a system comprising an automated feeder system, image-processing module, as well as machine learning classifiers. Furthermore, the system substitutes conventional, complex modelling techniques with a robust, artificial intelligence approach. The findings presented are of interest to researchers, fish farmers, and aquaculture technologist wanting to gain insights into the productivity of fish and fish behaviour.

Machine Learning in Medicine: Part Two

Machine learning is concerned with the analysis of large data and multiple variables. However, it is also often more sensitive than traditional statistical methods to analyze small data. The first volume reviewed subjects like optimal scaling, neural networks, factor analysis, partial least squares, discriminant analysis, canonical analysis, and fuzzy modeling. This second volume includes various clustering models, support vector machines, Bayesian networks, discrete wavelet analysis, genetic programming, association rule learning, anomaly detection, correspondence analysis, and other subjects. Both the theoretical bases and the step by step analyses are described for the benefit of non-mathematical readers. Each chapter can be studied without the need to consult other chapters. Traditional statistical tests are, sometimes, priors to machine learning methods, and they are also, sometimes, used as contrast tests. To those wishing to obtain more knowledge of them, we recommend to additionally study (1) Statistics Applied to Clinical Studies 5th Edition 2012, (2) SPSS for Starters Part One and Two 2012, and (3) Statistical Analysis of Clinical Data on a Pocket Calculator Part One and Two 2012, written by the same authors, and edited by Springer, New York.

Machine Learning in Medicine

Machine learning is a novel discipline concerned with the analysis of large and multiple variables data. It involves computationally intensive methods, like factor analysis, cluster analysis, and discriminant analysis. It is currently mainly the domain of computer scientists, and is already commonly used in social sciences, marketing research, operational research and applied sciences. It is virtually unused in clinical research. This is probably due to the traditional belief of clinicians in clinical trials where multiple variables are equally balanced by the randomization process and are not further taken into account. In contrast, modern computer data files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required. This book was written as a hand-hold presentation accessible to clinicians, and as a must-read publication for those new to the methods.

The Machines of Evolution and the Scope of Meaning

A groundbreaking account of the origin and place of meaning in the earthly biosphereWhat is meaning? How does it arise? Where is it found in the world? In recent years, philosophers and scientists have answered these questions in different ways. Some see meaning as a uniquely human achievement, others extend it to trees, microbes, and even to the bonding of DNA and RNA molecules. In this groundbreaking book, Gary Tomlinson defines a middle path. Combining emergent thinking about evolution, new research on animal behaviors, and theories of information and signs, he tracks meaning far out into the animal world. At the same time he discerns limits to its scope and identifies innumerable life forms, including many animals and all other organisms, that make no meanings at all.Tomlinson’s map of meaning starts from signs, the fundamental units of reference or aboutness. Where signs are at work they shape meaning-laden lifeways, offering possibilities for distinctive organism/niche interactions and sometimes leading to technology and culture. The emergence of meaning does not, however, monopolize complexity in the living world. Countless organisms generate awe-inspiring behavioral intricacies without meaning. The Machines of Evolution and the Scope of Meaning offers a revaluation of both meaning and meaninglessness, uncovering a foundational difference in animal solutions to the hard problem of life.

The Machines of Evolution and the Scope of Meaning

A groundbreaking account of the origin and place of meaning in the earthly biosphereWhat is meaning? How does it arise? Where is it found in the world? In recent years, philosophers and scientists have answered these questions in different ways. Some see meaning as a uniquely human achievement, others extend it to trees, microbes, and even to the bonding of DNA and RNA molecules. In this groundbreaking book, Gary Tomlinson defines a middle path. Combining emergent thinking about evolution, new research on animal behaviors, and theories of information and signs, he tracks meaning far out into the animal world. At the same time he discerns limits to its scope and identifies innumerable life forms, including many animals and all other organisms, that make no meanings at all.Tomlinson’s map of meaning starts from signs, the fundamental units of reference or aboutness. Where signs are at work they shape meaning-laden lifeways, offering possibilities for distinctive organism/niche interactions and sometimes leading to technology and culture. The emergence of meaning does not, however, monopolize complexity in the living world. Countless organisms generate awe-inspiring behavioral intricacies without meaning. The Machines of Evolution and the Scope of Meaning offers a revaluation of both meaning and meaninglessness, uncovering a foundational difference in animal solutions to the hard problem of life.

