- Table View
- List View
Chapel and Haeney's Essentials of Clinical Immunology (Essentials)
by Gavin P. Spickett Siraj A. Misbah Virgil A.S.H. DalmCHAPEL AND HAENEY’S ESSENTIALS OF CLINICAL IMMUNOLOGY The Essentials are an international, best-selling series of textbooks, all of which are designed to support lecture series or themes on core topics within the health sciences. See www.wiley.com for further details. The fully updated new edition of the classic textbook, introducing the pathophysiology and management of immunological disorders Chapel and Haeney’s Essentials of Clinical Immunology contains the knowledge necessary to understand the diagnosis and treatment of immunological disorders. With easy-to-read text and a wealth of colour clinical images and diagrams, this well-regarded textbook introduces complex concepts using effective pedagogical tools such as bulleted lists, key point boxes, real-life case studies, practical examples, figures and tables, chapter introductions, and keywords in bold integrated in each chapter. Fully updated throughout, the seventh edition provides up-to-date coverage of the clinical relevance that immunology has in medicine. These new and revised sections examine current research trends, the implementation of automation in laboratories, the emerging field of neuro-psychiatric disorders such as NMDA receptor encephalitis and more. This edition includes new end-of-chapter summaries, updated clinical information, additional real-life case histories illustrating key concepts, and linking immunological testing to diseases. The new edition also includes: Covers the investigations required for diagnosis of immunological disorders and for management of patients Describes what occurs when diagnosing conditions in real-world laboratories Features case studies highlighting the connections between immunological theory and clinical cases Includes an updated companion website that features: case studies, interactive questions, photographs, illustrations, web links and review articles from the journal Clinical and Experimental Immunology Chapel and Haeney’s Essentials of Clinical Immunology is an ideal resource for clinical medical students, junior doctors, medical residents and other medical professionals who are looking to expand or refresh their knowledge in clinical immunology, as well as being an excellent introductory textbook for undergraduate courses in the subject. For more information on the complete range of Wiley medical student and junior doctor publishing, please visit: www.wiley.com To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email All content reviewed by students for students Wiley Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more. This title is also available as an e-book. For more details, please see www.wiley.com/buy/9781119542384
The Chaperonopathies: Diseases with Defective Molecular Chaperones (SpringerBriefs in Biochemistry and Molecular Biology)
by Alberto J.L. Macario Everly Conway de Macario Francesco CappelloThis Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.
Chapman & Nakielny's Aids to Radiological Differential Diagnosis
by Hameed Rafiee MBBS FRCRChapman & Nakielny’s Aids to Radiological Differential Diagnosis is a well-loved radiology resource, used by trainees and practitioners worldwide to hone their knowledge of radiological differential diagnosis for the most commonly encountered conditions throughout the body. It is an invaluable quick-reference companion in everyday practice, as well as an essential study tool when preparing for the FRCR or similar examinations. First published 35 years ago Stephen Chapman and Richard Nakielny’s original aims remain as relevant today as when the book was originally conceived. However radiology has expanded rapidly in recent years and this Seventh Edition is the biggest revision this book has had in its long history with major changes incorporated into nearly every section.Comprehensive lists of differential diagnoses to aid effective diagnoses Closely aligned to the needs of current FRCR curriculum Brief, to the point text and clear page format allows for rapid access to key information Part 2 of the book has been restructured to focus on multisystem disorders which cannot be fully covered in the individual chapters in Part 1. A new chapter on Nuclear Medicine has been added to reflect its importance in modern medical imaging. The chapter on head and neck conditions has been significantly expanded. Important discriminating features have been added to nearly every differential to aid the reader in developing a strategy for reaching a diagnosis. The top differentials in each list which are considered important for radiology trainees to learn for exams are underlined.
