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Central Auditory Processing and Neural Modeling: Proceedings Of An International Workshop Held In Kaohsiung, Taiwan, January 26-29, 1997
by Paul W. F. Poon John F. BruggeThe full power of combining experiment and theory has yet to be unleashed on studies of the neural mechanisms in the brain involved in acoustic information processing. In recent years, enormous amounts of physiological data have been generated in many laboratories around the world, characterizing electrical responses of neurons to a wide array of acoustic stimuli at all levels of the auditory neuroaxis. Modern approaches of cellular and molecular biology are leading to new understandings of synaptic transmission of acoustic information, while application of modern neuro-anatomical methods is giving us a fairly comprehensive view ofthe bewildering complexity of neural circuitry within and between the major nuclei of the central auditory pathways. Although there is still the need to gather more data at all levels of organization, a ma jor challenge in auditory neuroscience is to develop new frameworks within which existing and future data can be incorporated and unified, and which will guide future laboratory ex perimentation. Here the field can benefit greatly from neural modeling, which in the central auditory system is still in its infancy. Indeed, such an approach is essential if we are to address questions related to perception of complex sounds including human speech, to the many di mensions of spatial hearing, and to the mechanisms that underlie complex acoustico-motor behaviors.
Central Cardiovascular Control: Basic and Clinical Aspects (Current Topics in Neuroendocrinology #3)
by M. R. Brown L. A. Fisher W. G. Forssmann W. Gaida D. Ganten K. Hermann W. Hoefke M. M. Knuepfer K. Kraft R. R. Lang S. Lundin G. Mancia M. Schmelz G. Stock P. Thoren T. Unger A. WeindlThe most prominent function of the central nervous system is the control of motor functions by rapidly transmitted impulses through efferent cranial and spinal peripheral nerves. Besides electrically transmitted neural impulses, humoral mechanisms with more sustained actions are exercised by the brain and spinal cord to regulate body homeostasis. Thus, the brain may be regarded as an "endocrine gland" discharging neurohormones (peptides) either into the general circulation (neurohypophyseal hormones) or into the hypothalamo-adenohypophyseal portal circulation (releasing and inhibiting hormones). The brain, therefore, which is protected by the blood-brain barrier from disturbing and potentially noxious exogenous and endogenous agents circulating in the blood, has to have certain neurohemal regions beyond this barrier, such as the neural lobe and the median eminence (infundibulum), where neurohor mones have free access to the blood stream. To regulate somatic and autonomic functions in the best possible way, the central nervous system is highly dependent on feedback signals conveyed through somatic and visceral afferent nerves as well as on peripheral humoral signals such as peripheral hormones and other circulating substances that are under homeostatic regulation, e. g. , peptides, arnines, electrolytes, and other biologically active agents. In this chapter, the role of the blood-brain barrier in the regulation of these sub stances will be discussed with special emphasis on the access through the blood-brain barrier to cardiovascular centers. 2 The Blood-Brain Barrier 2.
Central Cholinergic Mechanisms and Adaptive Dysfunctions
by HarbansLal David M. Warburton Man MohanSinghAlthough serious interest in studying the role of central cho linergic processes in psychopathology is just beginning to emerge, experimental literature on the part played by cholinergic mechanisms in brain behavior. reiations is quite extensive. During the past thirty years, cholinergic research has contributed significantly to the characterization and differentiation of adaptive mechanisms in volved in input selection, perception, cortical, autonomic and behav ioral activation, learning, memory, and inhibitory control of behav ioral outputs. To say that dysfunction of one or more of these mech anisms may be at the root of neuropsychiatric illnesses such as schiz ophrenia would be stating the obvious. This book examines the part cholinergic processes might play in dysfunctions of the adaptive processes involved in higher brain func tions and their significance for the pathogenesis, classification, etiology, and treatment of psychopathological conditions. In a series of wide ranging reviews of the available information, the subject is discussed from a variety of perspectives, using data derived from both experimental and clinical research. The purpose is not so much to determine whether cholinergic excess or deficiency is causal in this or that neuropsychiatric syndrome, but rather to try to understand the disease mechanisms in terms of adaptive processes in which cholinergic systems seem to play an important part.
