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The Local Cardiac Renin-Angiotensin Aldosterone System (Basic Science For The Cardiologist Ser. #Vol. 20)

Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system. Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

The Local Cardiac Renin-Angiotensin Aldosterone System (Basic Science For The Cardiologist Ser.)

Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system. Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

Local Cortical Circuits: An Electrophysiological Study (Studies of Brain Function #6)

Neurophysiologists are often accused by colleagues in the physical sci­ ences of designing experiments without any underlying hypothesis. This impression is attributable to the ease of getting lost in the ever-increasing sea of professional publications which do not state explicitly the ultimate goal of the research. On the other hand, many of the explicit models for brain function in the past were so far removed from experimental reality that they had very little impact on further research. It seems that one needs much intimate experience with the real nerv-. ous system before a reasonable model can be suggested. It would have been impossible for Copernicus to suggest his model of the solar system without the detailed observations and tabulations of star and planet motion accu­ mulated by the preceeding generations. This need for intimate experience with the nervous system before daring to put forward some hypothesis about its mechanism of action is especially apparent when theorizing about cerebral cortex function. There is widespread agreement that processing of information in the cor­ tex is associated with complex spatio-temporal patterns of activity. Yet the vast majority of experimental work is based on single neuron recordings or on recordings made with gross electrodes to which tens of thousands of neurons contribute in an unknown fashion. Although these experiments have taught us a great deal about the organization and function of the cor­ tex, they have not enabled us to examine the spatio-temporal organization of neuronal activity in any detail.

Local Flaps in Facial Reconstruction: A Defect Based Approach

Written by three experienced consultants with a large skin cancer practice and international reputations for excellence, this book provides comprehensive practical solutions to defects in the head and neck region that are confronted by the clinician in day-to-day practice. Essential information is first provided on anesthesia, defect assessment and individual flaps, while the core chapters focus on the reconstruction of specific defects at specific sites. The defects and reconstructive solutions are depicted by means of sequential, clinically relevant line drawings that are complemented by clear supporting text highlighting the intricacies and nuances of the procedure and the decision-making process. Helpful algorithms at the end of each chapter summarize the solutions. This book will be ideal for use in daily practice by clinicians and trainees and will assist in achieving excellent cosmetic outcomes in this aesthetically sensitive part of the body.

Local Flaps in Facial Reconstruction: A Defect Based Approach

Written by three consultants with extensive skin cancer experience and international reputations for excellence, this book provides comprehensive practical solutions for defects in the head and neck region that clinicians are confronted with in day-to-day practice. The first edition of the “local flaps in facial reconstruction- a defect base approach” was published nearly four years ago and has since been well received around the world and translated into other languages. This second edition is intended to facilitate the decision-making process and provide practical,step-by-step guidance on reconstructing specific defects in the facial region.The frequency of skin cancer continues to rise around the globe, and clinicians with various backgrounds are involved in the care of these patients. In this book, new procedures are described and “old” ones re-evaluated. The current edition has been extensively updated with new text and diagrams so as to provide comprehensive practical solutions for frequently encountered facial defects. Color diagrams and clinical photographs have been included where necessary to provide additional details. The original ethos of creating a text that can be used in everyday practice, while also including personal comments, is maintained.Given the scope, the book is ideal for use by clinicians and trainees in daily practice, and will help to achieve excellent cosmetic outcomes in this aesthetically sensitive part of the body.

Local Flaps in Facial Reconstruction E-Book: Expert Consult

Local Flaps in Facial Reconstruction brings you the detailed visual guidance and unmatched expertise you need to achieve the best results for the full range of facial flap procedures. Full-color clinical photographs and line drawings—along with high-quality surgical video clips—capture the latest facial reconstruction practices and effective methods like reconstruction of skin defects on the head and neck following tumor removal or trauma. Perspectives from facial plastic surgeons, dermatologists, ophthalmologists, and otolaryngologists help you take all of these considerations into account in treatment planning.Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make the most effective clinical decisions with a better understanding of the anatomy, physiology, and biomechanics of the skin Understand skin flap anatomy and physiology—vital to the performance of successful local flap reconstruction for facial defects. Implement the latest techniques with updated coverage of new wound closure techniques and materials (including glues and adhesives), scar revision, complications, and vascular abnormalities. Watch clips of key surgical procedures, including reconstructive surgery of the nose and lip. Avoid pitfalls and achieve the best outcomes thanks to a step-by-step approach to each procedure, complete with tips and tricks of the trade from leading experts. Minimize flap ischemia and other complications with proper preoperative planning and surgical techniques. Visualize what to look for and how to proceed with high-quality illustrations of rotation flaps, transposition flaps, advancement flaps, bilobe flaps, melolabial flaps, paramedian forehead flaps, and rhombic flaps. Access video clips at Expert Consult.