Chapman & Nakielny's Aids to Radiological Differential Diagnosis E-Book
by Stephen G. DaviesChapman and Nakielny’s Aids to Radiological Differential Diagnosis has become a classic resource for trainees and practitioners worldwide, to hone their knowledge of radiological differential diagnosis for the most commonly encountered conditions throughout the body. It is an invaluable quick-reference companion in everyday practice, as well as an essential study tool when preparing for the FRCR or similar examinations. This new edition is thoroughly revised and updated in line with latest clinical practice, knowledge and guidelines. The first section presents lists of differential diagnoses, supplemented by notes on useful facts and discriminating factors. These assist with the systematic assessment of radiographs and images from other modalities. The second section offers detailed summaries of the characteristic radiological appearance of a wide range of clinical conditions. Lists of differential diagnoses.Notes on radiological apperances.Ideal for preparation for radiological examinations.Contents revised and reduced to reflect current radiological practice.Existing lists modernised to reflect modern imaging practice, particularly where technological advances have been made (eg multislice CT and PET CT).Revised to take account of new imaging guidelines (eg Royal College of Radiologists: Making Best Use of the Radiology department; SIGN; NICE).Journal references updated.Increased number of diagrams.
Chapman & Nakielny's Guide to Radiological Procedures E-Book: Chapman & Nakielny's Guide to Radiological Procedures E-Book
by Ravivarma Balasubramaniam Nick WatsonChapman & Nakielny's Guide to Radiological Procedures provides a complete guide to all the imaging procedures and techniques that radiology trainees and advanced practice radiographers might be expected to undertake as part of their routine clinical practice. The eighth edition has been fully updated to reflect the continually changing skills, imaging practices and technology that radiology trainees must navigate every day. It clearly describes the optimal imaging methods and intervention techniques required for different clinical scenarios, with information on methods, indications, equipment, patient preparation, technique, aftercare, complications and further reading for each. Along with its sister book, Chapman & Nakielny's Guide to Radiological Diagnosis, this Guide is the most comprehensive text available for trainees to develop the essential skills they need in this fast moving and highly sought after field. - Comprehensive and well-referenced – suitable for trainees in modern Radiology Departments - Fully reviewed and updated throughout to incorporate latest techniques, clinical practice developments and key recent national and international guidelines - Standard headings and sections divided by anatomical regions make the book easy to navigate - Easy explanations – a perfect study aid for FRCR and similar examinations - Detailed description of diagnostic and interventional radiology procedures relevant to daily clinical practice - New chapter on Paediatric Radiology
Chapman & Nakielny's Guide to Radiological Procedures E-Book
by Nick Watson, MBChB MRCP FRCRChapman and Nakielny’s Guide to Radiological Procedures has become the classic, concise guide to the common procedures in imaging with which a radiology trainee will be expected to be familiar. Now fully revised and updated in line with current practice, it will also prove invaluable to the wider clinical team that now delivers modern imaging services, including radiographers and radiology nurses, as well as a handy refresher for radiologists at all levels. The highly accessible format has been retained, with every technique described under a set of standard headings, making it ideal for both quick reference and exam preparation. The important topic of ‘consent’ is reflected in an additional new chapter and the latest key guidelines are referenced throughout. Synoptic style makes for easy everyday quick refernce as well as exam preparation Selectivity of techniques covered focuses candidates' attention on what questions to expect.Use of standard headings makes information highly accessible.Reflects changes in examination.All new modalities fully covered.
Chapman & Nakielny's Guide to Radiological Procedures E-Book
by Nick Watson Hefin JonesThis book gives a synoptic description of the practical details of how to carry out the common procedures in imaging on which a trainee in radiology and related professionals will be expected to be familiar. It does not attempt to cover rarer techniques beyond the scope of the FRCR exam or to show the resulting images. Every technique is clearly described under a set of standard headings (e.g. methods, indications, equipment, patient preparation, technique, aftercare, complications, further reading).The text adopts a synoptic style which makes for easy preparation for the FRCR and similar examinations The selectivity of the techniques covered will focus a candidate’s attention on what questions to expect. The use of standard headings makes the contents highly accessible for a reader. The new edition has been comprehensively updated throughout and will reflect the very latest equipment and practice developments. It will reference the key recent national and international guidelines (Royal College, Dept. Of Health, WHO) A new chapter on the ‘Radiographer Role and Responsibilities in Interventional Radiology’ will reflect the evolving role of the advanced practitioner radiographer (working in collaboration with the radiologist). This will add utility/appeal to the radiographer market and aid understanding and be a more accurate reflection of the modern imaging service for radiologists There is a new chapter on ablative therapies.