Central Functions of the Ghrelin Receptor (The Receptors #25)
by Jeanelle Portelli Ilse SmoldersThe Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson’s disease, epilepsy, anxiety and depression.
Central Interaction Between Respiratory and Cardiovascular Control Systems
by Professor Dr. H. P. Koepchen Professor Dr. S. M. Hilton Professor Dr. A. TrzebskiThis book presents the proceedings of a satellite symposium of the XXVllth International Congress of IUPS held in Berlin, July 12-15, 1977 the latest of a series of meetings dealing with the organization of the autonomic nervous system, especially its central nervous control (Warsaw 1971, Tokyo 1974, Heidelberg 1976). This was an occasion for the discussion of the rapidly increasing experience of laboratories and research groups in a number of countries. Interest is growing in the organization of the sympathetic and parasympathetic nerve supplies, and there is much new material derived largely from single unit re cordings within both central and peripheral nervous structures. It has long been known that various rhythms originating in central ner vous structures, including the respiratory rhythm, are reflected in autonomic outflows. Moreover, the autonomic responses themselves rarely appear in isolation, and are usually seen as part of patterns of change involving a number of organs and systems. These facts alone imply com plex interactions within the central nervous system, which indicate that studies of relationships between the relevant inputs, intrinsic central nervous activity and autonomic outputs constitute a special branch of neurophysiology which needs to be developed in order to gain insights into the forms of central nervous organization which are in volved.
The Central Nervous System
by Per BrodalThe Fifth edition finds the text of The Central Nervous System thoroughly updated and revised, better equipping students with essential information in the field of clinical neuroscience. This text, reviewed to reflect new information as well as understanding of student needs for critical thinking, contains the systematic, in-depth coverage of topics of great clinical interest. This text seamlessly integrates data from all fields of neuroscience as well as clinical neurology and psychology. This textbook presents the functional properties of clinically-relevant disorders by incorporating data from molecular biology to clinical neurology. Key Features of the Fifth Edition Include... · Chapters knit together by numerous cross-references and explanations, helping the reader to connect data. · Carefully selected full color line drawings of the complexities of the nervous system. · Extensive use of text-boxes provides in-depth material without disturbing the flow of reading. · Provides a crucial list of references for further reading. While most neurological textbooks are cobbled together by multiple authors on a variety of topics within the field, Dr. Brodal pulls together a cohesive and comprehensive guide to neuroscience. This book reflects Dr. Brodal's concise and easy-to-read style, encouraging reflection and critical thinking in established facts and scientific conjecture. This is the perfect reference for medical, graduate, and undergraduate students alike.
The Central Nervous System
by Per BrodalThe Fifth edition finds the text of The Central Nervous System thoroughly updated and revised, better equipping students with essential information in the field of clinical neuroscience. This text, reviewed to reflect new information as well as understanding of student needs for critical thinking, contains the systematic, in-depth coverage of topics of great clinical interest. This text seamlessly integrates data from all fields of neuroscience as well as clinical neurology and psychology. This textbook presents the functional properties of clinically-relevant disorders by incorporating data from molecular biology to clinical neurology. Key Features of the Fifth Edition Include... · Chapters knit together by numerous cross-references and explanations, helping the reader to connect data. · Carefully selected full color line drawings of the complexities of the nervous system. · Extensive use of text-boxes provides in-depth material without disturbing the flow of reading. · Provides a crucial list of references for further reading. While most neurological textbooks are cobbled together by multiple authors on a variety of topics within the field, Dr. Brodal pulls together a cohesive and comprehensive guide to neuroscience. This book reflects Dr. Brodal's concise and easy-to-read style, encouraging reflection and critical thinking in established facts and scientific conjecture. This is the perfect reference for medical, graduate, and undergraduate students alike.
