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Disease, Diagnoses, and Dollars: Facing the Ever-Expanding Market for Medical Care

Here’s a conundrum: the U.S. health care system is the largest sector in the biggest economy in the world, and the US spends significantly more per capita on health care than any other country. Yet it ranks last among comparison nations on the major health indicators. Robert Kaplan attempts to tackle these anomalies head-on by taking the controversial position that mass markets have been created for services that may offer little or no benefit to patients. Kaplan forcefully argues that the overuse of medications and tests runs up the costs of health care, and offers potential solutions for policy makers and for patients.

Disease Diplomacy: International Norms and Global Health Security

In the age of air travel and globalized trade, pathogens that once took months or even years to spread beyond their regions of origin can now circumnavigate the globe in a matter of hours. Amid growing concerns about such epidemics as Ebola, SARS, MERS, and H1N1, disease diplomacy has emerged as a key foreign and security policy concern as countries work to collectively strengthen the global systems of disease surveillance and control. The revision of the International Health Regulations (IHR), eventually adopted by the World Health Organization’s member states in 2005, was the foremost manifestation of this novel diplomacy. The new regulations heralded a profound shift in international norms surrounding global health security, significantly expanding what is expected of states in the face of public health emergencies and requiring them to improve their capacity to detect and contain outbreaks. Drawing on Martha Finnemore and Kathryn Sikkink’s "norm life cycle" framework and based on extensive documentary analysis and key informant interviews, Disease Diplomacy traces the emergence of these new norms of global health security, the extent to which they have been internalized by states, and the political and technical constraints governments confront in attempting to comply with their new international obligations. The authors also examine in detail the background, drafting, adoption, and implementation of the IHR while arguing that the very existence of these regulations reveals an important new understanding: that infectious disease outbreaks and their management are critical to national and international security.The book will be of great interest to academic researchers, postgraduate students, and advanced undergraduates in the fields of global public health, international relations, and public policy, as well as health professionals, diplomats, and practitioners with a professional interest in global health security.

Disease Dispersion and Impact in the Indian Ocean World (Palgrave Series in Indian Ocean World Studies)

This volume views the study of disease as essential to understanding the key historical developments underpinning the foundation of contemporary Indian Ocean World (IOW) societies. The interplay between disease and climatic conditions, natural and manmade crises and disasters, human migration and trade in the IOW reveals a wide range of perceptions about disease etiologies and epidemiologies, and debates over the origin, dispersion and impact of disease form a central focus in these essays. Incorporating a wide scope of academic and scientific angles including history, social and medical anthropology, archaeology, epidemiology and paleopathology, this collection focuses on diseases that spread across time, space and cultures. It scrutinizes disease as an object, and engages with the subjectivities of afflicted inhabitants of, and travellers to, the IOW.

Disease Gene Identification: Methods and Protocols (Methods in Molecular Biology #1706)

This volume presents detailed laboratory procedures in an easy to follow format that can be carried out with success by investigators lacking previous exposure to a specific research method. Chapter guide readers through the application of molecular approaches to disease gene identification and overviews, and case studies are also presented. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Disease Gene Identification: Methods and Protocols, Second Edition aims to help with the identification and characterization of many more disease-related genes and provide novel, and effective strategies for disease treatment and prevention.

Disease Gene Identification: Methods and Protocols (Methods in Molecular Biology #700)

Recent efforts to characterize genetic variation in the human genome, coupled with the rapidly developing field of genomics, have lead directly to the development of new and innovative approaches to the identification of genes contributing to complex human diseases. In Disease Gene Identification: Methods and Protocols, expert researchers in the field provide up-to-date molecular methodologies used in the process of identifying a disease gene, from the initial stage of study design to the next stage of preliminary locus identification, and ending with stages involved in target characterization and validation. As a volume in the highly successful Methods in Molecular Biology™ series, chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and detailed tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, Disease Gene Identification: Methods and Protocols seeks to aid scientists striving toward the identification and characterization of the many disease-related genes, which may someday pave the way for more accurate and improved methods of disease diagnosis as well as vital strategies for disease treatment and prevention.

