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Biostatistics in Public Health Using STATA

Striking a balance between theory, application, and programming, Biostatistics in Public Health Using STATA is a user-friendly guide to applied statistical analysis in public health using STATA version 14. The book supplies public health practitioners and students with the opportunity to gain expertise in the application of statistics in epidemiolo

The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness

A practical and clarifying approach to aging and aging-related diseases Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population. With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features: Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values A comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations The development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology An explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles The amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software Technical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.

The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness

A practical and clarifying approach to aging and aging-related diseases Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population. With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features: Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values A comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations The development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology An explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles The amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software Technical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.

Biostatistics with R: An Introduction to Statistics Through Biological Data (Use R!)

Biostatistics with R is designed around the dynamic interplay among statistical methods, their applications in biology, and their implementation. The book explains basic statistical concepts with a simple yet rigorous language. The development of ideas is in the context of real applied problems, for which step-by-step instructions for using R and R-Commander are provided. Topics include data exploration, estimation, hypothesis testing, linear regression analysis, and clustering with two appendices on installing and using R and R-Commander. A novel feature of this book is an introduction to Bayesian analysis.This author discusses basic statistical analysis through a series of biological examples using R and R-Commander as computational tools. The book is ideal for instructors of basic statistics for biologists and other health scientists. The step-by-step application of statistical methods discussed in this book allows readers, who are interested in statistics and its application in biology, to use the book as a self-learning text.

Biostatistics With 'R': A Guide for Medical Doctors

This book aims not only to introduce fundamental biostatistics topics but to explain them through R-project (R-studio). 'R' is perhaps the more used statistical software in the medical field. It is structured as a 'scientific journey' and comes with a sham yet realistic dataset ready to be analysed. The dataset along with the R-script can be downloaded from GitHub, and each chapter has dedicated scripts that will enhance the understanding of R and biostatistics. Specifically designed for whoever works in the medical-academic environment, this practical guide will help the reader to become familiar with basic to advanced biostatistics topic (descriptive - analysis / regression etc.) and to gain solid knowledge of R.

Biostatistik: Einführung in die Biometrie für Biologen und Agrarwissenschaftler (Springer-Lehrbuch)

Diese sehr gut verständliche Einführung in die Biometrie ist für all jene geeignet, die möglichst rasch statistische Verfahren zur Auswertung experimenteller Ergebnisse lernen und handhaben möchten. Grundlagen und Anwendung werden gleichermaßen dargestellt, wobei biologische und agrarwissenschaftliche Beispiele besonders berücksichtigt werden. Dabei legt das Buch keinen Wert auf Vollständigkeit, sondern versucht exemplarisch, an den für die Zielgruppe wesentlichen Verfahren das Verständnis für die dahinterstehenden Ideen zu entwickeln. Übersichtliche Rechenanleitungen regen den Leser an, die Verfahren anhand der Beispieldaten wirklich nachzuvollziehen. In der Neuauflage wurde insbesondere die "Versuchsplanung" erweitert und der Anhang durch grundlegende Aspekte der Wahrscheinlichkeitsrechnung ergänzt.

Biostatistik: Eine Einführung für Biologen und Agrarwissenschaftler (Springer-Lehrbuch)

Diese bewährte und sehr gut verständliche Einführung in die Biometrie wurde für die Neuauflage überarbeitet und erweitert. Sie ist für all jene geeignet, die möglichst rasch statistische Verfahren zur Auswertung experimenteller Ergebnisse lernen und handhaben möchten. Grundlagen und Anwendung werden gleichermaßen dargestellt, wobei biologische und agrarwissenschaftliche Beispiele besonders berücksichtigt werden. Unter möglichst weitgehender Vermeidung von Formeln und mathematischer Symbolik wird dem Anwender zunächst ein Verständnis für die hinter dem Verfahren stehende Grundidee vermittelt. Übersichtliche Rechenanleitungen regen den Leser an, die Verfahren anhand der Beispieldaten wirklich nachzurechnen. Das Buch ist als Begleittext zu einer Vorlesung ebenso geeignet wie zum Selbststudium, um darauf aufbauend alleine oder mit dem Statistiker komplexe statistische Verfahren anzuwenden.

Biostatistik (Springer-Lehrbuch)

Biostatistik: die Vermessung des Lebendigen. Diese bewährte und leicht verständliche Einführung in die Biometrie eignet sich für all jene, die rasch statistische Verfahren zur Auswertung experimenteller Ergebnisse erlernen möchten. Die Autoren stellen Grundlagen und Anwendung gleichermaßen dar. Dabei berücksichtigen sie insbesondere biologische und agrarwissenschaftliche Beispiele. Sie vermitteln Anwendern ein Verständnis für die hinter dem Verfahren stehende Grundidee und vermeiden dabei weitgehend Formeln und mathematische Symbolik. Übersichtliche Anleitungen regen dazu an, die Verfahren anhand der Beispieldaten wirklich nachzurechnen.

