- Table View
- List View
Biomolecular Electronics: An Introduction via Photosensitive Proteins (Bioengineering of Materials)
by Nikolai VsevolodovThe properties of materials depend on the nature of the macromolecules, small molecules and inorganic components and the interfaces and interactions between them. Polymer chemistry and physics, and inorganic phase structure and density are major factors that influence the performance of materials. In addition, molecular recognition, organic-inorganic interfaces and many other types of interactions among components are key issues in determining the properties of materials for a wide range of applications. Materials require ments are becoming more and more specialized to meet increasingly demand ing needs, from specific environmental stresses to high performance or biomedical applications such as matrices for controlled release tissue scaf folds. One approach to meet these performance criteria is to achieve better control over the tailoring of the components and their interactions that govern the material properties. This goal is driving a great deal of ongoing research in material science laboratories. In addition, control at the molecular level of interactions between these components is a key in many instances in order to reach this goal since traditional approaches used to glue, stitch or fasten parts together can no longer suffice at these new levels of manipulation to achieve higher performance. In many cases, molecular recognition and self-assembly must begin to drive these processes to achieve the levels of control desired. This same need for improved performance has driven Nature over millenia to attain higher and higher complexity.
Biomolecular Feedback Systems
by Domitilla Del Vecchio Richard M. MurrayThis book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources.Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems.Provides a user-friendly introduction to essential concepts, tools, and applicationsCovers the most commonly used modeling methodsAddresses the modular design problem for biomolecular systemsUses design examples from both natural systems and synthetic circuitsSolutions manual (available only to professors at press.princeton.edu)An online illustration package is available to professors at press.princeton.edu
Biomolecular Feedback Systems (PDF)
by Domitilla Del Vecchio Richard M. MurrayThis book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources.Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems.Provides a user-friendly introduction to essential concepts, tools, and applicationsCovers the most commonly used modeling methodsAddresses the modular design problem for biomolecular systemsUses design examples from both natural systems and synthetic circuitsSolutions manual (available only to professors at press.princeton.edu)An online illustration package is available to professors at press.princeton.edu
Biomolecular Interfaces: Interactions, Functions and Drug Design
by Ariel Fernández StiglianoThe book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior.The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.
Biomolecular Kinetics: A Step-by-Step Guide (Foundations of Biochemistry and Biophysics)
by Clive R. Bagshaw"a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide"–Mark Leake, University of York "destined to become a standard reference…. Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice."–Michael Geeves, University of Kent "covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account of transient kinetics and rapid reaction techniques, and then on to the new single molecule techniques" –Stephen Halford, University of Bristol This illustrated treatment explains the methods used for measuring how much a reaction gets speeded up, as well as the framework for solving problems such as ligand binding and macromolecular folding, using the step-by-step approach of numerical integration. It is a thoroughly modern text, reflecting the recent ability to observe reactions at the single-molecule level, as well as advances in microfluidics which have given rise to femtoscale studies. Kinetics is more important now than ever, and this book is a vibrant and approachable entry for anyone who wants to understand mechanism using transient or single molecule kinetics without getting bogged down in advanced mathematics. Clive R. Bagshaw is Emeritus Professor at the University of Leicester, U.K., and Research Associate at the University of California at Santa Cruz, U.S.A.
Biomolecular Kinetics: A Step-by-Step Guide (Foundations of Biochemistry and Biophysics)
by Clive R. Bagshaw"a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide"–Mark Leake, University of York "destined to become a standard reference…. Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice."–Michael Geeves, University of Kent "covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account of transient kinetics and rapid reaction techniques, and then on to the new single molecule techniques" –Stephen Halford, University of Bristol This illustrated treatment explains the methods used for measuring how much a reaction gets speeded up, as well as the framework for solving problems such as ligand binding and macromolecular folding, using the step-by-step approach of numerical integration. It is a thoroughly modern text, reflecting the recent ability to observe reactions at the single-molecule level, as well as advances in microfluidics which have given rise to femtoscale studies. Kinetics is more important now than ever, and this book is a vibrant and approachable entry for anyone who wants to understand mechanism using transient or single molecule kinetics without getting bogged down in advanced mathematics. Clive R. Bagshaw is Emeritus Professor at the University of Leicester, U.K., and Research Associate at the University of California at Santa Cruz, U.S.A.