Disease, Health Care and Government in Late Imperial Russia: Life and Death on the Volga, 1823-1914 (BASEES/Routledge Series on Russian and East European Studies)

This book addresses fundamental issues about the last decades of Tsarist Russia, contributing significantly to current debates about how far and how successfully modernisation was being implemented by the Tsarist regime. It focuses on successive outbreaks of cholera in the city of Saratov on the Volga, in particular contrasting the outbreak of 1892 - widely regarded at the time as a national fiasco and a transformative episode for the Russian Empire - with the cholera epidemics of 1904-1910 when - despite completely new scientific discoveries and administrative arrangements - Russia suffered another national outbreak of the disease. The book sets these outbreaks fully in their social, economic, political and cultural context, and explains why a medical and social disaster - which had long since been overcome in other parts of Europe - continued much later in Russia. It explores autocratic government, urban renewal, public health, and disaster management, including the management of widespread public hysteria and social unrest. The book further analyses the assimilation of Western medical knowledge, and the resulting institutional and epistemological changes. Overall, it demonstrates that Russia’s medical history was inseparably linked to the nature of the tsarist regime itself in its confrontation with modernity.

Disease, Health Care and Government in Late Imperial Russia: Life and Death on the Volga, 1823-1914 (BASEES/Routledge Series on Russian and East European Studies)

This book addresses fundamental issues about the last decades of Tsarist Russia, contributing significantly to current debates about how far and how successfully modernisation was being implemented by the Tsarist regime. It focuses on successive outbreaks of cholera in the city of Saratov on the Volga, in particular contrasting the outbreak of 1892 - widely regarded at the time as a national fiasco and a transformative episode for the Russian Empire - with the cholera epidemics of 1904-1910 when - despite completely new scientific discoveries and administrative arrangements - Russia suffered another national outbreak of the disease. The book sets these outbreaks fully in their social, economic, political and cultural context, and explains why a medical and social disaster - which had long since been overcome in other parts of Europe - continued much later in Russia. It explores autocratic government, urban renewal, public health, and disaster management, including the management of widespread public hysteria and social unrest. The book further analyses the assimilation of Western medical knowledge, and the resulting institutional and epistemological changes. Overall, it demonstrates that Russia’s medical history was inseparably linked to the nature of the tsarist regime itself in its confrontation with modernity.

Disease in the Merchant Navy: A History of the Seamen's Hospital Society

In this unique, highly detailed examination, Gordon C Cook explores disease in the merchant navy through the history of the Seamen's Hospital Society. From its foundation in 1812, until the present day, the Seamen's Hospital Society has been responsible for the physical welfare of merchant seamen and has headed many remarkable advances in medical science. This handsome volume is ideal for all those with an interest in the Seamen's Hospital Society, medical and naval historians, and general readers with an interest in maritime and naval history.

Disease in the Merchant Navy: A History of the Seamen's Hospital Society

In this unique, highly detailed examination, Gordon C Cook explores disease in the merchant navy through the history of the Seamen's Hospital Society. From its foundation in 1812, until the present day, the Seamen's Hospital Society has been responsible for the physical welfare of merchant seamen and has headed many remarkable advances in medical science. This handsome volume is ideal for all those with an interest in the Seamen's Hospital Society, medical and naval historians, and general readers with an interest in maritime and naval history.

Disease in Wild Animals: Investigation and Management

Gary Wobeser's successful book from 1994 has been completely updated and enlarged in a new second edition. An in-depth overview of the available techniques for the investigation and management of disease in free-ranging animals is provided. The subjects are illustrated with examples drawn from around the world, with emphasis on the special requirements involved in working with wild animals. The book draws on the author’s training as a wildlife biologist.