Biostatistik: Eine Einführung für Biologen und Agrarwissenschaftler (Springer-Lehrbuch)

Die Auswertung experimenteller Ergebnisse ist für Biologen und Agrarwissenschaftler ein wichtiges Handwerkszeug. Mit dieser gut verständlichen Einführung in Grundlagen und Anwendungen der Biometrie ist ein schneller Einstieg in die Statistik möglich. Soweit wie möglich wird ohne Formeln und mathematische Symbolik die hinter den Verfahren stehende Grundidee komplexer statistischer Verfahren erläutert. Die 5. Auflage enthält zusätzlich Schemata zur Versuchsplanung und Auswertung sowie ein erweitertes Glossar englischer Fachausdrücke.

Biostatistik: Eine Einführung für Biologen und Mediziner

Biostatistik: Eine Einführung für Biologen

Es ist das Ziel des Buches, ein statistisches Basiswissen zu vermitteln, das zu einfachen Auswertungen befähigt. Behandelt werden u.a. Beschreibungsmöglichkeiten bei eindimensionalen Stichproben, die deskriptive Korrelations- und Regressionsrechnung, wichtige diskrete und stetige Wahrscheinlichkeitsverteilungen, die Grundlagen zum Verständnis von statistischen Schätzungen und Signifikanztests sowie ausgewählte Testverfahren in Verbindung mit Zweistichprobenproblemen und der Varianz- bzw. Regressionsanalyse. Vorausgesetzt werden nur Kenntnisse der Schulmathematik. Es wurde versucht, einen starken Anwendungsbezug durch eine Fülle von durchgerechneten Beispielen herzustellen. Diese sollen zusammen mit den am Abschluß eines jeden Kapitels beigefügten Aufgaben, zu denen es im Anhang einen ausführlichen Lösungsteil gibt, der Biostatistik den Charakter eines Arbeitsbuches verleihen, das sich vor allem auch zum Selbststudium eignet.

Biosurfactants: Research Trends and Applications

Microbially derived surfactants, called biosurfactants, provide a promising alternative to synthetic surfactants, displaying better availability and being generally nontoxic and biodegradable. Biosurfactants also have the advantage of diverse chemical properties and the potential to be less expensive. They demonstrate properties such as reducing su

Biosurfactants (Advances in Experimental Medicine and Biology #672)

The microbial world has given us many surprises including microbes that grow under extremely harsh conditions (122C at 40 MPa), novel metabolisms such as the uranium and perchlorate reduction, and novel chemicals that can be used to control diseases. We continually face new and difficult problems such as the need to transition to more carbon-neutral energy sources and to find eco-friendly chemicals and to find new drugs to treat disease. Will it be possible to tap into the seemingly limitless potential of microbial activity to solve our current and future problems?The answer to this question is probably yes. We are already looking to the microbial world to provide new energy sources, green chemicals to replace those made from petroleum, and new drugs to fight disease. To help us along these paths, we are deciphering how microorganisms interact with each other. We know that microbial populations interact and communicate with each other. The language that microbes use is chemical where small molecules are exchanged among different microbial cells. Sometimes, these chemicals suppress activities of competitors and could be used as antibiotics or may have other therapeutic uses. Other times, the chemicals stimulate complex responses in microbial populations such as fruiting body or biofilm formation. By understanding the conversation that microbes are having among themselves, e. g.

Biosurfactants: Microbial Surfactants

This book illustrates the importance and significance of the biosurfactants obtained from microorganisms, preferably from bacteria and yeast. It explains the superiority of biosurfactants (green molecule) over chemically synthesized surfactants for the sustainable future. The content of the present book addresses the quest for novel biosurfactants producing strains, high throughput screening methods, and production strategies. It finely describes the aptness of biosurfactants for industrial and environmental applications. It elaborately describes the technical background and cutting-edge advancement of the commercial aspect of biosurfactants. In the later part of the book, the role of green biosurfactants in food processing, control of food spoilage, incorporation in personal health care products, environmental and agricultural remediation are discussed. Finally, the book elucidates a comprehensive and representative description of toxicity assessment of the biosurfactants, which highlights the risk assessment of the incorporation of the microbial biosurfactants in food, healthcare, and pharmaceutical formulations.

