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The Diabetic Kidney (Contemporary Diabetes)

A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and complete descriptions of the most up-to-date views on the diagnosis and treatment of the disease. The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.

Diabetic Kidney Disease

This book presents the latest information on the clinical-pathological features of diabetic kidney disease. The data included is based on a cohort study of biopsy-proven diabetic nephropathy patients and nephrosclerosis patients, who were observed over a long term, and on the long-term registry for diabetic nephropathy (diabetic kidney disease) in Japan. It provides a clinical-pathological axis in clinical settings, including differential pathological/clinical diagnoses of CKD in diabetic patients (e.g. the presence of “classic” diabetic nephropathy and/or nephrosclerosis and/or other primary kidney diseases). The abundant biopsy specimens with long-term medical records provide a detailed pathological and clinical description. The book also includes urine-sample data for developing and validating possible candidates for novel biomarkers for diabetic kidney disease.Many countries, including Japan, have ageing populations, in which nephrosclerosis contributes to the progression of kidney lesions in patients with diabetic kidney disease. As such, a comparison of a diabetic nephropathy cohort with nephrosclerosis is indispensable to offer better treatments.This comprehensive and informative book is an indispensible reference resource for all physicians and researchers in the field of nephrology and diabetes.

Diabetic Macular Edema

The book focuses on diabetic macular edema and provides comprehensive practical knowledge on the subject. This timely book summarizes all the aspects of diabetic macular edema. The book is edited by leading authorities of vitreoretinal diseases having expertise in diabetic macular edema. It comprises over dozen chapters, authored by a subject authority in the world. Chapters provide diagnostic, medical and surgical approach. The book is clinically relevant, covers application of the latest clinical trials as well as application of novel imaging technologies. It includes uniquely structured chapters for easy learning.The book is beneficial to ophthalmic resident doctors, retina fellows and practicing retina specialists throughout the world.

Diabetic Nephropathy: Methods and Protocols (Methods in Molecular Biology #2067)

This book provides a toolkit of novel research approaches for investigators to study diabetic nephropathy, including critical experimental models from the fly to the fish, cells in culture, and in vivo mammalian approaches. The collection also explores powerful techniques to image the kidney, such as traditional histological techniques as well as electron, confocal, and two-photon microscopy, pathophysiology of the diabetic kidney, and gene editing and regenerative medicine. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Diabetic Nephropathy: Methods and Protocols seeks to foster new research directions and inspire ideas to enhance our understanding of diabetic nephropathy and to develop treatments for this condition.

Diabetic Nephropathy: Strategy for Therapy (Developments in Nephrology #9)

Diabetic nephropathy is a tragic illness. Its often insidious onset in the insulin­ dependent (type I) diabetic, typically a young adult, heralds the last act in the course of a disease that will increasingly become the dominant preoccupation in the patient's shortened life. For most type II diabetics, the beginning of clinical renal insufficiency is but a phase in a continuous deterioration that affects the integrity ofjob, marriage, and family. The nephropathic diabetic is hypertensive, has worsening retinopathy, and more often than not, is also plagued by peripheral vascular insufficiency, heart disease, gastrointestinal malfunction, and deepening depression. Until the 1980's, few type I diabetics who became uremic (because ofdiabetic nephropathy) lived for more than two years. Hardly any attained true rehabilitation. This dismal prognosis is changing substantially for the better. Research in diabetes has resulted in striking advances at both ends of the type I diabetic's natural history. In one exciting clinical trial now underway in London, Ontario, halfofchildhood diabetics treated with cyclosporine within six weeks of onset evince"permanent" disappearanceofhyperglycemia and the need for insulin. At the otherendofthe natural historyofdiabetes for the nephropathic patientwith worsening eye disease (renal-retinal syndrome), who receives a kidney transplant, patient and graft survival, two years after cadaveric kidney transplantation in type I diabetics is now equal to that of the nondiabetic.

Diabetic Nephropathy: Pathophysiology And Clinical Aspects

This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed. Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.

Diabetic Neurology

Diabetic Neurology offers a unique focus on the broad neurological complications of diabetes, bridging the clinical divide between diabetology and neurology with a practitioner-friendly guide for the recognition, investigation and management of diabetic patients with neurological disease.This book provides a comprehensive, practical review of the p

Diabetic Neuropathy: Advances in Pathophysiology and Clinical Management (Contemporary Diabetes)

In this updated edition, leading medical specialists critically review for the general practitioner the latest techniques for the clinical management of diabetic neuropathy. The contributors focus on the practical aspects of diabetic neuropathy and describe in detail the treatments that are currently available or expected to become available in the near future. They also include concise discussions of the pathogenesis of diabetic neuropathy.