Central Nervous System: Studies on Metabolic Regulation and Function
by H. Herken E. GenazzaniThis book is based on the Symposium "Metabolic Regulation and Functional Activity in the Central Nervous System" which was held on September 16 and 17, 1972, at Saint Vincent (Aosta)/Italy, and was sponsored by the Accademia di Medicina di Torino with the scientific cooperation of the Istituto di Farmacologia, Universita di Torino, and the Pharmakologisches Institut der Freien Universitat Berlin. Its purpose was to give a greater number of scientists from different countries an opportunity to report their latest results under a heading concerning general relationships between metabolism and function. We quite deliberately refrained from pursuing the partly heterogenous subjects into details. Thus, the organizers hoped to be able to interest a greater circle of readers for the manifold subjects from various fields dealing with the investigation of metabolic processes in the central nervous system. The discussion remarks to the lectures could not be considered for printing. The Accademia di Medicina di Torino and all others concerned do not only thank Dr. R. Di Carlo and other members of the Istituto di Farmacologia, Universita di Torino, for the excellent work they performed in preparing this Symposium, but also the Amministrazione Regionale della Valle di Aosta and SIT A V di Saint-Vincent for their generous support and their kind hospitality which made the stay at Saint-Vincent most agreeable for all participants.
Central Nervous System Cancer Rehabilitation
by Adrian CristianOffering a well-rounded overview of CNS cancers and best practices for rehabilitation of the cancer patient, Spinal and Brain Cancer Rehabilitation provides succinct, easy-to-digest coverage for practicing and trainee physiatrists, as well as physical and occupational therapists. This concise resource by Dr. Adrian Cristian begins with an introduction to CNS cancers and progresses to rehabilitation practice, associated symptom management, and palliative care.
Central Nervous System Control of the Heart: Proceedings of the IIIrd International Brain Heart Conference Trier, Federal Republic of Germany (Topics in the Neurosciences #4)
by T. Stober K. Schimrigk D. Ganten D. G. ShermanThe first two "Brain Heart Conferences" in Jerusalem in 1978 and 1983 were based upon the common interests of clinically orientated neurologists and cardiologists in the problems of centr'al autonomic control and autonomic disturbances of the cardiovascular system. The relatively slow scientific progress, at least clinically, in this area may be due to the fact that neither cardiologists nor neurologists felt competent in both topics. Furthermore, it has become increasingly difficult to have an overall view of the basic research and its clinical applications in this field. New research methods, based on a comtination of morphological, biochemical, and physiological techniques, have enabled the functional differentiation of various areas of the brain and subsequently also of the autonomic nervous system. The simple dualistic concept of an antagonistic sympathetic-parasympathetic regulation of the circulatory system is no longer valid. It is clear that numerous neurotransmitters, in particular the neuropeptides, are involved in a highly differentiated subdivision of the autonomic system. One of the aims of the IIIrd International Brain Heart Conference was therefore to supply a synopsis of the latest developments in basic research undertaken in this field by exceptionally competent scientists, to clinically orientated neurologists and cardiologists, and thus to provide new impulses for clinical research.
Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic (Contemporary Neuroscience)
by Dwaine F. Emerich Paul R. Sanberg Reginald L. Dean IIIProminent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
Central Nervous System Diseases and Inflammation
by Thomas E. Lane Monica Carson Conni Bergmann Tony Wyss-CorayEdited and authored by top names in the field, this book provides a succinct reference on inflammatory central nervous system disease. It focuses on current areas of investigation in the fields of neuroimmunology, virology, pharmacology, and disease. Sections focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. This book’s unique organization provides a concise overview of inflammatory CNS disease.
The Central Nervous System in AIDS: Neurology · Radiology · Pathology · Ophthalmology
by Juan Artigas Gernot Grosse Fred NiedobitekCompact and clearly arranged, this book details present knowledge of AIDS research in the fields of neurology and ophthalmology.The experience gained by clinical experts through working with a large number of patients is presented together with the detailed morphologic results of neuropathology. To describe the various disease complexes, morphology takes into account all methods of result representation, including immunohistochemistry and electron microscopy.The four disciplines mentioned in the subtitle describe all aspects of the CNS with regard to AIDS, including clinically significant opthalmologic results.Richly illustrated clinical and morphological descriptions helps you to understand the widely diverse CNS symptoms as well as ophthalmic involvement.