Biosynthese und Alterung von Kollagen: Vorgelegt in der Sitzung vom 5. Juli 1974 (Sitzungsberichte der Heidelberger Akademie der Wissenschaften #1974 / 3)

Biosynthesis (Antibiotics #4)

The Series on Antibiotics produced by Springer-Verlag began more than a decade ago with the nearly simultaneous appearance of two volumes, one dealing with the mode of action of antibiotics and the other concerning the biosynthesis of them. The standards set by the original Editors were high, and these books have proved useful to many. The rapid advances in our knowl­ edge of the mode of action of antibiotics and other antitumor agents has stimu­ lated two further works in the same series (Volume III, 1975; and Volumes Vj1 and Vj2, 1979). For some time it had appeared to Dr. Konrad Springer that the time might' be ripe' for bringing the subject of the biosynthesis of antibiotics up-to-date. This Editor agreed to survey the literature and discuss this possibility with his colleagues who are active in research on antibiotics. In spite of the appearance of numerous review articles, both of a highly special­ ized and general nature, on the biosynthesis of antibiotics, it was agreed generally that it would be extremely useful to add a new volume on biosynthesis to the Series. Such a work should focus on collecting a group of contributions dealing with those antibiotics whose biosynthesis is understood in much greater detail now than it was in the middle 1960's. Since Volume II on biosynthesis continues to be available, this addition to the series has not dealt with each and every antibiotic whose biosynthesis was studied long ago.

Biosynthesis (Antibiotics)

Biosynthetic Products for Cancer Chemotherapy: Volume 2

An overall view of the cancer problem and development of cancer chemothera­ 231 peutic biosynthetic products to February 1976 was presented in Volume 1. In the short time that has elapsed since the preparation of Volume 1, several very stimulating advances in application of biosynthetic cancer chemotherapeutic drugs in cancer treatment have been reported. At the May 1976 meeting (in Toronto) of the American Association for Cancer Research, a Sloan-Kettering research group summarized an improved treatment of human neuroblastoma using a combination of vincristine, cytoxan, trifluorothymidine, and papaverine. In the same period other clinical groups described significant advances in the cancer chemotherapeutic treatment of human breast cancer and oat cell carcinoma of the lung. Each of these newer advances in cancer treatment was based on combinations of biosynthetic and synthetic cancer chemotherapeutic drugs. Certainly, further examination of the antineoplastic biosynthetic agents summarized in this volume and the vast number yet to be discovered will eventually provide the means for controllil).g and/or curing the various types of human cancer.

Biosynthetic Products for Cancer Chemotherapy: Volume 1

Cancer exacts an incredibly destructive toll on the world's human populations. In recent years we have frequently heard the expression "war on cancer," but compared to the carnage inflicted by cancer, our scientific and medical efforts, to date, would seem more like a minor skirmish. Some comprehension of the cancer problem can be obtained from a look at the current and projected casualty list for the United States. In this country, about 700,000 new cases of cancer will be diagnosed in 1976 and over 1 million known cases will continue to be treated. Over 400,000 of these patients will die from cancer in our bicentennial year. With the incidence of cancer in the United States increasing to 5.2% in 1975, compared to the 1.1 % yearly rate experienced for decades, Dr. F. J. Rauscher, Jr.,338 Director of the National Cancer Institute, has estimated that more than 10 million people will be under treatment for cancer and nearly 4 million will expire from cancer in this decade. At that rate, cancer will appear in nearly two of three families and the necessary medical care will cost some $15-20 billion per year. Thus unless methods for the treatment and control of cancer are markedly improved, about 53 million Americans now alive will eventually be cancer patients. Unfor­ tunately the major types of human cancer are still beyond curative care by surgical and radiological techniques and because of the paucity of currently available cancer chemotherapeutic drugs with curative potential.

Biosynthetic Products for Cancer Chemotherapy: Volume 3

Fortunately the scientific and medical literature related to cancer chemo­ therapy is now expanding rapidly. While this is most excellent for future cancer treatment prospects, it is becoming more difficult for all the resear­ chers in chemotherapy-bio-organic chemists involved with the discovery of new anticancer drugs, biologists and pharmacologists developing these new drugs, and physicians doing the clinical research-to keep abreast of current achievements in these disciplines so vitally important to effective cancer treatment. The purpose of Volumes 1 and 2 of this work was to provide useful reviews of current progress in discovery and clinical applica­ tion of new biosynthetic cancer chemotherapeutic drugs. Volume 1 gave a general view of the cancer problem and cancer treatment using biosynthetic products, based on literature available through December 1975. Volume 2 included mainly the first summary of plant and animal biosynthetic antineoplastic and/or cytotoxic constituents to April 1976. The survey comprising this third volume has been divided into two sections. Section A provides an extension of the Volume 2 data on plant and animal antineoplastic and/or cytotoxic constituents to July 1977. The introduction to Section A brings the summary of such biosynthetic products to literature available November 1, 1977. Section B incorporates a summary of data of essentially all previously isolated and characterized marine animal constituents irrespective of biological activity.

