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Biobetters: Protein Engineering to Approach the Curative (AAPS Advances in the Pharmaceutical Sciences Series #19)

“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.

Biocalorimetry: Foundations and Contemporary Approaches

Connecting past, present, and future instrument development and use, Biocalorimetry: Foundations and Contemporary Approaches explores biocalorimetry's history, fundamentals, methodologies, and applications. Some of the most prominent calorimeter developers and users share invaluable personal accounts of discovery, discussing innovative techniques a

Biocatalysis: Enzymatic Basics and Applications

This book introduces readers to industrially important enzymes and discusses in detail their structures and functions, as well as their manifold applications. Due to their selective biocatalytic capabilities, enzymes are used in a broad range of industries and processes. The book highlights selected enzymes and their applications in agriculture, food processing and discoloration, as well as their role in biomedicine. In turn, it discusses biochemical engineering strategies such as enzyme immobilization, metabolic engineering, and cross-linkage of enzyme aggregates, and critically weighs their pros and cons. Offering a wealth of information, and stimulating further research by presenting new concepts on enzymatic catalytic functions in basic and applied contexts, the book represents a valuable asset for researchers from academia and industry who are engaged in biochemical engineering, microbiology and biotechnology.

Biocatalysis and Nanotechnology (Pan Stanford Series on Biocatalysis)

Nanobiocatalysis has rapidly developed into a subarea of enzyme biotechnology. It combines the advances in nanotechnology that have generated nanoscale materials of different sizes, shapes, and physicochemical properties, and the excellent characteristics of biocatalysts into an innovative technology. This book provides an overview of the various relations between nanotechnology and biocatalysis. It discusses the fabrication and application of nanomaterials for the immobilization of enzymes used in the sustainable production of goods and chemicals. Nanosupports have several advantages compared with bulk solid materials because of their high surface area, which results in a significantly reduced mass transfer limitation and comparatively high enzyme loading. These characteristics are also of great use for applications in the fields of enzymatic biosensors, biofuel cells, bioelectronics, and photoelectrochemical analyte detection, where conductive nanomaterials improve the rate of electron transfer. The book also presents an overview of nanotoxicology and covers nanostructured enzyme catalysis in organic solvents and its potential application for biodiesel production, probing of enzymatic activity, and identification of enzyme functions of inorganic nanoparticles as enzyme mimics.

Biocatalysis and Nanotechnology (Pan Stanford Series on Biocatalysis)

Nanobiocatalysis has rapidly developed into a subarea of enzyme biotechnology. It combines the advances in nanotechnology that have generated nanoscale materials of different sizes, shapes, and physicochemical properties, and the excellent characteristics of biocatalysts into an innovative technology. This book provides an overview of the various relations between nanotechnology and biocatalysis. It discusses the fabrication and application of nanomaterials for the immobilization of enzymes used in the sustainable production of goods and chemicals. Nanosupports have several advantages compared with bulk solid materials because of their high surface area, which results in a significantly reduced mass transfer limitation and comparatively high enzyme loading. These characteristics are also of great use for applications in the fields of enzymatic biosensors, biofuel cells, bioelectronics, and photoelectrochemical analyte detection, where conductive nanomaterials improve the rate of electron transfer. The book also presents an overview of nanotoxicology and covers nanostructured enzyme catalysis in organic solvents and its potential application for biodiesel production, probing of enzymatic activity, and identification of enzyme functions of inorganic nanoparticles as enzyme mimics.

Biocatalysts for Industry (Topics in Applied Chemistry)

The application of enzymes or whole cells (fermentatively active or resting; microbial, plant, or animal) to carry out selective transformations of commercial importance is the central theme of industrial biocatalysis. Traditionally, biocatalysis has been in the domain of the life scientist or biochemical engineer. However, recent advances in this field have enabled biocatalytic processes to compete head on with, and in some cases out­ perform, conventional chemical processing. Chemo-biocatalytic systems are being developed thereby combining the most attractive features of bio­ catalysts, namely high specificity, with those of chemical catalysts, such as high reactivities and wide substrate specificities. Hence, synthetic chemists and chemical engineers are now beginning to use biocatalysts as highly selective reagents in chemical synthesis and processing. This book is about biocatalysts and their past, present, and potential applications in the food, pharmaceutical, and chemical industries. The con­ cept of the book did not emanate from a meeting. Rather, it is a compila­ tion of selected examples where biocatalysis either has already made a significant impact in the aforementioned industries, or has the potential to make a substantial contribution. I have been fortunate to have assembled contributions from world-class researchers in the field of biocatalysis. Their timely contributions are sincerely appreciated.

