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Lung Cancer: Clinics In Chest Medicine (The\clinics)
by Lynn T. Tanoue Frank C DetterbeckGet a quick, expert overview of the many key facets of lung cancer evaluation and management with this concise, practical resource by Drs. Lynn T. Tanoue and Frank Detterbeck. This easy-to-read reference presents a summary of today’s best evidence-based approaches to diagnosis and management in this critical area.Covers diagnosis and evaluation, treatment considerations, and comprehensive care options for patients with lung cancer. Provides insight on evidence for today’s best practices, as well as future directions in the field. Consolidates today’s evidence-based information on the clinical aspects of lung cancer into one convenient resource.
Lung Cancer 1 (Cancer Treatment and Research #1)
by R. B. LivingstonWhere do you begin to look for arecent, authoritative article on the diagnosis or management of a particular malignancy? The few general onco logy textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals fre quently publish good in-depth reviews of cancer topics, and published sym posium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is aseries of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. Wehave approached the problem in the following fashion. First, by divid ing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, supportive care, etc. Second, by asking eminent autho rities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Lung Cancer and Autoimmune Disorders (Advances in Experimental Medicine and Biology #833)
by Mieczyslaw PokorskiLung cancer and autoimmune diseases are complex entities in that they involve gene disturbance, gene polymorphism, and impaired gene repair mechanisms. The volume focuses on altered gene expression in tumor processes and in chronic autoimmune disorders. The chapters discuss the biological rationale for novel disease protein markers, present relevant clinical results, and give some diagnostic and therapeutic tips.
Lung Cancer and Personalized Medicine: Current Knowledge and Therapies (Advances in Experimental Medicine and Biology #893)
by Aamir Ahmad Shirish GadgeelThis, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.
Lung Cancer and Personalized Medicine: Novel Therapies And Clinical Management (Advances in Experimental Medicine and Biology #890)
by Aamir Ahmad Shirish M. GadgeelThis, the second of two volumes on personalized medicine in lung cancer, touches upon the recent progress in targeted drug development based on genomics; emerging biomarkers and therapeutic targets such as EMT, cancer stem cells, and the tumor microenvironment; current personalized clinical management and radiation therapy for lung cancers; and the promise of epigenetics and next-generation sequencing for the advancements towards personalized therapy of lung cancer patients. With chapters on state-of-the-art therapies and technologies written by leading experts working to develop novel companion diagnosis tools for the personalized treatment of lung cancer patients, this volume brings readers up-to-date by presenting the current knowledge on the efforts to make personalized management of lung cancer patients a reality.
Lung Cancer Imaging (Contemporary Medical Imaging)
by James G. RavenelWhile specialists often guide the care to lung cancer patients, it is often a general radiologist who is left to interpret studies that impact patient care and management. Lung Cancer Imaging provides a comprehensive guide to the diagnosis, staging and overview of the management of lung cancer relevant to practicing radiologists so that they can better understand the decision making issues and provide more directed and useful communication to the treating physicians. It Primary Care physicians will also find this book valuable to understand the relevant issues that they face when one of their patients is being treated for lung cancer.
Lung Cancer Metastasis: Novel Biological Mechanisms and Impact on Clinical Practice
by Venkateshwar G. Keshamouni Gregory P. Kalemkerian Douglas A. ArenbergLung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.
Lung Cancer Rehabilitation
by Adrian CristianEdited by cancer rehabilitation specialist Dr. Adrian Cristian, Lung Cancer Rehabilitation provides clinicians with a concise and accessible resource covering the holistic rehabilitation of lung cancer patients. Beginning with the epidemiology, genetics, and pathophysiology of lung cancer, it then covers clinical assessment and treatment options before providing comprehensive coverage of rehabilitation. Offering practical information, best practices and the latest advances and research, this book is a valuable reference for physical medicine and rehabilitation physicians and residents, as well as occupational therapists and physical therapists. Provides a clear understanding of the current medical, surgical and radiation treatments for lung cancer. Covers the whole spectrum of lung cancer rehabilitation, including the role of physical and occupational therapy, the treatment of anxiety and depression, integrative care, pain management, nutritional rehabilitation and more. Offers a timely and convenient resource written by leading experts in lung cancer and rehabilitation.
