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Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis book presents a case history of a patient with leukocyte adhesion deficiency to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems often seen in the clinic. It is helpful for medical and pre-medical students.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis book presents a case history of a patient with leukocyte adhesion deficiency to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems often seen in the clinic. It is helpful for medical and pre-medical students.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis book presents a case history of a patient with X-linked lymphoproliferative syndrome, to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems seen in the clinic. It is intended to help medical students and pre-medical students.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis case study of a boy with juvenile diabetes illustrates a complication of poorly controlled insulin-dependent diabetes mellitus (IDDM), namely diabetic glomerulosclerosis. In IDDM, the kidneys are damaged, renal failure ensues and the only therapy, except hemodialysis, is renal transplantation.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis book presents a case history of a patient with interferon-gamma receptor deficiency to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems seen in the clinic. It is intended to help medical students and pre-medical students.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis is a case study of a 12-year-old boy who received massive intravenous penicillin and ampicillin injections to treat pneumonia and developed a serum sickness reaction to the antibiotics. Serum sickness can prove fatal if it provokes kidney shutdown or bleeding in a critical area.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis book presents a case history of a patient with a mixed essential cryoglobulinemia, to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems often seen in the clinic. It is helpful for medical and pre-medical students.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis book presents case histories that are chosen for two purposes: to illustrate in a clinical context essential points about the mechanisms of immunity; and to describe and explain some of the immunological problems often seen in the clinic.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis case study is about a 25-year-old male admitted into hospital for the 28th time. He was later diagnosed with a genetic deficiency in factor I that were instrumental in deciphering the mechanism of activation of the alternative pathway of complement activation important in innate immunity.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis book presents a case history of a patient with Wiskott-Aldrich syndrome to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems seen in the clinic. It is intended to help medical students and pre-medical students.
Case Studies in Immunology: A Clinical Companion
by Raif Geha FRED RosenThis book presents a case history of a patient with deficiency of the C8 complement component, to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems often seen in the clinic. It is helpful for medical and pre-medical students.
Case Studies in Immunology: A Clinical Companion
by Lois N. MagnerCase Studies in Immunology, Seventh Edition is intended for medical students and undergraduate and graduate students in immunology. It presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. Each case history is preceded by essential scientific facts about the immunological mechanisms o
Case Studies in Immunology (AID) Deficiency: A Clinical Companion
by Raif Geha FRED RosenThis book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.
Case Studies in Immunology (AID) Deficiency: A Clinical Companion
by Raif Geha FRED RosenThis book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.
Case Studies in Immunology (ALPS): A Clinical Companion
by Raif Geha FRED RosenThis book presents a case history of a patient with autoimmune lymphoproliferative syndrome, to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems seen in the clinic. It is helpful for medical students and pre-medical students.
Case Studies in Immunology (ALPS): A Clinical Companion
by Raif Geha FRED RosenThis book presents a case history of a patient with autoimmune lymphoproliferative syndrome, to illustrate essential points about the mechanisms of immunity and to explain some of the immunological problems seen in the clinic. It is helpful for medical students and pre-medical students.
Case Studies in Infection Control
by John Holton Meera ChandCase Studies in Infection Control has 25 cases, each focusing on an infectious disease, which illustrate the critical aspects of infection control and prevention. Scenarios in the cases are real events from both community and hospital situations, and written by experts. Although brief comments are included in relation to the organism, diagnosis, and treatment the main emphasis is on the case, its epidemiology, and how the situation should be managed from the perspective of infection control and prevention. Each case also has multiple choice questions and answers as well as listing international guidelines and references. All the cases will be an invaluable learning tool for anyone studying or practicing infection control.
Case Studies in Infection Control
by John Holton Meera ChandCase Studies in Infection Control has 25 cases, each focusing on an infectious disease, which illustrate the critical aspects of infection control and prevention. Scenarios in the cases are real events from both community and hospital situations, and written by experts. Although brief comments are included in relation to the organism, diagnosis, and treatment the main emphasis is on the case, its epidemiology, and how the situation should be managed from the perspective of infection control and prevention. Each case also has multiple choice questions and answers as well as listing international guidelines and references. All the cases will be an invaluable learning tool for anyone studying or practicing infection control.
