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Dermal Absorption and Decontamination: A Comprehensive Guide

This book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a “wash-in effect” (an increased penetration of contaminant). Decontamination with other substances (e.g. RSDL) is explored, and factors that affect dermal penetration (e.g. anatomical variation) are summarized. All systematic reviews are comprehensive and up-to-date. Dermal Absorption and Decontamination will be useful for many fields and disciplines. Firstly, information on dermal decontamination may be used by governments for military and national defense purposes in the event of chemical warfare. Additionally, this information would be of use to many production companies, whose employees are at risk of an accident with toxic industrial chemicals. Topics covered in the book will also be of use to pharmaceutical companies, especially those exploring transdermal delivery of drugs and is of great relevance to those in the medical field, particularly dermatologists.

Dermal Absorption and Toxicity Assessment

The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab

Dermal Drug Delivery: From Innovation to Production

With the continued advancement of better-quality control and patient outcome reporting systems, changes in the development, control, and regulation of all pharmaceutical delivery systems including transdermal and topical products have been happening on a continuous basis. In light of various quality issues that have been reported by patients and practitioners resulting in the recall or removal of products from the market, both the pharmaceutical industries and regulatory agencies have been adopting new measures to address these issues. With chapters written by experts in this field, this book takes a 21st century multidisciplinary and cross-functional look at these dosage forms to improve the development, design, manufacturing, quality, clinical performance, safety, and regulation of these products. This book offers a wealth of up-to-date information organized in a logical sequence corresponding to various stages of research, development, and commercialization of dermal drug delivery products. The authors have been carefully selected from different sectors of pharmaceutical science for their expertise in their selected areas to present objectively a balanced view of the current state of these products development and commercialization via regulatory approval. Their insights will provide useful information to others to ensure the successful development of the next generation dermal drug products. Key Features: Presents current advancements including new technologies of transdermal and topical dosage forms. Presents challenges in the development of the new generation of transdermal and topical dosage forms. Introduces new technologies and QbD (quality by design) aspects of manufacturing and control strategies. Includes new perspectives on pre-clinical and clinical development, regulatory considerations, safety and quality. Discusses regulatory challenges, gaps, and future considerations for dermal drug delivery systems.

Dermal Drug Selection and Development: An Industrial Perspective

The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.

The Dermal Lymphatic Capillaries

From the preface: "The importance of the lymphatic system has been known for a long time. It was therefore surprising to learn that the status of dermal lymphatics, under both normal and pathological conditions of man, had been largely neglected to date, particularly with respect to their ultrastructure. Moreover, the existing information is incomplete, relating only to narrow segments of the skin, and it is controversial. This monograph represents an effort to overcome some of the existing deficiencies in the area of the structure (with emphasis on ultrastructure) of lymphatic capillaries. It is an account of our experience in the evaluation of dermal lymphatics in normal, edematous, and some other pathological conditions in man and in experimental animals. It is hoped that this information will prove useful for other investigators as a basis for evaluation of the structural and functional status of dermal lymphatics under a wide variety of pathological conditions."

Dermal Replacements in General, Burn, and Plastic Surgery: Tissue Engineering in Clinical Practice

The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. The most common cause of significant skin loss is thermal injury, followed by trauma and chronic ulcerations. Over the past decades extraordinary advances have been made in the understanding of cellular and molecular processes of wound healing and the pathobiology of chronic wounds. This knowledge has led to wound care innovations that facilitate more rapid closure of wounds with better functional and aesthetic outcome. A sensible and resource-saving utilization of these innovative technologies requires a broad knowledge of these processes and innovations.This book intends to give an overview about today's wound care developments in tissue engineering and skin replacement. It presents a variety of indications and diversities of clinical applications to help the surgeon select a specific procedure for each clinical situation.

Dermal Tumors: The Basics

Dermal Tumors: The Basics will serve as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The reader will be able to focus upon a single histologic observation, i.e., inflammatory conditions without epidermal changes, and use this as a starting point from which to build a differential diagnosis based upon pattern recognition. As each entity is addressed, there will be a concise discussion of the basic clinical findings and epidemiologic associations. This will be followed by a histologic description, highlighting areas that serve to discriminate between the entity under discussion and similar ones. Any immunologic studies that might augment the diagnostic sensitivity or specificity will be discussed.The chapters are thematically based and consist of essential bullet points arranged in organized outlines allowing for easy access and direct comparison between entities. The salient histologic features are depicted with abundant high quality, full-color photomicrographs placed immediately adjacent to the appropriate histologic bullet points. This volume will serve as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The elaborate pictorial documentation will also enable the book to serve as an atlas of the commonest dermatologic disorders.