MACPF/CDC Proteins - Agents of Defence, Attack and Invasion (Subcellular Biochemistry #80)

This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.

Macro Photography for Gardeners and Nature Lovers: The Essential Guide to Digital Techniques

Gardeners and nature lovers delight in taking pictures—especially close-ups of flowers, butterflies, and insects. And though advances in digital camera technology have made taking, storing, and sharing photos easier than ever, taking top-quality pictures requires familiarity with both digital technology and the general principles of photography. Macro Photography for Gardeners and Nature Lovers provides exactly the information that aspiring photographers—no matter their level of skill—need to take their photos to the next level. Clear and concise chapters cover the basics of macro (close-up) photography, explain the features of current digital single-lens reflex cameras, show the many ways images can be composed, and share tips on digital effects, storage, and manipulation of imagery. Throughout the text, helpful tips, definitions, exercises, and case studies serve to demystify digital photography. Each lesson is supported by examples of the author's stunning photography. Whether taking photos of flowers and insects, compiling a photographic record of your garden, or simply sharing beautiful images with friends and family, everyone can become accomplished photographers of the world's small-scale wonders.

Macroevolution in Deep Time (SpringerBriefs in Evolutionary Biology)

The prerequisite to investigating the underlying causes behind mass extinction is a profound understanding of the evolutionary history of both living and dead species. It is especially important to appreciate the significance of such studies in extinct organisms; especially in organisms that were abundant in a certain geologic era, but have subsequently dwindled or become extinct. Such studies should help to accurately evaluate patterns of evolution in extinct species lineages and help predict the same in its modern analogs. The book includes cutting edge research in evolutionary biology that should serve as a starting point for conservation. ​

Macromolecules in the Functioning Cell

Mad About Bugs

Mad About Bugs, from Ladybird, is full of buggy facts!Are you mad about bugs? From spiders and snails to butterflies and bees, this book is packed with fascinating facts and key information for all young creepy-crawly enthusiasts. Also includes a link to fantastic downloadable Mad About posters.Ladybird's Mad About series is all about giving its readers all the facts they could possibly need about their favourite subjects. Get ready to impress all your friends with all your new knowledge!Look out for Mad About Dinosaurs and Mad About Sharks, too!

Mad About Deadly Creatures

Are you mad about deadly creatures? From snakes and spiders to piranhas and porcupines, the world of claws, fangs and poison is brought to life in this informative book. It is ideal for all young animal enthusiasts. Ladybird's Mad About series is all about giving its readers all the facts they could possibly need about their favourite subjects. Get ready to impress all your friends with all your new knowledge!

Mad About Dinosaurs

Are you mad about dinosaurs? From food and fossils to herds and horns, this book is packed with fascinating facts and key information for all young dinosaur enthusiasts. Ladybird's Mad About series is all about giving its readers all the facts they could possibly need about their favourite subjects. Get ready to impress all your friends with all your new knowledge!

Mad About Monkeys (Owen Davey Animal Series #2)

Ever wondered what monkeys are and what makes them so special? With over 250 species inhabiting our planet, this book explores the many different types of monkeys from the smallest Pygmy Marmoset to the largest Mandrill as well as providing all the facts you wanted to know and more. Discover where monkeys come from, how they swing from tree to tree and why they fight and play with each other. After reading this beautifully illustrated book by Owen Davey, you'll soon be raving mad about monkeys!

Mad About Ponies

Are you mad about ponies? From breeds and brushes to markings and mucking out, this book is packed with fascinating facts and key information that will delight all young pony enthusiasts. Ladybird's Mad About series is all about giving its readers all the facts they could possibly need about their favourite subjects. Get ready to impress all your friends with all your new knowledge!

Mad About Sharks

Mad About Sharks, from Ladybird, is full of shark facts!Are you mad about sharks? From fins and teeth to babies and ancient ancestors, this book is full of fascinating facts and information for all young shark enthusiasts. Also includes a link to fantastic downloadable Mad About posters.Ladybird's Mad About series is all about giving its readers all the facts they could possibly need about their favourite subjects. Get ready to impress all your friends with all your new knowledge!Look out for Mad About Dinosaurs and Mad About Sharks, too!