Chapple's Principles of Wound Care and Healing: The Physiological Challenge
by Michael F. Klaassen Peter CharlesworthThis book is a tribute to Dr Joan Chapple CNZM FRACS, who qualified as New Zealand's first formally trained female plastic surgeon in the late 1950s and practised as a plastic and hand surgeon in Auckland, New Zealand for over 38 years. She was selected for surgical training by the late Sir William Manchester, who started the Middlemore Plastic Surgery Unit in December 1950. Joan was an original thinker and a pioneer in the fields of wound care and healing in her own right. She self-published “The Management of Soft Tissue Injuries: Philosophy, Principles and Practice” in 1994, followed by her definitive “Wound Care and Healing: The Physiological Challenge” in 2003. Dr Chapple developed principles of a practical physiological approach to acute wounds that not only benefited their recovery and healing, but also demonstrably reduced the post-operative pain in her patients. She practised and taught these principles at her Soft Tissue Trauma Clinics, based at the Emergency Department of the then Auckland Public Hospital. She also lectured widely to nurses, medical students, general practitioners and surgeons. Joan Chapple’s primary hypotheses were: 1. Injury initiates a series of coordinated living responses. 2. Living cells need to be nurtured in a moist and non-toxic environment. 3. The speed and quality of recovery and repair after injury depends on the circulation. 4. The body recovers and heals with or without treatment, but never without circulation. This republication of “Chapple's Wound Care and Healing” comes with a modern orientation and includes expert commentaries, many of which confirm that Dr Chapple’s thinking, knowledge and surgical principles were ahead of their time. In addition, it contains a new chapter explaining her extraordinary life and career for a world readership. Joan Chapple remains an important virtual mentor to future generations of surgeons, nurses, emergency specialists and general practitioners.
Character Building and Competence Development in Medical and Health Professions Education: The First Biennial Indonesian Medical and Health Professions Education Conference (Springer Proceedings in Humanities and Social Sciences)
by Mora Claramita Diantha Soemantri Rachmadya Nur Hidayah Ardi Findyartini Dujeepa D. SamarasekeraThis book is a collection of the best scientific research presented during the First International Conference of Indonesian Medical and Health Professions Education (INA-MHPE Conference 2022) hosted by the Departments of Medicine, Health Professions Education, and Bioethics in the Faculty of Medicine, Public Health, and Nursing at the Universitas Gadjah Mada (UGM) in Indonesia. The conference was held in co-operation with the co-hosts of Department of Medical Education at Universitas Indonesia (UI) and the Medical Education Unit in the Faculty of Medicine at Universitas Airlangga (UA), who will host the forthcoming INA-MHPEC in 2024 and 2026, respectively. This collection presents selected papers presented by health professionals and bioethicists from these leading institutions in Indonesia, focusing on the theme of character building in the context of health education for medical professionals in the twenty-first century. It considers effective learning strategies for character building, appropriate methods of character assessment, means of assessing and improving the learning environment in the community, clinics, university classes and hospitals, and addresses the role of the healthcare educator in providing resources, program evaluations, and effective medical management to support the development of healthcare professionals’ characters, and their modus operandi, in the future. The book is relevant to medical and public health professionals in Indonesia, Southeast Asia, and beyond.
The Character of Consciousness (Philosophy of Mind)
by David J. ChalmersIn this book David Chalmers follows up and extends his thoughts and arguments on the nature of consciousness that he first set forth in his groundbreaking 1996 book, The Conscious Mind.
The Character of Consciousness (Philosophy of Mind)
by David J. ChalmersIn this book David Chalmers follows up and extends his thoughts and arguments on the nature of consciousness that he first set forth in his groundbreaking 1996 book, The Conscious Mind.