Biomolecular Simulations in Structure-Based Drug Discovery (Methods and Principles in Medicinal Chemistry)
by Helmut Buschmann Jörg HolenzA guide to applying the power of modern simulation tools to better drug design Biomolecular Simulations in Structure-based Drug Discovery offers an up-to-date and comprehensive review of modern simulation tools and their applications in real-life drug discovery, for better and quicker results in structure-based drug design. The authors describe common tools used in the biomolecular simulation of drugs and their targets and offer an analysis of the accuracy of the predictions. They also show how to integrate modeling with other experimental data. Filled with numerous case studies from different therapeutic fields, the book helps professionals to quickly adopt these new methods for their current projects. Experts from the pharmaceutical industry and academic institutions present real-life examples for important target classes such as GPCRs, ion channels and amyloids as well as for common challenges in structure-based drug discovery. Biomolecular Simulations in Structure-based Drug Discovery is an important resource that: -Contains a review of the current generation of biomolecular simulation tools that have the robustness and speed that allows them to be used as routine tools by non-specialists -Includes information on the novel methods and strategies for the modeling of drug-target interactions within the framework of real-life drug discovery and development -Offers numerous illustrative case studies from a wide-range of therapeutic fields -Presents an application-oriented reference that is ideal for those working in the various fields Written for medicinal chemists, professionals in the pharmaceutical industry, and pharmaceutical chemists, Biomolecular Simulations in Structure-based Drug Discovery is a comprehensive resource to modern simulation tools that complement and have the potential to complement or replace laboratory assays for better results in drug design.
Biomolecular Simulations in Structure-Based Drug Discovery (Methods and Principles in Medicinal Chemistry)
by Helmut Buschmann Jörg HolenzA guide to applying the power of modern simulation tools to better drug design Biomolecular Simulations in Structure-based Drug Discovery offers an up-to-date and comprehensive review of modern simulation tools and their applications in real-life drug discovery, for better and quicker results in structure-based drug design. The authors describe common tools used in the biomolecular simulation of drugs and their targets and offer an analysis of the accuracy of the predictions. They also show how to integrate modeling with other experimental data. Filled with numerous case studies from different therapeutic fields, the book helps professionals to quickly adopt these new methods for their current projects. Experts from the pharmaceutical industry and academic institutions present real-life examples for important target classes such as GPCRs, ion channels and amyloids as well as for common challenges in structure-based drug discovery. Biomolecular Simulations in Structure-based Drug Discovery is an important resource that: -Contains a review of the current generation of biomolecular simulation tools that have the robustness and speed that allows them to be used as routine tools by non-specialists -Includes information on the novel methods and strategies for the modeling of drug-target interactions within the framework of real-life drug discovery and development -Offers numerous illustrative case studies from a wide-range of therapeutic fields -Presents an application-oriented reference that is ideal for those working in the various fields Written for medicinal chemists, professionals in the pharmaceutical industry, and pharmaceutical chemists, Biomolecular Simulations in Structure-based Drug Discovery is a comprehensive resource to modern simulation tools that complement and have the potential to complement or replace laboratory assays for better results in drug design.
Biomolecular Thermodynamics: From Theory to Application (Foundations of Biochemistry and Biophysics)
by Douglas Barrick"an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus…. the ample problems and tutorials throughout are much appreciated." –Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago "Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels." –Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University "a masterful tour de force…. Barrick's rigor and scholarship come through in every chapter."–Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation. Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon.
Biomolecular Thermodynamics: From Theory to Application (Foundations of Biochemistry and Biophysics)
by Douglas Barrick"an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus…. the ample problems and tutorials throughout are much appreciated." –Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago "Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels." –Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University "a masterful tour de force…. Barrick's rigor and scholarship come through in every chapter."–Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation. Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon.
Biomotors: Linear, Rotation, and Revolution Motion Mechanisms
by Peixuan Guo Zhengyi ZhaoThis book provides a comprehensive overview of biomotors (molecular motors) within the body with a specific concentration on revolving molecular motors. The bioengineering of these new revolving molecular motors will go a long way in creating machines that will be able to carry RNA and DNA drugs directly to diseased cells to destroy them. The book goes into specific details regarding the bioengineering, fabrication, synthesis, and future utilization of these devices for nanomedicine.
Biomotors: Linear, Rotation, and Revolution Motion Mechanisms
by Peixuan Guo and Zhengyi ZhaoThis book provides a comprehensive overview of biomotors (molecular motors) within the body with a specific concentration on revolving molecular motors. The bioengineering of these new revolving molecular motors will go a long way in creating machines that will be able to carry RNA and DNA drugs directly to diseased cells to destroy them. The book goes into specific details regarding the bioengineering, fabrication, synthesis, and future utilization of these devices for nanomedicine.