Lung Cancer Screening: Practical Aspects for Primary Care
by Janelle V. Baptiste Richard M. Schwartzstein Carey C. ThomsonLung cancer is the second most diagnosed cancer and remains the leading cause of cancer-related deaths in the United States. The high mortality is largely the consequence of late diagnosis; lung cancer is typically asymptomatic in early stages when a surgical cure is most likely. As a result, there has been great interest in and research on early detection of lung cancer through screening. There is evidence for reduced disease-specific mortality through screening for lung cancer. However, creating an integrated, systematic approach to lung cancer screening remains a challenge for providers. A successful lung cancer screening program weighs the benefits and harms of screening, clearly defines the target population and the screening process, and does not exclude eligible patient populations based on race, ethnicity, or socioeconomic status, In addition it should promote shared decision-making and address risk reduction. Lung Cancer Screening: Essentials for Primary Care provides a comprehensive and pragmatic guide to screening for lung cancer in real world clinical practice. The first two chapters summarize the epidemiology, risk factors and disparities in lung cancer, and provide the evidence base for screening for lung cancer. The disparities in lung cancer among different groups within the US population are well known. This text highlights how health disparities in lung cancer affect screening and have led to modification of lung cancer screening guidelines. Subsequent chapters provide a guide to implementing a successful lung cancer screening program and address the barriers that arise during implementation. The book concludes with real-world solutions to overcoming barriers in lung cancer screening. This pocket guide is an essential read and bookshelf reference for providers who do not have the specialized knowledge of screening for lung cancer. It also appeals to pulmonologists, fellows in Pulmonary Medicine, chest radiologists, and advanced practice providers with an interest in setting up lung cancer screening in any clinical practice.
Lung Cancer Screening: A Population Approach
by Gregory C. Kane Julie A. Barta Ronald E. Myers Nathaniel R. Evans IIIThis book is a comprehensive guide to lung cancer screening for clinicians, healthcare systems, community leaders, and public health officials with the hope of creating a more equitable landscape in both lung cancer screening and lung cancer-related outcomes, at local, state, and national levels. Authors take a new approach to primary and secondary lung cancer prevention that is in the early stages of adoption in the United States. The last decade ushered in recognition of screening as an effective intervention, but unfortunately, despite the wide acceptance of the importance of this new screening modality, nationally, not more than 5% of eligible subjects have undergone screening to date in the United States, although in some states uptake has reached as high as 16%. As is common with any new preventive cancer screening, racial and socioeconomic disparities emerge in utilization, stage at diagnosis, and mortality. Over time, these disparities decline, but consequential differences endure. Therefore, it is critical to establish equitable screening practices. The true measure of the effectiveness of any lung cancer screening program needs to be viewed through the lens of its impact on populations, including those most affected by the morbidity and mortality of smoking-related illness and lung cancer. As such, this book emphasizes a number of important public health topics, including community outreach to vulnerable populations, social justice issues, addressing stigma and fatalism in the general community, and the use of geocoding to assess a program’s impact at a population level. This book weaves traditional topics related to lung cancer screening, such as promoting initial and repeat screening, interpreting Lung RADs, and managing the follow-up of findings, into the population perspective in order to present a unified, comprehensive approach to the subject. Further, it serves as a guide that health systems, health care professionals, community leaders, and other stakeholders can use to achieve the promise of lung cancer screening.
Lung Development (Clinical Physiology)
by Claude Gaultier Jacques R. Bourbon Martin PostKnowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.
Lung Development and Regeneration
by Donald J. Massaro Gloria DeCarlo Massaro Pierre ChambonThis reference compiles the most current technical and biological data available to survey the state-of-science in the care and management of patients with bronchopulmonary dysplasia, COPD, and other forms of lung disease-tracking the initiation and progression of processes that cause airway obstruction, the biologic and physiological abnormalities
Lung Disease Associated with Rheumatoid Arthritis
by Takahisa Gono Hitoshi Tokuda Fumikazu Sakai Tamiko TakemuraThis comprehensive text expounds the pathophysiology, diagnosis, and treatment of lung disease associated with rheumatoid arthritis (RA), an autoimmune disease that primarily affects joints. Recent advances in therapy for RA provide the benefit of achieving a better outcome in patients with arthritis, and a large number of reports on RA are now available. Moreover, the American College of Rheumatology and the European League Against Rheumatism have proposed guidelines and recommendations for management of RA patients. Therefore, clinicians around the world can adequately understand how to manage patients who have joint symptoms in RA. At the same time, however, the management of RA patients who have lung problems has not been disseminated sufficiently, although lung disease is a common complication in approximately 30–40 % of patients with RA. Unfortunately, there has been a lack of tangible evidence regarding the pathophysiology, diagnosis, and management of lung disease associated with RA. Each expert author in this book elucidates the current status of knowledge about lung disease in RA and the management of RA patients with lung diseases. Thus this valuable collection benefits not only rheumatologists but also respirologists, radiologists, pathologists, general practitioners, and medical staff such as nurses who are involved in the management of RA.