Biosynthetic Technology and Environmental Challenges (Energy, Environment, and Sustainability)

This book provides a comprehensive review of biosynthetic approaches to the production of industrially important chemicals and the environmental challenges involved. Its 19 chapters discuss different aspects of biosynthetic technology from the perspective of leading experts in the field. It covers various biorefinery approaches, including the use of microbes, metabolically engineered plants, biomass-based and green technology methods. Further, it examines important research in the areas of organic and hazardous waste composting, management and recovery of nutraceuticals from agro-industrial waste, biosynthesis and technological advancements of biosurfactants and waste water bioremediation. This book contributes to the scientific literature on biosynthetic technologies and the related environmental challenges for researchers and academics working in this area around the globe.

Biosystems Approach to Industrial Patient Monitoring and Diagnostic Devices, A (Synthesis Lectures on Biomedical Engineering)

A medical device is an apparatus that uses engineering and scientific principles to interface to physiology and diagnose or treat a disease. In this Lecture, we specifically consider thosemedical devices that are computer based, and are therefore referred to as medical instruments. Further, the medical instruments we discuss are those that incorporate system theory into their designs. We divide these types of instruments into those that provide continuous observation and those that provide a single snapshot of health information. These instruments are termed patient monitoring devices and diagnostic devices, respectively.Within this Lecture, we highlight some of the common system theory techniques that are part of the toolkit of medical device engineers in industry. These techniques include the pseudorandom binary sequence, adaptive filtering, wavelet transforms, the autoregressive moving average model with exogenous input, artificial neural networks, fuzzy models, and fuzzy control. Because the clinical usage requirements for patient monitoring and diagnostic devices are so high, system theory is the preferred substitute for heuristic, empirical processing during noise artifact minimization and classification. Table of Contents: Preface / Medical Devices / System Theory / Patient Monitoring Devices / Diagnostic Devices / Conclusion / Author Biography

Biosystems, Biomedical & Drug Delivery Systems: Characterization, Restoration and Optimization

The book gives an insight into the thorough study and examination of incumbent biosystems, their present status and disruption in their integrity, causes and effects, measures to be taken for their characterization and restoration apart from advances and applications in the field of biosciences, drug design, discovery, bio-systems, biomedical and drug delivery technologies, tools in particular. The book collates information from several disciplines, such as chemistry, biology, material science, engineering, statistics, biomedicine, genetics, etc., as the subject in question is a confluence of many disciplines exhibiting numerous applications such as bioimaging, novel biological agents, synthesis, discovery testing, characterization of drugs right from selecting a suitable precursor to discovering and designing a drug following a correct synthetic route, adoption of computer simulation-based models, AI/ML-based models, application of statistical tools in analyzing and interpreting data, design, multi-functional, and operational drug delivery systems, their bio-compatibility, capacity of carrying and release of drug reproducibly etc. The book is helpful to postgraduate students, research scholars, academicians, and scientists from the pharmaceutical, biotechnology, and chemical engineering domains. The book covers a conceptual understanding of the exploration of drugs in unity with the applications desired, sound bio-system development, and carriers for drug and supplement delivery.

Biosystems Engineering I: Creating Superior Biocatalysts (Advances in Biochemical Engineering/Biotechnology #120)

-Integration of Systems Biology with Bioprocess Engineering: L-Threonine Production by Systems Metabolic Engineering of Escherichia Coli, By Sang Yup Lee and Jin Hwan Park; -Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium glutamicum, By Christoph Wittmann; -Systems Biology of Industrial Microorganisms, Marta Papini, Margarita Salazar, and Jens Nielsen; -De Novo Metabolic Engineering and the Promise of Synthetic DNA, By Daniel Klein-Marcuschamer, Vikramaditya G. Yadav, Adel Ghaderi, and Gregory N. Stephanopoulos; -Systems Biology of Recombinant Protein Production in Bacillus megaterium, Rebekka Biedendieck, Boyke Bunk, Tobias Fürich, Ezequiel Franco-Lara, Martina Jahn, and Dieter Jahn; -Extending Synthetic Routes for Oligosaccharides by Enzyme, Substrate and Reaction Engineering; By Jürgen Seibel, Hans-Joachim Jördening, and Klaus Buchholz; -Regeneration of Nicotinamide Coenzymes: Principles and Applications for the Synthesis of Chiral Compounds; By Andrea Weckbecker, Harald Gröger, and Werner Hummel;

Biotargets of Cancer in Current Clinical Practice (Current Clinical Pathology)

Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (individualized) therapy through biotarget-specific new molecular treatments, with the latest information on the validation status of each novel biomarker. Individual chapters are dedicated to the major cancer types, plus a special chapter on metastasis. The present debate on patentability of genetic information applied to diagnostics and therapeutics of cancer is also discussed.