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Chronic Myeloid Leukemia

Chronic Myeloid Leukemia (CML) remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level and has been used by researchers to develop a variety of therapies and therapeutic assessment methods. This concise, readable guide assembles and synthesizes the latest developments and trends in the treatmen

Chronic Myeloid Leukemia: Diagnosis And Treatment (Hematologic Malignancies)

This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib.

Chronic Myeloid Leukemia (Hematologic Malignancies)

This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the impact of availability of generic imatinib.

Chronic Myeloid Leukemia: A Handbook for Hematologists and Oncologists

Highly Commended, BMA Medical Book Awards 2014 Chronic myeloid leukemia is a clonal disease that results from an acquired genetic change in a single pluripotential hemopoietic stem cell. Efforts to confront this disease have been assisted by advances in cellular and molecular biology and the speed at which these findings have transformed the therapeutic algorithm. Nevertheless, there is some uncertainty with regards to how best to assess efficacy of treatment, especially with regards to the most appropriate surrogate markers for overall survival. From the standpoint of biology and clinical management, this handbook provides an authoritative state-of-the-art review of current and developing progress.

Chronic Myeloid Leukemia: Methods and Protocols (Methods in Molecular Biology #1465)

This volume highlights the molecular and cellular methods used in studying Chronic Myeloid Leukimia (CML) pathogenesis and stem cell biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chronic Myeloid Leukemia: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Chronic Myeloid Neoplasias and Clonal Overlap Syndromes: Epidemiology, Pathophysiology and Treatment Options

Introduction The understanding of the genetic, epigenetic, immuno- well as for practicing hematologists or oncologists. logical and biological causes of myeloproliferative dis- Each chapter follows a similar architecture and leads orders has substantially improved in the last few years. through epidemiology, genetic and molecular causes, Together with refined tools in pathology, the successful hematological and clinical findings, prognostic factors establishment of mouse models mimicking at least some and current treatment approaches of the diseases. of the myeloproliferative disorders, and murine models Effort has been made to point out the evolving field of novel drugs in this arena but simultaneously diff- allowing to carefully dissect the role of mutations and gene dosage effects of, for example JAK2, this has led to entiate between standard and experimental treatment ever increasing numbers of modified classification approaches. schemes. It is therefore important for the heamtologist Together with the co-editors and all the authors of or oncologist to keep up with this rapid change in classi- the various chapters I hope that the readers of the book fication language, the upcoming of new entities or differ- will enjoy reading and benefit from the information entiation between, or subclassification of, rare diseases provided.

Chronic Myeloproliferative Disorders

With the new classification of chronic myeloproliferative disorders, and the rise of interest in molecularly targeted therapies, this timely text brings together international experts on the topic to discuss the current technologies and their implications for the treatment of patients.This title comprehensively covers chronic myeloid leukemia and P

Chronic Myofascial Pain: A Patient-Centered Approach

This comprehensive easy-to-read compendium on renal drugs has been revised and updated with 200 additional drugs that affect renal function. It has been compiled by the UK Renal Pharmacy Group who have specific expertise in this field. It should be of interest to: hospital pharmacists; hospital, medical school and general practice libraries; and doctors and nurses treating patients with impaired kidney function (not necessarily for kidney disease).

Chronic Myofascial Pain: A Patient-Centered Approach

This comprehensive easy-to-read compendium on renal drugs has been revised and updated with 200 additional drugs that affect renal function. It has been compiled by the UK Renal Pharmacy Group who have specific expertise in this field. It should be of interest to: hospital pharmacists; hospital, medical school and general practice libraries; and doctors and nurses treating patients with impaired kidney function (not necessarily for kidney disease).

Chronic Non-communicable Diseases in Low and Middle-income Countries

Low and middle income countries in Africa, Asia and Latin America bear a significant proportion of the global burden of chronic non-communicable diseases. This book synthesizes evidence across countries that share similar socio-economic, developmental and public health profiles, including rapid urbanization, globalization and poverty. Providing insights on successful and sustainable interventions and policies, it shows how to slow and reverse the rising burden of chronic diseases in resource-poor settings.

Chronic Obstructive Pulmonary Disease: Cellular And Molecular Mechanisms (Lung Biology In Health And Disease Ser.)

This book provides an up-to-date perspective on the inflammatory cells, mediators, and molecular pathology of Chronic obstructive pulmonary disease (COPD), emphasizing the urgent need to clearly understand the underlying cellular and molecular mechanisms involved in COPD.

