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Anoikis: How the Extracellular Matrix Regulates Life-or-Death Decisions

Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant. In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis. While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized. The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment; c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment; e. regulation by EMT.

Anomalies and Curiosities of Medicine

Anomalies of the Developing Dentition: A Clinical Guide To Diagnosis And Management

This book is an up-to-date, succinct, and easily accessible reference on the diverse anomalies that may arise in the developing dentition, including those relating to crown size and shape, tooth formation, tooth eruption, tooth number, and enamel and dentin formation. For each anomaly, information is provided on clinical and radiographic features, etiology, and management. Attention is also drawn to clinically relevant associations among anomalies. The inclusion of numerous high-quality photographs and images will assist the practitioner in establishing the correct diagnosis in each patient and in understanding the rationale for specific interventions. The book will also facilitate discussion of the anomaly with the caregiver or patient, including with respect to genetic and other implications and the appropriate treatment path. Anomalies of the Developing Dentition is an excellent clinical guide to the subject that will aid in timely identification and appropriate management. It will meet the needs of students and practitioners in multiple disciplines of both medicine and dentistry.

Anomia: Neuroanatomical and Cognitive Correlates (Foundations of Neuropsychology)

Anomia is the inability to access spoken names for objects, most often associated with the elderly or those with brain damage to the left hemisphere. Anomia offers the state-of-the-art review of disorders of naming, written by acknowledged experts from around the world, approached from both clinical and theoretical viewpoints. Goodglass, known around the world for his research in aphasia and speech pathology, edits this first book devoted exclusively to naming and its disorders. Wingfield is known for his classic studies of lexical processing in aphasic and normal speakers. The book includes comprehensive literature reviews, a summary of relevant research data, as well as astudy of recent advances in cognitive analysis and anatomic findings. Anomia is an immensely useful work for all those involved in the study of language, particularly those in cognitive neuroscience, neurology, speech pathology, and linguistics.Devoted entirely to naming and its disordersIncludes up-to-date descriptions of advances in cognitive analysisContains approaches from both clinical and theoretical viewpointsBrings together the top researchers from the U.S., England, and Italy

Anomia: Theoretical and Clinical Aspects (Brain, Behaviour and Cognition)

This important book provides a broad, integrated overview of current research on word-finding deficit, anomia, the most common symptom of language dysfunction occurring after brain damage. Besides its clinical importance, anomia gives a fascinating view on the inner workings of language in the brain. Written by two internationally known researchers in the field, the book begins with an overview of psycholinguistic research on normal word retrieval as well as the influential cognitive models of naming and goes on to review the major forms of anomia. Neuroanatomical aspects, clinical assessment and therapeutic approaches are reviewed and evaluated. This edition has been fully updated to include coverage of advances in cognitive modeling of lexical retrieval disorders, structural and functional neuroimaging findings on the neural basis of naming and anomia, anomia diagnostics and new approaches to the challenging task of anomia therapy. Covering both theory and practice, this book provides invaluable reading for researchers and practitioners in speech and language disorders, neuropsychology and neurology, as well as for advanced undergraduate students and graduate students in the field.

Anomia: Theoretical and Clinical Aspects (Brain, Behaviour and Cognition)

This important book provides a broad, integrated overview of current research on word-finding deficit, anomia, the most common symptom of language dysfunction occurring after brain damage. Besides its clinical importance, anomia gives a fascinating view on the inner workings of language in the brain. Written by two internationally known researchers in the field, the book begins with an overview of psycholinguistic research on normal word retrieval as well as the influential cognitive models of naming and goes on to review the major forms of anomia. Neuroanatomical aspects, clinical assessment and therapeutic approaches are reviewed and evaluated. This edition has been fully updated to include coverage of advances in cognitive modeling of lexical retrieval disorders, structural and functional neuroimaging findings on the neural basis of naming and anomia, anomia diagnostics and new approaches to the challenging task of anomia therapy. Covering both theory and practice, this book provides invaluable reading for researchers and practitioners in speech and language disorders, neuropsychology and neurology, as well as for advanced undergraduate students and graduate students in the field.

Anonymization of Electronic Medical Records to Support Clinical Analysis (SpringerBriefs in Electrical and Computer Engineering)

Anonymization of Electronic Medical Records to Support Clinical Analysis closely examines the privacy threats that may arise from medical data sharing, and surveys the state-of-the-art methods developed to safeguard data against these threats. To motivate the need for computational methods, the book first explores the main challenges facing the privacy-protection of medical data using the existing policies, practices and regulations. Then, it takes an in-depth look at the popular computational privacy-preserving methods that have been developed for demographic, clinical and genomic data sharing, and closely analyzes the privacy principles behind these methods, as well as the optimization and algorithmic strategies that they employ. Finally, through a series of in-depth case studies that highlight data from the US Census as well as the Vanderbilt University Medical Center, the book outlines a new, innovative class of privacy-preserving methods designed to ensure the integrity of transferred medical data for subsequent analysis, such as discovering or validating associations between clinical and genomic information. Anonymization of Electronic Medical Records to Support Clinical Analysis is intended for professionals as a reference guide for safeguarding the privacy and data integrity of sensitive medical records. Academics and other research scientists will also find the book invaluable.