Case Studies in Infectious Disease
by Michael Cole Kate Ward Peter Lydyard John Holton Will Irving Nino Porakishvili Pradhib VenkatesanCase Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, followed by clinical presentation, diagnosis and treatment. Five core sets of questions are posed in each case. What is the nature of the infectious agent, how does it gain access to the body, what cells are infected, and how does the organism spread? What are the host defense mechanisms against the agent and how is the disease caused? What are the typical manifestations of the infection and the complications that can occur? How is the infection diagnosed and what is the differential diagnosis? How is the infection managed, and what preventative measures can be taken to avoid infection? This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms, fully integrating microbiology and immunology throughout.
Case Studies in Infectious Disease
by Peter Lydyard Michael Cole John Holton Will Irving Nino Porakishvili Pradhib Venkatesan Kate WardCase Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, followed by clinical presentation, diagnosis and treatment. Five core sets of questions are posed in each case. What is the nature of the infectious agent, how does it gain access to the body, what cells are infected, and how does the organism spread? What are the host defense mechanisms against the agent and how is the disease caused? What are the typical manifestations of the infection and the complications that can occur? How is the infection diagnosed and what is the differential diagnosis? How is the infection managed, and what preventative measures can be taken to avoid infection? This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms, fully integrating microbiology and immunology throughout.
Case Studies in Infectious Disease
by Peter Lydyard Michael Cole John Holton Will Irving Nino Porakishvili Pradhib Venkatesan Kate WardCase Studies in Infectious Disease presents 40 case studies featuring the most important human infectious diseases worldwide. Fully revised and updated in this second edition, the book describes the natural history of infection from point of entry of the pathogen through to clinical management of the resulting disease or condition. A further 8 case studies have been provided online as supplementary material, and these can be downloaded by students. Five core sets of questions are posed in each case, with the answers covering the nature of the infectious agent, route(s) of spread and of infection, pathogenesis of disease, host response to infection, clinical manifestations, diagnosis, treatment and prevention. This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms and diseases, fully integrating microbiology and immunology throughout. KEY FEATURES High-resolution photos accompany each case, from the causative agents of disease to the clinical manifestations of the infection. Exquisite artwork helps to illustrate important concepts throughout the book. Eight new cases added to this new edition, extending coverage of important infectious diseases of worldwide significance. A standardized set of core questions allows students to compare directly differences between microbes such as their structure, clinical manifestations, host response, pathogenesis and availability of vaccines. Questions and answers available online, test the reader’s understanding of each case study. The book provides essential case-based learning for undergraduate and graduate microbiology students, while medical students and trainee physicians will also find the up-to-date information on 48 globally important infectious diseases outlined in a clear, digestible form, invaluable during undergraduate studies and in future clinical practice.
Case Studies in Infectious Disease
by Peter Lydyard Michael Cole John Holton Will Irving Nino Porakishvili Pradhib Venkatesan Kate WardCase Studies in Infectious Disease presents 40 case studies featuring the most important human infectious diseases worldwide. Fully revised and updated in this second edition, the book describes the natural history of infection from point of entry of the pathogen through to clinical management of the resulting disease or condition. A further 8 case studies have been provided online as supplementary material, and these can be downloaded by students. Five core sets of questions are posed in each case, with the answers covering the nature of the infectious agent, route(s) of spread and of infection, pathogenesis of disease, host response to infection, clinical manifestations, diagnosis, treatment and prevention. This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms and diseases, fully integrating microbiology and immunology throughout. KEY FEATURES High-resolution photos accompany each case, from the causative agents of disease to the clinical manifestations of the infection. Exquisite artwork helps to illustrate important concepts throughout the book. Eight new cases added to this new edition, extending coverage of important infectious diseases of worldwide significance. A standardized set of core questions allows students to compare directly differences between microbes such as their structure, clinical manifestations, host response, pathogenesis and availability of vaccines. Questions and answers available online, test the reader’s understanding of each case study. The book provides essential case-based learning for undergraduate and graduate microbiology students, while medical students and trainee physicians will also find the up-to-date information on 48 globally important infectious diseases outlined in a clear, digestible form, invaluable during undergraduate studies and in future clinical practice.