Diabetic Neuropathy: Clinical Management (Clinical Diabetes)

In this updated edition, leading medical specialists critically review for the general practitioner the latest techniques for the clinical management of diabetic neuropathy. The contributors focus on the practical aspects of diabetic neuropathy and describe in detail the treatments that are currently available or expected to become available in the near future. They also include concise discussions of the pathogenesis of diabetic neuropathy.

Diabetic Neuropathy and Clinical Practice

Diabetic Neuropathy and Clinical Practice aims to improve the pathophysiological understanding of the entire spectrum from sensory motor to autonomic diabetic neuropathy, its correlation with the symptoms, improving thereby the communication with the patient including prognostication and other tools that one should utilize to better management. It also emphasizes the need to regain the grip on the basic sciences of clinical medicine to deal with it better - Anatomy, Physiology, Biochemistry and Pathology and gives the necessary details. The volume aims at explaining what the clinicians need most to help patients and may not possess.

The Diabetic Pancreas

Since the publication of the first edition of The Diabetic Pancreas in 1977, much progress has been made in various areas of diabetes research. While only a rela­ tively short while ago diabetes was considered a single disease, in more recent years it has become apparent that it is a heterogeneous group of disorders, all of which are characterized by a decreased tolerance of carbohydrates and most of which have a genetic basis, although the genetic types vary. In more recent years, an International Work Group sponsored by the National Diabetes Data Group of the NIH proposed a now generally accepted classification, according to which the insulin-dependent ketosis-prone diabetes, formerly and inappropriately called the juvenile type, is considered a subclass of diabetes, type 1. Because it can occur at any age, it was recommended that the diagnosis based on age be eliminated. The non-insulin-dependent, non-keto sis-prone type of diabetes, which is not secondary to other diseases or conditions, and which was formerly called matu­ rity-onset diabetes, was considered a second subclass, type II, because although this form usually develops after age 40, it also occurs in young persons, who do not require insulin or are not ketotic. Although this classification is not entirely agreed upon by all diabetologists, for practical purposes it has been generally accepted and has been utilized by the contributors to this volume.

The Diabetic Pancreas

I consider it an honor to have been asked to write the Foreword for The Diabetic Pancreas. Although I have been involved in the study of the pancreas since 1921, my interest goes back even further to the time, in 1918, that my father's sister, a nurse who had trained at the Massachusetts General Hospit.al, devel­ oped diabetes, lost weight, and died in diabetic coma. This sad event made a deep impression on me and was certainly pardy responsible for my choosing to join the Department of Physiology of the University of Toronto to begin a career in research into diabetes. This is not the place to describe in detail the wide-ranging research and study of the diabetic pancreas in which I have engaged in the past 56 years. Suffice it to say that I am familiar enough with the subject area to be able to predict a great future for this book. The editors have undertaken a very ambitious and worthwhile project, and their efforts have been supported and strengthened by contributors who are respected authorities in their fields, thus ensuring a successful presentation of this major work.

The Diabetic Patient Agent: Modeling Disease in Humans and the Healthcare System Response (Intelligent Systems Reference Library #133)

This book provides a pioneering approach to modeling the human diabetic patient using a software agent. It is based on two MASc (Master of Applied Science) theses: one looking at the evolution of the patient agent in time, and another looking the interaction of the patient agent with the healthcare system. It shows that the software agent evolves in a manner analogous to the human patient and exhibits typical attributes of the illness such as reacting to food consumption, medications, and activity. This agent model can be used in a number of different ways, including as a prototype for a specific human patient with the purpose of helping to identify when that patient’s condition deviates from normal variations. The software agent can also be used to study the interaction between the human patient and the health care system. This book is of interest to anyone involved in the management of diabetic patients or in societal research into the management of diabetes. The diabetic patient agent was developed using the Ackerman model for diabetes, but this model can be easily adapted for any other model subject with the necessary physiological data to support that model.

Diabetic Renal-Retinal Syndrome: Pathogenesis and Management Update 2002

Fresh insights into the pathogenic mechanisms by which hyperglycemia induces tissue and organ injurt are the basis for rapidly evolving promising therapies in diabetes. Especially promising as targets for intervention are products of oxidative stress, including kinins and growth factors. Improving results of renal replacement regimes now incorporating pancreatic islet transplants are able to delay and prevent end-organ damage in diabetic individuals. The evolving story of the taming of diabetes is of direct concern to nephrologists, endocrinologists, ophthalmologists, primary care physicians and medical students.