Biomotors and their Nanobiotechnology Applications
by Peixuan GuoThis book – a collection of reviews and research articles by the top academics in the field – provides a glimpse of the cutting-edge technology and research being carried out and shows how researchers are utilizing this knowledge to develop new areas of study and novel applications. It serves as a valuable resource while exploring the latest advances in virus particle assembly and demonstrating how the knowledge of fundamental processes has been used to advance bio-nanotechnology. Chapters detail biophysical approaches and biomotor research, discus the latest advances in DNA/RNA nanoparticle assembly and use, and introduce the use of DNA/RNA nanoparticles for drug delivery.
Biomotors and their Nanobiotechnology Applications
by Peixuan Guo Aibing WangThis book – a collection of reviews and research articles by the top academics in the field – provides a glimpse of the cutting-edge technology and research being carried out and shows how researchers are utilizing this knowledge to develop new areas of study and novel applications. It serves as a valuable resource while exploring the latest advances in virus particle assembly and demonstrating how the knowledge of fundamental processes has been used to advance bio-nanotechnology. Chapters detail biophysical approaches and biomotor research, discus the latest advances in DNA/RNA nanoparticle assembly and use, and introduce the use of DNA/RNA nanoparticles for drug delivery.
Biomphalaria Snails and Larval Trematodes
by Rafael Toledo and Bernard FriedThe purpose of this book is to provide an overview of the biology of the planorbid snail Biomphalaria glabrata mainly as related to the snail’s role as a host of larval trematodes . This snail is of great importance in medical and economic zoology as a vector of important trematode (fluke) diseases in human and veterinary medicine and in wildlife biology. Moreover, this snail is a useful model for numerous basic studies in biology and chemistry. A book that provides modern coverage of diverse topics from the molecule to the community of this snail as related to larval trematode parasitism is not available. This book should appeal to a wide audience of biologists, ecologists, biochemists, malacologists, parasitologists, public health workers, epidemiologists, and graduate and advanced undergraduate students in biomedical and allied health sciences.
BioNanoFluidic MEMS (MEMS Reference Shelf)
by Peter J. HeskethThis book explains biosensor development fundamentals. It also initiates awareness in engineers and scientists who would like to develop and implement novel biosensors for agriculture, biomedicine, homeland security, environmental needs, and disease identification. In addition, the book introduces and lays the basic foundation for design, fabrication, testing, and implementation of next generation biosensors through hands-on learning.
Bionanomaterials for Biosensors, Drug Delivery, and Medical Applications (Emerging Materials and Technologies)
by Won-Chun Oh Suresh SagadevanThis book covers advances in nanostructured materials across a variety of biomedical applications as the field evolves from development of prototype devices to real-world implementation. It provides an in-depth look at the current state of the art in oxide nanostructures, carbon nanostructures, and 2D material fabrication and highlights the most important biomedical applications and devices of nanomaterials, including drug delivery, medical imaging, gene therapy, biosensors, and diagnostics. FEATURES Presents the findings of cutting-edge research activities in the field of nanomaterials, with a particular emphasis on biological and pharmaceutical applications Details finished and ongoing toxicity evaluations of emerging nanomaterials Offers a multidisciplinary perspective This book is recommended for senior undergraduate and graduate students, professionals, and researchers working in the fields of bioengineering, materials science and engineering, and biotechnology.
Bionanomaterials for Biosensors, Drug Delivery, and Medical Applications (Emerging Materials and Technologies)
This book covers advances in nanostructured materials across a variety of biomedical applications as the field evolves from development of prototype devices to real-world implementation. It provides an in-depth look at the current state of the art in oxide nanostructures, carbon nanostructures, and 2D material fabrication and highlights the most important biomedical applications and devices of nanomaterials, including drug delivery, medical imaging, gene therapy, biosensors, and diagnostics. FEATURES Presents the findings of cutting-edge research activities in the field of nanomaterials, with a particular emphasis on biological and pharmaceutical applications Details finished and ongoing toxicity evaluations of emerging nanomaterials Offers a multidisciplinary perspective This book is recommended for senior undergraduate and graduate students, professionals, and researchers working in the fields of bioengineering, materials science and engineering, and biotechnology.
Bionanotechnology: Principles and Applications
by Anil Kumar AnalThis book deals with a subject of high interest and importance in all sectors, including: biomedical, food, agriculture, energy, and environment. Biological systems are essential in nanotechnology and many new applications are being developed by mimicking the natural systems. Approaching these topics from an engineering perspective, the book offers insight on the details of nanoscale fabrication processes, as well as cell biology. The basics of biology and chemistry, with a focus on how to engineer the behavior of molecules at the nanoscale, are also explored and analyzed. The course is designed so as to focus on broad accessibility for students from engineering and natural sciences; build design problems of interest that cross the traditional boundaries; accelerate assimilation of new knowledge spanning multiple domains through individual and constrcut0-centered design problems; and effectively exchange knowledge of state of the art developments and capabilities using collaborative learning projects.