Disease, Karma and Healing: Spiritual-Scientific Enquiries into the Nature of the Human Being

Today, illness is almost universally regarded as either a nuisance or a grave misfortune. In contrast to this conventional thinking, Rudolf Steiner places the suffering caused by disease in a broad vista that includes an understanding of karma and personal metamorphosis. Illness comes to expression in the physical body, but mostly does not originate in it, says Steiner, and thus a key part of the physician’s work involves gaining insight into the whole nature of an individual – his essential core being. From this perspective, illness offers us the opportunity for deeper healing. Throughout this volume Rudolf Steiner draws our attention to the greater scope of the smallest phenomena – even a seemingly insignificant headache. He casts vivid light on things we normally take for granted, such as the human capacity to laugh or cry, and in the process broadens our vision of human existence. The apparently mundane human experiences of forgetting and remembering are intrinsic to our humanity, for example, and have unsuspected moral and spiritual dimensions. Steiner’s insights are never merely ‘lofty’ or nebulously ‘spiritual’ but time and again connect with the minutest realities of everyday life. In these 18 lectures, delivered on a weekly basis as part of an ongoing course covering ‘the whole field of spiritual science’, Steiner elaborates in detail on the diverse interplay of the human being’s constituting aspects (physical body, etheric body, astral body and ego or ‘I’) in relation to rhythmic processes, developing consciousness, the history of human evolution, and our connection with the cosmos. Within this broad canvas, some of his themes acquire a very distinctive focus – such as vivid accounts of the ‘intimate history’ of Christianity, ‘creating out of nothing’, the interior of the earth, and health and illness. Other topics include: the nature of pain, suffering, pleasure and bliss; the four human group souls of lion, bull, eagle and man; the significance of the Ten Commandments; the nature of original sin; the deed of Christ and the adversary powers of Lucifer, Ahriman and the Asuras; evolution and involution; the Atlantean period – and even Friedrich Nietzsche’s madness!

Disease Management in Cocoa: Comparative epidemiology of witches’ broom

The Monograph deals with the conception, planning, implementation, results and conclusions of the International Witches' Broom Project (IWBP), which was set up in 1985 with the aim of producing an economic management system for witches' broom disease of cocoa. The contributions of the various sponsors, and the roles played by the participating organizations and scientists are described in the introductory chapter. Chapter 2 provides a review of what was, and what was not known from published literature about the cocoa­ witches' broom pathosystem in 1989. The scope of the project and the approaches used are covered in Chapter 3, while Chapters 4 to 13 report on the field studies themselves in detail. The recent appearance of witches' broom in the important cocoa area of Bahia in Brazil is described in Chapter 14, before disease management recommendations are summarised and future prospects considered in the closing chapters. The many man-years of field research in the IWBP in a total of six countries generated much useful information which was analyzed both in the individual countries and collectively. Even with a document of this size, certain information and analyses with less direct relevance to disease management had to be omitted. It is expected that more detailed treatments of certain aspects will emerge in scientific papers, and further analyses will be undertaken.

Disease Mapping: From Foundations to Multidimensional Modeling

Disease Mapping: From Foundations to Multidimensional Modeling guides the reader from the basics of disease mapping to the most advanced topics in this field. A multidimensional framework is offered that makes possible the joint modeling of several risks patterns corresponding to combinations of several factors, including age group, time period, disease, etc. Although theory will be covered, the applied component will be equally as important with lots of practical examples offered. Features: Discusses the very latest developments on multivariate and multidimensional mapping. Gives a single state-of-the-art framework that unifies most of the previously proposed disease mapping approaches. Balances epidemiological and statistical points-of-view. Requires no previous knowledge of disease mapping. Includes practical sessions at the end of each chapter with WinBUGs/INLA and real world datasets. Supplies R code for the examples in the book so that they can be reproduced by the reader. About the Authors: Miguel A. Martinez Beneito has spent his whole career working as a statistician for public health services, first at the epidemiology unit of the Valencia (Spain) regional health administration and later as a researcher at the public health division of FISABIO, a regional bio-sanitary research center. He has been also the Bayesian Hierarchical Models professor for several seasons at the University of Valencia Biostatics Master. Paloma Botella Rocamora has spent most of her professional career in academia although she now works as a statistician for the epidemiology unit of the Valencia regional health administration. Most of her research has been devoted to developing and applying disease mapping models to real data, although her work as a statistician in an epidemiology unit makes her develop and apply statistical methods to health data, in general.

