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Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene (SpringerBriefs in Applied Sciences and Technology)

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies.This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

Bioinformatics of the Brain

The brain consisting of billions of neurons is probably the most complex and mysterious organ of the body. Understanding the functioning of the brain in its health and disease states has baffled the researchers working in this area for many years. The diversity of brain diseases and disorders makes the analysis of brain functions an even more challenging area of research. In vitro and in vivo studies regarding the brain may be laborious, however, bioinformatics using in silico approaches may take the burden off the experimental studies and give us a clearer perspective on disease and healthy states of the brain, its functions, and disease mechanisms.Recent advancements in neuroimaging technologies, the development of high-performance computers and the development of software, algorithms and methods to analyze data obtained from various neuroimaging processes have opened new frontiers in neuroscience enabling unprecedented finer analysis of the brain functions. This relatively new approach of brain analysis which may be termed Bioinformatics of the Brain is the main subject of this volume aiming to provide a thorough review of various bioinformatics approaches for analyzing the functioning of the brain and understanding brain diseases such as neurodegenerative diseases, brain tumors, and neuropsychiatric disorders. Authors from various disciplines in this volume each focus on a different aspect aiming to expand our understanding of this area of research. Topics included are: Brain diseases and disorders Stem cell therapy of neurodegenerative diseases Tissue engineering applications of gliomas Brain tumor detection and modeling Brain tumor growth simulation Brain-computer interface Bioinformatics of brain diseases Graph-theoretical analysis of complex brain networks Brain proteomics This book is intended to aid scientists, researchers, and graduate students in carrying out interdisciplinary research in the areas of bioinformatics, bioengineering, computer engineering, software engineering, mathematics, molecular biology, genetics, and biotechnology.

Bioinformatics of the Brain

The brain consisting of billions of neurons is probably the most complex and mysterious organ of the body. Understanding the functioning of the brain in its health and disease states has baffled the researchers working in this area for many years. The diversity of brain diseases and disorders makes the analysis of brain functions an even more challenging area of research. In vitro and in vivo studies regarding the brain may be laborious, however, bioinformatics using in silico approaches may take the burden off the experimental studies and give us a clearer perspective on disease and healthy states of the brain, its functions, and disease mechanisms.Recent advancements in neuroimaging technologies, the development of high-performance computers and the development of software, algorithms and methods to analyze data obtained from various neuroimaging processes have opened new frontiers in neuroscience enabling unprecedented finer analysis of the brain functions. This relatively new approach of brain analysis which may be termed Bioinformatics of the Brain is the main subject of this volume aiming to provide a thorough review of various bioinformatics approaches for analyzing the functioning of the brain and understanding brain diseases such as neurodegenerative diseases, brain tumors, and neuropsychiatric disorders. Authors from various disciplines in this volume each focus on a different aspect aiming to expand our understanding of this area of research. Topics included are: Brain diseases and disorders Stem cell therapy of neurodegenerative diseases Tissue engineering applications of gliomas Brain tumor detection and modeling Brain tumor growth simulation Brain-computer interface Bioinformatics of brain diseases Graph-theoretical analysis of complex brain networks Brain proteomics This book is intended to aid scientists, researchers, and graduate students in carrying out interdisciplinary research in the areas of bioinformatics, bioengineering, computer engineering, software engineering, mathematics, molecular biology, genetics, and biotechnology.

Bioinformatics Research and Application: 7th International Symposium, ISBRA 2011, Changsha, China, May 27-29, 2011, Proceedings (Lecture Notes in Computer Science #6674)

This volume constitutes the refereed proceedings of the 7th International Symposium on Bioinformatics Research and Applications, ISBRA 2011, held in Changsha, China, in May 2011. The 36 revised full papers presented together with 4 invited talks were carefully reviewed and selected from 92 submissions. Topics presented span all areas of bioinformatics and computational biology, including the development of experimental or commercial systems.

