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The Cerebrospinal Fluid
by Robert M. Herndon and Roger A. BrumbackFor centuries the great minds of medical science puzzled over the importance of the cerebrospinal fluid. As far back as Hippocrates, it was thought that this "phlegm" that flooded the intracranial contents had pathological significance. However, not until the late 1800s, when Quincke introduced and popularized lumbar puncture, did physicians take an interest in the study of this fluid in relation to clinical illness. Since then a variety of techniques for obtaining cerebrospinal fluid from various sites have developed, and the relationship of cerebrospinal fluid to a variety of disease processes has received considerable study. In this volume, we have attempted to assemble reviews of some of these important developments during the past century. Chapter 1 contains a historical review of key investigations that helped shape our concepts of cerebrospinal fluid from the earliest recorded description by the author of the Edwin Smith Surgical Papyrus in the seventeenth century B. C. to contemporaries such as Kabat, Glusman, and Knaub, who introduced quantitative determinations of cerebrospinal fluid gamma globulin levels. In Chapter 2 there is a description of our current understanding of the anatomical compartment for the cerebrospinal fluid and the physiology of its formation, circulation, and absorption. Dr. Richard Leech in Chapter 3 contributes a comprehensive description of the disorders associated with excessive quanti ties of cerebrospinal fluid-commonly referred to as hydrocephalus. A variety of techniques for properly collecting and evaluating cerebrospinal fluid are detailed in Chapter 4.
Cerebrospinal Fluid: Methods and Protocols (Methods in Molecular Biology #2044)
by Enrique Santamaría Joaquín Fernández-IrigoyenThis volume focuses on protein analysis, including a wide range of the use of mass spectrometry and other protein methods within neurobiological disciplines. Chapters cover topics such as cerebrospinal fluid (CSF) processing and biobanking; label-free quantitative proteomics; SWATH; top-down proteomics; and experimental strategies based on other –omics applied to CSF metabolome, lipidome, and microRNAome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Cerebrospinal Fluid (CSF) Proteomics: Methods and Protocols is a valuable resource for graduate students and post-doctoral fellows interested in learning more about CSF proteotyping. It is also useful to established researchers seeking further insight into this growing field.
Cerebrospinal Fluid Analysis in Multiple Sclerosis
by Paolo Livrea E.J. Thompson Maria TrojanoIn the spring of 1993 a meeting of the European Charcot Foundation was held in Bari as it was quite clear that there was a renaissance of Italian interest in cerebro spinal fluid. Two of the influential figures with a long-standing commitment to this field were Professor Paolo Livrea and Dr. Maria Trojano. At this meeting we con sidered the possibility of collecting together the various papers which had been presented, however the idea evolved further to the present volume, which incor porates a broader view. This starts with the anatomical approach, including neuro pathology, CSF cells and MRI correlations. It also includes virology, physiology of the blood-CSF barrier and the immunology of intrathecal responses. It further con siders the relevance of the CSF parameters to therapy. Finally, the importance of quality assurance and handling of the precious fluid is discussed. The original plan was to have the book published in Italian, but we are grateful to the publishers for allowing English text, in order to have a wider, international audience. As is fate of any book, interest in this area has been accelerated considerably; nevertheless we hope this provides a summary from a multi-disciplinary point of view. From a pu rely personal point of view, it certainly reflects the warmth of feeling which was evident at the meeting, and which led to the toast "Arrivederci, Bari". E. J.
Cerebrospinal Fluid Biomarkers (Neuromethods #168)
by Charlotte E. Teunissen Henrik ZetterbergThis volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
Cerebrospinal Fluid Diagnostics in Neurology: Paradigm Change in Brain Barriers, Immune System and Chronic Diseases (essentials)
by Hansotto ReiberThis Springer essential explains the theoretical foundations for knowledge-based interpretation of medical laboratory data. Self-organization of biological structure, non-linear dynamics of complex systems and immunological network theories make it possible to describe pathomechanisms and diagnostics, especially of chronic diseases, as an expression of a phenotypic biology and to develop concepts for causal therapies.The book shows how CSF diagnostics with a diagnostic report integrating all laboratory data can identify disease-typical patterns for the differential diagnosis of bacterial, viral, parasitic, oncological, chronic inflammatory, autoimmunological and psychiatric diseases. A CSF app is provided as a tutorial program.The translation from German was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.
