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Lone-Actor Terrorism: An Integrated Framework
by Holzer, Jacob C. / Dew, Andrea J. / Patricia R. Recupero / Paul, GillLone-actor terrorism has unfortunately been on the rise in recent decades, causing major adverse societal effects in the United States and abroad. While lone-actor terrorists can be driven by a range of identifiable factors such as extremist views or availability of weapons, the process of becoming and identifying these individuals is deeply complicated. Lone-Actor Terrorism: An Integrated Framework outlines the societal causes and impacts of lone-actor terrorism from a multi-disciplinary, international perspective. Drawing together seasoned insights across clinical and forensic mental health, sociology, criminology, law, military and intelligence, and security, this volume explores patterns common to lone-actor terrorists across four major sections: historical and case examples, clinical aspects, non-clinical professional and allied perspectives, and assessment and potential approaches to reducing the risk of lone-actor terrorism. Contributors describe both individual clinical factors affecting lone-actors, including developmental aspects, mental health variables, psychoactive drugs, psychometrics and linguists, along with broader social factors such as propaganda and rhetoric, social media, and geographical considerations. This volume concludes with a review of the available threat and risk assessment tools applicable to lone-actor terrorism cases and provides guidance for professionals seeking to reduce risk. While there is no uniform approach to the concept of lone-actor terrorism, this edited volume provides a diverse yet authoritative overview for those interested in better understanding the threats of lone-actor terrorism and its professional response.
Lone-Actor Terrorism: An Integrated Framework
Lone-actor terrorism has unfortunately been on the rise in recent decades, causing major adverse societal effects in the United States and abroad. While lone-actor terrorists can be driven by a range of identifiable factors such as extremist views or availability of weapons, the process of becoming and identifying these individuals is deeply complicated. Lone-Actor Terrorism: An Integrated Framework outlines the societal causes and impacts of lone-actor terrorism from a multi-disciplinary, international perspective. Drawing together seasoned insights across clinical and forensic mental health, sociology, criminology, law, military and intelligence, and security, this volume explores patterns common to lone-actor terrorists across four major sections: historical and case examples, clinical aspects, non-clinical professional and allied perspectives, and assessment and potential approaches to reducing the risk of lone-actor terrorism. Contributors describe both individual clinical factors affecting lone-actors, including developmental aspects, mental health variables, psychoactive drugs, psychometrics and linguists, along with broader social factors such as propaganda and rhetoric, social media, and geographical considerations. This volume concludes with a review of the available threat and risk assessment tools applicable to lone-actor terrorism cases and provides guidance for professionals seeking to reduce risk. While there is no uniform approach to the concept of lone-actor terrorism, this edited volume provides a diverse yet authoritative overview for those interested in better understanding the threats of lone-actor terrorism and its professional response.
The Lone Wolf's Craving (Men of Honour #2)
by Tina BeckettAfter a tour of duty in Afghanistan, ex-soldier Dr Luke Blackman hides his lingering physical and emotional scars. He keeps everyone at a distance – until emotions explode in his ER and he loses himself with the beguiling Kate Bradley in the dark of a hospital supply closet!
Loneliness Among Children With Special Needs: Theory, Research, Coping, and Intervention
by Malka MargalitLoneliness Among Children With Special Needs is a groundbreaking volume that examines this vitally important, but heretofore neglected topic. Based on the shared view, from both clinical experience and research, that children with disabilities experience more loneliness than nondisabled children. This book integrates the existing knowledge, research, and applications in order to provide a model for the examination and understanding of the loneliness experiences of children with learning disabilities, behavior disorders, mild mental retardation, and emotional difficulties. Divided into five sections, the first attempts to clarify the characteristics of the lonely child, followed by a section with chapters devoted to environments and interpersonal relations. The third section is concerned with the subtyping of loneliness and adjustment and the fourth section discusses the outcomes comes of loneliness through coping and interventions. The final section provides a summary of the research using the proposed loneliness model for children with disabilities. This volume is essential reading for all researchers, clinicians, educators and students who work with children with special needs and who, as stated in the Preface, "see the importance of companionship for promoting growth of children with special needs and the costs of loneliness for current life and future adjustment."