DermARTologie/DermARTtology: Das Inkarnat Die Haut in der bildenden Kunst/Carnation Skin in the fine arts

Kunst schafft betörende Illusionen für unsere Sinne, die unser Gehirn zu einem erhabenen Glücksgefühl kata­lysiert. Bei den Gemälden «Grosser Meister» rezipiert der Betrachter das Ganze und übersieht oft Details, die im vor­liegenden Buch aus mehreren Tausend Kunstwerken aufge­spürt und aus der Perspektive der Dermatologie eingeord­net und vergleichend mit Krankheitsbildern interpretiert werden. Alterungsprozesse, Muttermale, Neubildungen, Veränderungen an Hautanhangsgebilden, Binde- und Fett­gewebe, an Gefässen und Nerven stören die Makellosigkeit des Inkarnats und wurden daher -wenn überhaupt- meist unbewusst ohne medizinische Sachkenntnis vom Künstler in der zweidimensionalen Form eines Portraits dargestellt. Hingegen werden bei den dreidimensionalen dermatolo­gischen Wachsmoulagen die krankhaften Veränderungen an der Haut in bester akademischer Absicht bewusst mög­lichst naturgetreu und wirklichkeitsnah abgebildet. Der Versuch einer Erkundung von Parallelen zwischen Hautdarstellungen einst und heute zeigt, dass sich am Per­fektionswahn und dem Streben nach Makellosigkeit des Inkarnates damals wie heute nichts geändert hat und die wirklichkeitsgetreue Darstellung häufig dem vermeintli­chen Schönheitsideal geopfert und alles Krankhafte oder Anormale verdeckt wird. Art creates beguiling illusions for our senses, which cat­alyzes our brain into a sublime feeling of happiness. In the paintings of “Great Masters”, the viewer admires the whole painting and often overlooks details that are tracked down in the present book from several thousand works of art, clas­sified from the perspective of dermatology and interpreted comparatively with clinical pictures. Aging processes, moles, neoplasms, changes in skin appendages, connective and fatty tissue, vessels and nerves disturb the flawlessness of the in­carnate and were therefore - if at all - usually unconsciously depicted by the artist in the two-dimensional form of a por­trait without medical expertise. On the other hand, in the three-dimensional dermatologi­cal wax moulages, the pathological changes of the skin are deliberately depicted as realistically as possible with the best academic intentions. The attempt to explore parallels between skin representa­tions then and now shows that nothing has changed in the perfection mania and the striving for flawlessness of the in­carnate then as now and that the realistic representation is often sacrificed to the supposed ideal of beauty and every­thing pathological or abnormal is concealed.

Dermatitiden II · Örtlich Übertragbare Infektiöse Gewebsneubildungen · Tierische Parasiten und Fremdkörper · Störungen des Kreislaufs · Entwicklungsstörungen Echte Geschwülste

Dermato-Oncology Study Guide: Essential Text and Review

This book provides clinicians, clinicians-in-training and researchers with a unique rapid-access educational resource on the spectrum of issues at the intersection of skin and malignancy. In it, there is clinical detail provided on how the skin reveals systemic malignancy via cutaneous metastases, genodermatoses or paraneoplastic dermatoses. At the same time, it reviews pharmacologic treatment of internal malignancy and how this can result in cutaneous adverse reactions; conversely, therapeutics for skin conditions can increase risk for internal malignancy. As arguably the most significant cutaneous malignancy, melanoma receives specific attention for its metastatic potential, current diagnostic advances, and recent therapeutic breakthroughs. Dermato-Oncology Study Guide: Essential Text and Review serves a critical educational need for clinicians caring for patients with systemic malignancy by creating an easy-to-use resource that provides practical tools to recognize skin signs of internal malignancy. Furthermore it helps in anticipating and managing adverse reactions of therapeutics for systemic malignancy, and gives the reader the opportunity to weigh the risks of malignancy of pharmacologic agents for skin disease.