Cerebrospinal Fluid Disorders
by Jeffrey R. Leonard David D. Limbrick Jr.Hydrocephalus is one of the most common diseases of pediatric and adult neurosurgery. With the introduction of modern neurosurgical procedures, this disease has become a life-long problem. Even with optimal treatment, there is still significant morbidity and mortality along with a significant cost to the medical system. This has caused patients and their families to demand improvements in treatments and forced clinicians to evaluate their treatments in large consortiums while utilizing both genetics and technology to improve outcomes or avoid placement of shunt all together. This text is designed to present the current treatments for hydrocephalus across the lifespan. The foundation for understanding cerebral spinal fluid (CSF) abnormalities begins with the understanding of physiology and pathogenesis of disease. These chapters are written by published experts in the field and detail the significant advances in the detection of CSF abnormalities. This section will discuss the current advances in imaging and current research in biomarkers for both pediatric and adult patients. We will then systematically discuss the treatment of both pediatric and adult CSF disorders. These will be broken down by cause, since the physiology of each can be different. We will end the book with a discussion both of the technological advances and a discussion of consortiums and how they have advanced treatment of this chronic disease.
Cerebrospinal Fluid in Clinical Neurology (Handbook Of Clinical Neurology Ser. #Volume 146)
by Florian Deisenhammer Finn Sellebjerg Charlotte E Teunissen Hayrettin TumaniThe cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. The first part addresses preclinical aspects such as the history of CSF, as well as the anatomical, physiological, and biological background of this valuable fluid. In addition, CSF collection, its preanalytical and methodological implications, and the increasing number of disease-specific markers in CSF are discussed in detail. Lastly, CSF analyses are put into context with clinical syndromes, demonstrating their diagnostic value in neurological clinical practice. Cerebrospinal Fluid in Clinical Neurology helps readers understand the preanalytical and analytical aspects of CSF diagnostics and offers a valuable reference guide for interpreting CSF results during the clinical work-up for neurological patients.
Cerebrospinal Fluid in Clinical Practice E-Book
by David N. IraniGiven the evolution of cerebrospinal testing (CSF) testing methods, the near future is certain to see an explosion of new CSF analysis methodologies. Broad-based and extensively illustrated, Cerebrospinal Fluid in Clinical Practice provides in-depth coverage of CSF examination and analysis, CSF physiology and pathophysiology, approach to diagnosis, and future directions in CSF analysis. It examines the alterations of the composition of CSF in relation to diseases and disorders of the nervous system, emphasizing the findings that are useful in clinical practice. This expansive reference is perfect regardless of your level of experience in central nervous system diseases.Provides in-depth coverage of CSF examination and analysis, CSF physiology and pathophysiology, approach to diagnosis, and future directions in CSF analysis. Explores the gamut of all CNS infections for a broad but detailed review of the scope of neurological disease. Contains detailed discussion on the proper use of specific diagnostic screens on CSF, so you may gain knowledge on how new diagnostic methods impact clinical medicine. Incorporates extensive illustrations and tables, with visual emphasis on diagnostic, laboratory, and anatomic data.