Disease Mapping: From Foundations to Multidimensional Modeling

Disease Mapping: From Foundations to Multidimensional Modeling guides the reader from the basics of disease mapping to the most advanced topics in this field. A multidimensional framework is offered that makes possible the joint modeling of several risks patterns corresponding to combinations of several factors, including age group, time period, disease, etc. Although theory will be covered, the applied component will be equally as important with lots of practical examples offered. Features: Discusses the very latest developments on multivariate and multidimensional mapping. Gives a single state-of-the-art framework that unifies most of the previously proposed disease mapping approaches. Balances epidemiological and statistical points-of-view. Requires no previous knowledge of disease mapping. Includes practical sessions at the end of each chapter with WinBUGs/INLA and real world datasets. Supplies R code for the examples in the book so that they can be reproduced by the reader. About the Authors: Miguel A. Martinez Beneito has spent his whole career working as a statistician for public health services, first at the epidemiology unit of the Valencia (Spain) regional health administration and later as a researcher at the public health division of FISABIO, a regional bio-sanitary research center. He has been also the Bayesian Hierarchical Models professor for several seasons at the University of Valencia Biostatics Master. Paloma Botella Rocamora has spent most of her professional career in academia although she now works as a statistician for the epidemiology unit of the Valencia regional health administration. Most of her research has been devoted to developing and applying disease mapping models to real data, although her work as a statistician in an epidemiology unit makes her develop and apply statistical methods to health data, in general.

Disease Maps: Epidemics on the Ground

In the seventeenth century, a map of the plague suggested a radical idea—that the disease was carried and spread by humans. In the nineteenth century, maps of cholera cases were used to prove its waterborne nature. More recently, maps charting the swine flu pandemic caused worldwide panic and sent shockwaves through the medical community. In Disease Maps, Tom Koch contends that to understand epidemics and their history we need to think about maps of varying scale, from the individual body to shared symptoms evidenced across cities, nations, and the world. Disease Maps begins with a brief review of epidemic mapping today and a detailed example of its power. Koch then traces the early history of medical cartography, including pandemics such as European plague and yellow fever, and the advancements in anatomy, printing, and world atlases that paved the way for their mapping. Moving on to the scourge of the nineteenth century—cholera—Koch considers the many choleras argued into existence by the maps of the day, including a new perspective on John Snow’s science and legacy. Finally, Koch addresses contemporary outbreaks such as AIDS, cancer, and H1N1, and reaches into the future, toward the coming epidemics. Ultimately, Disease Maps redefines conventional medical history with new surgical precision, revealing that only in maps do patterns emerge that allow disease theories to be proposed, hypotheses tested, and treatments advanced.

Disease Maps: Epidemics on the Ground

In the seventeenth century, a map of the plague suggested a radical idea—that the disease was carried and spread by humans. In the nineteenth century, maps of cholera cases were used to prove its waterborne nature. More recently, maps charting the swine flu pandemic caused worldwide panic and sent shockwaves through the medical community. In Disease Maps, Tom Koch contends that to understand epidemics and their history we need to think about maps of varying scale, from the individual body to shared symptoms evidenced across cities, nations, and the world. Disease Maps begins with a brief review of epidemic mapping today and a detailed example of its power. Koch then traces the early history of medical cartography, including pandemics such as European plague and yellow fever, and the advancements in anatomy, printing, and world atlases that paved the way for their mapping. Moving on to the scourge of the nineteenth century—cholera—Koch considers the many choleras argued into existence by the maps of the day, including a new perspective on John Snow’s science and legacy. Finally, Koch addresses contemporary outbreaks such as AIDS, cancer, and H1N1, and reaches into the future, toward the coming epidemics. Ultimately, Disease Maps redefines conventional medical history with new surgical precision, revealing that only in maps do patterns emerge that allow disease theories to be proposed, hypotheses tested, and treatments advanced.