Diabetic Renal-Retinal Syndrome: 21st Century Management Now

After a decade or longer, approximately one-third of individuals with either type 1 or type 2 diabetes commence a downhill course in which decreasing renal function and failing vision define a Renal-Retinal Syndrome, dominating all aspects of life and presaging early death. Only a generation ago, survival after onset of end-stage renal disease (ESRD) in diabetes was limited because rehabilitation was preempted by blindness, limb amputation, stroke, and heart disease. By 1998, however, team management has improved the outlook, with preserved sight and return to work and home responsibilities, usually for a decade or longer, following kidney transplantation and laser photocoagulation. Recognition of the critical requirement for blood pressure regulation and metabolic control are central themes in management. In this unique book, the accomplishments of ophthalmologists, nephrologists, diabetologists, transplant surgeons, and basic scientists are blended into a strategic approach that may be readily applied by all those caring for diabetic patients. Each of twenty-one presentations suitable for primary care physicians, as well as for subspecialists concerned with macrovascular and microvascular complications of diabetes, is placed in perspective by an introductory editorial analysis. Promising near-term innovative therapies, including insertion of genetically engineered beta cells or polymer-coated islets of Langerhans, interdiction of kinins that promote retinal angiogenesis, and prevention of synthesis of advanced glycosylated endproducts (AGEs), are presented in detail. While comprehensive care of diabetic patients reflects multiple incremental advances that in sum afford major benefit, this text envisions further remarkable changes likely to suppress and possibly entirely prevent the Diabetic Renal-Retinal Syndrome.

Diabetic Retinopathy: Evidence-Based Management

Contains information from the Diabetic Retinopathy Clinical Research network not to be found in other published works Evidence-based approach includes material labeled with level of supporting evidence and many clinical examples Includes discussions of area of controversy

Diabetic Retinopathy (Contemporary Diabetes)

Diabetic retinopathy is the most common microvascular complication of diabetes. It remains a major cause of new-onset visual loss in the United States and other industrialized nations. In Diabetic Retinopathy, Elia Duh and a panel of internationally recognized experts comprehensively assess the current state of knowledge regarding the clinical management of DR as well as its underlying mechanisms. The authors outline the current understanding of diabetic retinopathy from the perspective of clinical practice, while reviewing the multi-factorial pathogenesis and pathophysiology of DR from the standpoint of biomedical research. Also included is a discussion of emerging concepts relating to the management and treatment of DR. Informative and highly-practical, Diabetic Retinopathy provides ophthalmologists, diabetologists, endocrinologists, and internists with a highly readable guide not only to understanding diabetic retinopathy, but also to its optimal clinical management.

Diabetic Retinopathy: Methods and Protocols (Methods in Molecular Biology #2678)

This detailed volume provides various cellular and experimental animal models and research methodologies to understand the complex interrelated pathophysiological mechanisms triggered by hyperglycemia that underlie the development of diabetic retinopathy. The book covers methods for understanding the pathogenesis of diabetic retinopathy, detection and screening of biomarkers in diabetic retinopathy, as well as novel technologies for diabetic retinopathy management. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Diabetic Retinopathy: Methods and Protocols serves as an invaluable resource for scientists and clinicians who are interested in the area of ophthalmology research.

Diabetic Retinopathy: Clinical Evaluation, Prognosis and Treatment with Photocoagulation

The evaluation of diabetic retinopathy is often difficult, because the clinical picture is complex due to the mUltiplicity of symptoms. Omission of treatment by photocoagulation at the right moment may have grave consequences. Forthe evaluation of diabetic retinopathy we have to estimate first the developmental degree of each symptom and secondly we have to estimate what the natural history of each particular retinopathy will be. There exists a number of classification systems, into the frame of which the clinical picture of diabetic retinopathy can be placed. Without entering into the details of these systems we want to mention that our classification has been developed from the method of Oakley and the classification model conceived at the Airlie House meeting in 1968. The essence of this classification is that standard pictures are used for the estimation of the developmental degree of the different symptoms in diabetic retinopathy. In our classification we use for each symptom two standard photographs instead of one, as originally proposed at the Airlie House meeting. (1,2). Standard photograph number one stands for the moderate (grade 1 ) manifestation and standard photograph numbertwo stands forthe marked (grade 2) manifestation of the symptom. Ifthe manifestation ofthe sympton is less marked than in standard photograph one, it is referred to as 2.

Diabetic Retinopathy: Current Pharmacologic Treatment and Emerging Strategies

A well-illustrated and comprehensive analysis of the treatment of diabetic retinopathy, this book covers current treatment options and guidelines, whilst also providing a detailed discussion of emerging therapeutic targets. Existing therapeutic options are covered in depth, with a major focus on anti-vascular endothelial growth factor drugs and sustained release corticosteroids, including a review of trial results supporting current treatment guidelines. The use of agents off-label is also discussed. Controversial topics are discussed in detail with an emphasis on helping the reader make informed decisions, particularly when treating patients for which several treatment approaches may be appropriate because trial data does not clearly define the best option.Emerging therapeutic areas are evaluated, as work continues to identify agents that produce superior morphologic responses and visual acuity gains by targeting other molecules that contribute to diabetic retinopathy. Promising new drugs, targets and delivery systems are identified, and their development analysed.