Bioceramic Materials in Clinical Endodontics

This book focuses on hydraulic calcium silicate-based materials available in clinical dentistry, used as pulp capping materials, root canal sealers, root-end fillers, or root repair materials and which offer improved properties and easier clinical application compared with the original mineral trioxide aggregate. The book introduces the current classification of bioceramic materials and explains their characterization and their physicochemical and biological properties. Thereafter, the various clinical applications of these materials are discussed in depth with reference to the evidence base. The coverage includes applications in endodontic treatments and complications, traumatic dental injuries, management of the vital pulp in both dentitions, and regenerative endodontic procedures. Apart from presenting the latest research on hydraulic calcium silicate-based materials, Bioceramic Materials in Clinical Endodontics promotes an essential balance between basic laboratory and clinical research. It will thus be an important reference for materials science specialists, clinical researchers, and clinicians.

Bioceramics: Properties, Characterizations, and Applications (Lecture Notes In Mathematics #Vol. 741)

Bioceramics: Properties, Characterization, and Applications will be a general introduction to the uses of ceramics and glasses in the human body for the purposes of aiding, healing, correcting deformities, and restoring lost function. With over 30 years experience, the author developed the text as an outgrowth of an undergraduate course for senior students in biomedical engineering and will emphasize the fundamentals and applications in modern implant fabrication, and will also deal with tissue engineering scaffolds made of ceramics.Organized as a textbook for the student needing to acquire the core competencies, it will meet the demands of advanced undergraduate or graduate coursework in bioceramics, biomaterials, biomedical engineering, and biophysics.

Bioceramics: Materials · Properties · Applications

As recently as 20 years ago, ceramics were widely ignored as potential biomaterials. Interest in bioceramics has increased dramatically over the past decade to the point where it is anticipated they will be the materials of choice for many orthopedic, otologic, maxillofacial and dental applications during the decade of the '90s. Alumina ceramics are being used extensively as articulating comJ1onents in total joint prostheses because of Ithe materials low coefficient of friction and excellent wear resistances. Alumina ceramics are also being used in dental and maxillofacial applica­ tions because of the materials excellent biocompatibility. Because of its ability to chemically bond to bone, hydroxyapatite is rapidly becoming the material of choice for many dental and maxillofacial applications. For the past decade, one of the most widely researched topics in the field of orthopedics has been the clinical evaluation of joint prostheses based upon stabili­ zation via tissue ingrowth. It appears that the next generation of joint prostheses will be based upon direct chemically bonding to bone using hydroxyapatite, surface-active glass or surface-active glass ceramics coatings. Resorbable bioceramics are limited to temporary bone space fillers, periodontal pockets treatment and resorbable pharma­ ceutical delivery systems. Bioceramics is a comprehensive reference textbook covering the history of bio­ ceramics, present status of bioceramics, and prediction for future use of bioceramics. This book will serve as a major reference for students, as well as experienced bio­ material researchers. The book presents the state-of-the-art of bioceramics as of 1991.

Bioceramics and Alternative Bearings in Joint Arthroplasty: 11th BIOLOX Symposium. Proceedings (Ceramics in Orthopaedics)

Dear Colleague and Participant in Bioceramics and Alternative Bearings in Joint th ® Arthroplasty: 11 International BIOLOX Symposium We are once again very proud of the fact that we have been able to provide you with the proceedings of this Symposium as a part of your registration materials. This is a mayor achievement that could only be made possible by the excellent cooperation of all of the speakers, the publishing house and their staff and the Symposium Administrator and her support staff. Our special thanks to all of them for their hard work and dedication to meet the difficult deadlines required to make this a reality. The proceedings for this Symposium continue the on-going tradition to provide all of us with a valuable and useful addition to our reference library. We hope that within its covers, you will find the most up to date scientific and clinical information regarding the use of ceramic solutions to address wear related problems in Orthopedic Surgery. This is the first time that the symposium takes place in Italy. The reason we chose Italy and in particular Rome is obvious as CeramTec has had a long term and close relationship with the Italian. CeramTec is pleased that our Symposium Chairmen, Professors F. Benazzo and F. Falez have collaborated with us in the preparation and in th the execution of Bioceramics and Alternative Bearings in Joint Arthroplasty - 11 ® International BIOLOX Symposium.