Lonely Children and Adolescents: Self-Perceptions, Social Exclusion, and Hope
by Malka MargalitFrom texting and social networking sites to after-school activities, young people have many opportunities to interact with one another, and yet loneliness and isolation trouble today’s youth in increasing numbers. Many children and teens report feeling lonely even in the midst of family and friends, and childhood loneliness is a prime risk factor for adult alienation.Lonely Children and Adolescents: Self-Perceptions, Social Exclusion, and Hope illuminates seldom-explored experiences of social isolation among young people as well as the frustrations of the parents and teachers who wish to help. This groundbreaking book conceptualizes loneliness not simply as the absence of social connections, but as a continuum of developmental experience, often growing out of the conflict between opposite needs: to be like one’s peers yet be one’s unique self. The author draws clear distinctions between loneliness and solitude and identifies genetic and environmental characteristics (i.e., social, psychological, familial, and educational) that can be reinforced to help children become more resilient and less isolated. In addition, therapeutic approaches are described that challenge loneliness by encouraging empowerment, resilience, and hope, from proven strategies to promising tech-based interventions.Highlights include:• Developmental perspectives on loneliness.• Schools and the role of teachers, from preschool to high school.• Peer relations (e.g., cliques, bullies, exclusion, and popularity).• Lonely children, lonely parents: models of coping.• Loneliness in the virtual world.• Prevention and intervention strategies at home, at school, in therapy.Asking its readers to rethink many of their assumptions about social competence and isolation, this volume is essential reading for researchers and professionals in clinical child, school, developmental, and educational psychology; allied education disciplines; social work; and social and personality psychology.
The Long 2020: Reflections of Epidemiological Times (India Studies in Business and Economics)
by Subhas Ranjan Chakraborty Paula Banerjee Kaustubh Mani SenguptaThis book looks at the current crises of life and livelihood following the global epidemiological crisis and various strategies to manage them as a long unfolding of past trends and future possibilities of epidemiological governance, restructuring of global economy, public health, systems of protection and care and the role of state in that, and precarities of the migrants and the refugees. It brings together scholars from different fields to think of our present in the time of COVID-19 pandemic in a longer temporal frame. The essays compiled in this book investigate issues mentioned above, covering a period from the colonial past to the postcolonial present with an aim towards encouraging scholarly debates on protection, care and justice. Although the experiences of last two years have inspired some very important academic and scholarly interventions, this book compiles original research to contextualise the present in a longue duree framework and arrive at a more complex understanding of it. It is a must-have resource for researchers of developmental studies especially in the above mentioned areas, as well as policy makers, think tanks and other non-governmental organizations interested in these areas.
Long Acting Animal Health Drug Products: Fundamentals and Applications (Advances in Delivery Science and Technology)
by Michael J. Rathbone Arlene McDowellLong acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such technologies offer beneficial advantages to the veterinarian, farmer and pet owner. These advantages have resulted in them growing in popularity in recent years. The pharmaceutical scientist is faced with many challenges when innovating new products in this demanding field of controlled release. This book provides the reader with a comprehensive guide on the theories, applications, and challenges associated with the design and development of long acting veterinary formulations. The authoritative chapters of the book are written by some of the leading experts in the field. The book covers a wide scope of areas including the market influences, preformulation, biopharmaceutics, in vitro drug release testing and specification setting to name but a few. It also provides a detailed overview of the major technological advances made in this area. As a result this book covers everything a formulation scientist in industry or academia, or a student needs to know about this unique drug delivery field to advance health, production and reproduction treatment options and benefits for animals worldwide.
Long Acting Injections and Implants (Advances in Delivery Science and Technology)
by Jeremy C. Wright and Diane J. BurgessLong acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants.This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
The Long and Short Non-coding RNAs in Cancer Biology (Advances in Experimental Medicine and Biology #927)
by Erwei SongThe book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.
The Long Baby Boom: An Optimistic Vision for a Graying Generation
by Jeff GoldsmithIn 2006, the first baby boomers turned 60, unleashing a veritable tidal wave of gloomy punditry, advertising for financial services, and forecasts of impending national bankruptcy. In The Long Baby Boom, Jeff Goldsmith counters the predictions of such "catastropharians" with a far more optimistic scenario.Drawing on evidence that most baby boomers plan on working long past age 65, Goldsmith argues that they will have a constructive impact on society over the next twenty years. By assuming a much larger portion of the financial burden of their own retirement and health costs, they will help preserve Social Security and Medicare for the less fortunate and for successive generations.The Long Baby Boom is the first comprehensive forecast of baby boomers’ career plans, health trends, and cultural and political values. Goldsmith's pro-work, pro-savings, pro-health social policy emphasizes personal responsibility without ripping the social safety net. Optimistic and innovative, The Long Baby Boom doesn't promise a cloud-free future, but it does reassure us that the sky isn't falling.