Character Strengths and Abilities Within Disabilities: Advances in Science and Practice (Positive Psychology and Disability Series)
by Ryan M. Niemiec Dan TomasuloThis book examines the science and practice of character strengths as the backbone for understanding, studying, and applying positive interventions across a wide range of disabilities. It explores character strengths as positive personality qualities most central to an individual’s identity that create positive outcomes for building well-being and managing adversities and contribute to the collective good. The book recognizes disability as a part of the human experience that can emerge for anyone and the necessity for examining and applying strengths-based approaches. It explores what is known about character strengths and various disabilities from a science and practice perspective. The book reviews research on the assessment, correlations, concepts, populations, and applications of character strengths across disabilities. It disseminates disparate research and little-known best practices and hypothetical practices, along with multiple case examples, in the effort to advance the science and practice, bring a balanced approach to the field, and contribute to human flourishing. Key topics of coverage include: Attention-deficit/hyperactivity disorder (ADHD) and character strengths. Intellectual and physical disabilities, medical illness and character strengths. Mental and emotional disorders (e.g., trauma) and character strengths. Character strengths and disability across special issues including justice, inclusion, dual-diagnosis, and spirituality. Understanding character strengths as internal capacities and abilities across disabilities, problems, and suffering. Character Strengths - the Abilities Within Disabilities is an essential and valuable resource for researchers, professors, clinicians, practitioners, and therapists as well as graduate students in the fields of developmental and positive psychology, rehabilitation, social work, special education, occupational, speech and language therapy, public health, and healthcare policy.
Characterisation of the Mechanical Properties of Heat-Induced Protein Deposits in Immersed Cleaning Systems (Mechanics and Adaptronics)
by Jintian LiuDuring heat treatment in dairy production, the rapid formation of heat-induced fouling deposits on the plant surface leads to reduced efficiency of heat transfer. Therefore, a regular cleaning process is required to soften the heat-induced protein deposits and then remove them from the plant surface. The mechanical property of the deposits is one of the key issues of the cleaning mechanisms since the non-fractured behaviour dominates the deformation of the fouling layer and the failure behaviour has a great impact on the cohesive removal of fouling deposits. Considering the complicated geometry of fouling deposits and their irregular distribution, indentation experiments were carried out on various kinds of protein deposits. The experimental results reveal the significant influence of the thickness of fouling deposits on their mechanical behaviour and the time-dependent nonlinear behaviour of the deposits.Furthermore, heat-induced whey protein gel was used as the model material for fouling deposits and the non-fractured and fracture behaviour was characterized using compression and wire cutting experiments, respectively. The material parameters identified using the inverse finite element method allow the prediction of fracture behaviour under localized external loads and provide a deeper insight into cohesive removal. To investigate the softening effect during caustic washing, tensile experiments were conducted on chemically treated and untreated whey protein gels. Adequate chemical degradation leads to a softer mechanical response and increased stress relaxation, making whey protein gels more flowable and more resistant to tensile deformation. The experimental results provide useful data on the failure behaviour of chemically treated whey protein gels.
The Characteristics Of Aphasia
by Chris CodeA survey of the main behavioural characteristics or symptoms of aphasia, which presents a series of essays on the history and current developments in this field of neuropsychological research. Contributors discuss recovery, rehabilitation and other contemporary issues.
Characterization and Development of Biosystems and Biomaterials (Advanced Structured Materials #29)
by Andreas Öchsner, Lucas F. M. Silva and Holm AltenbachThis collection of recent activities provides researchers and scientists with the latest trends in characterization and developments of biosystems and biomaterials. Well known experts present their research in materials for drug delivery, dental implants and filling materials, biocompatible membranes, bioactive surface coatings and bio-compatible and eco-sustainable building materials. In The book covers also topics like microorganisms, the human eye, the musculoskeletal system and human body parts.
Characterization of Compounds in Solution: Theory and Practice
by William H. StrengScientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such as pharmacology. Historically, information would be obtained by observing a response for a given set of conditions and then the conditions would be changed and a new response obtained. In this approach there would be little effort made to actually understand how a compound was behaving in solution but rather just the response was noted. Understanding the behavior of compounds in solution is critical to understanding their behavior in biological systems. This has become increasingly important during the last twenty years as an understanding of the biochemistry related to human illness has become better understood. The development of the pharmaceutical industry and the need to rapidly screen large numbers of compounds has made scientists in the area of drug development aware that the pharmacological activity of compounds can be predicted by knowing their solution physical chemical properties. This is not to say that a specific drug-active site interaction can be predicted but rather a prediction can be made whether or not a compound will be absorbed, transported, or distributed within a physiological system in such a way that an interaction can occur.
