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The Bipolar Book: History, Neurobiology, and Treatment

As a major mainstay of clinical focus and research today, bipolar disorder affects millions of individuals across the globe with its extreme and erratic shifts of mood, thinking and behavior. Edited by a team of experts in the field, The Bipolar Book: History, Neurobiology, and Treatment is a testament and guide to diagnosing and treating this exceedingly complex, highly prevalent disease. Featuring 45 chapters from an expert team of contributors from around the world, The Bipolar Book delves deep into the origins of the disorder and how it informs clinical practice today by focusing on such topics as bipolar disorder occurring in special populations, stigmatization of the disease, the role genetics play, postmortem studies, psychotherapy, treatments and more. Designed to be the definitive reference volume for clinicians, students and researchers, Aysegül Yildiz, Pedro Ruiz and Charles Nemeroff present The Bipolar Book as a "must have" for those caregivers who routinely deal with this devastating disease.

The Bipolar Brain: Integrating Neuroimaging and Genetics

Bipolar disorder is one of the most common, and disabling, conditions affecting humankind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletely understood. However, significant technological advances in both neuroimaging and genetic research have revealed clues about the neurophysiological basis of bipolar illness. In this second edition of The Bipolar Brain, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. New technologies such as miRNA, cerebral blood flow, and fMRI are presented. Based upon these discussions, the authors then integrate these diverse considerations to develop a specific neurophysiological model of bipolar disorder. This model provides a resource to guide clinicians as they struggle to understand this illness, as well as a guide for future investigations into the causes of bipolar disorder. With this guide in hand, this book will lead to a new framework for understanding bipolar disorder in order to, ultimately, develop improved therapies for affected individuals and novel strategies to prevent the onset in children at risk for this condition.

The Bipolar Brain: Integrating Neuroimaging and Genetics

Bipolar disorder is one of the most common, and disabling, conditions affecting humankind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletely understood. However, significant technological advances in both neuroimaging and genetic research have revealed clues about the neurophysiological basis of bipolar illness. In this second edition of The Bipolar Brain, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. New technologies such as miRNA, cerebral blood flow, and fMRI are presented. Based upon these discussions, the authors then integrate these diverse considerations to develop a specific neurophysiological model of bipolar disorder. This model provides a resource to guide clinicians as they struggle to understand this illness, as well as a guide for future investigations into the causes of bipolar disorder. With this guide in hand, this book will lead to a new framework for understanding bipolar disorder in order to, ultimately, develop improved therapies for affected individuals and novel strategies to prevent the onset in children at risk for this condition.

Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis And Pharmacotherapy (Milestones in Drug Therapy)

This book brings together mental health professionals and researchers to offer the most up-to-date information on the diagnosis, treatment, and research surrounding bipolar depression. Its individual chapters provide valuable diagnostic information, allowing clinicians to distinguish between the various mood disorders. Further, they: review the course, outcome, and genetics of this highly heritable condition; offer a thorough overview of the neurobiology of the disorder, including what is known from neuroimaging work; delineate the treatment of bipolar depression in special populations such as children and pregnant women; address suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient’s symptoms and history; and cover acute and long-term treatment strategies for bipolar depression, including both traditional and novel therapeutics for the disorder, as well as non-pharmacological treatments.This second edition reflects significant advances, including an improved understanding of the altered neurobiology of patients suffering from bipolar depression, new information on pathophysiology and genetic findings drawn from diverse studies, and a discussion of the significant strides made towards improved treatment with already available and novel agents.

Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (Milestones in Drug Therapy)

Although our knowledge of mood disorders is expanding, comparatively little is known about bipolar depression in particular. This book offers the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression. Early chapters provide diagnostic information and review the course, outcome and genetics of this heritable condition. The book gives a thorough and unique overview of the neurobiology of the disorder, including neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women. Furthermore, the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment, are addressed. Finally, acute and long-term treatment strategies for bipolar depression are discussed, including both traditional and novel therapeutics, as well as non-pharmacological treatments. This volume offers researchers and clinicians key insights into this devastating disorder.