Bioceramics and Alternative Bearings in Joint Arthroplasty: 12th BIOLOX® Symposium Seoul, Republic of Korea September 7 - 8, 2007. Proceedings (Ceramics in Orthopaedics)

This proceedings book of the Biolox Symposium in Seoul is composed of 10 sessions and plenary lectures of the most current knowledge available in the use of Bioceramics and alternative bearings. More than 50 speakers with world-famous reputations from 12 countries cover 52 topics on recent developments in Bioceramic and alternative bearings in arthroplasty.

Bioceramics and Alternative Bearings in Joint Arthroplasty: 10th BIOLOX Symposium. Washington D.C., June 10-11, 2005. Proceedings (Ceramics in Orthopaedics)

Dear Colleague and Participant in Bioceramics and Alternative Bearings In Joint Arthroplasty: 10*" International BIOLOX® Symposium We are once again very proud that we are able to present to you the proceedings of the Symposiunn as part of your registration materials. This group accomplishment has been made possible by the superb cooperation received from the speakers in sending us their manuscripts on a timely basis as well as by the supporting staff at both CeramTec and at the Publishing House in executing all of the details needed. We specially extend our most heartfelt thanks to the Scientific Committee for their assistance in evaluating and selecting the submissions as well as developing the Symposium program. We are more convinced than ever that the proceedings of this Symposium are a continuation of CeramTec's tradition of providing all members of the orthopedic surgical community with a valuable addition to your reference libraries. We hope that this book will present you with the latest and most up to date source of scientific and clinical information regarding the use of ceramics and other alternative bearings in joint replacement surgery.

Bioceramics and Biocomposites: From Research to Clinical Practice

Provides comprehensive coverage of the research into and clinical uses of bioceramics and biocomposites Developments related to bioceramics and biocomposites appear to be one the most dynamic areas in the field of biomaterials, with multiple applications in tissue engineering and medical devices. This book covers the basic science and engineering of bioceramics and biocomposites for applications in dentistry and orthopedics, as well as the state-of-the-art aspects of biofabrication techniques, tissue engineering, remodeling, and regeneration of bone tissue. It also provides insight into the use of bionanomaterials to create new functionalities when interfaced with biological molecules or structures. Featuring contributions from leading experts in the field, Bioceramics and Biocomposites: From Research to Use in Clinical Practice offers complete coverage of everything from extending the concept of hemopoietic and stromal niches, to the evolution of bioceramic-based scaffolds. It looks at perspectives on and trends in bioceramics in endodontics, and discusses the influence of newer biomaterials use on the structuring of the clinician’s attitude in dental practice or in orthopedic surgery. The book also covers such topics as biofabrication techniques for bioceramics and biocomposites; glass ceramics: calcium phosphate coatings; brain drug delivery bone substitutes; and much more. Presents the biggest trends in bioceramics and biocomposites relating to medical devices and tissue engineering products Systematically presents new information about bioceramics and biocomposites, developing diagnostics and improving treatments and their influence on the clinicians' approaches Describes how to use these biomaterials to create new functionalities when interfaced with biological molecules or structures Offers a range of applications in clinical practice, including bone tissue engineering, remodeling, and regeneration Delineates essential requirements for resorbable bioceramics Discusses clinical results obtained in dental and orthopedic applications Bioceramics and Biocomposites: From Research to Use in Clinical Practice is an excellent resource for biomaterials scientists and engineers, bioengineers, materials scientists, and engineers. It will also benefit mechanical engineers and biochemists who work with biomaterials scientists.

Bioceramics and Biocomposites: From Research to Clinical Practice

Provides comprehensive coverage of the research into and clinical uses of bioceramics and biocomposites Developments related to bioceramics and biocomposites appear to be one the most dynamic areas in the field of biomaterials, with multiple applications in tissue engineering and medical devices. This book covers the basic science and engineering of bioceramics and biocomposites for applications in dentistry and orthopedics, as well as the state-of-the-art aspects of biofabrication techniques, tissue engineering, remodeling, and regeneration of bone tissue. It also provides insight into the use of bionanomaterials to create new functionalities when interfaced with biological molecules or structures. Featuring contributions from leading experts in the field, Bioceramics and Biocomposites: From Research to Use in Clinical Practice offers complete coverage of everything from extending the concept of hemopoietic and stromal niches, to the evolution of bioceramic-based scaffolds. It looks at perspectives on and trends in bioceramics in endodontics, and discusses the influence of newer biomaterials use on the structuring of the clinician’s attitude in dental practice or in orthopedic surgery. The book also covers such topics as biofabrication techniques for bioceramics and biocomposites; glass ceramics: calcium phosphate coatings; brain drug delivery bone substitutes; and much more. Presents the biggest trends in bioceramics and biocomposites relating to medical devices and tissue engineering products Systematically presents new information about bioceramics and biocomposites, developing diagnostics and improving treatments and their influence on the clinicians' approaches Describes how to use these biomaterials to create new functionalities when interfaced with biological molecules or structures Offers a range of applications in clinical practice, including bone tissue engineering, remodeling, and regeneration Delineates essential requirements for resorbable bioceramics Discusses clinical results obtained in dental and orthopedic applications Bioceramics and Biocomposites: From Research to Use in Clinical Practice is an excellent resource for biomaterials scientists and engineers, bioengineers, materials scientists, and engineers. It will also benefit mechanical engineers and biochemists who work with biomaterials scientists.