Bioinformatics Research and Applications: 18th International Symposium, ISBRA 2022, Haifa, Israel, November 14–17, 2022, Proceedings (Lecture Notes in Computer Science #13760)

This book constitutes the proceedings of the 18th International Symposium on Bioinformatics Research and Applications, ISBRA 2022, held in Haifa, Israel, in November 14–17, 2022.The 30 full papers and 4 short papers presented in this book were carefully reviewed and selected from 72 submissions. They were organized in topical sections named: AI and disease; computational proteomics; biomedical imaging; drug screening and drug-drug interaction prediction; Biomedical data; sequencing data analysis.

Bioinformatics Research and Applications: 10th International Symposium, ISBRA 2014, Zhangjiajie, China, June 28-30, 2014, Proceedings (Lecture Notes in Computer Science #8492)

This book constitutes the refereed proceedings of the 10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014, held in Zhangjiajie, China, in June 2014. The 33 revised full papers and 31 one-page abstracts included in this volume were carefully reviewed and selected from 119 submissions. The papers cover a wide range of topics in bioinformatics and computational biology and their applications including the development of experimental or commercial systems.

Bioinformatics Research and Applications: 6th International Symposium, ISBRA 2010, Storrs, CT, USA, May 23-26, 2010. Proceedings (Lecture Notes in Computer Science #6053)

Bioinformatics Research and Applications: 12th International Symposium, ISBRA 2016, Minsk, Belarus, June 5-8, 2016, Proceedings (Lecture Notes in Computer Science #9683)

This book constitutes the proceedings of the 12th International Symposium on Bioinformatics Research and Applications, ISBRA 2016, held in Minsk, Belarus, in June 2016. The 25 papers presented in this volume were carefully reviewed and selected from 77 submissions. They were organized in topical sections named: next generation sequencing data analysis; protein-protein interactions and networks; protein and RNA structure; phylogenetics; sequence analysis; and statistical methods.

Bioinformatics Research and Applications: 9th International Symposium, ISBRA 2013, Charlotte, NC, USA, May 20-22, 2013, Proceedings (Lecture Notes in Computer Science #7875)

This book constitutes the refereed proceedings of the 9th International Symposium on Bioinformatics Research and Applications, ISBRA 2013, held in Charlotte, NC, USA, in May 2013. The 25 revised full papers presented together with 4 invited talks were carefully reviewed and selected from 46 submissions. The papers cover a wide range of biomedical databases and data integration, high-performance bio-computing, biomolecular imaging, high-throughput sequencing data analysis, bio-ontologies, molecular evolution, comparative genomics and phylogenomics, molecular modeling and simulation, pattern discovery and classification, computational proteomics, population genetics, data mining and visualization, software tools and applications.

Bioinformatics Research and Applications: 16th International Symposium, ISBRA 2020, Moscow, Russia, December 1–4, 2020, Proceedings (Lecture Notes in Computer Science #12304)

This book constitutes the proceedings of the 16th International Symposium on Bioinformatics Research and Applications, ISBRA 2020, held in Moscow, Russia, in December 2020. The 23 full papers and 18 short papers presented in this book were carefully reviewed and selected from 131 submissions. They were organized in topical sections named: genome analysis; systems biology; computational proteomics; machine and deep learning; and data analysis and methodology.

Bioinformatics Research and Applications: 15th International Symposium, ISBRA 2019, Barcelona, Spain, June 3–6, 2019, Proceedings (Lecture Notes in Computer Science #11490)

This book constitutes the proceedings of the 15th International Symposium on Bioinformatics Research and Applications, ISBRA 2019, held in Barcelona, Spain, in June 2019. The 22 full papers presented in this book were carefully reviewed and selected from 95 submissions. They were organized in topical sections named: genome analysis; systems biology; computational proteomics; machine and deep learning; and data analysis and methodology.

Bioinformatics Research and Applications: 19th International Symposium, ISBRA 2023, Wrocław, Poland, October 9–12, 2023, Proceedings (Lecture Notes in Computer Science #14248)

This book constitutes the refereed proceedings of the 19th International Symposium on Bioinformatics Research and Applications, ISBRA 2023, held in Wrocław, Poland, during October 9–12, 2023.The 28 full papers and 16 short papers included in this book were carefully reviewed and selected from 89 submissions. They were organized in topical sections as follows: reconciling inconsistent molecular structures from biochemical databases; radiology report generation via visual recalibration and context gating-aware; sequence-based nanobody-antigen binding prediction; and hist2Vec: kernel-based embeddings for biological sequence classification.