Cerebrospinal Fluid in Neurologic Disorders (ISSN #Volume 146)
by Florian Deisenhammer Hayrettin Tumani Charlotte E. TeunissenCerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker. The second part addresses the main purpose of the volume, describing CSF from a research perspective in context with the most important diagnostic entities in neurology. The book's authors provide insight into the current understanding of CSF changes in these various conditions and what it tells us about the nature of neurological diseases. Furthermore, methodological aspects are discussed, as are shortcomings that need to be addressed. Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice.Provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarkerAddresses relevant research in context with the most important diagnostic entities in neurologyEdited by leading authors in CSF research from around the globe, presenting the broadest, most expert coverage available
Cerebrospinal Fluid in Neurology and Psychiatry
by Joseph R. Bianchine H. McConnellScientists have speculated as to the nature of cerebrospinal fluid (CSF) - "the third circulation" or "vital spirit" for centuries. Just what is this mysterious bathing solution of the central nervous system? Is it a vehicle of transport for an "animal spirit" directing all our activities, as thought by Galen (Singer, 1956) or but a "modified tap water" (Halliburton, 1917)? With the advent of lumbar puncture, cerebrospinal fluid has become a readily available and important means of studying disease affecting the nervous system. In recent years, many sophisticated tools including com puter guided gas chromatography/mass spectrometry and high performance liquid chromatography have made it possible to identify and quantify many constituents of this fluid. The CSF has an enormous, though largely "untapped", potential in aiding diagnosis and evaluating treatment of many neurological, psychiatric and systemic disorders. As the ependyma is only a diffusional barrier between the CSF and extracellular fluid of the brain for many compounds, changes in the concentration of these compounds in the CSF may reflect disease processes in the brain.
Cerebrospinal Fluid Rhinorrhea - E-Book: Comprehensive Guide to Evaluation and Management
by Raj Sindwani Christopher R. RoxburyOffering up-to-date, multidisciplinary coverage of this nuanced and evolving field, Cerebrospinal Fluid Rhinorrhea provides a comprehensive overview of the evaluation and diagnosis, as well as the medical and surgical management options, for all causes of cerebrospinal fluid (CSF) rhinorrhea. It covers all aspects of CSF leaks, synthesizing current knowledge on pathophysiology, diagnosis, perioperative care, and operative techniques for this complex group of patients. Leading experts in otolaryngology and neurosurgery, as well as ophthalmology, neurology, and radiology, provide detailed coverage of the distinctions between management of patients with differing etiologies of CSF rhinorrhea, including spontaneous, traumatic/iatrogenic, and tumor-related. Focuses exclusively on the comprehensive evaluation, and management of patients presenting with CSF leaks from the anterior cranial base, offering a reliable, one-stop resource for experienced clinicians as well as those in training. Covers the full breadth of cerebrospinal fluid rhinorrhea, with expert discussion of spontaneous CSF leaks, including evolving management techniques for patients with idiopathic intracranial hypertension; traumatic CSF leaks, including advanced management of complex anterior cranial base trauma; and up-to-date techniques for intraoperative skull base reconstruction after tumor resection. Includes tips and pearls on surgical approaches and postoperative management strategies for this complex and varied patient population. Features abundant high-definition images of anatomy, radiographic imaging, and intraoperative techniques, as well as videos that highlight intraoperative techniques in patients with spontaneous, traumatic, and tumor-related CSF leaks. Provides a detailed review of the different laboratory, examination (endoscopic nasal, as well as ophthalmologic) and imaging studies used to evaluate patients with CSF leaks. Discusses the evaluation and growing medical and procedural management options for patients with idiopathic intracranial hypertension. Offers state-of-the-art reconstruction options for CSF leaks and complex skull base defects, ranging from the nasoseptal flap and beyond. Addresses the controversial role of lumbar drains in CSF leak management, as will new and upcoming technological advances in operating room instrumentation. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Cerebrospinal Vascular Diseases: Recent Advances in Diagnosis and Treatment
by NorihikoTamakiRecent advances in technology have opened up new possibilities in the diagnosis and treatment of cerebrospinal vascular diseases. It is now possible to use magnetic resonance imaging to map brain function and metabolism as an aid to diagnosis. Novel applications of magnetic resonance angiography allow three-dimensional imaging, and the magnetization transfer contrast technique gives us a new window on cerebral vascular function. This volume presents work in all these fields as well as previewing the techniques of endovascular surgery for cerebrospinal vascular diseases. These include modern stereotactic radiosurgery for arteriovenous malformations and for angiographically occult vascular malformations of the brain. This book presents an overview of the latest applications of technology to this rapidly developing and challenging field.