Local Flaps in Facial Reconstruction E-Book: Expert Consult - Online And Print

New clinical cases, enlarged photographs, new abstracts and algorithms, and more make the 4th Edition of Local Flaps in Facial Reconstruction your state-of-the-art resource for achieving optimal results for the full range of facial flap procedures. It offers detailed visual guidance and unmatched expertise from prominent surgeons in facial plastic surgery, ophthalmology, and dermatology, reflecting the multi-specialty nature of this dynamic field. Full-color clinical photographs and line drawings, along with high-quality surgical video clips, capture the latest, most effective facial reconstruction practices and methods. Clearly demonstrates practical and effective methods of reconstruction of skin defects in a variety of sizes, configurations, and locations on the head and neck. Covers the basic concepts of flap physiology, design, and mechanics of flap transfer, including multiple clinical examples for each flap; the second section describes the use of local flaps in reconstruction of individual facial structures including the auricles, lips, eyelids, cheeks, forehead, and nose. Contains many new clinical cases, new abstracts preceding each chapter, new algorithms for selecting the preferred local flap, an updated and expanded bibliography, newer approaches to facial reconstruction, and enlarged photographs to better view flap design, planes of dissection, and methods of flap transfer. Offers new, more complex clinical cases of nasal reconstruction, as well as updated coverage of new wound closure techniques and materials. Includes an outstanding video library demonstrating the design, dissection, and transfer of the majority of local flaps and grafts currently in use today, accompanied by expert commentary. Features more than 2,300 superb illustrations and photographs of rotation flaps, transposition flaps, advancement flaps, bilobe flaps, melolabial flaps, paramedian forehead flaps, rhombic flaps, and mucosal flaps.

Local Food Environments: Food Access in America

Local Food Environments: Food Access in America provides information on the complex nature of food delivery systems as well as the historical and political trends that have shaped them over time. The book presents the empirical evidence demonstrating disparities in access to healthy affordable foods across the United States and how these disparitie

Local Food Environments: Food Access in America

"In this book, Morland, Lehmann, and Karpyn discuss the critical need for healthy food financing programs as a vehicle to improve food access for all Americans. In my career as a public servant, there are very few legislative achievements that I’m prouder of than the Healthy Food Financing Initiative, which started in my home state of Pennsylvania. The program gained status as a proven and economically sustainable federal program that is helping to improve the quality of life in our neighborhoods: by allowing millions access to healthy, affordable food." – Congressman Dwight Evans United States House of Representatives, Pennsylvania, District 3 "If we work together, we can create a healthy food system that is equitable and accessible to all. This book highlights the importance of healthy food projects like grocery stores, farmers markets, co-ops, and other healthy food retail in revitalizing local communities across the country. Without basic nourishment, kids and families simply won’t be successful – which is why this book is a must read." – Sam Kass President Obama’s Senior Nutrition Policy Advisor and Executive Director of Let’s Move! "Morland and colleagues’ new second edition provides an excellent foundation for courses in food policy and community nutrition. Their detailed review of the economics of local and national food financing will open students’ minds to the complexity inherent in measuring and interpreting outcomes." – Robert S. Lawrence, MD, MACP Founder and Former Director of the Center for a Livable Future Johns Hopkins University, Bloomberg School of Public Health Features ● Describes how disparities in food access formed in the United States ● Includes federal policies and programs aimed at addressing food access in underserved areas, including the Healthy Food Financing Initiative ● Features examples of state initiatives that address poor access to food retailers ● Provides methods for program evaluation utilizing principals of implementation and dissemination science ● Includes critical thinking questions and embedded videos aimed to generate discussions on how restricted local food environments in the United States are rooted in economic disparities that impact food access as well as housing, education, and job opportunities