Chronic Obstructive Pulmonary Disease: (pdf)

Chronic Obstructive Pulmonary Disease: Co-Morbidities and Systemic Consequences (Respiratory Medicine)

Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality worldwide. By 2020, COPD is expected to be the fifth leading cause of disability and the third leading cause of death. COPD is associated with significant co-morbid illnesses including cardiovascular disease, pulmonary vascular disease, osteoporosis, depression and thoracic malignancies. In addition, COPD patients often have systemic manifestations of their disease, including peripheral muscle dysfunction, decreased activity levels and nutritional abnormalities, all of which contribute to poor functional status, decreased quality of life and increased health care utilization. Lack of recognition and understanding of the complex interactions of these common co-morbid conditions and systemic effects often contributes to sub-optimal care for patients with COPD. Comprehensive in covering the range of co-morbidities that often accompany COPD, Chronic Obstructive Pulmonary Disease: Co-Morbidities and Systemic Consequences provides a concise, evidence-based review of the problem and its systemic manifestations. All physicians interested in this growing disorder – from subspecialists to primary care providers –will find in this timely and informative title the practical, state-of-the art approaches needed to provide targeted, integrated care for patients with COPD.

Chronic Obstructive Pulmonary Disease: A Systemic Inflammatory Disease (Respiratory Disease Series: Diagnostic Tools and Disease Managements)

This book considers chronic obstructive pulmonary disease (COPD) not as a simple inflammation of the lung but as a systemic inflammatory disease. Beginning with epidemiological studies, etiology, diagnosis and treatment, it elaborates further, illustrating some comorbidities and associations with other respiratory diseases. As such it provides numerous improved and more comprehensive treatment methods, including drug therapies as well as some non-drug therapies. There are also chapters describing the pathogenesis, genetic abnormalities and newly discovered pathogenetic mechanisms that are expected to be studied further in the future.Edited and written by pioneering researchers, each chapter summarizes the latest trends, describes future prospects and explores the unresolved and critical questions. Chronic Obstructive Pulmonary Disease - A Systemic Inflammatory Disease is a valuable resource to beginning researchers, physicians engaged in clinical practice, supervisors, and basic researchers whose work includes COPD.

Chronic Obstructive Pulmonary Disease: Critical Debates (Challenges In)

This book brings a new approach to the subject of chronic obstructive pulmonary disease, highlighting the current areas of controversy and debate. It addresses many of the key issues surrounding the diseases, its causes, clinical assessment and management. Internationally renowned experts critically appraise the literature and combine this with their own clinical and research experience to present an informed view of a wide range of issues. Arguments are therefore supported by the most recently available evidence. Chronic Obstructive Pulmonary Disease – Critical Debates provides the reader with an up-to-date interpretation of the clinical trial data in this field and their relevance to daily practice.

Chronic Obstructive Pulmonary Disease

The only international clinical textbook for COPD – one of the top 5 causes of death and disability worldwide The only COPD textbook to include the latest national and international guidelines and the newer therapeutic agents in COPD treatment International team of contributors covers all aspects of COPD – from physiology and epidemiology to diagnosis and treatment Everything the busy physician needs to understand, diagnose and treat the COPD patient: Structure and physiology of the respiratory system Clinical considerations and allied conditions Therapy (including current and developing treatments) Diagnostic tests used in daily practice

Chronic Obstructive Pulmonary Disease Exacerbations

Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbat

Chronic Obstructive Pulmonary Disease in Primary Care

Until recently COPD was largely neglected by health professionals and viewed as the Cinderella of respiratory conditions. Many patients were seen as heart-sink cases with a self-inflicted disease. But views are now changing and COPD, like other chronic conditions managed within primary care, has taken on a higher profile within the Government and NHS agenda. This book reflects that change. It looks at the treatment of COPD in primary care: in the GP surgery, in outpatient clinics, and through district and community nursing. COPD management does not depend on purely medical intervention; much can be done to help these patients from a psychological, social and holistic perspective to cope with their everyday activities. Patients lead a frightening existence, struggling to breathe and to cope with their symptoms. The book helps nurses and other healthcare professionals to support these patients.

Chronic Obstructive Pulmonary Disease: pocketbook

This book provides an up-to-date perspective on the inflammatory cells, mediators, and molecular pathology of Chronic obstructive pulmonary disease (COPD), emphasizing the urgent need to clearly understand the underlying cellular and molecular mechanisms involved in COPD.

Chronic Pain: A resource for effective manual therapy

The effective management of pain is a problem which confronts all manual therapists. This book provides a clear picture of our current understanding of pain mechanisms and shows how that knowledge should inform approaches to treatment. The knowledge of pain science that the book conveys will help the therapist select the best approach to the clinical management of each patient. Different types of pain disorder may require different management strategies which may involve only one discipline or, at other times, a multidisciplinary team which may also include medical clinicians, psychologists, occupational therapists, nurses and other healthcare practitioners as well as manual therapists. The book is divided into three parts: An introduction to the concept of pain and its neurophysiological mechanisms. A review and discussion of current and potential evidence-based evaluation methods. A review and discussion of common types of functional pain disorders.This approach provides readers with a comprehensive reference to evidence-based information that should enable them to manage their clients' pain as effectively as possible.