Cerebrovascular and Endovascular Neurosurgery: Complication Avoidance and Management
by Chirag D. Gandhi Charles J. PrestigiacomoThis book is an up-to-date, well-referenced practical resource that offers detailed guidance on the avoidance and management of complications in patients treated for cerebrovascular and spinal vascular disease. All complication avoidance and management techniques currently available to the endovascular/cerebrovascular surgeon are reviewed by pioneers and leaders in the field to provide the clinician with an advanced single point of reference on the subject.The book is divided into four sections. It opens by discussing general issues, such as definition of complications, medicolegal aspects, the role of resident training, and checklists. The subsequent three sections address the avoidance and management of complications when performing surgical, endovascular, and radiosurgical procedures, covering the full range of indications and potential adverse events. All chapters have a standardized format, simplifying the search for information on a specific disease process. Numerous intraoperative images are included, and, when appropriate, algorithms for the avoidance, early recognition, and management of complications are presented. Each chapter concludes with a checklist of preparatory steps and “emergency procedures” that each member of the team must perform in order to ensure the best possible outcomes.
Cerebrovascular Disease (What Do I Do Now)
by Ji Y. ChongPatients suffering from cerebrovascular disease pose many clinical challenges and even experienced clinicians can arrive at the point where diagnostic, work-up, treatment, or prognostic thinking falters. Authored by a vascular neurologist whose work spans the entire spectrum of this group of brain dysfunctions, Cerebrovascular Disease helps clinicians evaluate and manage patients suffering from stroke, embolism, thrombosis, hemorrhage, and other critical presentations. In a medical field where it's often difficult to distill the vast array of research and apply it in any meaningful clinical way, this next volume in the "What Do I Do Now?" series focuses on walking the clinician through evidence-based decision-making. Each clinical scenario featured in Cerebrovascular Disease describes in careful detail the presentation, diagnostic studies, treatment options, and rationale for handling these tricky cases.
Cerebrovascular Disease (What Do I Do Now)
by Ji Y. Chong Michael P. LerarioPart of the "What Do I Do Now?" series, Cerebrovascular Disease a case-based approach to cover common and important topics in the examination, investigation, and management of stroke, embolism, thrombosis, hemorrhage, and other critical presentations of cerebrovascular disease. Each chapter provides a discussion of the diagnosis, key points to remember, and selected references for further reading. For this edition, all cases and references have been updated and new cases have been added including: Ischemic stroke in cancer, posterior reversible encephalopathy syndrome (PRES), primary angiitis of the central nervous system, symptomatic spinal vascular malformation, anoxic brain injury, and vascular dementia. Cerebrovascular Disease is an engaging collection of thought-provoking cases which clinicians can utilize when they encounter difficult patients. The volume is also a self-assessment tool that tests the reader's ability to answer the question, "What do I do now?"
Cerebrovascular Disease (What Do I Do Now)
by Ji Y. Chong Michael P. LerarioPart of the "What Do I Do Now?" series, Cerebrovascular Disease a case-based approach to cover common and important topics in the examination, investigation, and management of stroke, embolism, thrombosis, hemorrhage, and other critical presentations of cerebrovascular disease. Each chapter provides a discussion of the diagnosis, key points to remember, and selected references for further reading. For this edition, all cases and references have been updated and new cases have been added including: Ischemic stroke in cancer, posterior reversible encephalopathy syndrome (PRES), primary angiitis of the central nervous system, symptomatic spinal vascular malformation, anoxic brain injury, and vascular dementia. Cerebrovascular Disease is an engaging collection of thought-provoking cases which clinicians can utilize when they encounter difficult patients. The volume is also a self-assessment tool that tests the reader's ability to answer the question, "What do I do now?"