Dermatoanthropology of Ethnic Skin and Hair

Dermatoanthropology of Ethnic Skin and Hair is a comprehensive text that extensively examines cutaneous disease in persons with skin of color. The breadth of knowledge in this book encompasses the wide scope of dermatologic disease with 26 distinct and unique chapters. It serves as a guide to the diagnosis and treatment of skin disorders for those populations with darker skin types. Vashi and Maibach’s Dermatoanthropology of Ethnic Skin and Hair provides an overview of medical, surgical, and cosmetic dermatology in addition to providing an extensive anthropological and basic science background to fully understand skin disorders in persons of color. Topics of discussion include anthropology of skin and hair, biophysical properties of ethnic skin, structure and function of the skin, physiologic pigmentation, mucosal lesions, acne, rosacea, inflammatory disorders, infections, autoimmune disorders, connective tissue disease, hyperpigmentation, hypopigmentation and depigmentation, keloids, scarring, pediatric disease, alopecias, adnexal disorders, common cosmetic concerns and treatments, and cultural considerations.

Dermatoethics: Contemporary Ethics and Professionalism in Dermatology

This extensively updated textbook reviews the ethical issues faced within dermatology. Bringing together practical real-life case scenarios and scholarly analysis, it covers the foundations of bioethics, as well as ethical issues associated with the various roles dermatologists play, including clinician, professional, educator, business person, and scholar. New chapters on the ethics of dermatologic care during pandemics, non-traditional interventions, private equity in dermatology, self-care and improvement, skin cancer screening, maintenance of certification, the ethics of clinical trial design are also included. Dermatoethics: Contemporary Ethics and Professionalism in Dermatology, 2nd Edition creates a dialogue around issues of ethics and professionalism within dermatology and is an essential text for both trainee and practicing dermatologists wishing to immerse themselves in the key questions in the discipline.

Dermatoethics: Contemporary Ethics and Professionalism in Dermatology

There has been a sea-change in dermatology in the last three decades. Managed care, electronic records and communication, cosmetic dermatology, direct-to-consumer advertising, core competencies, and conflicts of interest were either nascent concepts or not even on the horizon as recently as the mid-1980s. The public, accrediting organizations, and physicians themselves recognize the need for training resources in dermatology ethics and professionalism. There is a need to address these topics in a format that will stimulate dialogue and reflection.

Dermatoglyphics in Medical Disorders

The skin on the fingertips and palmar and plantar surfaces of man is not smooth. It is grooved by curious ridges, which form a variety of configurations. These ridge configurations have attracted the at­ tention of laymen for millenia. They have also evoked the serious interest of scientists for more than three centuries. The anatomist Bidloo provided a description of ridge detail in the seventeenth cen­ tury. Since then, additional information has been added by anthro­ pologists, biologists, and geneticists. For the last century, the fact that each individual's ridge configurations are unique has been uti­ lized as a means of personal identification especially by law enforce­ ment officials. Widespread medical interest in epidermal ridges de­ veloped only in the last several decades when it became apparent that many patients with chromosomal aberrations had unusual ridge formations. Inspection of skin ridges, therefore, promised to provide a simple, inexpensive means for determining whether a given patient had a particular chromosomal defect. However, the promise was only partially fulfilled because of the inherent variability of skin ridge configurations. It was possible to draw conclusions about ridge ab­ normalities in groups of patients but not always in a given individual. Patients and clinicians became somewhat disenchanted with the clinical value of studying ridges.

Dermatokosmetik

Das Buch behandelt die wesentlichen Aspekte der Hautphysiologie und Hautpathophysiologie sowie kosmetisch relevante Hautzustände. Ein besonderer Schwerpunkt liegt auf der umfassenden vergleichenden Bewertung der wissenschaftlich evaluierten dermatokosmetischen Wirkstoffe, auch im Hinblick auf ihre chemischen Grundlagen. Darüber hinaus werden die wichtigsten minimal-invasiven dermatokosmetischen Verfahren anwendungsorientiert dargestellt. Die 2. Auflage enthält zusätzlich neue farbige Abbildungen sowie ein Kapitel zur Haarpflege und –kosmetik.

Dermatokosmetik

Dermatologia allergologica nel bambino e nell'adolescente

Un bambino con una malattia cutanea non è soltanto un problema medico ma anche sociale e soprattutto familiare con pesanti risvolti psicologici. Il volume fornisce un aggiornamento degli aspetti più attuali della dermatologia allergologica in età pediatrica e si propone come aiuto e guida per tutti quei medici che intendono approfondire le conoscenze in questo settore sempre più in espansione. Tutti i capitoli sono stati infatti realizzati da specialisti con molti anni di ricerca e di esperienza pratica in questa disciplina.