Local Food Environments: Food Access in America

"In this book, Morland, Lehmann, and Karpyn discuss the critical need for healthy food financing programs as a vehicle to improve food access for all Americans. In my career as a public servant, there are very few legislative achievements that I’m prouder of than the Healthy Food Financing Initiative, which started in my home state of Pennsylvania. The program gained status as a proven and economically sustainable federal program that is helping to improve the quality of life in our neighborhoods: by allowing millions access to healthy, affordable food." – Congressman Dwight Evans United States House of Representatives, Pennsylvania, District 3 "If we work together, we can create a healthy food system that is equitable and accessible to all. This book highlights the importance of healthy food projects like grocery stores, farmers markets, co-ops, and other healthy food retail in revitalizing local communities across the country. Without basic nourishment, kids and families simply won’t be successful – which is why this book is a must read." – Sam Kass President Obama’s Senior Nutrition Policy Advisor and Executive Director of Let’s Move! "Morland and colleagues’ new second edition provides an excellent foundation for courses in food policy and community nutrition. Their detailed review of the economics of local and national food financing will open students’ minds to the complexity inherent in measuring and interpreting outcomes." – Robert S. Lawrence, MD, MACP Founder and Former Director of the Center for a Livable Future Johns Hopkins University, Bloomberg School of Public Health Features ● Describes how disparities in food access formed in the United States ● Includes federal policies and programs aimed at addressing food access in underserved areas, including the Healthy Food Financing Initiative ● Features examples of state initiatives that address poor access to food retailers ● Provides methods for program evaluation utilizing principals of implementation and dissemination science ● Includes critical thinking questions and embedded videos aimed to generate discussions on how restricted local food environments in the United States are rooted in economic disparities that impact food access as well as housing, education, and job opportunities

Local Government and the COVID-19 Pandemic: A Global Perspective (Local and Urban Governance)

The book provides a global perspective of local government response towards the COVID-19 pandemic through the analysis of a sample of countries in all continents. It examines the responses of local government, as well as the responses local government developed in articulation with other tiers of government and with civil society organizations, and explores the social, economic and policy impacts of the pandemic. The book offers an innovative contribution on the role of local government during the pandemic and discusses lessons for the future. The COVID-19 pandemic had a global impact on public health, in the well-being of citizens, in the economy, on civic life, in the provision of public services, and in the governance of cities and other human settlements, although in an uneven form across countries, cities and local communities. Cities and local governments have been acting decisively to apply the policy measures defined at national level to the specific local conditions. COVID-19 has exposed the inadequacy of the crisis response infrastructures and policies at both national and local levels in these countries as well as in many others across the world. But it also exposed much broader and deeper weaknesses that result from how societies are organized, namely the insecure life a substantial proportion of citizens have, as a result of economic and social policies followed in previous decades, which accentuated the impacts of the lockdown measures on employment, income, housing, among a myriad of other social dimensions. Besides the analysis of how governments, and local government, responded to the public health issues raised by the spread of the virus, the book deals also with the diversity of responses local governments have adopted and implemented in the countries, regions, cities and metropolitan areas. The analysis of these policy responses indicates that previously unthinkable policies can surprisingly be implemented at both national and local levels.

Local Immunosuppression of Organ Transplants (Medical Intelligence Unit)

For the first time a complete review of the research work done over the past 30 years by leading investigators around the world in targeting immunosuppressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields of transplant immunology, pharmacology and drug delivery and targeting, particularly those involved in drug development.

Local Infiltration Analgesia: A Technique to Improve Outcomes after Hip, Knee or Lumbar Spine Surgery

The concept of integrating pain management into the surgical process as a single entity is new and exciting. The use of local anaesthetic to block post-operative pain at the site of its generation is here refined into a management program allowing early mobilisation and dramatic pain control in the early post-operative period. This multimodal techn

Local Invasion and Spread of Cancer (Cancer Growth and Progression #7)

Local Maladies, Global Remedies: Reclaiming the Right to Health in Latin America

This forward-looking book provides an in-depth analysis of the major transformations of the right to health in Latin America over the past decades, marked by the turn towards the pharmaceuticalisation of health care. Everaldo Lamprea-Montealegre investigates how health-based litigation has deepened inequalities in the global South, exploring the practices of key actors that are reclaiming the right to health in the region. Taking a deep dive into the health care systems of Brazil and Colombia, Local Maladies, Global Remedies illustrates how transnational pharmaceutical companies are influencing the litigation of health rights, from moulding doctors’ preferences for branded drugs to controlling the availability of cheaper generics and bio-similars. The book deploys a wide range of theoretical perspectives and insights from socio-legal literature to map out the practices of stakeholders that are reclaiming the right to health in Latin America. Its concluding remarks propose a set of remedies to help alleviate the challenges faced by global South countries when trying to guarantee their population’s right to health, ultimately calling for a major shift of decision-making responsibilities from a local to a global level. The wide-ranging, interdisciplinary scope of this cutting-edge book will benefit scholars, practitioners, policymakers, and students operating at the intersections between socio-legal studies, sociology, health anthropology, public health, globalisation, and human rights.