Disease, Medicine and Society in England, 1550–1860 (Studies in Economic and Social History)

Incorporates the findings of recent researches into hospital history, provincial medical history and the history of childbirth, and draws upon new perspectives offered by women's studies in the social history of medicine. It also examines the impact of disease upon English people.

Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals: Proceedings of the European Society of Toxicology Meeting Held in Rome, March 28 – 30, 1983 (Archives of Toxicology #7)

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progressSummarizes how patients are treated today, providing a glance at future disease managementIncludes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientistsWritten and peer reviewed by outstanding scientists in their respective fields

Disease-modifying Therapy in Vasculitides (Progress in Inflammation Research)

Especially the past two decades have seen renewed interest in the vasculitides. In this volume an international expert group presents the current state of knowledge and concentrates on principles of immune modulating therapy. Drawing from their work in rheumatology, nephrology, internal medicine, connective tissue disease and clinical immunology, they present new concepts in classificiation, diagnosis and pathophysiology of the vasculitides. Evidence from experimental and clinical trials is reviewed, as well as the outlook for further research.

Disease, Pain, and Suicidal Behavior

Estimating the risk for suicidal behavior among patients is often a very complex challenge for psychiatrists, general practitioners, psychologists, surgeons, specialists in internal medicine, neurologists, nurses, and social workers. Disease, Pain, and Suicidal Behavior is designed to help you understand the methodological problems involved in the assessment of risk for suicidal behavior in patients with various somatic and psychiatric disorders so you can establish effective approaches to the psychosocial treatment of endangered patients. Through the book’s comprehensive and insightful discussions, you will even learn specific strategies for improving the quality of life of such patients.Disease, Pain, and Suicidal Behavior discusses psychiatric disorders such as depression, schizophrenia, personality disorders, anxiety disorders, and alcohol and drug abuse as risk factors for suicidal behavior. From its helpful and clearly written pages, you will also learn about the role of social factors in suicidal behavior and the relationship between suicidal behavior and biological factors. Perhaps most important of all, you will learn which groups of patients and which disorders are associated with the highest risk of suicide through the book’s critical discussions of: the lifetime risk of suicide in depressed patients the stages of diseases like multiple sclerosis and the strains placed on the patient young male schizophrenics and their vulnerability to self-destructive acts mortality in patients with spinal cord injuries forced reduction in daily activities for patients with heart and lung conditions and resulting emotional instability the high risk of suicide immediately after a cancer diagnosis is given identifying risk factors for a second attempt at suicide questions to ask those at risk for suicidal behaviorRecognizing which of your patients run the risk of committing suicide can be an overwhelming task because of the multiplicity of factors involved. Disease, Pain, and Suicidal Behavior, because it examines critically the existing literature and studies on suicide and suicide risk, can help you evaluate and prevent suicidal behavior in a timely manner. You will turn the last of its pages with a much improved understanding of which illnesses and sufferings present an increased risk of suicidal behavior.