Dermatologic and Cosmetic Procedures in Office Practice E-Book

Dermatologic and Cosmetic Procedures in Office Practice, by Drs. Richard Usatine, John Pfenninger, Daniel Stulberg, and Rebecca Small, provides you with the clear, step-by-step guidance you need to provide these options to your patients. Full-color photographs and drawings in combination with high-definition narrated videos clearly demonstrate key procedures, including skin biopsies, cryosurgery, electrosurgery, botulinum toxin injections, and more. Access to the full text, and a downloadable image bank online at www.expertconsult.com make this an ideal reference for performing key dermatologic and cosmetic procedures in your practice.Access the fully searchable contents and downloadable image bank online at www.expertconsult.com. Incorporate key dermatologic and cosmetic procedures into your practice with coverage of using dermoscopy to more accurately detect skin cancer, the latest information on lasers, botulinum toxin injections and dermal fillers, the diagnosis and treatment of benign and malignant lesions, and more. See how to perform each procedure clearly from detailed, full-color photographs and drawings and step-by-step instructions. Maximize the value of providing dermatologic and cosmetic procedures with guidance on combination treatments as well as coding and billing details.

Dermatologic Complications with Body Art: Tattoos, Piercings and Permanent Make-Up

Originally published in 2010, this book has since become one of the seminal works in the rapidly evolving field of body piercings, tattoos, and permanent make-up. Authorities, body art professionals, and the general public have become increasingly aware of the risks associated with these practices and the need for better regulation. This second, extensively revised edition includes an update on the literature and focuses more on the epidemiology and classification of adverse reactions. In particular, it addresses recent findings on tattoo inks, their potential side effects and the initiatives being launched by regulating authorities to reduce the risks related to body art.Dermatologic Complications with Body Art details tattooing procedures in line with the coming European Standards on hygiene (CEN 435 in preparation-release 2018-2019) with extra attention to aftercare. The book features step-by-step video illustrations of different body-art procedures (tattooing, medical tattooing, piercing, and laser tattoo removal). Innovations including medical applications of tattooing are presented. Possible complications, including infections, granulomatous reactions, and allergies are discussed, while new insights on the pathogenesis of allergic reactions are illustrated with the help of recent research data. The book also presents the latest techniques and devices for tattoo removal, together with their risks and benefits. Richly illustrated with videos and pictures, it offers an indispensable guide for dermatologists, physicians and practitioners dealing with body art.

Dermatologic Complications with Body Art: Tattoos, Piercings and Permanent Make-Up

Body piercings, tattoos, and permanent make-up have become very popular as a fashion statement in recent decades. This book guides the reader through the world of body art. An overview is first provided of the history and epidemiology of tattoos and piercings. Subsequent chapters go on to examine in detail the materials and devices used in various forms of body art, and the techniques employed. All relevant risks and potential complications are clearly described with the aid of color illustrations. Special attention is paid to allergic reactions and the management of complications. The closing chapter examines the techniques and devices used for tattoo removal, with a particular focus on the use of different lasers.

Dermatologic, Cosmeceutic, and Cosmetic Development: Therapeutic and Novel Approaches

Recent advances in our understanding of the development and morphology of normal skin have led to improved methods to deliver therapeutic compounds to selected targeted areas both within the skin and systemically. This reference provides a clear overview of pharmaceutical and cosmetic practices, drugs, and therapies to manage and treat major and mi

Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients

The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patients According to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with these events, which pose serious quality-of-life issues with so many patients, and will become more prevalent as survival rates improve, thanks in part to new cancer treatments and drug regimens. Concentrating on a topic that has only been briefly touched upon by other texts, this book offers a focused perspective on the clinical presentation, underlying pathophysiologic mechanisms, and management of skin, hair, and nail conditions for oncologists, dermatologists, and allied practitioners. Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients: • Covers in detail the dermatologic adverse events of oncologic therapies, clinical presentations, and treatment recommendations • Enables dermatologists and other practitioners to significantly improve the care of patients with cancer • Addresses the dermatologic adverse events of cancer therapies used globally, of which a large number are found in developing countries • Emphasizes prophylactic measures – based on treatments used and type of cancer – to prevent the appearance of adverse events • Provides built-in discussions on patient education for practical counseling during therapies • Offers rapid-reference sections on topical dermatology drugs The first book to present dermatologic conditions in cancer patients and survivors in a uniform and in-depth manner, Dermatologic Principles and Practice in Oncology is ideal for oncologists, oncology nurses, and dermatologists who wish to take better care of those with adverse skin, hair, and nail conditions.

Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients

The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patients According to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with these events, which pose serious quality-of-life issues with so many patients, and will become more prevalent as survival rates improve, thanks in part to new cancer treatments and drug regimens. Concentrating on a topic that has only been briefly touched upon by other texts, this book offers a focused perspective on the clinical presentation, underlying pathophysiologic mechanisms, and management of skin, hair, and nail conditions for oncologists, dermatologists, and allied practitioners. Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients: • Covers in detail the dermatologic adverse events of oncologic therapies, clinical presentations, and treatment recommendations • Enables dermatologists and other practitioners to significantly improve the care of patients with cancer • Addresses the dermatologic adverse events of cancer therapies used globally, of which a large number are found in developing countries • Emphasizes prophylactic measures – based on treatments used and type of cancer – to prevent the appearance of adverse events • Provides built-in discussions on patient education for practical counseling during therapies • Offers rapid-reference sections on topical dermatology drugs The first book to present dermatologic conditions in cancer patients and survivors in a uniform and in-depth manner, Dermatologic Principles and Practice in Oncology is ideal for oncologists, oncology nurses, and dermatologists who wish to take better care of those with adverse skin, hair, and nail conditions.

Dermatologic Procedures in Office Practice - E-Book

Now in a convenient and easy-to-use softcover format, Dermatologic Procedures in Office Practice, 2nd Edition, offers clear, step-by-step guidance on the many dermatologic procedures successfully performed in the office setting. This highly visual reference provides full-color photographs and drawings in combination with high-definition, narrated videos to demonstrate key procedures, including the diagnosis and treatment of benign and malignant lesions; cryosurgery; electrosurgery; dermoscopy; excision of skin cancers, cysts, lipomas; and more. The eBook and online videos are the perfect companion when adding a new procedure to your practice.Covers in-office dermatologic procedures focused on today’s primary care practice.Uses a concise, step-by-step, bulleted format, including set-up, complication avoidance, pearls and pitfalls, and recovery for each procedure.Features an exclusive online library of more than 100 videos, as well as procedural images and patient photographs, photographs of devices and instruments, diagrams, and medical illustrations throughout the text from expert clinicians.Contains new chapters on Biopsies and Excisions in Challenging Locations (face, ears, nose, genital areas) and Dermoscopy of Other Lesions in General Dermatology.Includes handy appendices with sample consent forms, patient education handouts, and a table recommending when to use various procedures based on the diagnosis. Any additional digital ancillary content may publish up to 6 weeks following the publication date.

Dermatologic Radiotherapy

TO THE ENGLISH EDITION Ionizing radiation has played an important role in the treatment of skin diseases for many decades. With strict adherence to modern standards of radiation protection, radiotherapy is a safe and effective method that benefits many patients who cannot be treated adequately by other means. Although indications for dermatologic radiotherapy have decreased significantly due to advances in other therapeutic modalities, many dermatologists feel strongly that ionizing radiation is an integral part of dermatologic therapy that should not be relinquished to other specialties because of the highly specialized anatomic, pathologic, and technologic knowledge required. A recent survey of the National Program for Dermatology showed that 44% of 2,444 responding dermatologists use radiotherapy regularly for various skin conditions, particularly in the treatment of cutaneous carcinomas. Significantly, the American Board of Dermatology has decided to continue its requirement of special knowledge in dermatologic radiation therapy for board certification. Because I have taught this dermatologic subspecialty at various levels, both in Europe and in the United States, I readily agreed to accept Pro­ fessor Braun-Falco's invitation to cooperate with him and Dr. Lukacs in the preparation of the English edition of this new guide. The text deals mostly with modern concepts of dermatologic radiotherapy and empha­ sizes practical aspects of treatment. Although it is written as an introduc­ tion for young dermatologists, it may also be useful to experienced clinicians who want to keep up with recent developments in this field.