Local-spinal Therapy of Spasticity

Historical photograph of spinal anaesthesia In 1884 the American neurologist J. L. eases. His discovery, however, marks the Corning, by blocking the neural con­ onset of the era of regional anaesthesia. It took almost one hundred years until his duction to the hind extremities of a dog by injecting cocaine-solution into the lumbar original idea of "local medication of the vertebral interspace, was the first to per­ cord" was again reconsidered due to two form spinal (or epidural?) anaesthesia [1]. reasons: At that time, he was unaware of the local I. The discovery of different drug receptors anaesthetic properties of cocaine (dis­ in the spinal cord made it possible, by in­ covered in the same year by C. Koller, who trathecal injection (or epidural appli­ cation, if the drug penetrates the dura), applied cocaine to the eye of one of his pa­ tients [3]) and did not intend to introduce to alter nociceptive or motor transmis­ an anaesthetic procedure. Corning's pri­ sion within the spinal cord. mary aim was the application of drugs in 2. Implantable devices for long-term appli­ proximity of the central nervous system, i. e. cation of drugs to specific sites of the spinal cord, in order to treat or even heal body, including the spinal spaces, were developed during the 1970's.

Local Therapies for Glioma: Present Status and Future Developments (Acta Neurochirurgica Supplement #88)

In addition to surgery and radiotherapy, local treatment modalities for the management of brain tumours are increasingly being developed and clinically tested. This book describes for the first time basic tumour biology as well as all current procedures in progress at the most recent level of knowledge, presented by leading experts in the respective fields. Image guided resection procedures, fluorescence guided surgery, developments in interstitial radiosurgery are addressed, just as intracavitary chemotherapy and all current concepts and studies of interstitial targeted therapy. Owing to its topicality this book will remain for long the standard for this comprehensively treated subject.

Local Treatment of Inflammatory Joint Diseases: Benefits and Risks

This book presents a systematic survey of different local treatments in inflammatory joint diseases and their potential side effects and complications. Both surgical therapies and pharmaceutical strategies involving local or systemic application of anti-inflammatory and immunomodulating drugs are addressed. Special emphasis is placed on nuclear medicine therapy by intra-articular instillation of beta radiation emitters, known as radiosynoviorthesis or radiation synovectomy. Possible complications, in particular radionecrosis, infection, and thromboembolism, are described and available treatment strategies are examined in detail. In addition, radiation safety considerations are critically reviewed and relevant clinical questions are discussed.While radiosynoviorthesis is an effective and safe treatment if a proper indication is secured and if the application is performed by an experienced nuclear medicine physician, local complications can never be excluded with certainty. This book will support physicians who are engaged in the care and treatment of patients with inflammatory joint disease, approximately 30,000 of whom undergo radiosynoviorthesis in Europe each year.

Local Wound Care for Dermatologists (Updates in Clinical Dermatology)

Focusing on local wound care specifically for the dermatologist, this concise text provides a go-to source for practitioners looking for a quick solution for many of the most common wounds as well as an update on what's new in the field. From the most basic principles of local wound care to a look at what upcoming therapies like stem cells and lasers can do, this text is comprehensive and informed. Providing quality local wound care requires an ample knowledge of available products, their cost effectiveness, and the principles for the optimal interventions; Local Wound Care for Dermatologists includes these three guiding points in each chapter that focuses on a specific therapy. Expertly written text is accompanied by multiple tables of drug-specific names, current price points, and comparable products. Chapters include many color images, thereby providing insight to a given wound and the various therapies available to treat it. While the basics are reviewed in the opening chapters, later chapters feature updates in therapies including discussions on what's new in skin substitutes, negative pressure wound therapy, oxygen therapy, and an update in cell based therapy. Written with the dermatologist in mind, Local Wound Care for Dermatologists is an indispensable reference for students, residents, and practicing doctors alike. General practitioners and plastic surgeons will also find this title a useful refresher.

Localization and Its Discontents: A Genealogy of Psychoanalysis and the Neuro Disciplines

Psychoanalysis and neurological medicine have promoted contrasting and seemingly irreconcilable notions of the modern self. Since Freud, psychoanalysts have relied on the spoken word in a therapeutic practice that has revolutionized our understanding of the mind. Neurologists and neurosurgeons, meanwhile, have used material apparatus—the scalpel, the electrode—to probe the workings of the nervous system, and in so doing have radically reshaped our understanding of the brain. Both operate in vastly different institutional and cultural contexts. Given these differences, it is remarkable that both fields found resources for their development in the same tradition of late nineteenth-century German medicine: neuropsychiatry. In Localization and Its Discontents, Katja Guenther investigates the significance of this common history, drawing on extensive archival research in seven countries, institutional analysis, and close examination of the practical conditions of scientific and clinical work. Her remarkable accomplishment not only reframes the history of psychoanalysis and the neuro disciplines, but also offers us new ways of thinking about their future.