Bioinformatics Research and Applications: 11th International Symposium, ISBRA 2015 Norfolk, USA, June 7-10, 2015 Proceedings (Lecture Notes in Computer Science #9096)

This book constitutes the refereed proceedings of the 11th International Symposium on Bioinformatics Research and Applications, ISBRA 2015, held in Norfolk, VA, USA, in June 2015. The 34 revised full papers and 14 two-page papers included in this volume were carefully reviewed and selected from 98 submissions. The papers cover a wide range of topics in bioinformatics and computational biology and their applications.

Bioinformatics Research and Applications: 5th International Symposium, ISBRA 2009 Fort Lauderdale, FL, USA, May 13-16, 2009, Proceedings (Lecture Notes in Computer Science #5542)

This book constitutes the refereed proceedings of the 5th International Symposium on Bioinformatics Research and Applications, ISBRA 2009, held in Fort Lauderdale, FL, USA, in May 2009. The 26 revised full papers presented together four invited papers were carefully reviewed and selected from a total of 55 submissions. The papers cover a wide range of topics, including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.

Bioinformatics Research and Applications: Fourth International Symposium, ISBRA 2008, Atlanta, GA, USA, May 6-9, 2008, Proceedings (Lecture Notes in Computer Science #4983)

This book constitutes the refereed proceedings of the Fourth International Symposium on Bioinformatics Research and Applications, ISBRA 2008, held in Atlanta, GA, USA in May 2008. The 35 revised full papers presented together with 6 workshop papers and 6 invited papers were carefully reviewed and selected from a total of 94 submissions. The papers cover a wide range of topics, including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.

Bioinformatics Research and Applications: Third International Symposium,ISBRA 2007, Atlanta, GA, USA, May 7-10, 2007, Proceedings (Lecture Notes in Computer Science #4463)

This book constitutes the refereed proceedings of the Third International Symposium on Bioinformatics Research and Applications, ISBRA 2007, held in Atlanta, GA, USA in May 2007. The 55 revised full papers presented together with three invited talks cover a wide range of topics, including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.

Bioinformatics Research and Applications: 20th International Symposium, ISBRA 2024, Kunming, China, July 19–21, 2024, Proceedings, Part I (Lecture Notes in Computer Science #14954)

This book constitutes the refereed proceedings of the 20th International Symposium on Bioinformatics Research and Applications, ISBRA 2024, held in Kunming, China, in July 19–21, 2024. The 93 full papers included in this book were carefully reviewed and selected from 236 submissions. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and practitioners working on all aspects of bioinformatics and computational biology and their applications.

Bioinformatics Research and Applications: 20th International Symposium, ISBRA 2024, Kunming, China, July 19–21, 2024, Proceedings, Part II (Lecture Notes in Computer Science #14955)

This book constitutes the refereed proceedings of the 20th International Symposium on Bioinformatics Research and Applications, ISBRA 2024, held in Kunming, China, in July 19–21, 2024. The 93 full papers included in this book were carefully reviewed and selected from 236 submissions. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and practitioners working on all aspects of bioinformatics and computational biology and their applications.

Bioinformatics Research and Applications: 20th International Symposium, ISBRA 2024, Kunming, China, July 19–21, 2024, Proceedings, Part III (Lecture Notes in Computer Science #14956)

This book constitutes the refereed proceedings of the 20th International Symposium on Bioinformatics Research and Applications, ISBRA 2024, held in Kunming, China, in July 19–21, 2024. The 93 full papers included in this book were carefully reviewed and selected from 236 submissions. The symposium provides a forum for the exchange of ideas and results among researchers, developers, and practitioners working on all aspects of bioinformatics and computational biology and their applications.

Bioinformatics Research and Applications: 14th International Symposium, ISBRA 2018, Beijing, China, June 8-11, 2018, Proceedings (Lecture Notes in Computer Science #10847)

This book constitutes the proceedings of the 14th International Conference on Bioinformatics Research and Applications, ISBRA 2018, held in Beijing, China, in June 2018.The 24 full and 10 short papers presented in this volume were carefully reviewed and selected from a total of 138 submissions. They were organized in topical sections named: network analysis and modelling; genomic data analysis; cancer data analysis; structure and interaction; HPC and CryoEM; machine and deep learning; data analysis and methodology; analysis and visualization tools; and RNA-Seq data analysis.