Cerebrovascular Diseases in Children (Principles of Pediatric Neurosurgery)
by Anthony J. RaimondiIt is estimated that the functionally significant body of knowledge for a given medical specialty changes radically every 8 years. New special ties and "sub-specialization" are occurring at approximately an equal rate. Historically, established journals have not been able either to absorb this increase in publishable material or to extend their reader ship to the new specialists. International and national meetings, sympo sia and seminars, workshops, and newsletters successfully bring to the attention of physicians within developing specialties wh at is occur ring, but generally only in demonstration form without providing historical perspective, pathoanatomical correlates, or extensive discus sion. Page and time limitations oblige the authors to present only the essence of their material. Pediatric neurosurgery is an example of a specialty that has devel oped during the past 15 years. Over this period neurosurgeons have obtained special training in pediatric neurosurgery and then dedicated themselves primarily to its practice. Centers, Chairs, and educational programs have been established as groups of neurosurgeons in different countries throughout the world organized themselves respectively into national and international societies for pediatric neurosurgery. These events were both preceded and followed by specialized courses, national and international journals, and ever-increasing clinical and invest igative studies into all aspects of surgically treatable diseases of the child's nervous system.
Cerebrovascular Disorders (Neuromethods #170)
by Fawaz Al-Mufti Krishna AmuluruThis volume focuses on three areas of neurointervention: aneurysms, non-aneurysmal cerebrovascular malformations, and stroke. Each chapter provides readers with relevant summaries of anatomy, physiology, and clinical presentations, and explores methodologies for diagnosis clinical workup, imaging, and management of each pathological entity. In the Neuromethods series style, chapters include details and advice from the specialists that contains the most up-to-date evidence in an easily digestible format.Cutting-edge and authoritative, Cerebrovascular Disorders is a valuable resource for medical students, residents, fellows, nurse practitioners, and any member of the medical community who desire an easy-to-follow guide on the methods of disease management.
Cerebrovascular Evaluation with Doppler Ultrasound (Developments in Cardiovascular Medicine #6)
by M. P. Spencer J. M. ReidThis book represents tangible results of the Institute of Applied Physiology and Medicine's objectives of bringing into clinical application the concepts and results of bioengineers and physiologists. lt has grown out of our experience in development of original Doppler diagnostic instrumentation and its application to more than 6,000 patients in non-invasive diagnosis of the extracranial cerebrovascular circulation. It gath ers together bioengineering and physiological concepts which were initially developed for a graduate course for physicians and specialized medical tech nicians. lt should be of particular interest to physicians and medical technol ogists whose specialties lie in the field of neurology, vascular surgery, and radiology. The particular selection of techniques on our complete cerebrovascular non-invasive evaluation was chosen primarily to provide an integrated approach relying primarily on Doppler ultrasonic audio signals, but in addition utilizing a pertinent history and physical examination of the patient. The examination is performed by a specially trained physiology technician. Suffi cient data is provided to the interpreting physician who develops a consulta tive report for the referring physician. The ultimate objective is prevention of stroke and symptoms of cerebrovascular insufficiency. The Doppler functional information supplements the angiography anatomical management decisions for angiography and surgery, anti-platelet or anti-coagulant medication, or to follow the patient with no special treatment.
Cerebrovascular Neurosurgery (Neurosurgery by Example)
by Peter Nakaji and Michael R. LevittPart of the Neurosurgery by Example series, this volume on cerebrovascular neurosurgery presents exemplary cases in which renowned authors guide readers through the assessment and planning, decision making, surgical procedure, after care, and complication management of common and uncommon disorders. The cases explore the spectrum of clinical diversity and complexity within cerebrovascular neurosurgery, including aneurysms, ischemic/occlusive disease, arteriovenous malformation, dural arteriovenous fistula, and more. Each chapter also contains 'pivot points' that illuminate changes required to manage patients in alternate or atypical situations, and pearls for accurate diagnosis, successful treatment, and effective complication management. Containing a focused review of medical evidence and expected outcomes, Cerebrovascular Neurosurgery is appropriate for neurosurgeons who wish to learn more about a subspecialty, and those preparing for the American Board of Neurological Surgery oral examination.