Bipolar Disorder: An Evidence-Based Guide to Manic Depression

This book examines in detail the diagnostic approach to manic depressive (bipolar) illness, with special reference to the borderline zones with unipolar depression and schizoaffective disorder. Among other diagnostic issues considered are mixed episodes (often misdiagnosed by psychiatrists), rapid cycling, and the confusion with personality disorders. Within the context of diagnosis and understanding of the dynamics of bipolar disorder, temperament, character, and personality are all extensively discussed. Neurocognitive deficit and disability are covered, as are elements of evolutionary biology and behavior. With regard to treatment, the major focus is on evidence-based therapy, with reference to the results of randomized controlled trials and meta-analyses; in addition, contemporary guidelines and future trends are examined. Careful consideration is also given to the psychosocial treatment approach and issues relating to societal and economic costs and burdens.

Bipolar Disorder (WPA Series in Evidence & Experience in Psychiatry #15)

Bipolar disorder is a serious mental disorder involving episodes of serious mania and depression and affects approximately one to three percent of the population. According to the National Institute of Mental Health nearly two million individuals in the United States alone are diagnosed with this disorder. * This title aims to provide an overview of recent research progress * It explores the impact of this evidence on the practice of expert clinicians of many different countries * It will be an unbiased and reliable reference point with the kudos of WPA endorsement

Bipolar Disorder (Oxford American Psychiatry Library)

Bipolar disorder is one of the most common and disabling conditions affecting humankind. It is a leading cause of disability and mortality worldwide, affecting millions of people. The illness is complex and dynamic, so that many individuals are misdiagnosed for years and clinicians struggle with identifying the most appropriate and successful treatment. Because it is complex and common, people suffering from bipolar disorder seek help from clinicians of all types - from psychiatrists, family doctors, gynecologists, and internists to psychologists, social workers and other therapists. For clinicians without significant experience with bipolar disorder, how to manage the condition can be mystifying. Even experienced psychiatrists will frequently find themselves uncertain of the best approach to a given individual with bipolar illness. This pocket-sized guide was specifically written with this diverse group of clinicians in mind. It provides a concise, practical and current overview of bipolar disorder, including making a correct diagnosis, identifying important medical and psychiatric comorbidities, and describing our current understanding of the epidemiology, genetics and neurobiology of the condition. In addition to these topics to provide context, the majority of the book is focused on a programmatic approach toward managing bipolar disorder, including discussions of specific subpopulations, such as children or women who are pregnant. The book may also be of interest for people with bipolar disorder and their families, to help guide treatment seeking and provide education about this sometimes mystifying condition. The author is an internationally recognized and trusted expert in the study and treatment of bipolar disorder, annually named a Best Doctor® and recognized by US News and World Report® as a Top 1% Psychiatrist, whose own extensive clinical experience working with people with bipolar disorder guides this book.

Bipolar Disorder (Oxford American Psychiatry Library)

Bipolar disorder is one of the most common and disabling conditions affecting humankind. It is a leading cause of disability and mortality worldwide, affecting millions of people. The illness is complex and dynamic, so that many individuals are misdiagnosed for years and clinicians struggle with identifying the most appropriate and successful treatment. Because it is complex and common, people suffering from bipolar disorder seek help from clinicians of all types - from psychiatrists, family doctors, gynecologists, and internists to psychologists, social workers and other therapists. For clinicians without significant experience with bipolar disorder, how to manage the condition can be mystifying. Even experienced psychiatrists will frequently find themselves uncertain of the best approach to a given individual with bipolar illness. This pocket-sized guide was specifically written with this diverse group of clinicians in mind. It provides a concise, practical and current overview of bipolar disorder, including making a correct diagnosis, identifying important medical and psychiatric comorbidities, and describing our current understanding of the epidemiology, genetics and neurobiology of the condition. In addition to these topics to provide context, the majority of the book is focused on a programmatic approach toward managing bipolar disorder, including discussions of specific subpopulations, such as children or women who are pregnant. The book may also be of interest for people with bipolar disorder and their families, to help guide treatment seeking and provide education about this sometimes mystifying condition. The author is an internationally recognized and trusted expert in the study and treatment of bipolar disorder, annually named a Best Doctor® and recognized by US News and World Report® as a Top 1% Psychiatrist, whose own extensive clinical experience working with people with bipolar disorder guides this book.