Lung Disease in Rheumatoid Arthritis (Respiratory Medicine)
by Aryeh Fischer Joyce S. LeeThis book addresses the manifestation of lung disease in patients with rheumatoid arthritis (RA). Lung disease in RA is common and often associated with significant morbidity and mortality. This stems partially from the nature of RA and partially from the many therapies used to manage RA that are associated with pneumotoxicity. Despite the severity and commonality of this comorbidity, little has been written on the topic. This book thus takes a multidisciplinary approach to provide: a concise overview of RA and why lung disease so commonly coincides with it; overviews of the specific lung diseases, including interstitial lung disease, and their epidemiology, associated imaging, histopathology, biomarkers, and management; a presentation of risk factors for these diseases; and specifics on what still needs to be uncovered about these pulmonary manifestations. Lung Disease in Rheumatoid Arthritis is a comprehensive and practical resource for clinicians and clinician scientists in pulmonology, rheumatology, pathology, and primary care.
Lung Function: Physiology, Measurement and Application in Medicine
by John E. Cotes David J. Chinn Martin R. MillerThe only text to cover lung function assessment from first principles including methodology, reference values and interpretation New for this edition: - More illustrations to convey concepts clearly to the busy physician - Text completely re-written in a contemporary style: includes user-friendly equations and more diagrams - New material covering the latest advances in the treatment of lung function, including more on sleep-related disorders, a stronger clinical and practical bias and more on new techniques and equipment - Uses the standard Vancouver referencing system What the experts say: "I have always considered Dr Cotes' book the most authoritative book published on lung function. It is also the most comprehensive." —Dr Robert Crapo, Pulmonary Division, LDS Hospital, Salt Lake City, USA "I think I can fairly speak on behalf of staff in lung function departments the length and breadth of the country - that a sixth edition of Cotes would be gratefully received." —Dr Brendan Cooper, Clinical Respiratory Scientist, Nottingham City Hospital
Lung Function
by Benoit Nemery Sarah J. Pearce Peter D. Wagner Robert L. Maynard Brendan G. CooperThe seventh edition of the most authoritative and comprehensive book published on lung function, now completely revised and restructured Lung function assessment is the central pillar of respiratory diagnosis. Most hospitals have lung function laboratories where patients are tested with a variety of physiological methods. The tests and techniques used are specialized and utilize the expertise of respiratory physicians, physiologists, and technicians. This new edition of the classic text on lung function is a theoretical textbook and practical manual in one that gives a comprehensive account of lung function and its assessment in healthy persons and those with all types of respiratory disorder, against a background of respiratory, exercise, and environmental physiology. It incorporates the technical and methodological recommendations for lung function testing of the American Thoracic Society and European Respiratory Society. Cotes' Lung Function, 7th Edition is filled with chapters covering respiratory surveys, respiratory muscles, neonatal assessment, exercise, sleep, high altitude, hyperbaria, the effects of cold and heat, respirable dusts, fumes and vapors, anesthesia, surgery, and respiratory rehabilitation. It also offers a compendium of lung function in selected individual diseases and is filled with more diagrams and illustrative cases than previous editions. The only text to cover lung function assessment from first principles including methodology, reference values, and interpretation Completely re-written in a contemporary style—includes user-friendly equations and more diagrams Covers the latest advances in the treatment of lung function, including a stronger clinical and practical bias and more on new techniques and equipment Keeps mathematical treatments to a minimum Cotes' Lung Function is an ideal guide for respiratory physicians and surgeons, staff of lung function laboratories, and others who have a professional interest in the function of the lungs at rest or on exercise and how it may be assessed. Physiologists, anthropologists, pediatricians, anesthetists, occupational physicians, explorers, epidemiologists, and respiratory nurses should also find the book useful.