Anophthalmia: The Expert's Guide to Medical and Surgical Management

This book provides a comprehensive review on the surgical care of patients requiring removal of an eye, as well as consequent functional and cosmetic rehabilitation. In addition to covering the crafting of ocular prosthetics, Anophthalmia: The Expert's Guide to Medical and Surgical Management also addresses the psychological and physical adjustments to losing an eye, and adapting to that loss.Divided into five parts, Anophthalmia functions as a go-to reference for ophthalmologists and oculoplastic surgeons. The book begins by laying out the clinical foundations and history of anophthalmia. Part II and III discuss surgical removal techniques, prosthesis fitting and maintenance, congenital anophthalmia, infections and inflammations, and newer surgical techniques such as osseointegration after orbital exenteration. Finally, the book concludes with chapters on prosthetic options including scleral shells, keratopigmentation procedures, and cosmetic contact lenses.Unique in content, Anophthalmia is a vital resource for practicing ophthalmologists, oculoplastic surgeons, and all medical professionals who care for patients with surgical and traumatic loss of the eye and orbital tissues. Additionally, sufficient detail and explanation make this work accessible to those in training, such as medical students, ophthalmology residents, and fellows.

Anorectal and Colon Diseases: Textbook and Color Atlas of Proctology

Patients with perianal diseases such as dermatitis do not just visit the dermatologist; they are seen by family doctors, internists, pediatricians, general surgeons, gynecologists, and urologists. This book is truly multi-disciplinary, introducing the surgical specialties to medical proctology and related fields. The procedures described allow effective management of both common and less common diseases, including all the secondary problems that may arise. With increasing travel and increasing immunosuppression, parasitic intestinal diseases are now seen in every type of practice. The standard diagnostic procedures described herein reduce costs in therapy. This new reference in proctology and perianal skin disease gives detailed descriptions of clinical features, laboratory diagnosis, and treatment strategies. It will empower a wide variety of physicians to manage these disorders more effectively.

Anorectal and Colonic Diseases: A Practical Guide to their Management

Anorectal Disease: Contemporary Management

This book provides a concise yet comprehensive summary of the current status of the field that guides patient management and stimulate investigative efforts. It is an easy reference for day-to-day anorectal pathology. The text reviews new testing procedures for anorectal diseases and provides new treatment options about anorectal disease both benign and malignant. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information. The text includes highly practical presentations of typical patients seen in the clinical practice of proctology in the form of case presentations with expert analysis and commentary. Example cases would include common but challenging cases such as an anal tumor, chronic anal pain and anal discharge.Anorectal Disease: Contemporary Management is a comprehensive, state-of-the-art review of this field and serves as a valuable resource for residents, clinicians, surgeons and researchers with an interest anorectal disease.

Anorectal Malformations in Children: Embryology, Diagnosis, Surgical Treatment, Follow-up

The revised 4th edition of this classic textbook represents an international consensus in understanding and treating anorectal malformations. New topics include tethered cord, vaginal reconstruction, continent catheterizable channels, and the impact on family studies by parents' organizations. Special attention is given to new surgical techniques: posterior sagittal anorectal plasty (PSARP), urogenital sinue advancement, and laparoscopy. Includes the results of a recent conference.

Anorectal Physiology: A Clinical and Surgical Perspective

This is the first comprehensive book exclusively dedicated to anorectal physiology and the importance of diagnostic tools in guiding the evaluation and treatment of anorectal dysfunction. Functional disorders, and specifically fecal incontinence and evacuatory disorders, are prevalent in the general population, affecting up to 20% of individuals. As many of these conditions have extremely complex mechanisms, a thorough understanding of anorectal physiology is a crucial element in the surgeon’s “arsenal" to ensure accurate evaluation and to inform treatment. At this time, there is no other title that specifically addresses all aspects of anorectal physiology, as well as anorectal and pelvic floor disorders, including fecal incontinence and defecation disorders. Specifically, the book provides detailed descriptions of diagnostic methods and treatment algorithms for a range of anorectal conditions, including modern treatment modalities such as sacral neuromodulation.A unique and comprehensive reference covering all aspects of the evaluation and treatment of anorectal disorders, Anorectal Physiology – A Clinical and Surgical Perspective will be of significant interest to proctologists and coloproctologists, gastroenterologists, colorectal surgeons, gynecologists and all other professionals interested in anorectal physiology.