Bionanotechnology: Principles and Applications
by Anil Kumar AnalThis book deals with a subject of high interest and importance in all sectors, including biomedical, food, agriculture, energy, and environment. Biological systems are essential in nanotechnology, and many new applications are being developed by mimicking the natural systems. Approaching these topics from an engineering perspective, the book offers insight on the details of nanoscale fabrication processes as well as cell biology. The basics of biology and chemistry, with a focus on how to engineer the behavior of molecules at the nanoscale, are also explored and analyzed. The aim of the text is to provide the reader with broader knowledge of biological methods for signal transduction and molecular recognitions systems and how they can be replicated in bio-sensing applications. The reader will learn the basic structures and interactions of biomacromolecules for developing biocompatible and eco-friendly devices.
Bionanotechnology: Principles and Applications
by Anil Kumar AnalThis book deals with a subject of high interest and importance in all sectors, including biomedical, food, agriculture, energy, and environment. Biological systems are essential in nanotechnology, and many new applications are being developed by mimicking the natural systems. Approaching these topics from an engineering perspective, the book offers insight on the details of nanoscale fabrication processes as well as cell biology. The basics of biology and chemistry, with a focus on how to engineer the behavior of molecules at the nanoscale, are also explored and analyzed. The aim of the text is to provide the reader with broader knowledge of biological methods for signal transduction and molecular recognitions systems and how they can be replicated in bio-sensing applications. The reader will learn the basic structures and interactions of biomacromolecules for developing biocompatible and eco-friendly devices.
Bionanotechnology: Radio Controlled Antimicrobial and Genetic Vectors
by Johnathan L. KielThis book describes how methodologies in biochemistry, molecular and cellular biology, electromagnetic bioeffects, and nanotechnology were brought together to construct a nanostructure that is a composite of nucleic acid, carbon nanotube, paramagnetic metallic nanoparticles, and aromatic polymer that is responsive to nonionizing electromagnetic radiation, RFR to microwaves. It demonstrates that the construct can act as a redox catalyst accelerated by nonionizing electromagnetic radiation, and also as a conveyor of genetic modification of specifically targeted eukaryotic and prokaryotic cells. The scientific knowledge necessary to accomplish this is described and step-by-step progress supported by data and examples are noted. The general purpose is to show how such interdisciplinary approaches can lead to disruptive technologies. This book is most valuable to those (molecular biologists, vaccinologists, biomedical engineers, microbiologists) looking for more externally controllable gene vectors, antimicrobials, and antiparasitics, using a totally new nanoparticle platform. Those pursuing biological applications of nanotechnology will also be interested. This text has uniquely multidisciplinary approaches, drawing together chemistry, physics, molecular biology, biochemistry, and biomedical and electrical engineering.
BioNanotechnology (Synthesis Lectures on Biomedical Engineering)
by Elisabeth Papazoglou Aravind ParthasarathyThis book aims to provide vital information about the growing field of bionanotechnology for undergraduate and graduate students, as well as working professionals in various fields. The fundamentals of nanotechnology are covered along with several specific bionanotechnology applications, including nanobioimaging and drug delivery which is a growing $100 billions industry. The uniqueness of the field has been brought out with unparalleled lucidity; a balance between important insight into the synthetic methods of preparing stable nano-structures and medical applications driven focus educates and informs the reader on the impact of this emerging field. Critical examination of potential threats followed by a current global outlook completes the discussion. In short, the book takes you through a journey from fundamentals to frontiers of bionanotechnology so that you can understand and make informed decisions on the impact of bionano on your career and business.
Bionanotechnology: Global Prospects
by David E. ReisnerAs the impact and importance of nanotechnology continues to grow, nanomedicine and biotechnology have become areas of increased development. Drug delivery by nanoparticulates and nanocoatings for medicial devices are among the many new techniques on the horizon. Years from now we will laugh at the approaches to treating disease we currently conside
Bionanotechnology: Proteins to Nanodevices
by V. Renugopalakrishnan Randy V. LewisBionanotechnology is the key integrative technology of the 21st century and aims to use the knowledge, gathered from the natural construction of cellular systems, for the advancement of science and engineering. Investigating the topology and communication processes of cell parts can lead to invention of novel biological devices with exciting applications. Though microscale to nanoscale research offers an excellent space for the development of futuristic technologies, a number of challenges must be overcome. Due to paucity of a dedicated literature on the protein based nanodevices we bring you this monograph that combines collective research works of scientists probing into this fascinating universe of bionanotechnology. The monograph has been written with an aim of surveying engineering design principles of biomolecular nanodevices, prototype nanodevices based on redox proteins, bacteriorhodopsins and natural fibers, and touching upon the future developments in the field.