Lung Function
by Sarah J. Pearce Peter D. Wagner Robert L. Maynard John E. Cotes Benoit B. Nemery Brendan G. CooperThe seventh edition of the most authoritative and comprehensive book published on lung function, now completely revised and restructured Lung function assessment is the central pillar of respiratory diagnosis. Most hospitals have lung function laboratories where patients are tested with a variety of physiological methods. The tests and techniques used are specialized and utilize the expertise of respiratory physicians, physiologists, and technicians. This new edition of the classic text on lung function is a theoretical textbook and practical manual in one that gives a comprehensive account of lung function and its assessment in healthy persons and those with all types of respiratory disorder, against a background of respiratory, exercise, and environmental physiology. It incorporates the technical and methodological recommendations for lung function testing of the American Thoracic Society and European Respiratory Society. Cotes' Lung Function, 7th Edition is filled with chapters covering respiratory surveys, respiratory muscles, neonatal assessment, exercise, sleep, high altitude, hyperbaria, the effects of cold and heat, respirable dusts, fumes and vapors, anesthesia, surgery, and respiratory rehabilitation. It also offers a compendium of lung function in selected individual diseases and is filled with more diagrams and illustrative cases than previous editions. The only text to cover lung function assessment from first principles including methodology, reference values, and interpretation Completely re-written in a contemporary style—includes user-friendly equations and more diagrams Covers the latest advances in the treatment of lung function, including a stronger clinical and practical bias and more on new techniques and equipment Keeps mathematical treatments to a minimum Cotes' Lung Function is an ideal guide for respiratory physicians and surgeons, staff of lung function laboratories, and others who have a professional interest in the function of the lungs at rest or on exercise and how it may be assessed. Physiologists, anthropologists, pediatricians, anesthetists, occupational physicians, explorers, epidemiologists, and respiratory nurses should also find the book useful.
Lung Function Tests Made Easy E-Book (Made Easy)
by Robert J. Shiner Joerg SteierLung function testing has evolved over the years from a tool purely used for research and is now a commonly utilised form of clinical investigation. This new book is clear, concise and easy to read, providing both the essential scientific information as well as focusing on the practical aspects of lung function testing. The book is designed so that different chapters can be read as stand-alone sections, but cross-referencing to the other chapters completes the picture for the interested reader.The book begins with an outline of lung structure and anatomy, and then proceeds to basic functional considerations before discussing the tests themselves. Particular attention is given to spirometry and lung volume measurements. The text covers the functional assessment of exercise capacity, respiratory muscle strength and concludes with preoperative evaluation and recommendations. The text emphasises practical problems, including controversies associated with lung function testing. Boxes emphasise important topics throughout the text. Highlighted questions can be used for short tutorials or problem-based learning
Lung Health and the Exposome: How Environmental Factors Influence Lung Health (Respiratory Medicine)
by Sumita B. Khatri Emily J. PenningtonThis book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including: How air pollution effects airways disease, including asthma, COPD, and cystic fibrosis Risk factors and effects of indoor mold exposure Both medical and non-medical exposures that increase the risk of or cause interstitial lung disease (ILD) also known as diffuse parenchymal lung disease (DPLD) Acute and chronic lung disease associated with recreational inhalants The epidemiologic and molecular mechanisms of air pollution effects on pulmonary hypertension Climate change and weather-related lung health issues Areas in this field that need further evaluation
Lung Imaging and CADx
by Ayman El-Baz Jasjit SuriDeveloping an effective computer-aided diagnosis (CAD) system for lung cancer is of great clinical importance and can significantly increase the patient's chance for survival. For this reason, CAD systems for lung cancer have been investigated in a large number of research studies. A typical CAD system for lung cancer diagnosis is composed of four main processing steps: segmentation of the lung fields, detection of nodules inside the lung fields, segmentation of the detected nodules, and diagnosis of the nodules as benign or malignant. This book overviews the current state-of-the-art techniques that have been developed to implement each of these CAD processing steps. Overviews the latest state-of-the-art diagnostic CAD systems for lung cancer imaging and diagnosis Offers detailed coverage of 3D and 4D image segmentation Illustrates unique fully automated detection systems coupled with 4D Computed Tomography (CT) Written by authors who are world-class researchers in the biomedical imaging sciences Includes extensive references at the end of each chapter to enhance further study Ayman El-Baz is a professor, university scholar, and chair of the Bioengineering Department at the University of Louisville, Louisville, Kentucky. He earned his bachelor’s and master’s degrees in electrical engineering in 1997 and 2001, respectively. He earned his doctoral degree in electrical engineering from the University of Louisville in 2006. In 2009, he was named a Coulter Fellow for his contributions to the field of biomedical translational research. He has 17 years of hands-on experience in the fields of bio-imaging modeling and noninvasive computer-assisted diagnosis systems. He has authored or coauthored more than 500 technical articles (132 journals, 23 books, 57 book chapters, 211 refereed-conference papers, 137 abstracts, and 27 U.S. patents and disclosures). Jasjit S. Suri is an innovator, scientist, a visionary, an industrialist, and an internationally known world leader in biomedical engineering. He has spent over 25 years in the field of biomedical engineering/devices and its management. He received his doctorate from the University of Washington, Seattle, and his business management sciences degree from Weatherhead School of Management, Case Western Reserve University, Cleveland, Ohio. He was awarded the President’s Gold Medal in 1980 and named a Fellow of the American Institute of Medical and Biological Engineering for his outstanding contributions in 2004. In 2018, he was awarded the Marquis Life Time Achievement Award for his outstanding contributions and dedication to medical imaging and its management.
