- Table View
- List View
The Development of the Visual System of the Albino Rat (Advances in Anatomy, Embryology and Cell Biology #50/3)
by A. Raedler J. Sievers
Development of Therapeutic Agents Handbook (Pharmaceutical Development Series #8)
by Shayne Cox GadA comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.
Development of Therapeutic Agents Handbook (Pharmaceutical Development Series #8)
by Shayne Cox GadA comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.
Development of Vaccines: From Discovery to Clinical Testing
by Manmohan Singh Indresh K. SrivastaDevelopment of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experiences of toxicology testing and regulatory filing for vaccines is also included.
Development of Vaccines: From Discovery to Clinical Testing
by Manmohan Singh Indresh K. SrivastavaDevelopment of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experiences of toxicology testing and regulatory filing for vaccines is also included.
The Development of Vision (Studies in Development Paediatrics #3)
by P.A. GardinerThis book is intended to be an aid to all who are concerned with assessing vision and handling day-to-day problems during the growth of infants and children. It is directed mainly to com munity doctors, health visitors, school nurses, general practitioners, paediatricians and teachers. Members of all these groups have expressed to the author their ignorance and indeed fear of visual problems resulting either in nonchalance or over-anxiety based on the traditional misinformation which most of us have about our eyesight. It is particularly important that nurses and teachers should be able to identify and scale the severity or otherwise of any visual problem. The book is not primarily one of theory nor does it make any pretence of being weighty or encyclopaedic. It is hoped that it will be of use in conjunction with training courses. Those who wish to go deeper will be helped by the references to further reading. It is inevitable that technical jargon should creep in, but this has been resisted where possible and a glossary has been provided in the hope that anyone interested in children's eyesight will find the book readable. May 1981 P. A. Gardiner Guy's Hospital 7 7 ACKNOWLEDGEMENTS I would like to record my thanks to the band of illustrators.
Developmental and Acquired Dyslexia: Neuropsychological and Neurolinguistic Perspectives (Neuropsychology and Cognition #9)
by Che Kan Leong R. Malatesha Joshi
Developmental and Adapted Physical Education: Making Ability Count
by Michael Horvat Ronald V. Croce Caterina Pesce Ashley Eason FallaizeNow in a fully revised and updated 6th edition, reflecting changes in legislation and cutting-edge research, this is a complete introduction to adapted physical education, from the underpinning science to practical teaching strategies and program design. The book covers a broader range of disabilities, developmental disorders, and health conditions than any other textbook and includes brand new material on developmental coordination disorders and cognitive development. Full of teaching and coaching strategies and techniques, it introduces scientific fundamentals, key legislation, and best practice in designing effective programs. It encourages the reader to consider the individual before the disability and to focus on what learners can do rather than what they can’t. This is an essential reference for teachers, coaches, or exercise professionals working with children with disabilities. It is also an invaluable resource for undergraduate or postgraduate students of adapted physical education, kinesiology, physical education, physical therapy, exercise science, athletic training, or sports coaching. The new edition features updated online resources, including PowerPoint slides, web links, an example syllabus, and quizzes.
Developmental and Adapted Physical Education: Making Ability Count
by Michael Horvat Ronald V. Croce Caterina Pesce Ashley Eason FallaizeNow in a fully revised and updated 6th edition, reflecting changes in legislation and cutting-edge research, this is a complete introduction to adapted physical education, from the underpinning science to practical teaching strategies and program design. The book covers a broader range of disabilities, developmental disorders, and health conditions than any other textbook and includes brand new material on developmental coordination disorders and cognitive development. Full of teaching and coaching strategies and techniques, it introduces scientific fundamentals, key legislation, and best practice in designing effective programs. It encourages the reader to consider the individual before the disability and to focus on what learners can do rather than what they can’t. This is an essential reference for teachers, coaches, or exercise professionals working with children with disabilities. It is also an invaluable resource for undergraduate or postgraduate students of adapted physical education, kinesiology, physical education, physical therapy, exercise science, athletic training, or sports coaching. The new edition features updated online resources, including PowerPoint slides, web links, an example syllabus, and quizzes.
Developmental and Reproductive Toxicology (Methods in Pharmacology and Toxicology)
by Ali S. FaqiThis meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study.