Case Studies in Innovative Clinical Trials (Chapman & Hall/CRC Biostatistics Series)
by Kristine Broglio Binbing YuDrug development is a strictly regulated area. As such, marketing approval of a new drug depends heavily, if not exclusively, on evidence generated from clinical trials. Drug development has seen tremendous innovation in science and technology that has revolutionized the treatment of some diseases. And yet, the statistical design and practical conduct of the clinical trials used to test new therapeutics for safety and efficacy have changed very little over the decades. Our approach to clinical trials is steeped in convention and tradition. The large, fixed, randomized controlled trial methods that have been the gold standard are well understood and expected by many trial stakeholders. However, this approach is not well suited to all aspects of modern drug development and the current competitive landscape. We now see new therapies that target a small fraction of the patient population, rare diseases with high unmet medical needs, and pediatric populations that must wait for years for new drug approvals from the time that therapies are approved in adults. Large randomized clinical trials are at best inefficient and at worst completely infeasible in many modern clinical settings. Advances in technology and data infrastructure call for innovations in clinical trial design. Despite advances in statistical methods, the availability of information, and computing power, the actual experience with innovative design in clinical trials across industry and academia is limited. This book will be an important showcase of the potential for these innovative designs in modern drug development and will be an important resource to guide those who wish to undertake them for themselves. This book is ideal for professionals in the pharmaceutical industry and regulatory agencies, but it will also be useful to academic researchers, faculty members, and graduate students in statistics, biostatistics, public health, and epidemiology due to its focus on innovation. Key Features: Is written by pharmaceutical industry experts, academic researchers, and regulatory reviewers; this is the first book providing a comprehensive set of case studies related to statistical methodology, implementation, regulatory considerations, and communication of complex innovative trial design. Has a broad appeal to a multitude of readers across academia, industry, and regulatory agencies. Each contribution is a practical case study that can speak to the benefits of an innovative approach but also balance that with the real-life challenges encountered. A complete understanding of what is actually being done in modern clinical trials will broaden the reader’s capabilities and provide examples to first mimic and then customize and expand upon when exploring these ideas on their own.
Case Studies in Innovative Clinical Trials (Chapman & Hall/CRC Biostatistics Series)
Drug development is a strictly regulated area. As such, marketing approval of a new drug depends heavily, if not exclusively, on evidence generated from clinical trials. Drug development has seen tremendous innovation in science and technology that has revolutionized the treatment of some diseases. And yet, the statistical design and practical conduct of the clinical trials used to test new therapeutics for safety and efficacy have changed very little over the decades. Our approach to clinical trials is steeped in convention and tradition. The large, fixed, randomized controlled trial methods that have been the gold standard are well understood and expected by many trial stakeholders. However, this approach is not well suited to all aspects of modern drug development and the current competitive landscape. We now see new therapies that target a small fraction of the patient population, rare diseases with high unmet medical needs, and pediatric populations that must wait for years for new drug approvals from the time that therapies are approved in adults. Large randomized clinical trials are at best inefficient and at worst completely infeasible in many modern clinical settings. Advances in technology and data infrastructure call for innovations in clinical trial design. Despite advances in statistical methods, the availability of information, and computing power, the actual experience with innovative design in clinical trials across industry and academia is limited. This book will be an important showcase of the potential for these innovative designs in modern drug development and will be an important resource to guide those who wish to undertake them for themselves. This book is ideal for professionals in the pharmaceutical industry and regulatory agencies, but it will also be useful to academic researchers, faculty members, and graduate students in statistics, biostatistics, public health, and epidemiology due to its focus on innovation. Key Features: Is written by pharmaceutical industry experts, academic researchers, and regulatory reviewers; this is the first book providing a comprehensive set of case studies related to statistical methodology, implementation, regulatory considerations, and communication of complex innovative trial design. Has a broad appeal to a multitude of readers across academia, industry, and regulatory agencies. Each contribution is a practical case study that can speak to the benefits of an innovative approach but also balance that with the real-life challenges encountered. A complete understanding of what is actually being done in modern clinical trials will broaden the reader’s capabilities and provide examples to first mimic and then customize and expand upon when exploring these ideas on their own.