Characterization of Nanomaterials in Liquid Disperse Systems (Particle Technology Series #28)
by R. R. Retamal MarínThis book describes different aspects of characterization and detection of nanomaterials in liquid disperse systems, such as suspensions, emulsions and suspoemulsions. Natural and technical particulate nanomaterials (NMs) are often present in formulations and products consisting of several disperse phases and complex dispersion media. Specific interfacial properties of the particles, their interactions with each other and with the dispersion medium, have to be considered. For example, the interfacial properties determine whether the particles tend to be arranged in aqueous or lipid phases or at their phase boundaries. The interfacial properties are significantly influenced by the adsorption of dissolved species, i.e., they depend on the composition of the dispersion medium. This poses great challenges for the characterization of these nanoparticle systems and requires adequate preparation methods. The nanoparticle measurement techniques aim at a deep physico-chemical understanding of the dispersity state of nanoparticle systems. Since the dispersity state of nanoparticle systems in an application usually does not correspond to their original manufacturing process, the formulation of new or improved product properties is of decisive importance. The characterization of nanoparticles in complex formulations or matrices requires an adequate sample preparation based on an existing or yet to be developed Standard Operating Procedure (SOP). The structure of the SOPs includes the dispersion regulations, which are of essential importance for comparing reproducible results of nanoparticle measurement with respect to comparability and transferability worldwide. The aim is to separate and isolate relevant NMs with knowledge of the interrelationships.
Characterization of Nanoparticles Intended for Drug Delivery (Methods in Molecular Biology #1682)
by Scott E. McNeilThis second edition volume expands on the first edition by providing up-to-date protocols to characterize nanomaterials used as drug delivery agents. The chapters in this book are divided into 5 parts and cover topics such as: advances and obstacles in nanomedicine research; methods to test sterility and endotoxin, physicochemical features, immunological effects, drug release, and in vivo efficacy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Characterization of Nanoparticles Intended for Drug Delivery, Second Edition is a valuable tool for researchers and pharmaceutical and biotechnology developers who are evaluating the clinical potential of nanomedicines in preclinical studies.>
Characterization of Nanoparticles Intended for Drug Delivery (Methods in Molecular Biology #697)
by Scott E. McNeilIn recent years, there have been many exciting breakthroughs in the application of nanotechnology to medicine. In Characterization of Nanoparticles Intended for Drug Delivery, expert researchers explore the latest advances in the field, providing a set of basic methods for the characterization of nanomaterials for medical use. Chapters provide methods to characterize the physiochemical properties (size, aggregation, and surface chemistry) and in vitro immunological and biological characteristics of nanomaterials. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and informative, Characterization of Nanoparticles Intended for Drug Delivery is an essential survey of methods that are crucial to the preclinical characterization of nanomedicines.
Characterization of Neural Activity Using Complex Network Theory: An Application to the Study of Schizophrenia (Springer Theses)
by Javier Gomez-PilarThis book reports on the development and assessment of a novel framework for studying neural interactions (the connectome) and their dynamics (the chronnectome). Using EEG recordings taken during an auditory oddball task performed by 48 patients with schizophrenia and 87 healthy controls, and applying local and network measures, changes in brain activation from pre-stimulus to cognitive response were assessed, and significant differences were observed between the patients and controls. This book investigates the source of the network abnormalities and presents new evidence for the disconnection hypothesis and the aberrant salience hypothesis with regard to schizophrenia. Moreover, it puts forward a novel approach to combining local regularity measures and graph measures in order to characterize schizophrenia brain dynamics, and presents interesting findings on the regularity of brain patterns in healthy control subjects versus patients with schizophrenia. Besides providing new evidence for the disconnection hypothesis, it offers a source of inspiration for future research directions in the field.
Characterization of Plant Viruses: Methods and Protocols (Springer Protocols Handbooks)
by Govind Pratap Rao Alangar Ishwara BhatThis book provides detailed information on methodologies used in biological, serological and nucleic acid based assays for the detection, diagnosis and management of plant viruses. The content is divided into six main parts, the first of which presents techniques used in the biological characterization and transmission of viruses, while Part II covers purification and techniques concerning the physico-chemical properties of viruses. In turn, Part III focuses on in vitro expression, production of polyclonal and monoclonal antibodies; and on various serological assays including precipitin tests, ELISA, blot immunoassays, immunosorbent electron microscopy and lateral flow immunoassays. Part IV addresses the isolation of DNA and RNA from plants and nucleic acid based assays such as dot-blot, polymerase chain reaction, real-time PCR, loop-mediated isothermal amplification, rolling circle amplification, recombinase polymerase amplification, and next-generation sequencing approaches. Part V discusses cloning, sequencing, sequence analysis and the production of infectious clones, while the last part (Part VI) provides biotechnological approaches for the management of viruses. Given its scope, the book will be a valuable resource for every laboratory, student and teacher, and for everyone interested in plant virology, plant pathology, plant biology and molecular biology, offering them a practical manual on various aspects of plant viruses.