Localization and Its Discontents: A Genealogy of Psychoanalysis and the Neuro Disciplines

Psychoanalysis and neurological medicine have promoted contrasting and seemingly irreconcilable notions of the modern self. Since Freud, psychoanalysts have relied on the spoken word in a therapeutic practice that has revolutionized our understanding of the mind. Neurologists and neurosurgeons, meanwhile, have used material apparatus—the scalpel, the electrode—to probe the workings of the nervous system, and in so doing have radically reshaped our understanding of the brain. Both operate in vastly different institutional and cultural contexts. Given these differences, it is remarkable that both fields found resources for their development in the same tradition of late nineteenth-century German medicine: neuropsychiatry. In Localization and Its Discontents, Katja Guenther investigates the significance of this common history, drawing on extensive archival research in seven countries, institutional analysis, and close examination of the practical conditions of scientific and clinical work. Her remarkable accomplishment not only reframes the history of psychoanalysis and the neuro disciplines, but also offers us new ways of thinking about their future.

Localization and Its Discontents: A Genealogy of Psychoanalysis and the Neuro Disciplines

Psychoanalysis and neurological medicine have promoted contrasting and seemingly irreconcilable notions of the modern self. Since Freud, psychoanalysts have relied on the spoken word in a therapeutic practice that has revolutionized our understanding of the mind. Neurologists and neurosurgeons, meanwhile, have used material apparatus—the scalpel, the electrode—to probe the workings of the nervous system, and in so doing have radically reshaped our understanding of the brain. Both operate in vastly different institutional and cultural contexts. Given these differences, it is remarkable that both fields found resources for their development in the same tradition of late nineteenth-century German medicine: neuropsychiatry. In Localization and Its Discontents, Katja Guenther investigates the significance of this common history, drawing on extensive archival research in seven countries, institutional analysis, and close examination of the practical conditions of scientific and clinical work. Her remarkable accomplishment not only reframes the history of psychoanalysis and the neuro disciplines, but also offers us new ways of thinking about their future.

Localization and Its Discontents: A Genealogy of Psychoanalysis and the Neuro Disciplines

Psychoanalysis and neurological medicine have promoted contrasting and seemingly irreconcilable notions of the modern self. Since Freud, psychoanalysts have relied on the spoken word in a therapeutic practice that has revolutionized our understanding of the mind. Neurologists and neurosurgeons, meanwhile, have used material apparatus—the scalpel, the electrode—to probe the workings of the nervous system, and in so doing have radically reshaped our understanding of the brain. Both operate in vastly different institutional and cultural contexts. Given these differences, it is remarkable that both fields found resources for their development in the same tradition of late nineteenth-century German medicine: neuropsychiatry. In Localization and Its Discontents, Katja Guenther investigates the significance of this common history, drawing on extensive archival research in seven countries, institutional analysis, and close examination of the practical conditions of scientific and clinical work. Her remarkable accomplishment not only reframes the history of psychoanalysis and the neuro disciplines, but also offers us new ways of thinking about their future.

Localizing the Moral Sense: Neuroscience and the Search for the Cerebral Seat of Morality, 1800-1930

Due to the current revolution in brain research the search for the “moral brain” became a serious endeavour. Nowadays, neural circuits that are indispensable for moral and social behaviour are discovered and the brains of psychopaths and criminals - the classical anti-heroes of morality - are scanned with curiosity, even enthusiasm. How revolutionary this current research might be, the quest for a localisable ethical centre or moral organ is far from new. The moral brain was a recurrent theme in the works of neuroscientists during the 19th and 20th century. From the phrenology era to the encephalitis pandemic in the 1920s a wide range of European and American scientists (neurologists, psychiatrists, anthropologists and criminologists) speculated about and discussed the location of a moral sense in the human cortex. Encouraged by medical discoveries and concerned by terrifying phenomena like crime or “moral insanity” (psychopathy) even renowned and outstanding neurologists, including Moritz Benedikt, Paul Flechsig, Arthur Van Gehuchten, Oskar Vogt or Constantin von Monakow, had the nerve to make their speculations public. This book presents the first overview of believers and disbelievers in a cerebral seat of human morality, their positions and arguments and offers an explanation for these historical attempts to localise our moral sense, in spite of the massive disapproving commentary launched by colleagues.

Locating Health: Historical and Anthropological Investigations of Place and Health (Studies for the Society for the Social History of Medicine)

The essays in this collection focus on the dynamic relationship between health and place. Historical and anthropological perspectives are presented – each discipline having a long tradition of engaging with these concepts. The resulting dialogue should produce a new layer of methodology, enhancing both fields.