Developmental Aspects of the Lymphatic Vascular System (Advances in Anatomy, Embryology and Cell Biology #214)
by Friedemann Kiefer Stefan Schulte-MerkerThe book focuses on the lymphatic vascular system from a developmental biologist’s point of view. It provides an overview on the many recent advances in understanding the development of lymphatic vessels, using advanced genetic models in conjunction with state of the art imaging. For each chapter a synopsis is provided, highlighting the main points in a concise manner. The book is intended for professors and researchers in vascular biology, angiogenesis research and developmental biology. It furthermore offers an excellent basis for entry level researchers and newcomers to this field, as well as for teachers, graduate students, advanced science and medical students.
Developmental-Behavioral Disorders: Selected Topics (Critical Issues in Developmental and Behavioral Pediatrics)
by Marvin I. Gottlieb John E. WilliamsWe are most pleased to present Volume 3 of Developmental-Behavioral Disorders: Selected Topics, designed to serve as a companion for standard reference textbooks that address cogent issues in developmental pedi atrics. Periodic publications such as Selected Topics and theme-related articles, as well as continuing education programs, attempt to supple ment in a timely fashion the rapidly changing knowledge base in devel opmental-behavioral pediatrics. These media are important as forums for enhancing the quality of clinical practice, teaching skills, and re search activities. The need is critical for periodically disseminating and updating information about issues in developmental medicine, in as much as this field of study continues to expand at a meteoric pace. During the past several decades, developmental medicine has been recognized as a defined subspecialty in pediatrics. The spectrum of problems encompassed by this discipline is relatively broad and at times clinically overwhelming. The ultimate goal of preventing delays, disor ders, and/or dysfunctions from becoming chronic handicapping condi tions has, by volume per se, created clinical dilemmas for pediatric health care providers. There are numerous facets of providing efficient and effective care, which in the field of developmental-behavioral pediatrics are often exaggerated impediments to the delivery of services by pri mary health care specialists, e. g. , time, clinical skills, need for inter disciplinary management, medical-legal responsibilities, financial reim bursements. These issues, as well as clinical problems, are still very much part of the information base to be disseminated to concerned pro fessionals.
Developmental-Behavioral Disorders: Selected Topics Volume 1 (Critical Issues in Developmental and Behavioral Pediatrics)
by John E. Williams Marvin I. Gottlieb"Child development" has always been a traditional component of well child care and a particular area of interest for pediatricians, child neu rologists, and psychologists. However, it was not until the early 1960s that children with developmental disabilities (i. e. , chronic handicapping disorders) became a major focus of public and professional attention. During this period, children with "special needs" were dramatically catapulted into the limelight and "exceptional" became the buzzword of the day. Public and professional awareness of these issues reached new peaks and recognition of the potential psychosocial impairments of chil dren with developmental disabilities created national anxiety. A variety of factors contributed to an unprecedented societal advocacy for chil dren with developmental problems: (1) a national concern generated by President Kennedy'S particular interest in mental retardation; (2) in creased activity and visibility of parent advocacy/lobbying groups (e. g. , the Association for Children with Learning Disabilities); (3) the enact ment of federal legislation designed to protect the rights of the handi capped (e. g. , PL94-142); and (4) the popularization of developmental behavioral disabilities by the various communications media. Cumulatively these events precipitated a redefinition of the real mean ing of "comprehensive health care for children," resulting in an empha sis on the child's neurodevelopmental, educational, psychological, and social needs. For the pediatrician, a myriad of new management respon sibilities were mandated, in addition to the traditional health care con cerns.