Anorexia & Bulimia

Anorexia and bulimia are misunderstood and potentially life-threatening conditions which are increasing at an alarming rate. Anorexia affects menstruation, emotional and psychological development and fertility. Bulimia, due to the compulsive vomiting and purging, can cause permanent damage to the digestive system.

Anorexia Nervosa: hope for recovery

Anorexia nervosa is a potentially fatal disorder that is notoriously difficult to treat and provokes feelings of great frustration in carers, families and friends. Child & Adolescent Psychiatrist, Dr Agnes Ayton FRCPsych, offers a new perspective, bringing together what is currently known and scientifically verified with her own ground-breaking work combining psychotherapy with nutritional support. Providing sufferers and carers with a knowledge of the full range of treatment options empowers them to make informed choices that can be tailored to the individual's needs. To assist them, Anorexia Nervosa - hope for recovery: focuses entirely on anorexia and other eating disorders associated with being significantly underweight; emphasises nutrition, especially what is known about the physical and psychological effects of starvation and the process of recovery from these; offers dietary 'prescriptions', menu plans, and recovery strategies; integrates treatment options, showing how the individual can achieve a balance. This is a practical book helping sufferers and carers to make informed choices that can change the lives of all concerned for the better.

Anorexia Nervosa and Bulimic Disorders: Current Perspectives

Anorexia Nervosa and Bulimic Disorders: Current Perspectives covers the proceedings of Conference on Anorexia Nervosa and Related Disorders. The book presents 60 papers that cover various aspects that are essential in understanding the nature of eating disorders. The materials in the text are organized thematically into sections. The book first covers the historical aspects, and then proceeds to tackling the classification of eating disorders. The succeeding sections detail the different aspects of eating disorders, such as epidemiological, biological, familial, psychological, and clinical. The selection also discusses the treatment, outcome, and prognosis of eating disorders. The book will be of great use to students, researchers, and practitioners of health related disciplines.

Anorexia Nervosa and Other Dyscontrol Syndromes

What is that which gleams through me and smites my heart without wounding it? I am both a-shudder and a-glow. St. Augustine It is wonder and awe that I feel in view of the individual's power to create self-therapeutic devices. This book is the saga of these young in­ dividuals, who change and recreate the shape and dimensions of their bodies in a quest to achieve and finally demonstrate autonomy. Ironically, it seems that they can go on living thanks to their exces­ sive behavior, their hunger, and their deviances. They exhibit an ex­ treme polarity, an "either-or": the thrill of excesses, the joy of giving in to pleasure, versus masochistic enjoyment and pride curbing, procras­ tinating and mastering these impulses almost to the absolute by simple force of effort and sublimatory strength. Somewhat alien to the medi­ cal profession, these maladies are self-induced, and only make sense if their symbolism is recognized and understood using a hermeneutic ap­ proach. It aptly reflects their interaction with other objects, both human and nonhuman. The anorectic girl, to whom the book is specifically devoted, rejects any human bond in a masochistic way and also denies that her own body is a worthwhile object that deserves to be cared for. On the other hand, her body and its expressions are virtually under the most potent overcontrol. Thus, the narrative of the anorectics is strongly related to their incessant suffering, which is again of their own creation.

Anorexia Nervosa and Recovery: A Hunger for Meaning

Through the voices of twenty-one women, Karen Way presents the most objective, complete, and compassionate picture of what anorexia nervosa is about and, more importantly, of the complex individual variables and obstacles in the journey to recovery. From the premise that anorexia nervosa is an addiction--an obsession controlling all aspects of an individual’s life--and that complete recovery is possible by finding meaning in life, this enlightening book contrasts sharply to other books written on the subject by clinicians and theorists which merely speculate on the nature and etiology of anorexia nervosa. Anorexia Nervosa and Recovery lets the reader hear the personal struggles of women who have fought this powerful disease. They describe how anorexia controlled their lives and how, once they overcame their obsessions with food, weight, and thinness, they were able to lead fulfilling lives. This illuminating book encourages and inspires women who are in the throes of anorexia nervosa. They will recognize the emptiness in the voices and the descriptions of daily life. Therapists and clinicians who treat anorexic women will find intriguing chapters on events which trigger anorexia and what anorexics will do to maintain their strategies for coping. Concerned friends and family and others interested in understanding this controlling disease will be enlightened from this important and helpful book.