Chronic Pain: Reflex Sympathetic Dystrophy, Prevention, and Management

The most misunderstood and complex subject in medicine is the hyperpathic pain of sympathetic dystrophy. More common than previously thought, it comprises between 10 and 20 percent of chronic pain patients. Understanding this self-perpetuating pain -- which ""never stops"" -- requires unbiased knowledge of physiology and pathology. Chronic Pain: Reflex Sympathetic Dystrophy, Prevention, and Management is devoted to the subject of Reflex Sympathetic Dystrophy (RSD). The book classifies the different stages of RSD and describes the qualitative and quantitative differences between natural endorphins and synthetic narcotics. Included are long-term follow-ups on sympathectomy patients. This important reference explains why sympathectomy fails, but nerve block and physiotherapy is successful in the treatment of RSD. In addition, the mechanism of development of RSD is clarified through an extensive collection of drawings and anatomical pictures as well. Other topics include thermographic methods for the diagnosis of RSD, the role of ACTH in the management of chronic pain, and comparisons between the effects of ACTH and those of corticosteroids. FeaturesClassifies the different stages of RSD Features the most comprehensive coverage of the literature on RSD and its related aspectsDescribes qualitative and quantitative differences between natural endorphins and systemic narcotics Examines the role of ACTH in the management of chronic painClarifies the mechanism of development of RSD through an extensive collection of drawings and anatomical picturesExplains why sympathectomy fails, but nerve block and physiotherapy is successful in the treatment of RSD

Chronic Pain: Reflex Sympathetic Dystrophy, Prevention, and Management

The most misunderstood and complex subject in medicine is the hyperpathic pain of sympathetic dystrophy. More common than previously thought, it comprises between 10 and 20 percent of chronic pain patients. Understanding this self-perpetuating pain -- which ""never stops"" -- requires unbiased knowledge of physiology and pathology. Chronic Pain: Reflex Sympathetic Dystrophy, Prevention, and Management is devoted to the subject of Reflex Sympathetic Dystrophy (RSD). The book classifies the different stages of RSD and describes the qualitative and quantitative differences between natural endorphins and synthetic narcotics. Included are long-term follow-ups on sympathectomy patients. This important reference explains why sympathectomy fails, but nerve block and physiotherapy is successful in the treatment of RSD. In addition, the mechanism of development of RSD is clarified through an extensive collection of drawings and anatomical pictures as well. Other topics include thermographic methods for the diagnosis of RSD, the role of ACTH in the management of chronic pain, and comparisons between the effects of ACTH and those of corticosteroids. FeaturesClassifies the different stages of RSD Features the most comprehensive coverage of the literature on RSD and its related aspectsDescribes qualitative and quantitative differences between natural endorphins and systemic narcotics Examines the role of ACTH in the management of chronic painClarifies the mechanism of development of RSD through an extensive collection of drawings and anatomical picturesExplains why sympathectomy fails, but nerve block and physiotherapy is successful in the treatment of RSD

Chronic Pain

Providing a general approach to the understanding and management of all forms of chronic pain, this book offers a clear and reader-friendly format that clarifies procedures in the diagnosis, assessment, and treatment of the most common chronic non-cancer pain entities. Describing various types of intractable non-cancer pain, including neuropathic

Chronic Pain

Providing a general approach to the understanding and management of all forms of chronic pain, this book offers a clear and reader-friendly format that clarifies procedures in the diagnosis, assessment, and treatment of the most common chronic non-cancer pain entities. Describing various types of intractable non-cancer pain, including neuropathic

Chronic Pain: Biomedical and Spiritual Approaches

Help your clients achieve victory over chronic pain and lead more fulfilling lives!This insightful and informative book will help you deliver better pain management services to the people you care for. Incorporating biomedical, surgical, psychological, social, and spiritual perspectives, it provides vital, up-to-date information about how to reduce physical pain and explores techniques for improving people&’s ability to cope with it. Helpful tables provide easy access to information on medications for pain and managing side effects.Chronic Pain: Biomedical and Spiritual Approaches is filled with resources for the person in pain and for the health or religious professionals working to help them. It gives you very specific suggestions on how to manage chronic pain, including detailed information about medications, alternative therapies, psychological treatments, and spiritual strategies for pain management. The book is completed by two thoughtful appendixes: one examining pain medications and ways to manage their side effects and the other providing scriptural passages that can comfort those in pain.In addition to his experiences treating patients with chronic pain, the author suffers from chronic pain and disability himself. In this very personal book, he explores ways to help people coping with: low back pain fibromyalgia rheumatologic pain headaches the pain of multiple sclerosis other types of chronic unrelenting painChronic Pain: Biomedical and Spiritual Approaches can help people in pain and their families by showing them how to lead satisfying, joy-filled lives--whether their pain goes away or not. It is an essential reference book for everyone who works with pain sufferers as well as patients and their families!