Lung Imaging and CADx
by Ayman El-Baz Jasjit S. SuriDeveloping an effective computer-aided diagnosis (CAD) system for lung cancer is of great clinical importance and can significantly increase the patient's chance for survival. For this reason, CAD systems for lung cancer have been investigated in a large number of research studies. A typical CAD system for lung cancer diagnosis is composed of four main processing steps: segmentation of the lung fields, detection of nodules inside the lung fields, segmentation of the detected nodules, and diagnosis of the nodules as benign or malignant. This book overviews the current state-of-the-art techniques that have been developed to implement each of these CAD processing steps. Overviews the latest state-of-the-art diagnostic CAD systems for lung cancer imaging and diagnosis Offers detailed coverage of 3D and 4D image segmentation Illustrates unique fully automated detection systems coupled with 4D Computed Tomography (CT) Written by authors who are world-class researchers in the biomedical imaging sciences Includes extensive references at the end of each chapter to enhance further study Ayman El-Baz is a professor, university scholar, and chair of the Bioengineering Department at the University of Louisville, Louisville, Kentucky. He earned his bachelor’s and master’s degrees in electrical engineering in 1997 and 2001, respectively. He earned his doctoral degree in electrical engineering from the University of Louisville in 2006. In 2009, he was named a Coulter Fellow for his contributions to the field of biomedical translational research. He has 17 years of hands-on experience in the fields of bio-imaging modeling and noninvasive computer-assisted diagnosis systems. He has authored or coauthored more than 500 technical articles (132 journals, 23 books, 57 book chapters, 211 refereed-conference papers, 137 abstracts, and 27 U.S. patents and disclosures). Jasjit S. Suri is an innovator, scientist, a visionary, an industrialist, and an internationally known world leader in biomedical engineering. He has spent over 25 years in the field of biomedical engineering/devices and its management. He received his doctorate from the University of Washington, Seattle, and his business management sciences degree from Weatherhead School of Management, Case Western Reserve University, Cleveland, Ohio. He was awarded the President’s Gold Medal in 1980 and named a Fellow of the American Institute of Medical and Biological Engineering for his outstanding contributions in 2004. In 2018, he was awarded the Marquis Life Time Achievement Award for his outstanding contributions and dedication to medical imaging and its management.
The Lung in Its Environment (Ettore Majorana International Science Series #6)
by G. BonsignoreThis volume documents the proceedings of a symposium on "Lung in its Environment" held at the Ettore Majorana 'Center for Scientific Culture, in Erice, Sicily, between 16th June and 21st June 1980. This was attended by about 200 participants drawn from Europe as a whole, but the majority were from Southern Europe. The discussion was recorded either in English or Italian and the tapes were reduced to a verbatim typescript by the Ente Nazionale Interpreti Congresso. The verbatim typescript has been edited using a few guiding principles as follows:- 1. Titles and honorifics have been eliminated unless the statement is addressed to a specific person. 2. The style of the speakers in the discussion has been preserved as far as possible and not reduced to a strictly grammatical format. 3. Where references to illustrations (e.g., on the blackboard) are made, the comments have been left unaltered and many are understandable. Removing them detracted from the sense. 4. The air of informality in the proceedings has been preserved so far as possible. 5. The responsibility for the discussion rests solely with the editors, and no contributor has had the opportunity of correcting what he said. 6. No manuscript was received from two participants, but the discussion of their presentations has been included since it contains some points of substance. 7.
Lung Inflammation in Health and Disease, Volume I (Advances in Experimental Medicine and Biology #1303)
by Yong-Xiao WangRespiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected.Current treatment options for lung disease are neither effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.
Lung Inflammation in Health and Disease, Volume II (Advances in Experimental Medicine and Biology #1304)
by Yong-Xiao WangLung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.
Lung Injury: Mechanisms, Pathophysiology, and Therapy
by Robert H. Notter Jacob Finkelstein Bruce HolmProgressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. Extensive coverage is provided on key mediators and pathways important in acute and chr