Disease, Pain, and Suicidal Behavior

Estimating the risk for suicidal behavior among patients is often a very complex challenge for psychiatrists, general practitioners, psychologists, surgeons, specialists in internal medicine, neurologists, nurses, and social workers. Disease, Pain, and Suicidal Behavior is designed to help you understand the methodological problems involved in the assessment of risk for suicidal behavior in patients with various somatic and psychiatric disorders so you can establish effective approaches to the psychosocial treatment of endangered patients. Through the book’s comprehensive and insightful discussions, you will even learn specific strategies for improving the quality of life of such patients.Disease, Pain, and Suicidal Behavior discusses psychiatric disorders such as depression, schizophrenia, personality disorders, anxiety disorders, and alcohol and drug abuse as risk factors for suicidal behavior. From its helpful and clearly written pages, you will also learn about the role of social factors in suicidal behavior and the relationship between suicidal behavior and biological factors. Perhaps most important of all, you will learn which groups of patients and which disorders are associated with the highest risk of suicide through the book’s critical discussions of: the lifetime risk of suicide in depressed patients the stages of diseases like multiple sclerosis and the strains placed on the patient young male schizophrenics and their vulnerability to self-destructive acts mortality in patients with spinal cord injuries forced reduction in daily activities for patients with heart and lung conditions and resulting emotional instability the high risk of suicide immediately after a cancer diagnosis is given identifying risk factors for a second attempt at suicide questions to ask those at risk for suicidal behaviorRecognizing which of your patients run the risk of committing suicide can be an overwhelming task because of the multiplicity of factors involved. Disease, Pain, and Suicidal Behavior, because it examines critically the existing literature and studies on suicide and suicide risk, can help you evaluate and prevent suicidal behavior in a timely manner. You will turn the last of its pages with a much improved understanding of which illnesses and sufferings present an increased risk of suicidal behavior.

Disease Prevention: A Critical Toolkit

Preventive medical interventions and non-medicalised public health programmes that promise health benefits in the future, from actions taken now, carry a strong ethical requirement of 'first, do no harm' or primum non nocere. New preventive advice and interventions are being promoted on a daily basis, Disease Prevention: A Critical Toolkit provides a set of appraisal tools to guide those considering a preventive action to make sure that it is effective (does more good than harm), efficient (is a competitive use of scarce resources), and equitable in its impact across society. Case studies and worked examples illustrate the risks and benefits of specific preventive interventions. Divided into 10 chapters this practical and concise book focuses on multiple aspects of prevention including the hierarchy of preventive options; the assessment of causation; finding and appraising scientific evidence; prevention directed at entire populations (as opposed to individuals); measuring chronic disease risk factors and medically managing them: statin treatment of high cholesterol; PSA screening for prostate cancer; genetic screening for future disease risk; and assessing the health equity implications of prevention. Aimed at front-line public health and primary care professionals, Disease Prevention: A Critical Toolkit will equip them with the up-to-date skills necessary to help them better inform and serve their patients and communities.

Disease Prevention: A Critical Toolkit

Preventive medical interventions and non-medicalised public health programmes that promise health benefits in the future, from actions taken now, carry a strong ethical requirement of 'first, do no harm' or primum non nocere. New preventive advice and interventions are being promoted on a daily basis, Disease Prevention: A Critical Toolkit provides a set of appraisal tools to guide those considering a preventive action to make sure that it is effective (does more good than harm), efficient (is a competitive use of scarce resources), and equitable in its impact across society. Case studies and worked examples illustrate the risks and benefits of specific preventive interventions. Divided into 10 chapters this practical and concise book focuses on multiple aspects of prevention including the hierarchy of preventive options; the assessment of causation; finding and appraising scientific evidence; prevention directed at entire populations (as opposed to individuals); measuring chronic disease risk factors and medically managing them: statin treatment of high cholesterol; PSA screening for prostate cancer; genetic screening for future disease risk; and assessing the health equity implications of prevention. Aimed at front-line public health and primary care professionals, Disease Prevention: A Critical Toolkit will equip them with the up-to-date skills necessary to help them better inform and serve their patients and communities.

Disease Prevention and Health Promotion in Developing Countries

This book brings together two important discussions in public health in developing countries: an understanding of the burden of disease, health equity and social determinants of health; and biomathematical models, epidemiological studies and estimation of the direct and indirect cost of disease. The empirical chapters in the first part discuss aspects of disease prevention and health promotion in developing countries, with a particular focus on countries that are part of the World Health Organization’s Eastern Mediterranean Region and the African Region. Health equity and social determinants of health constitute a cornerstone of this book, with the widespread recognition that addressing the social determinants of health is crucial not only for improving general health but importantly for reducing unfair and remediable health inequalities. Using mathematical models, epidemiological studies and statistical estimation of costs, the second part of this book shows the opportunities that exist for developing countries to prevent disease and promote health by adopting cost-effective strategies and cost–benefit analyses.