Diabetic Retinopathy: Screening to Treatment (Oxford Diabetes Library Series)

Diabetes mellitus is one of the leading causes of blindness worldwide, with diabetic retinopathy (DR) remaining the most common cause of eye disease for people with diabetes. Current guidelines state that all patients with diabetes should be screened for retinal problems. Diabetic Retinopathy, second edition, offers a practical, clinically focused guide to DR. Featuring 20 concise chapters this resource covers the basics of diabetes mellitus and ocular anatomy, why screening is required, the epidemiology and nature of diabetic retinopathy, as well as associated ocular diseases. It has been fully updated to include the latest trial data and newest developments in the management of diabetic retinopathy, as well as three new chapters covering patients of concern, imaging techniques in diabetic retinopathy, and an overview of treatment strategies for diabetic eye disease. Part of the Oxford Diabetes Library series, this pocketbook is a concise companion for professionals involved in screening and treating diabetic retinopathy.

Diabetic Retinopathy: Screening to Treatment (Oxford Diabetes Library Series)

Diabetes mellitus is one of the leading causes of blindness worldwide, with diabetic retinopathy (DR) remaining the most common cause of eye disease for people with diabetes. Current guidelines state that all patients with diabetes should be screened for retinal problems. Diabetic Retinopathy, second edition, offers a practical, clinically focused guide to DR. Featuring 20 concise chapters this resource covers the basics of diabetes mellitus and ocular anatomy, why screening is required, the epidemiology and nature of diabetic retinopathy, as well as associated ocular diseases. It has been fully updated to include the latest trial data and newest developments in the management of diabetic retinopathy, as well as three new chapters covering patients of concern, imaging techniques in diabetic retinopathy, and an overview of treatment strategies for diabetic eye disease. Part of the Oxford Diabetes Library series, this pocketbook is a concise companion for professionals involved in screening and treating diabetic retinopathy.

Diabetologie kompakt: Grundlagen und Praxis

Auf die Bedürfnisse der täglichen Praxis abgestimmtStrukturierte, klar definierte Vorgehensweisen für Diagnostik, Therapiekonzepte und personalisierte Therapieziele.Umfassende Information, inklusive- Prävention, Früherkennung- Begleiterkrankungen: Fettstoffwechselstörungen, Hypertonie ...- Folgeerkrankungen: Gefäßerkrankungen, Nephropathie, Neuropathien ...- Patientenschulung: Ernährung, Lebensführung ...Besonderheiten bei- Kindern/Jugendlichen, Schwangeren, alten Patienten- perioperativer Betreuung, enteraler und parenteraler Ernährung- psychiatrischen Erkrankungen einschließlich Demenz- Sport, ReisenKomplexe Fragen – kompetente Antworten- Stufentherapie individuell abgestimmt auf Begleiterkrankungen, Bedürfnisse und Möglichkeiten des Patienten- Praxistipps für typische und atypische Therapieprobleme- neue und zukünftige TherapieformenNEU u.a.- Bariatrische Chirurgie- Compliance und Empowerment- Qualitätssicherung und Versorgungsforschung- DMPs, DRGsNach den Leitlinien/Richtlinien- Deutsche Diabetes Gesellschaft (DDG)- Österreichische Diabetesgesellschaft (ÖDG)- Schweizerische Gesellschaft für Endokrinologie und Diabetologie (SGED)Interdisziplinär, topaktuell. Von den führenden Experten aus Deutschland, Österreich, Schweiz.Wissen für das optimale Diabetes-Management – gerade heute besonders wichtig.

Diagnose: Gespräche mit unheilbar Kranken, Angehörigen und Hinterbliebenen

Die Übermittlung der Diagnose "unheilbar" oder die Benachrichtigung vom Tod eines Angehörigen zählen zu den schwierigsten Gesprächen, die Ärzte mit Patienten und deren Familien führen müssen.Die Autorin, klinische Psychologin und erfahrene Psychotherapeutin, vermittelt in ihrem Leitfaden praktische Kommunikationshilfen für den Umgang mit Sterbenden und Trauernden.o Alltagsnah und verständlich geschriebeno So ausführlich wie nötig, so knapp wie möglicho Mit Praxis-Beispielen für die GesprächsführungEin Buch, das vor allem Ärzten hilft, bewußt, sensibel und sicher mit dem Thema Sterben, Tod und Trauer umzugehen und ihren Patienten ein verständnisvoller Gesprächspartner zu sein.

Diagnose, Behandlung und Prognose der Traumatischen Hämatome des Schädelinneren (Acta Neurochirurgica Supplement #8)