Cerebrovascular Neurosurgery (Neurosurgery by Example)
Part of the Neurosurgery by Example series, this volume on cerebrovascular neurosurgery presents exemplary cases in which renowned authors guide readers through the assessment and planning, decision making, surgical procedure, after care, and complication management of common and uncommon disorders. The cases explore the spectrum of clinical diversity and complexity within cerebrovascular neurosurgery, including aneurysms, ischemic/occlusive disease, arteriovenous malformation, dural arteriovenous fistula, and more. Each chapter also contains 'pivot points' that illuminate changes required to manage patients in alternate or atypical situations, and pearls for accurate diagnosis, successful treatment, and effective complication management. Containing a focused review of medical evidence and expected outcomes, Cerebrovascular Neurosurgery is appropriate for neurosurgeons who wish to learn more about a subspecialty, and those preparing for the American Board of Neurological Surgery oral examination.
Cerebrovascular Reactivity: Methodological Advances and Clinical Applications (Neuromethods #175)
by Jean Chen Jorn FierstraThis volume provides a comprehensive overview of the methodology, physiology, and contemporary and novel applications of cerebrovascular reactivity (CVR) measurements. The chapters in this book cover topics such as an introduction of the neurophysiology, neuroimaging, and clinical methods for CVR measurement; the use of CVR methods in the study of aging, cerebrovascular dysfunction, dementia, and brain tumors; and recommendations for measurement protocols and future applications in clinical translation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation.Thorough and comprehensive, Cerebrovascular Reactivity: Methodological Advances and Clinical Applications is a valuable tool that provides researchers in neuroscience and neurology with the latest resources on the measurement, interpretation, and application of CVR measurement.
Cerebrovascular Surgery: Volume I
by Eugene S. Flamm Jack M. FeinConsiderable impetus was given to the study and understanding of cere brovascular anatomy by Thomas Willis and his contemporaries in the seventeenth century, yet almost two hundred years were to pass before further significant advances were made in this field. Then, from the mid nineteenth century onwards, the dark ages of cerebrovascular research gradually lifted through the efforts of such workers as Luschka, Heubner, and Windle, whose pioneering anatomical studies formed the basis of the present-day understanding of the morphology of the cerebral circulation. The turn of the century saw an increasing influence of the early neurolo gists in describing anatomy of cerebral vessels in relation to their areas of distribution and to the production of focal deficits through specific vascu lar lesions and anomalies. Later still, Padget and others made important observations concerning phylogenetic and developmental aspects of the cerebral circulation. These anatomical and clinical studies were remarkable enough but the real breakthrough in investigating cerebral pathophysiology and in devis ing appropriate corrective neurosurgical procedures had to await the re markable advances in technology of the past fifty years. These began with the advent of cerebral angiography with all its subsequent refinements and progress has been accelerated through establishing noninvasive Doppler and high resolution ultrasound imaging techniques, methods for the accu rate measurement of cerebral blood flow, CT scanning, PET scanning, and, most recently, imaging and metabolic NMR scanning.
Cerebrovascular Surgery: Controversies, Standards and Advances (Advances and Technical Standards in Neurosurgery #44)
by Yoko Kato Ahmed AnsariThis book will discuss and cover standard treatments and advances in some of the most controversial topics in cerebrovascular surgery traversing the whole arena, including open and interventional surgeries. They will be discussed with case scenarios, bail out strategies and complication handling, followed by advances in the subject. Some of the best academic cereberovascular physician will author these chapters with their vast experience. The book will be of particular benefit to neurosurgeons, neurologists, and radiologists. It will be particularly targeting residents, young and experienced faculty in the subject, and will provide first hand up to the mark information and experiences in cerebrovascular surgery.