The Long Case OSCE: The Ultimate Guide for Medical Students
by Beth C. Walker Marsha Y. MorganA solid knowledge base and good clinical skills don’t necessarily guarantee examination success in the long case OSCE. This book is the ultimate guide for medical students needing to combine their knowledge and skills with an ability to interpret the clinical findings, the proficiency to present them clearly and the confidence to deal with the examiners questions. Adopting a proven, highly effective approach, this revision aid uses role play with simulated patients to hone clinical examination and presentation skills. The fifty cases are divided into six areas: cardiology, respiratory, abdomen, neurology, musculoskeletal and surgery. Written by successful candidates and examiners, the guide poses a number of important and commonly asked examination questions for each case to assist in preparation and confidence, and model answers are provided to ensure an understanding of exactly what is required. Working in groups or independently, students will welcome the large, colourful format, the breakdown of marking schemes, an overview of examiners expectations, a guide to presenting clinical findings and innumerable ‘insider’ tips throughout. See accompanying video here: https://www.youtube.com/watch?v=Cvr4y-NykUU
The Long Case OSCE: The Ultimate Guide for Medical Students
by Beth C. Walker Marsha Y. MorganA solid knowledge base and good clinical skills don’t necessarily guarantee examination success in the long case OSCE. This book is the ultimate guide for medical students needing to combine their knowledge and skills with an ability to interpret the clinical findings, the proficiency to present them clearly and the confidence to deal with the examiners questions. Adopting a proven, highly effective approach, this revision aid uses role play with simulated patients to hone clinical examination and presentation skills. The fifty cases are divided into six areas: cardiology, respiratory, abdomen, neurology, musculoskeletal and surgery. Written by successful candidates and examiners, the guide poses a number of important and commonly asked examination questions for each case to assist in preparation and confidence, and model answers are provided to ensure an understanding of exactly what is required. Working in groups or independently, students will welcome the large, colourful format, the breakdown of marking schemes, an overview of examiners expectations, a guide to presenting clinical findings and innumerable ‘insider’ tips throughout. See accompanying video here: https://www.youtube.com/watch?v=Cvr4y-NykUU
Long Circulating Liposomes: Old Drugs, New Therapeutics (Biotechnology Intelligence Unit)
by GerritStorm Martin C. WoodleThis book provides an up-to-date evaluation of clinical aspects of newly available "long-circulating liposome" formulations. Based on results from numerous clinical studies, the book describes the fundamentals of this new technology, discusses how it may influence the pharmacology of existing well-known agents reformulated in this manner, and elaborates on future expectations. It provides the practicing clinician - in particular, oncologists and critical care infectious disease physicians - with the tools needed to use these new formulations towards the best outcome for the patient.
The Long Covid Handbook
by Gez Medinger Professor Danny AltmannUnderstand, manage, and treat Long Covid.Reports suggest that over 100m people around the world are living with Long Covid (more than 1.5m in the UK) yet reliable, clear information and guidance remains scarce. This book is the definitive guide to understanding, managing and treating the condition.Written by the world's leading immunologist Professor Danny Altmann and expert patient Gez Medinger, The Long Covid Handbook translates cutting-edge science, patient-led research and practical guidance with clarity. This book will equip you with expert information and advice on:- Long Covid's 200 symptoms, which include fatigue, brain fog, breathlessness and more- Tips for recovery- Which treatments are most effective and why- Who is most susceptible to the condition and why- What we can learn about Long Covid from other chronic illnesses- The impact on mental healthThis is the essential guide for anyone living with the condition, as well as clinicians seeking to better understand this little-understood illness.
Long-Covid-/Post-Covid-Syndrom aus psychiatrischer Sicht: Ansätze zur psychiatrischen Differentialdiagnostik und Therapie (essentials)
by Katharina GrobholzDer Pathomechanismus von Long-/Post-Covid ist noch nicht endgültig geklärt, in ihrer Wirksamkeit ausreichend erprobte bzw. kurative Therapien stehen bisher nicht zur Verfügung.Die Differentialdiagnose zu psychischen Erkrankungen ist aufgrund der unspezifischen Symptomatik sowie des hohen Anteils psychischer Komorbiditäten oft schwierig. Psychiatrische und therapeutische Expertise sollte deshalb als Bestandteil der Diagnostik und des symptomatischen, interdisziplinären Behandlungskonzept bedacht werden. In diesem essential werden Diagnosekriterien, Möglichkeiten zur psychiatrischen Differentialdiagnostik sowie Ansatzpunkte zur psychotherapeutischen Behandlung bei Long-/Post-Covid dargestellt.
The Long COVID Survival Guide: How to Take Care of Yourself and What Comes Next—Stories and Advice from Twenty Long-Haulers and Experts
by Fiona LowensteinA patient-to-patient guide to Long COVID, from living with it to navigating its aftereffects, filled with personal and practical advice in thirteen chapters written by people who have experienced Long COVID firsthand and medical experts in the field.