Developmental-Behavioral Pediatrics: Expert Consult - Online And Print
by Ellen Roy Elias Heidi M. Feldman Nathan J. Blum Manuel E. Jimenez Terry StancinAddressing the major advances in biomedical, psychological, social, and environmental sciences over the past decade, Developmental-Behavioral Pediatrics, 5th Edition, remains the reference of choice for professionals in a wide range of fields, including medicine and health care, education, social service, advocacy, and public policy. This foundational, pioneering resource emphasizes children’s assets and liabilities, not just categorical labels. Comprehensive in scope, it offers information and guidance on normal development and behavior, psychosocial, and biologic influences on development, developmental disorders, neurodevelopmental disabilities, and mental health conditions. It also discusses tools and strategies for diagnosis and management, including new assessments that can be used in telehealth encounters. Offers a highly practical focus, emphasizing clinical approaches to evaluation, counseling, treatment, and ongoing care. Provides new or expanded information on theoretical foundations of human development and behavior; trauma, adverse childhood events, and resilience across the life span; mechanisms of genetic, epigenetic, and neurological conditions; and principles of psychological assessment, including a broad array of evaluation approaches. Discusses management and treatment for developmental and behavioral conditions, spanning common factors, cognitive behavior therapies, rehabilitative services, integrative medicine, and psychopharmacology. Contains up-to-date chapters on celebrating socio-cultural diversity and addressing racism and bias, acute stress and post-traumatic stress disorder in youth, sexuality and variation, and alternatives to restrictive guardianship. Begins each chapter with a colorful vignette that demonstrates the importance of the human dimensions of developmental-behavioral pediatrics. Offers viewpoints from an interdisciplinary team of editors and contributors, representing developmental-behavioral pediatrics, general pediatrics, psychiatry, psychology, occupational and physical therapy, speech-language pathology, and law. Provides the latest drug information in the updated and revised chapters on psychopharmacology. Includes key points boxes, tables, pictures, and diagrams to clarify and enhance the text.
Developmental-Behavioral Pediatrics: Evidence And Practice
by Mark Lee Wolraich Paul Howard Dworkin Dennis D. Drotar Ellen C. PerrinBased on the Diagnostic and Statistical Manual for Primary Care: Child and Adolescent Version (DSM-PC), this state-of-the-art reference expertly guides you through normal and abnormal development and behavior for all pediatric age groups. See how neurobiological, environmental, and human relationship factors all contribute to developmental and behavioral disorders and know how to best diagnose and treat each patient you see.Accurately identify developmental and behavioral problems using the Diagnostic and Statistical Manual for Primary Care criteria, and evidence-based guidelines. Gain a clear understanding of the "normal" boundaries and variations within specific disorders. Make informed therapeutic decisions with the integration of basic science and practical information and recommendations from the Society of Developmental and Behavioral Pediatrics and the American Academy of Pediatrics. Avoid legal and ethical implications by consulting the Law, Policy, and Ethics chapter.
Developmental-Behavioral Pediatrics E-Book
by William B. Carey Allen C. Crocker Ellen Roy Elias Heidi M. Feldman William L. Coleman IIThe fourth edition of Developmental-Behavioral Pediatrics—the pioneering, original text— emphasizes children’s assets and liabilities, not just categorical labels. It includes fresh perspectives from new editors—Drs. William Coleman, Ellen Elias, and Heidi Feldman, as well as further contributions from two of the original editors, William B. Carey, M.D, and Allen C. Crocker, M.D. This comprehensive resource offers information and guidance on normal development and behavior: genetic influences, the effect of general physical illness and psychosocial and biologic factors on development and behavior. It is also sufficiently scholarly and scientific to serve as a definitive reference for researchers, teachers, and consultants. With a more user-friendly design, this resource offers comprehensive guidance.Features new chapters dealing with genetic influences on development and behavior, crisis management, coping strategies, self-esteem, self-control, and inborn errors of metabolism to cover the considerable advances and latest developments in the field. Focuses on the clinical aspects of function and dysfunction, rather than arranging subjects according to categorical labels. Emphasizes children’s assets as well as their liability so you get a well-developed approach to therapeutic management. Concludes each chapter with a summary of the principle points covered, with tables, pictures and diagrams to clarify and enhance the presentation. Offers a highly practical focus, emphasizing evaluation, counseling, medical treatment, and follow-up. Features superb photos and figures that illustrate a wide variety of concepts.Features new chapters dealing with—Genetic Influences on Development and Behavior, Crisis Management, Coping Strategies, Self-Esteem, Self-Control, and Inborn Errors of Metabolism.Presents a new two-color design and artwork for a more visually appealing and accessible layout.Provides the latest drug information in the updated and revised chapters on psychopharmacology.Introduces Drs. William Coleman, Ellen Elias, and Heidi Feldman to the editorial team to provide current and topical guidance and enrich the range of expertise and clinical experience.Covers the considerable advances and latest developments in this subspecialty through updates and revisions to existing material.