Anorexia Nervosa and Recovery: A Hunger for Meaning

Through the voices of twenty-one women, Karen Way presents the most objective, complete, and compassionate picture of what anorexia nervosa is about and, more importantly, of the complex individual variables and obstacles in the journey to recovery. From the premise that anorexia nervosa is an addiction--an obsession controlling all aspects of an individual’s life--and that complete recovery is possible by finding meaning in life, this enlightening book contrasts sharply to other books written on the subject by clinicians and theorists which merely speculate on the nature and etiology of anorexia nervosa. Anorexia Nervosa and Recovery lets the reader hear the personal struggles of women who have fought this powerful disease. They describe how anorexia controlled their lives and how, once they overcame their obsessions with food, weight, and thinness, they were able to lead fulfilling lives. This illuminating book encourages and inspires women who are in the throes of anorexia nervosa. They will recognize the emptiness in the voices and the descriptions of daily life. Therapists and clinicians who treat anorexic women will find intriguing chapters on events which trigger anorexia and what anorexics will do to maintain their strategies for coping. Concerned friends and family and others interested in understanding this controlling disease will be enlightened from this important and helpful book.

Anorexia nervosa bei Jugendlichen: Kontext der Störung und Ergebnisse familientherapeutischer Behandlungen

Anorexic Bodies: A Feminist and Sociological Perspective on Anorexia Nervosa

This book explores the ways in which anorexic women use their eating to control their bodies. It argues that the female body in modern Western culture is understood as open and accessible and female appetite as dangerous and voracious. Anorexia attempts to resist both these constructions in the creation of a closed, desireless body. Since anorexic women resist the power of collective ideologies their resistance cannot work - the closed body becomes its own prison.

Anorexic Bodies: A Feminist and Sociological Perspective on Anorexia Nervosa

This book explores the ways in which anorexic women use their eating to control their bodies. It argues that the female body in modern Western culture is understood as open and accessible and female appetite as dangerous and voracious. Anorexia attempts to resist both these constructions in the creation of a closed, desireless body. Since anorexic women resist the power of collective ideologies their resistance cannot work - the closed body becomes its own prison.

Anorganische Chemie: Chemie-Basiswissen I (Springer-Lehrbuch)

"Chemie-Basiswissen" in drei Bänden: Anorganische, Organische und Analytische Chemie. Mit dem gesamten Wissensstoff für das Diplomchemiker-Vorexamen. Zur Examensvorbereitung für Studenten mit Chemie im Nebenfach und Studierende des höheren Lehramtes. Band 1 "Anorganische Chemie" präsentiert den Lehrstoff kurz und übersichtlich. Äußerst beliebt: das didaktische Konzept, und die am Curriculum orientierte Stoffauswahl, überzeugen Studierende im Haupt- und Nebenfach Chemie sowie des höheren Lehramtes. Die 9. Auflage ist erneut gründlich überarbeitet, aktualisiert und den Curricula angepasst. In neuem lernfreundlichen Layout und mit Festeinband.

Another Twinkle in the Eye: Contemplating Another Pregnancy After Perinatal Mental Illness

Another Twinkle in the Eye is an essential guide for anyone contemplating another pregnancy after perinatal mental illness. The decision to bring a child into the world is rarely one that is taken lightly. When a previous pregnancy and early parenthood has resulted in poor maternal and/or paternal perinatal mental health, making a conscious decision to have another baby can be even more challenging. This unique book provides facts, resources, and discussion points to support people in making informed and comfortable decisions. It is also an essential resource for health professionals who support or are involved in the decision-making process of couples planning another pregnancy. The author combines personal experience with real-life stories from other parents. Also included are contributions from healthcare professionals. The book offers comprehensive coverage across five key areas: Reflection on the previous pregnancy, miscarriage or stillbirth, Decisions to be made when considering another pregnancy, Ways to plan for and to have a healthier experience, The role of healthcare professionals and facilities, and Self-help and complementary techniques for good mental health in the perinatal period.

Another Twinkle in the Eye: Contemplating Another Pregnancy After Perinatal Mental Illness

Another Twinkle in the Eye is an essential guide for anyone contemplating another pregnancy after perinatal mental illness. The decision to bring a child into the world is rarely one that is taken lightly. When a previous pregnancy and early parenthood has resulted in poor maternal and/or paternal perinatal mental health, making a conscious decision to have another baby can be even more challenging. This unique book provides facts, resources, and discussion points to support people in making informed and comfortable decisions. It is also an essential resource for health professionals who support or are involved in the decision-making process of couples planning another pregnancy. The author combines personal experience with real-life stories from other parents. Also included are contributions from healthcare professionals. The book offers comprehensive coverage across five key areas: Reflection on the previous pregnancy, miscarriage or stillbirth, Decisions to be made when considering another pregnancy, Ways to plan for and to have a healthier experience, The role of healthcare professionals and facilities, and Self-help and complementary techniques for good mental health in the perinatal period.