The Long Dark Road: An Addictive And Page-turning Thriller
by P.R. Black'A slow-burning thriller that builds to a devastating dénouement.' Mail on Sunday If you go, there's no coming back.Dr Georgia Healey can't grieve. Her nineteen-year-old daughter went for a walk two years ago and vanished. The police never found Stephanie's body. The case has gone stale, but Georgia can't let it go. She knows Stephanie's out there, somewhere.On the anniversary of Stephanie's disappearance, Georgia's ready to re-interrogate university students, lecturers, Steph's past boyfriends, everyone. She treads the exact path where Stephanie vanished. Yet the shocking truth is even more than she can handle.When you seek the lost, be prepared for what you find . . .Reviews for P.R. Black:'A tense thriller that kept me reading way past bedtime then kept me awake.' Kerry Watts 'It's edge-of-the-seat stuff... A cracker.' Bookbag 'Copious amounts of suspense.' Novel Kicks
Long-gap Esophageal Atresia: Prenatal Diagnosis of Congenital Malformations (Progress in Pediatric Surgery #19)
by Peter Wurnig
Long Life Strategy: A Guide for Living a Longer, Healthier, and More Fulfilling life
by Ronald M. CaplanThe second edition of Long Life Strategy builds upon the practical tips and knowledge in the first edition by providing readers with an outline to living a longer, healthier, more enjoyable life and late life. The book elaborates on three major areas, which include what you can do to live a long life, what your doctor should be doing to help you achieve this goal, and what society, of which we are all part, should be doing to better accommodate a growing number of older people in the coming decades. Dr. Caplan begins by introducing what it means to live a longer life and explaining the current research on delaying, preventing, and reversing aging in our cells. The next chapters detail how to prevent diseases and conditions commonly associated with aging, including diabetes, cancer, osteoporosis, mental health decline, sexual dysfunction, and heart disease. The author provides instruction for good diet and exercise choices. The concluding chapters provide useful advice for managing a fixed income, becoming a grandparent, dealing with the sickness and loss of a life partner, and how to maintain social relationships into late life. No matter where you are on life’s journey, Long Life Strategy can provide a roadmap to living a longer, healthier, and more fulfilling life.
Long-Lost Son: Their Lost-and-found Family / Long-lost Son: Brand-new Family / A Proposal Worth Waiting For (Crocodile Creek 24-hour Rescue #8)
by Lilian DarcyJaney Stafford is involved in an accident when searching for her nephew's father.
Long-Memory Processes: Probabilistic Properties and Statistical Methods
by Jan Beran Yuanhua Feng Sucharita Ghosh Rafal KulikLong-memory processes are known to play an important part in many areas of science and technology, including physics, geophysics, hydrology, telecommunications, economics, finance, climatology, and network engineering. In the last 20 years enormous progress has been made in understanding the probabilistic foundations and statistical principles of such processes. This book provides a timely and comprehensive review, including a thorough discussion of mathematical and probabilistic foundations and statistical methods, emphasizing their practical motivation and mathematical justification. Proofs of the main theorems are provided and data examples illustrate practical aspects. This book will be a valuable resource for researchers and graduate students in statistics, mathematics, econometrics and other quantitative areas, as well as for practitioners and applied researchers who need to analyze data in which long memory, power laws, self-similar scaling or fractal properties are relevant.
Long Non-Coding RNAs (Progress in Molecular and Subcellular Biology #51)
by Durdica UgarkovicLong non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.
Long Non-Coding RNAs: Methods and Protocols (Methods in Molecular Biology #1402)
by Yi Feng and Lin ZhangThis volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Long Non-Coding RNAs: Methods and Protocols also discusses methods used to study circular RNAs and RNA splicing, as well as influential findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and cutting-edge, Long Non-Coding RNAs: Methods and Protocols is a must-have for molecular biologists, cell and developmental biologists, specialists who conduct disease-oriented research, and bioinformatics experts who seek a better understanding on lncRNA expression and function by computational analysis of the massive sequencing data that are rapidly accumulating in recent years.
Long Non-Coding RNAs: Methods and Protocols (Methods in Molecular Biology #2372)
by Lin Zhang Xiaowen HuThis second edition provides a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Chapters guide readers through studies used to circular RNAs, RNA splicing, and findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Long Non-Coding RNAs: Methods and Protocols,Second Edition aims to ensure successful results in the further study of this vital field.
Long Non-Coding RNAs in Cancer (Methods in Molecular Biology #2348)
by Alfons NavarroThis volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.