Developmental Biology and Pathology (Current Topics in Pathology #62)
by A. GroppThe early development of the mammalian embryo belongs to a period which, for the student, provides the particularly deep fascination connected with the processes of germination of the fIrst tender buds of life. Moreover, developmental biology encompasses a very large part of biology; if broadly dermed - almost all of it. The same is true for the fIeld of pathology if the manifold possibilities of disorders of the orderly arranged pathways of developmental processes are considered. Normal development in its earliest steps - and it would be diffI cult to see it otherwise - means the functioning of very intricate systems of complex inter dependent cycles controlled by structural, genetic, physiological and biochemical determi nants. However, disturbances interfering with them in their very different ways, can lead to fetal death, disorders of growth and differentiation, malformation and disease, sometimes as late as in the next generation or later. This is, indeed, the concern of the pathologist to whom and to whose interest in developmental pathology, this book is dedicated. The outlines of the present volume were conceived at a symposium on "Control of early em bryogenesis and factors responsible for failure of embryonic development" held May 1-4, 1974 in Travemtinde and sponsored by the Deutsche Forschungsgemeinschaft. Almost fIfty active participants attended this conference. At the time and in keeping with the purpose of the conference, publication of the proceedings was not envisaged.
Developmental Biology of Flowering Plants
by V. RaghavanThe study of plant development using molecular and genetic techniques is rapidly becoming one of the most active areas of research on flowering plants. Developmental Biology of Flowering Plants relates classical developmental work with the outstanding problems of the future in the study of plant development. An important feature of this book is the integration of results from molecular and genetic studies on various aspects of plant development in a cellular and physiological context.
Developmental Biology of Neoplastic Growth (Progress in Molecular and Subcellular Biology #40)
by Alvaro Macieira-CoelhoIn this book, tumour growth is perceived as a deviation from the normal development of the human organism. The molecular, cellular, and tissue determinants of different tumours are discussed showing that each is a different disease, often corresponding to a particular developmental stage. The natural history of several cancers illustrates how clinical incidence can be just the visible part of the iceberg, while the first changes at the tissue level sometimes occur several years before tumour growth becomes manifest. Several mechanisms are proposed to explain the distribution of cancers during the human life span and the decline of the incidence of cancers during human senescence.
Developmental Biology of Peripheral Lymphoid Organs
by Peter BaloghThe human immune system is a complex network of tissues and organs dispersed throughout the body. Immunology, as one of the most rapidly evolving fields in bio¬medical research, has to date covered the essential cellular and molecular events neces¬sary for immune responses to occur. However, it has paid relatively little attention to important developmental processes underlying the formation of the tissues themselves that carry out immune responses in humans and other mammalians. In contrast to the thymus and bone marrow that are the sole tissues for generating mature leukocytes for antigen recognition and han¬dling in humans and most mammalian species, the peripheral lymphoid tissues where adaptive immune responses are focused display broad tissue distribution and possess diverse archi¬tectural characteristics. These organs develop prior to the individual’s exposure to external antigens, and despite their similar functions, their varied appearances indicate a substantial complexity of tissue ontogeny. This volume presents a comprehensive overview of the developmental features of the major peripheral lymphoid organs, thus examining the connection between immunological functionality and structural characteristics utilizing a developmental approach, for an audience ranging from undergraduate students to senior researchers in immunology, histology and clinical medicine.
Developmental Disabilities: Theory, Assessment, and Intervention
by Michael Lewis Lawrence T. TaftThe chapters in this volume are drawn from the presentations delivered at a symposium on Developmental Disabilities in the Preschool Child. This sym posium was held under the auspices of The Institute for Pediatric Service of Johnson and Johnson Baby Products. It was co-sponsored by The College of Medicine and Dentistry of New Jersey, Rutgers Medical School, and The In stitute for the Study of Exceptional Children, Educational Testing Service. The symposium was held in the Fall of 1979 in Chicago, Illinois and the participants, including Ph. D . 's, Ed. D . 's, and M. D . 's, represented the interdisciplinary approach which characterized the meetings. The interdisciplinary set of speakers was matched by an equally diverse audience who represented almost every profes sional group concerned with the needs of disabled children and their families. Because of the successful information exchange that took place, a published volume of the proceedings was determined to be useful for others who were not able to attend. To all those who toil to help developmentally disabled children and their families we dedicate this volume. Michael Lewis Lawrence T. Taft vii CONTENTS Introduction xiii Part I-Sensory Development 1 / Handicapped Child - Facts of Life 3 Me"itt B. Low 2 / Theoretical Issues in the Early Development of Visual Perception 9 Joseph F. Fagan III and Patricia Ann Shepherd 3 / Clinical Appraisal of Vision 35 Richard N.