The Central Nervous System in Pediatric Critical Illness and Injury
by Derek S. Wheeler Hector R. Wong Thomas P. ShanleyNeurologic emergencies are a common reason for admission to the pediatric intensive care unit (PICU). A thorough understanding of the diseases and disorders affecting the pediatric central nervous system is vital for any physician or healthcare provider working in the PICU. In the following pages, an international panel of experts provides an in-depth discussion on the res- citation, stabilization, and ongoing care of the critically ill or injured child with central nervous system dysfunction. Once again, we would like to dedicate this textbook to our families and to the physicians and nurses who provide steadfast care every day in pediatric intensive care units across the globe. Derek S. Wheeler Hector R. Wong Thomas P. Shanley v Preface to Pediatric Critical Care Medicine: Basic Science and Clinical Evidence The ? eld of critical care medicine is growing at a tremendous pace, and tremendous advances in the understanding of critical illness have been realized in the last decade. My family has directly bene? ted from some of the technological and scienti? c advances made in the care of critically ill children. My son Ryan was born during my third year of medical school. By some peculiar happenstance, I was nearing completion of a 4-week rotation in the newborn intensive care unit (NICU).
Central Nervous System Intraoperative Cytopathology (Essentials in Cytopathology #13)
by César R. Lacruz Javier Saénz de Santamaría Ricardo H. BardalesThe Essentials in Cytopathology book series fulfills the need for an easy-to-use and authoritative synopsis of site specific topics in cytopathology. These guide books fit into the lab coat pocket and are ideal for portability and quick reference. Each volume is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. Central Nervous System Intraoperative Cytopathology covers the full spectrum of benign and malignant conditions of the CNS with emphasis on common disorders. The volume is heavily illustrated and contains useful algorithms that guide the reader through the differential diagnosis of common and uncommon entities encountered in the field of intraoperative neuro-cytopathology. This book will be a valuable quick reference for pathologists, cytopathologists, and fellows and trainees dealing with this exigent field.Since the successful First Edition, the advances in radiological, clinical, morphological, and molecular aspects of CNS diseases, as well as the increasing options for different treatments modalities require updating of textbooks and revision of diagnostic algorithms. To reach this aim, Central Nervous System Intraoperative Cytopathology, Second Edition features the incorporation of 3 new chapters, 2 appendices, and all new full-color images in the text with updates of new diagnostic information according to 2016 WHO classification of CNS tumors. This fully updated edition also includes expanded clinic-radiological approach, recent biomarkers, and cytological features of new WHO entities. In summary, the text has been extensively revised and largely rewritten to offer the practicing pathologist a concise summary of the critical information needed to recognize and interpret the current exigent field of intraoperative neurocytopathology.
Central Nervous System Intraoperative Cytopathology (Essentials in Cytopathology #13)
by César R. Lacruz Javier Saénz de Santamaría Ricardo H. BardalesThe Essentials in Cytopathology book series fulfills the need for an easy-to-use and authoritative synopsis of site specific topics in cytopathology. These guide books fit into the lab coat pocket and are ideal for portability and quick reference. Each volume is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. Central Nervous System Intraoperative Cytopathology covers the full spectrum of benign and malignant conditions of the CNS with emphasis on common disorders. The volume is heavily illustrated and contains useful algorithms that guide the reader through the differential diagnosis of common and uncommon entities encountered in the field of intraoperative neuro-cytopathology. Central Nervous System Intraoperative Cytopathology is a valuable quick reference for pathologists, cytopathologists, and fellows and trainees dealing with this exigent field.