Bipolar Disorder (Primer On Series)

Bipolar disorder is among the most common conditions affecting humankind and one of the leading causes of disability worldwide. It is a complex and dynamic psychiatric condition that makes it difficult to both understand and manage. However, with good management, people affected by bipolar disorder can lead very successful lives. This book was written specifically with new psychiatrists and mental health practitioners in mind to facilitate their ability to care for this condition. Chapters review clinical presentation and epidemiology, etiology and neurobiology, and treatment of bipolar disorder.

Bipolar Disorder (Primer On Series)

Bipolar disorder is among the most common conditions affecting humankind and one of the leading causes of disability worldwide. It is a complex and dynamic psychiatric condition that makes it difficult to both understand and manage. However, with good management, people affected by bipolar disorder can lead very successful lives. This book was written specifically with new psychiatrists and mental health practitioners in mind to facilitate their ability to care for this condition. Chapters review clinical presentation and epidemiology, etiology and neurobiology, and treatment of bipolar disorder.

Bipolar Disorder: A Clinician's Guide to Treatment Management

First published in 2009. Routledge is an imprint of Taylor & Francis, an informa company.

Bipolar Disorder: A Clinician's Guide to Treatment Management

First published in 2009. Routledge is an imprint of Taylor & Francis, an informa company.

Bipolar Disorder E-book: Your Questions Answered (Your Questions Answered)

In the popular Q and A format of the Your Questions Answered series, this book provides succinct, expert information on bipolar disorder and its management in primary care. With an emphasis on evidence-based, up-to-date knowledge, the author discusses all aspects of this condition, including how to diagnose bipolar disorder, its impact on daily life, and current and emerging therapies to control it. Some frequently asked patient questions, in non-medical language, are included, and there is a list of sources of further information and patient support.Popular question-and-answer formatCovers both commonplace and rarer issuesIncludes information on other types of headacheLists useful websites, associations, patient resourcesSections on patient's frequently asked questions

Bipolar Disorder: From Neuroscience to Treatment (Current Topics in Behavioral Neurosciences #48)

Bipolar disorder is a common, complex and costly mental health disorder, which sits at the heart of the practice of clinical psychiatry.Effective treatments (pharmacological, psychological and brain stimulation based) have all been discovered serendipitously. With the huge advances in basic neuroscience the way is now clear for novel treatments to be developed based on brain science. This book reviews these possibilities.

Bipolar Disorder in Later Life

This comprehensive volume is the first to offer guidance to clinicians and researchers treating or studying bipolar disorder in older adults. Growing numbers of elderly people are affected by this serious mental illness. Presenting the most recent information, experts in the fields of bipolar disorder, geriatrics, and mental health services research cover late-life bipolar disorder in four major domains: epidemiology and assessment, treatment, complexity and comorbidity, and specialized care delivery. Revealing the effect of the aging process on the disease, they address diagnosis patterns over the life course, rating scales of assessment, pharmacologic and psychological therapies, adherence to treatment, effects of cultural factors, assessing the quality of care, and legal and ethical issues. An important tool for clinicians, this book will serve as a springboard for further research into this complex disorder.

Bipolar Disorder in Older Age Patients

This book provides a comprehensive but practical understanding of the clinical approach to evaluating and caring for older people with bipolar disorder. Aspects of aging that impact the diagnosis, clinical course, and management of bipolar disorder are explained; in particular, attention is drawn to the implications of comorbidities and medical complexity for the psychiatric care of older individuals with the disorder. On the other hand, similarities to treatment in younger patients are also identified. The coverage includes thorough review of current research in the field. Clinical case vignettes are used throughout to highlight practical points, and each chapter includes “clinical pearls” that summarize key points for the clinician. The book closes by examining anticipated research directions and the future needs of this patient population. Bipolar Disorder in Older Age Patients will be an ideal update for the practicing community or geriatric psychiatrist working with older patients with bipolar disorder.