Bioceramics in Endodontics

Bioceramics in Endodontics Practical reference book in the emerging field of endodontics, focusing on overall makeup of dental bioceramics and relevant clinical situations in endodontics where various forms of bioceramics has been used to treat teeth successfully. Bioceramics in Endodontics is a highly unique resource that blends together detailed information on the physico-chemical and biological properties of bioceramics with their clinical application in endodontics, exploring history and chemistry, mechanical properties, advantages of bioceramics over other materials, and clinical cases with high definition pictures and videos demonstrating their usage across wide variety of clinical situations in endodontics. Written by highly qualified authors with significant experience in the field, Bioceramics in Endodontics includes information on: Material characteristics of bioceramics that Endodontists/Clinicians should be aware of Evidence based decisions between coneless and coned obturations, and healing of periapical lesions over a recall period of 3-5 years Endodontic treatment of patients using bioceramic sealers Endodontic mishaps treated with bioceramic repair material Evidence based approach for apexification using bioceramics Use of bioceramics as a root end filling material and guidelines guidelines to finding new applications for bioceramics Comparison of Bioceramics with gold standard endodontic materials A highly unique exploration into the subject, Bioceramics in Endodontics provides an essential core overview of the field of bioceramics in endodontics and related applications, making it a must-have resource for dental practitioners, along with undergraduate and postgraduate students in endodontics and other related programs of study.

Bioceramics in Endodontics

Bioceramics in Endodontics Practical reference book in the emerging field of endodontics, focusing on overall makeup of dental bioceramics and relevant clinical situations in endodontics where various forms of bioceramics has been used to treat teeth successfully. Bioceramics in Endodontics is a highly unique resource that blends together detailed information on the physico-chemical and biological properties of bioceramics with their clinical application in endodontics, exploring history and chemistry, mechanical properties, advantages of bioceramics over other materials, and clinical cases with high definition pictures and videos demonstrating their usage across wide variety of clinical situations in endodontics. Written by highly qualified authors with significant experience in the field, Bioceramics in Endodontics includes information on: Material characteristics of bioceramics that Endodontists/Clinicians should be aware of Evidence based decisions between coneless and coned obturations, and healing of periapical lesions over a recall period of 3-5 years Endodontic treatment of patients using bioceramic sealers Endodontic mishaps treated with bioceramic repair material Evidence based approach for apexification using bioceramics Use of bioceramics as a root end filling material and guidelines guidelines to finding new applications for bioceramics Comparison of Bioceramics with gold standard endodontic materials A highly unique exploration into the subject, Bioceramics in Endodontics provides an essential core overview of the field of bioceramics in endodontics and related applications, making it a must-have resource for dental practitioners, along with undergraduate and postgraduate students in endodontics and other related programs of study.

Bioceramics in Joint Arthroplasty: 9th BIOLOX® Symposium Proceedings (Ceramics in Orthopaedics)

Bioceramics in Joint Arthroplasty: 8th BIOLOX® Symposium Berlin, March 28–29, 2003 Proceedings (Ceramics in Orthopaedics)

Dear Colleague and Participant of Bioceramics in Joint Arthroplasty 8'h Biolox" Symposium It is a pleasure for us to be able to present you with the proceedings of this Symposium. This is something that we are very proud of, as it is the first time that we have been able to achieve our objective of distributing this collection of all presentations made at this Symposium in a printed form at this time. The achievement of this goal was reached in great part as a result of the excellent cooperation of all of the speakers as well as the commitment of the publishing house to assist us in every way possible to meet the strict deadlines imposed. Additionally, a special thanks must also be given to some very special people who diligently worked to make sure our objective was met. They are: Gertrud Volkert. M. D. and Petra Elster of the Steinkopff Verlag Publishing company and our own Symposium Administrator, Hedi Kissinger. We believe that you will find this book to be a valuable and useful addition to your reference library. We hope that within its covers, you will find the most up to date scientific and clinical information regarding the use of ceramic solutions to address wear related problems in Orthopedic Surgery.