Central Nervous System Leukemia: Prevention and Treatment (Developments in Oncology #13)
by Renato Mastrangelo, David G. Poplack and Riccardo RiccardiIn the past 10 to IS years there has been dramatic improvement in the survival of children with acute lymphoblastic leukemia. At the present time, over 50% of children with this disease will be alive and free of their disease at least 5 years from the time of their initial diagnosis. Although a number of factors have contributed to this improvement, perhaps none has been as important as the institution of central nervous system preventive therapy (eNS prophylaxis). However, despite the efficacy of eNS prophylaxis, the prevention and treatment of central nervous system leukemia continues to pose a formidable clinical challenge to the pediatric oncologist. Although successful in most cases, eNS preventive therapy remains ineffective for a small but significant subset of patients at high risk for developing eNS disease. Moreover, it has become increasingly evident that some methods of eNS preventive therapy are associated with long-term, adverse eNS sequelae. Thus, considerable controversy exists regarding the optimal method of eNS prophylaxis. Treatment of the patient who develops overt meningeal leukemia has not been as successful and continues to pose a major clinical challenge. Despite the ability of intrathecal chemotherapy and/or radiation therapy to induce eNS remission, most patients suffer subsequent relapse and ultimate survival is usually signifi cantly compromised. It is evident that newer approaches to treatment for this patient group must be identified before major improvement for this patient group is likely to occur.
Central Nervous System Metastases
by Manmeet Ahluwalia Philippe Metellus Riccardo SoffiettiThis book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives.Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach.Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.
Central Nervous System Metastases: Diagnosis and Treatment
by Rohan Ramakrishna Rajiv S. Magge Ali A. Baaj Jonathan P. S. KniselyThis is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy.Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine.
Central Nervous System Metastasis, the Biological Basis and Clinical Considerations (Cancer Metastasis - Biology and Treatment #18)
by Diane PalmieriHere is a thorough survey of the biology and treatment of CNS metastasis, including natural history, risk factors, molecular biology, the blood-brain barrier, imaging, quality of life, surgery, chemotherapy, radiation and the future of targeted therapies.
Central Nervous System Monitoring in Anesthesia and Intensive Care
by Jochen Schulte Am Esch Eberhard KochsResearch in electrophysiologic monitoring in anesthesia and intensive care has focussed mostly on questions pertinent for patient care: First how to quantitate drug effects on brain electrical activity and the degree of anesthetic-induced suppression of the central nervous system. Second, how to monitor functional impairment following cerebral ischemia and hypoxia. And third, how to differ entiate between drug-induced effects on the central nervous system and deleteri ous events related to reductions in cerebral blood flow and/or oxygen delivery. Even though progress has been achieved over the last 10 years in this field and fascinating new techniques have been developed, it is still not clear which monitor parameter will provide adequate information on the depth of anes thesia and the analgesic level. Because the central nervous system has been one of the main research areas in our department over the last 10 years, we organized a workshop to summarize the latest developments in central nervous system monitoring. This book comprises the topics of this workshop and is intended to provide insight into the current status of central nervous system monitoring, elucidating possible indications and delineating its limitations.
The Central Nervous System of Vertebrates
by Rudolf Nieuwenhuys Hans J. Donkelaar Charles NicholsonThis comprehensive reference is clearly destined to become the definitive anatomical basis for all molecular neuroscience research. The three volumes provide a complete overview and comparison of the structural organisation of all vertebrate groups, ranging from amphioxus and lamprey through fishes, amphibians and birds to mammals. This thus allows a systematic treatment of the concepts and methodology found in modern comparative neuroscience. Neuroscientists, comparative morphologists and anatomists will all benefit from:* 1,200 detailed and standardised neuroanatomical drawings * the illustrations were painstakingly hand-drawn by a team of graphic designers, specially commissioned by the authors, over a period of 25 years * functional correlations of vertebrate brains * concepts and methodology of modern comparative neuroscience * five full-colour posters giving an overview of the central nervous system of the vertebrates, ideal for mounting and displayThis monumental work is, and will remain, unique; the only source of such brilliant illustrations at both the macroscopic and microscopic levels.