Developmental Dysplasia and Dislocation of the Hip in Adults
by Kuo-An LaiThis book provides descriptions of up-to-date treatment options for adult DDH/CDH (Dysplasia and Dislocation of the Hip/Congenital Dislocation of the Hip). It describes the author’s modification of peri-acetabular osteotomy for young adult DDH patients, resurfacing arthroplasty for selected patients and total hip arthroplasty for advanced arthritis and dislocation. Untreated high dislocation of the hip in adults are rare in developed countries now. The chapter of total hip describes more than 300 total hips for high dislocation with specific attempt to symmetrize the lower limbs. Techniques are described in detail, which includes ilio-femoral distraction, acetabular reconstruction, femoral osteoplasty, and shortening, derotation and corrective osteotomies. The editors invited several surgeons who are reputed for treating adult DDH with joint salvage and joint replacement to write chapters of this book.
Developmental Dysplasia of the Hip: From Early Sonographic Diagnosis to Effective Treatment
by Joseph O’Beirne Konstantinos ChlapoutakisThis book is a reference source containing all the relevant information about Developmental Dysplasia of the Hip (DDH), for people who practice or utilize hip sonography for the early detection and treatment of DDH. It aims at improving the population screening for DDH, thus contributing to the elimination of the disorder and its devastating consequences. What makes this book different from existing literature is the fact that, apart from the (updated) information about the disorder (including development, pathophysiology, etiology, pathogenesis, risk factors etc.) and a short technical guidance, the reader will find all relevant knowledge to organize training and set up screening. This includes analysis of the rationale behind universal sonographic screening, a comparative presentation of the sonographic techniques, teaching course structure / management and setting up a screening service, including audit, quality control of the scans etc. Special chapters about radiological diagnosis, imaging the consequences of non-diagnosis or maltreatment of the disorder, clinical management of DDH cases and shaping the future of hip sonography, are also provided. The book will be of interest to any medical doctor, but in particular to those working in the fields of radiology, pediatrics, orthopedics or general medicine, sonographers performing hip scans, or specialist nurses dealing with DDH.
Developmental Endocrinology: From Research to Clinical Practice (Contemporary Endocrinology)
by Erica A. EugsterLeading researchers comprehensively translate all the latest scientific information regarding endocrine physiology and development into an understanding of the clinical pathogenesis, diagnosis, and treatment of endocrine disease. Organized by endocrine system, each section of the book concisely describes the chronological development of the human organism, from the fetal/prenatal period through childhood, adolescence, and in some cases, into adulthood. The prenatal sections review recent discoveries concerning transcription factors, homeobox genes, and human molecular mutations-the basic processes governing prenatal development of the individual endocrine organs-and detail the pathophysiology, clinical characteristics, and treatment of pediatric endocrine disorders.
Developmental Hematopoiesis: Methods and Protocols (Methods in Molecular Medicine #105)
by Margaret H. BaronDuring the past few decades, technical and conceptual breakthroughs have led to a virtual revolution in developmental biology. In part through cross-species compa- sons and multidisciplinary approaches (combining, for example, classical embry- ogy, genetics, molecular biology, and systems biology), major questions have often been redefined and examined from new angles and with innovative tools. Analyses using such model systems as Drosophila, Xenopus, zebrafish, chick, human, and mouse have underscored the remarkable extent to which molecular and genetic pa- ways are conserved across species and throughout embryonic, fetal, and adult dev- opment. What we learn from the embryo, then, is not only of fundamental interest, but may well have future practical applications in the clinic. A number of excellent volumes, including several in this series (e. g. , Hema- poietic Stem Cell Protocols, Klug and Jordan, eds. , 2002), have surveyed methods used in the study of hematopoiesis—the processes by which the multiple lineages of the blood form from stem and progenitor cells during ontogeny and throughout the entire life of the animal. These collections of protocols have focused largely on the postnatal cells of mouse and human. Our understanding of hematopoietic devel- ment, however, has benefitted enormously from investigations in a variety of org- isms at different stages of ontogeny.