Bipolar Disorder in Youth: Presentation, Treatment and Neurobiology

Bipolar disorders affect up to 3% of the world's population and are the 6th leading cause of disability worldwide. The estimated annual costs of bipolar disorder approach $50 billion in the United States, and the associated societal and personal suffering is immeasurable. Bipolar disorder is a lifelong illness that typically begins in mid-adolescence, thereby disrupting healthy developmental processes. It is also a progressive illness, making early intervention even more critical. As the disorder presents differently in youth as it does in adults, considerable controversy exists around the diagnosis in young people. The neurobiological factors leading to the onset of bipolar disorder reflect abnormalities in adolescent brain development. Bipolar disorder is strongly heritable and therefore, these developmental abnormalities likely represent the culmination of processes that precede the expression of symptoms. Current studies of children who are at risk for bipolar disorder are identifying these processes. Again, controversy exists about how to move these neuroscience gains forward to help affected individuals and, particularly to manage children at risk to delay or prevent the onset or progression of bipolar disorder. With these considerations in mind, Bipolar Disorder in Youth provides a timely, focused review of the diagnosis, treatment, and neurobiology of bipolar disorder in youth. It addresses current controversies and resolves those in which evidence is available. The book is organized into three sections based on these topics to provide comprehensive discussions to aid clinicians managing these individuals in their practices, as well as scientists trying to advance the field. The three editors are widely recognized experts in bipolar disorder, and the authors of each chapter represent international experts in the respective topics. Consequently, this book is the most comprehensive volume available discussing this important population and is a 'must' for the libraries of clinicians and scientists working with bipolar children and adolescents.

Bipolar Disorder in Youth: Presentation, Treatment and Neurobiology

Bipolar disorders affect up to 3% of the world's population and are the 6th leading cause of disability worldwide. The estimated annual costs of bipolar disorder approach $50 billion in the United States, and the associated societal and personal suffering is immeasurable. Bipolar disorder is a lifelong illness that typically begins in mid-adolescence, thereby disrupting healthy developmental processes. It is also a progressive illness, making early intervention even more critical. As the disorder presents differently in youth as it does in adults, considerable controversy exists around the diagnosis in young people. The neurobiological factors leading to the onset of bipolar disorder reflect abnormalities in adolescent brain development. Bipolar disorder is strongly heritable and therefore, these developmental abnormalities likely represent the culmination of processes that precede the expression of symptoms. Current studies of children who are at risk for bipolar disorder are identifying these processes. Again, controversy exists about how to move these neuroscience gains forward to help affected individuals and, particularly to manage children at risk to delay or prevent the onset or progression of bipolar disorder. With these considerations in mind, Bipolar Disorder in Youth provides a timely, focused review of the diagnosis, treatment, and neurobiology of bipolar disorder in youth. It addresses current controversies and resolves those in which evidence is available. The book is organized into three sections based on these topics to provide comprehensive discussions to aid clinicians managing these individuals in their practices, as well as scientists trying to advance the field. The three editors are widely recognized experts in bipolar disorder, and the authors of each chapter represent international experts in the respective topics. Consequently, this book is the most comprehensive volume available discussing this important population and is a 'must' for the libraries of clinicians and scientists working with bipolar children and adolescents.

Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations

Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness.Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomicsExamines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorderExplores the interaction between genomic and environmental influences that shape behavior

Bipolar Disorders: 100 Years after Manic-Depressive Insanity

Bipolar for Psychotherapists and Their Clients

This unique book is needed because it aims to improve the care of Bipolar clients while strengthening the clinical practices of non-MD psychotherapists. What is different is the proposal that psychotherapists manage the overall care of Bipolar clients. The increased number of publications about Bipolar over the past decades has enhanced the recognition of Bipolar. As many as 16 million individuals in the US may have a Bipolar episode at some point.Psychiatrists have traditionally managed Bipolar clients but there are not enough psychiatrists and they generally spend only 10 to 15 minutes every one to six months with their clients—often not enough time to recognize oncoming Bipolar episodes. Therapeutic strategy has changed from treating acute episodes to postponing next episodes. Psychotherapists see their clients for 50 minutes every week and are in a better position to recognize developing episodes. Psychotherapists do not prescribe and medicines are usually needed along with psychotherapy for best results. This book encourages psychotherapists to vet and collaborate with prescribers in caring for the therapists’ Bipolar clients.Lacking in the psychotherapists’ armamentarium for treating Bipolar clients is education regarding diagnostic signs, symptoms, and treatment including the most productive medications. This book provides therapists and clients the needed information and encourages academic departments and other psychotherapy programs to institute training about Bipolar Disorders.