Central Nervous System Pathology: A New Approach
by G.N. KryzhanovskyOne hardly always receives due credit for working out a general theory. It is more enticing to be successful in discovering new phenomena of tangible facts even if they are particular ones. The great technical opportunities which now exist and the new methods of investigation which recently seemed to be fantastic have made that even more enticing. Therefore, the establishment of general regu larities seems to be an abstract occupation whose significance is not always clear. Nevertheless, a general theory should be elaborated. Factual material should be systematized and generalized as it accumu lates. As an increasing amount of data is obtained, it becomes increasingly urgent to ascertain the general regularities which determine the typical mechanisms of individual phenomena. Re searchers approach these aspects of scientific activity in different ways. Some of them are interested in analyzing the specifics of a phenomenon, while others try to find a general regularity in an individual fact and look for its confirmation in new material. Both of these indispensable forms of research have been reflected in this book.
Central Nervous System Tissue Engineering: Current Considerations and Strategies (Synthesis Lectures on Tissue Engineering)
by A. Wilkinson Nic Leipzig Aleesha McCormickCombating neural degeneration from injury or disease is extremely difficult in the brain and spinal cord, i.e. central nervous system (CNS). Unlike the peripheral nerves, CNS neurons are bombarded by physical and chemical restrictions that prevent proper healing and restoration of function. The CNS is vital to bodily function, and loss of any part of it can severely and permanently alter a person's quality of life. Tissue engineering could offer much needed solutions to regenerate or replace damaged CNS tissue. This review will discuss current CNS tissue engineering approaches integrating scaffolds, cells and stimulation techniques. Hydrogels are commonly used CNS tissue engineering scaffolds to stimulate and enhance regeneration, but fiber meshes and other porous structures show specific utility depending on application. CNS relevant cell sources have focused on implantation of exogenous cells or stimulation of endogenous populations. Somatic cells of the CNS are rarely utilized for tissue engineering; however, glial cells of the peripheral nervous system (PNS) may be used to myelinate and protect spinal cord damage. Pluripotent and multipotent stem cells offer alternative cell sources due to continuing advancements in identification and differentiation of these cells. Finally, physical, chemical, and electrical guidance cues are extremely important to neural cells, serving important roles in development and adulthood. These guidance cues are being integrated into tissue engineering approaches. Of particular interest is the inclusion of cues to guide stem cells to differentiate into CNS cell types, as well to guide neuron targeting. This review should provide the reader with a broad understanding of CNS tissue engineering challenges and tactics, with the goal of fostering the future development of biologically inspired designs. Table of Contents: Introduction / Anatomy of the CNS and Progression of Neurological Damage / Biomaterials for Scaffold Preparation / Cell Sources for CNS TE / Stimulation and Guidance / Concluding Remarks
Central Nervous System Tumors: Diagnostic Pathology
by César R. LacruzCovering all aspects of CNS tumors pathology, this book provides complete information on tumors of the brain and its coverings, sellar region, pineal region, and cranial and paraspinal nerves according to 2021 WHO classification, 5th edition, including new entities, as well as benign cysts and nonneoplastic disorders that are potentially misinterpreted as neoplasms. Throughout the book, emphasis has been placed on histopathologic characteristics and differential diagnosis, which are summarized in tables to make the explanation of certain topics clearer.This valuable text also includes the most recent clinical, pathological, histological, cytological, and molecular knowledge in the field, enabling pathologists to arrive at the correct diagnosis and prepare actionable, useful reports. Since pathology is one of the most visually oriented medical specialties, the myriad of annotated images throughout has been evaluated carefully and include neuroimaging studies, histology, cytology, and immunohistochemical stains that support a morphologic discussion in which differential diagnosis and potential pitfalls are emphasized. Central Nervous System Tumors: Diagnostic Pathology provides a comprehensive guide of the current critical information needed to recognize, understand, and interpret this demanding field of surgical neuropathology. It is designed with the needs of practicing surgical pathologists, pathologists-in training, and clinicians in mind.