Bioinformatics Research and Applications: 17th International Symposium, ISBRA 2021, Shenzhen, China, November 26–28, 2021, Proceedings (Lecture Notes in Computer Science #13064)

This book constitutes the proceedings of the 17th International Symposium on Bioinformatics Research and Applications, ISBRA 2021, held in Shenzhen, China, in November 2021. The 51 full papers presented in this book were carefully reviewed and selected from 135 submissions. They were organized in topical sections named: AI and disease; computational proteomics; biomedical imaging; drug screening and drug-drug interaction prediction; Biomedical data; sequencing data analysis.

Bioinformatics Research and Applications: 13th International Symposium, ISBRA 2017, Honolulu, HI, USA, May 29 – June 2, 2017, Proceedings (Lecture Notes in Computer Science #10330)

This book constitutes the proceedings of the 13th International Symposium on Bioinformatics Research and Applications, ISBRA 2017, held in Honolulu, HI, USA, in May/June 2017. The 27 full papers presented together with 18 short papers and 24 invited abstracts were carefully reviewed and selected from 131 submissions. They cover topics such as: biomarker discovery; biomedical databases and data integration; biomedical text mining and ortologies; biomolecular imaging; comparative genomics; computational genetic epidemiology; computational proteomics; data mining and visualization; gene expression analysis; genome analysis; high-performance bio-computing; metagenomics; molecular evolution; molecular modelling and simulation; next-generation sequencing data analysis; pattern discovery and classification; population genetics; software tools and applications; structural biology; and systems biology.

Bioinformatics Research and Applications: 8th International Symposium, ISBRA 2012, Dallas, TX, USA, May 21-23, 2012. Proceedings (Lecture Notes in Computer Science #7292)

This book constitutes the refereed proceedings of the International Symposium on Bioinformatics Research and Applications, ISBRA 2012, held in Dallas, Texas, USA, in May 2012. The 26 revised full papers presented together with five invited talks were carefully reviewed and selected from 66 submissions. The papers address issues on various aspects of bioinformatics and computational biology and their applications.

Bioinformatics Research and Development: Second International Conference, BIRD 2008, Vienna, Austria, July 7-9, 2008 Proceedings (Communications in Computer and Information Science #13)

This volume contains the papers which were selected for presentation at the second Bio- formatics Research and Development (BIRD) conference held in Vienna, Austria during July 7–9, 2008. BIRD covers a wide range of topics related to bioinformatics. This year sequence analysis and alignment, pathways, networks, systems biology, protein and RNA structure and function, gene expression/regulation and microarrays, databases and data integration, machine learning and data analysis were the subjects of main interest. The decisions of the Program Committee are based on the recommendations of at least three, up to five, reviews for each paper. As a result, 30 of the 61 submitted c- tributions could be accepted for the conference. We were happy to have three invited talks presented by experienced researchers providing visitors with a good overview but also some very important insights into the fascinating domain of bioinformatics. Abstracts and more information on these talks are provided in the conference program as well as at the conference site. In the second part of this volume the selected contributions of the two workshops which were held in parallel to the main conference are presented: Workshop on - namical Aspects of Perturbation, Intervention and Transition in Biological Systems – PETRIN 2008 and Workshop on Algorithms in Molecular Biology – ALBIO 2008 Poster presentations of the BIRD conference are in the companion proceedings published by the Trauner Verlag, Linz.

Bioinformatics Research and Development: First International Conference, BIRD 2007, Berlin, Germany, March 12-14, 2007, Proceedings (Lecture Notes in Computer Science #4414)

This book constitutes the refereed proceedings of the First International Bioinformatics Research and Development Conference, BIRD 2007, held in Berlin, Germany in March 2007. The 36 revised full papers are organized in topical sections on microarray and systems biology and networks, medical, SNPs, genomics, systems biology, sequence analysis and coding, proteomics and structure, databases, Web and text analysis.