Biochemical and Biophysical Roles of Cell Surface Molecules (Advances in Experimental Medicine and Biology #1112)

Cell surface small molecules and macromolecules, such as members of cholesterol family (including steroid hormones), the glycolipid family (sphingolipids), the glycoprotein family (both N-linked and O-linked), and a vast array of other receptors have been shown to be involved in normal and abnormal cellular processes. The 11th International Symposium on Cell Surface Macromolecules, held in Mohali, India, in February 2017 provided a comprehensive update on the major advances in this area. Presenting selected contributions from this meeting, this book comprises 24 chapters, which provide in-depth analyses of data on the role of cell surface macromolecules in cellular function and their alterations associated with pathological conditions. It includes comprehensive research papers and critical overviews of the functional role of cell surface molecules, discussing topics such as biochemical, biophysical, and cell biological approaches to study cell membrane molecules, and metabolism of glycoconjugates.

Biochemical Approaches for Glutamatergic Neurotransmission (Neuromethods #130)

This volume presents techniques and recent developments in biochemical approaches to study glutamatergic neurotransmission. This book contains detailed discussions on tracing neuronal pathways, functional or spectroscopic imaging, optogenetic or pharmacological tools, and extracellular neurochemistry in experimental clinical models. The chapters cover topics such as: identification of glutamatergic neurons in a discrete brain area, tools to study dynamics of single ionotropic receptors, in vivo extracellular glutamate monitoring in preclinical research using biosensors, capillary electrophoresis and liquid chromatography, and potential brain glutamatergic clinical biomarkers in biofluids and tissues. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and authoritative, Biochemical Approaches for Glutamatergic Neurotransmission is a valuable resource for researchers studying glutamate neurochemistry.

Biochemical Aspects of Human Malnutrition in the Tropics (Monographiae Biologicae)

Biochemical Aspects of Nervous Diseases

Within recent years basic knowledge concerning the chemistry, and the metabolic processes taking place in the brain, spinal cord, peripheral nerves and muscles has increased in a remarkable manner. As a consequence some very important books have been published both in America and in Europe in which some, at least, of this information has become available in an easily readable form to an ever increasing group of laboratory and scientific workers. The application of such studies in a variety of neurological diseases can now be made, thus making possible an explanation of many of the clinical and pathological peculiarities that have been known for decades. Although a few small manuals have already been published, combining both biochemical and clinical aspects of such disorders and these have been studied by neurologists and chemical pathologists throughout the world, yet a volume devoted exclusively to the biochemistry of neurological diseases has not yet been readily available. The present volume is an attempt to remedy this omission in relation to just a few of the conditions. Individual writers of each of the six chapters have been chosen who are intimately concerned both with biochemistry and with its application to disease in man. Each author has been responsible for the accuracy of his chapter together with appropriate references from the literature, but the Editor does not necessarily concur with all the opinions expressed by the authors.

Biochemical Basis and Therapeutic Implications of Angiogenesis (Advances in Biochemistry in Health and Disease #6)

Angiogenesis is a highly complex phenomenon where new blood vessels are formed for the supply of oxygen and nutrients in different organs of the body. It plays a critical role in both physiological processes such as growth and development as well as pathological processes including cancer and different types of tumors. Angiogenesis is also essential for the regeneration and survival of cells in several disease conditions such as ischemic heart disease (myocardial infarction), atherosclerosis, brain injury (stroke) and diabetes. Since the mechanisms of angiogenesis are organ specific and differ among various diseases, it is proposed to devote one section of this book to the development of angiogenesis in some selected diseases such as cancer, ischemic heart disease, atherosclerosis, diabetes and stroke. It is pointed out that extensive research work in this regard has been carried out in the area of cancer and heart disease, whereas relatively less attention has been paid to studying angiogenesis in other disease conditions.

Biochemical Basis and Therapeutic Implications of Angiogenesis (Advances in Biochemistry in Health and Disease #6)

This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis’ role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis.This book also:Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integrins in angiogenesis, angiogenesis and exercise physiology, and moreDetails the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease

Biochemical Evolution: The Pursuit of Perfection

Biochemical Evolution: The Pursuit of Perfection, Second Edition by Athel Cornish-Bowden describes the relationship between biochemistry and evolutionary biology, arguing that each depends on the other to be properly understood. There are many aspects of evolution that make sense only in the light of biochemical knowledge, just as there are many as