Bipolar Psychopharmacotherapy: Caring for the Patient

"If a colleague were to ask me, "What would you recommend I read if I want to become a real expert on bipolarity?" I would respond Bipolar Psychopharmacotherapy: Caring for the Patient." Journal of Bipolar Disorders And the second edition is even better! Bipolar Psychopharmacotherapy covers both pharmacotherapy and the supportive role of psychotherapy, psychoeducation and social approaches to provide a broad integrative philosophy of care for bipolar patients. Extensive coverage is given to special management issues such as the pharmacological care of women with bipolar disorder, children and the elderly, as well as bipolar depression and suicide prevention. The mood swings that characterize bipolar disorder can now be better stabilized in most patients than in the past, but the illness must be carefully managed throughout a person's life. Pharmacotherapy is central to the acute treatment and long-term management and as there are several classes of drugs which are often prescribed concurrently, treatment issues are complex. This essential reference work features critical reviews of the existing literature, plus information on new treatments that have been reported at peer reviewed scientific meetings, often written by the pioneering experts on a particular treatment. The second-generation antipsychotics are now covered in separate chapters to provide in-depth coverage of these agents. There are also new chapters on the pharmacological treatments of mixed states and rapid cycling and novel therapeutic vistas.

Bipolar Psychopharmacotherapy: Caring for the Patient

"If a colleague were to ask me, "What would you recommend I read if I want to become a real expert on bipolarity?" I would respond Bipolar Psychopharmacotherapy: Caring for the Patient." Journal of Bipolar Disorders And the second edition is even better! Bipolar Psychopharmacotherapy covers both pharmacotherapy and the supportive role of psychotherapy, psychoeducation and social approaches to provide a broad integrative philosophy of care for bipolar patients. Extensive coverage is given to special management issues such as the pharmacological care of women with bipolar disorder, children and the elderly, as well as bipolar depression and suicide prevention. The mood swings that characterize bipolar disorder can now be better stabilized in most patients than in the past, but the illness must be carefully managed throughout a person's life. Pharmacotherapy is central to the acute treatment and long-term management and as there are several classes of drugs which are often prescribed concurrently, treatment issues are complex. This essential reference work features critical reviews of the existing literature, plus information on new treatments that have been reported at peer reviewed scientific meetings, often written by the pioneering experts on a particular treatment. The second-generation antipsychotics are now covered in separate chapters to provide in-depth coverage of these agents. There are also new chapters on the pharmacological treatments of mixed states and rapid cycling and novel therapeutic vistas.

Bipolar Psychopharmacotherapy: Caring for the Patient

Bipolar disorder is often not recognized as an illness, and people may suffer for years before it is properly diagnosed and treated. Like diabetes or heart disease, bipolar disorder is a long-term illness that must be carefully managed throughout a person's life. Pharmacotherapy is central to the acute treatment and long-term management of the disorder and as there are several classes of drugs, which are often prescribed concurrently, treatment issues are complex. This essential reference work examines major pharmacological treatments in the different phases of bipolar disorder. Chapters are devoted to commonly use pharmacological treatments with a critical review of the existing literature. Each chapter includes information not only on studies that have been published but also on new treatments that have been reported in peer reviewed scientific meetings. Bipolar Psychopharmacotherapy covers both pharmacotherapy and the role of psychotherapy, psychoeducation and social approaches to provide a broad integrative philosophy of care for bipolar patients. Extensive coverage is given to special management issues such as the care of women with bipolar disorder, children and the elderly, as well as bipolar depression and suicide prevention. With contributions from the pioneers in the field and an expert editor team, Bipolar Psychopharmacotherapy provides psychiatrists and all mental health practitioners with an invaluable guide to the management of these complex patients. From the reviews: “If a colleague were to ask me, “What would you recommend I read if I want to become a real expert on bipolarity?” I would respond ‘Bipolar Psychopharmacotherapy: Caring for the Patient’.” JOURNAL OF BIPOLAR DISORDERS "... a very useful reference on the pharmacological treatment of bipolar disorder that is written in a very practical and user-friendly format... a must for anyone dealing with patients with bipolar disorder." DOODY'S HEALTH SERVICES "... a multifaceted text with broad clinical value… recommended as an in-office reference for the practicing physician who treats the bipolar patients… to all Health Science libraries as a general reference text." THE ELECTRIC REVIEW