Characterization of Protein Therapeutics using Mass Spectrometry
by Guodong ChenThis book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.
Characterizing Consciousness: From Cognition to the Clinic? (Research and Perspectives in Neurosciences)
by Stanislas Dehaene and Yves ChristenFifteen of the foremost scientists in this field presented testable theoretical models of consciousness and discussed how our understanding of the role that consciousness plays in our cognitive processes is being refined with some surprising results.
Characterizing Interdependencies of Multiple Time Series: Theory and Applications (SpringerBriefs in Statistics)
by Yuzo Hosoya Kosuke Oya Taro Takimoto Ryo KinoshitaThis book introduces academic researchers and professionals to the basic concepts and methods for characterizing interdependencies of multiple time series in the frequency domain. Detecting causal directions between a pair of time series and the extent of their effects, as well as testing the non existence of a feedback relation between them, have constituted major focal points in multiple time series analysis since Granger introduced the celebrated definition of causality in view of prediction improvement.Causality analysis has since been widely applied in many disciplines. Although most analyses are conducted from the perspective of the time domain, a frequency domain method introduced in this book sheds new light on another aspect that disentangles the interdependencies between multiple time series in terms of long-term or short-term effects, quantitatively characterizing them. The frequency domain method includes the Granger noncausality test as a special case.Chapters 2 and 3 of the book introduce an improved version of the basic concepts for measuring the one-way effect, reciprocity, and association of multiple time series, which were originally proposed by Hosoya. Then the statistical inferences of these measures are presented, with a focus on the stationary multivariate autoregressive moving-average processes, which include the estimation and test of causality change. Empirical analyses are provided to illustrate what alternative aspects are detected and how the methods introduced here can be conveniently applied. Most of the materials in Chapters 4 and 5 are based on the authors' latest research work. Subsidiary items are collected in the Appendix.
Charakterisierung des Wirkmechanismus von Selektiven Serotonin-Wiederaufnahme-Inhibitoren (BestMasters)
by Nina GeigerDie auftretenden Varianten von SARS-CoV-2 beschleunigen durch ihre höheren Übertragungsraten die globale COVID-19-Pandemie, wodurch dringend neue therapeutische Angriffsziele benötigt werden. Hierbei wurde die antivirale Wirkung von Fluoxetin - einem Antidepressivum - gegen SARS-CoV-2 entdeckt. Mithilfe biochemischer und bildgebenden Methoden wurde der antivirale Wirkmechanismus von Fluoxetin näher analysiert und die saure Ceramidase als SARS-CoV-2 Wirtsfaktor charakterisiert. Veröffentlichte Studien zeigten, dass auch Aspirin eine antivirale Wirkung gegen Erkältungsviren, wie Rhinoviren und Influenzaviren zeigt. Diese antivirale Wirkung wurde in Bezug auf SARS-CoV-2 in Zellkultur und einem patienten-nahen 3D-Infektionsmodell untersucht und bestätigt. Um die Pathologie einer SARS-CoV-2-Infektion zu verstehen, wurde der Eintrittsweg des Virus in das Gehirn untersucht. Im Gegensatz zu anderen Viren überwindet SARS-CoV-2 die Blut-Hirnschranke ohne T-Zellen oder Makrophagen. Ebenso wurde der Einbau eines lipophilen Fluoreszenzfarbstoffs in die Virusmembran etabliert, womit die direkte Markierung verschiedener Viren trotz ihrer unterschiedlicher Membranzusammensetzung möglich ist. Mit superauflösender Mikroskopie (SIM) wurde der virale Eintritt verschiedener umhüllter Viren visualisiert.