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Long Non-Coding RNAs: Methods and Protocols (Methods in Molecular Biology #2372)
by Lin Zhang Xiaowen HuThis second edition provides a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Chapters guide readers through studies used to circular RNAs, RNA splicing, and findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Long Non-Coding RNAs: Methods and Protocols,Second Edition aims to ensure successful results in the further study of this vital field.
Long Non-Coding RNAs in Cancer (Methods in Molecular Biology #2348)
by Alfons NavarroThis volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
Long Non-coding RNAs in Human Disease (Current Topics in Microbiology and Immunology #394)
by Kevin V. MorrisThis volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
Long Non Coding RNA Biology (Advances in Experimental Medicine and Biology #1008)
by M.R.S. RaoThis contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
Long Noncoding RNA: Mechanistic Insights and Roles in Inflammation (Advances in Experimental Medicine and Biology #1363)
by Susan CarpenterThis book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.
Long Noncoding RNAs: Structures and Functions
by Riki KurokawaThis book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests.
Long-Term Ambulatory Electrocardiography (Developments in Cardiovascular Medicine #20)
by J. RoelandtRecent technological developments have brought long-term ambulatory electro cardiography to the front of clinical cardiology. Its application for solving clinical problems potentially related to cardiac arrhythmias is rapidly increasing. In the meantime, the method has found widespread use in the identification of patients at risk for cardiac death as well as in the assessment of therapeutic interventions. It was the purpose of this symposium to bring together an international group of authorities in order both to provide an overall view of the field and to discuss critically the value of clinical, epidemiological and research applications of long term ambulatory electrocardiography in the light of new concepts and recent advances. The first section of this volume discusses the methodology and the performance criteria of the equipment and analysis systems. In the second section, the potentials and problems encountered in the use of long-term ambulatory electrocardiography for solving clinical questions and for predicting the occurrence of clinically important arrhythmias are extensively as continuous ST segment monitoring, blood dealt with. New applications such pressure measurement and other physiologic parameters are also included. Prevalence variability and prognostic aspects of ventricular arrhythmias, both in normals and in patients with cardiac disease, are the subject of section 3. The last section provides a critical review of the use of the method for the evaluation of therapeutic interventions with drugs. The editors feel that this volume represents the 'state of the art' in this newly important area of clinical cardiology.
Long-Term Care: Economic Issues and Policy Solutions (Developments in Health Economics and Public Policy #5)
by Roland Eisen Frank A. SloanEnsuring long-term care (LTC) is one of the most urgent problems in health care today. Demographic trends are expected to lead to a higher proportion of old and very old people in the global population. As a result, an increased proportion of global income will be devoted to LTC services. With this in mind, Long-term Care: Economic Issues and Policy Solutions aims to address the following important objectives: to provide a detailed analysis of the arrangements and institutions designed to protect the disabled and dependent elderly people in various countries, and to try to evaluate their respective merits. to discuss the projections of future costs of protection for dependent elderly, and to assess the impact of improvements in disability-free life expectancy on the future cost of care and choices between informal and formal care. to present empirical research on these decisions, with special consideration of primary caregivers, and on the substitution between in kind and cash benefits as well as between institutional (or formal) care and home (or informal) care. to analyze different theoretical approaches in modeling decisions referring to LTC services to be provided both within and between generations. With its mix of empirical, theoretical and policy-related contributions, Long-term Care: Economic Issues and Policy Solutions will be of interest not only to health economists, but also to social scientists, health insurers, and public policy advocates.
Long-Term Care for Frail Older People: Reaching for the Ideal System (Keio University International Symposia for Life Sciences and Medicine #4)
by NaokiIkegami John CreightonCampbellThe aging of society is a growing concern in all advanced nations, and at the forefront of concern is long-term care for frail older people. Enactment of a new public long-term care insurance program by the Japanese government in 1997 provided an excellent opportunity for a conference focusing on an ideal long-term care system for frail older people. The conference was organized around four major themes: Social aspects, including family dynamics and the role of formal providers; Clinical aspects, including effective treatments for physical and mental disabilities; Macroeconomic and macropolitical settings for public policy; Program design and management issues. With contributions from the fields of medicine, nursing, social work, gerontology, political science, economics, and sociology, this volume provides an overview of key problems and possible solutions in programs for frail older people from a unique international perspective.
Long-term Care, Globalization, and Justice
by Lisa A. EckenwilerLong-term care can be vexing on a personal as well as social level, and it will only grow more so as individuals continue to live longer and the population of aged persons increases in the United States and around the world. This volume explores the ethical issues surrounding elder care from an ecological perspective to propose a new theory of global justice for long-term care.Care work is organized not just nationally, as much current debate suggests, but also transnationally, through economic, labor, immigration, and health policies established by governments, international lending bodies, and for-profit entities. Taking an epistemological approach termed "ecological knowing," Lisa A. Eckenwiler examines this organizational structure to show how it creates and sustains injustice against the dependent elderly and those who care for them, including a growing number of migrant care workers, and how it weakens the capacities of so-called source countries and their health care systems. By focusing on the fact that a range of policies, people, and places are interrelated and mutually dependent, Eckenwiler is able not only to provide a holistic understanding of the way long-term care works to generate injustice but also to find ethical and practicable policy solutions for caring for aging populations in the United States and in less well-off parts of the world.Deeply considered and empirically informed, this examination of the troubles in transnational long-term care is the first to probe the issue from a perspective that reckons with the interdependence of policies, people, and places, and the first to recommend ways policymakers, planners, and families can together develop cohesive, coherent long-term care policies around the ideal of justice.
Long-term Care, Globalization, and Justice
by Lisa A. EckenwilerLong-term care can be vexing on a personal as well as social level, and it will only grow more so as individuals continue to live longer and the population of aged persons increases in the United States and around the world. This volume explores the ethical issues surrounding elder care from an ecological perspective to propose a new theory of global justice for long-term care.Care work is organized not just nationally, as much current debate suggests, but also transnationally, through economic, labor, immigration, and health policies established by governments, international lending bodies, and for-profit entities. Taking an epistemological approach termed "ecological knowing," Lisa A. Eckenwiler examines this organizational structure to show how it creates and sustains injustice against the dependent elderly and those who care for them, including a growing number of migrant care workers, and how it weakens the capacities of so-called source countries and their health care systems. By focusing on the fact that a range of policies, people, and places are interrelated and mutually dependent, Eckenwiler is able not only to provide a holistic understanding of the way long-term care works to generate injustice but also to find ethical and practicable policy solutions for caring for aging populations in the United States and in less well-off parts of the world.Deeply considered and empirically informed, this examination of the troubles in transnational long-term care is the first to probe the issue from a perspective that reckons with the interdependence of policies, people, and places, and the first to recommend ways policymakers, planners, and families can together develop cohesive, coherent long-term care policies around the ideal of justice.
Long-Term Care in Europe: A Juridical Approach
by Ulrich Becker Hans-Joachim ReinhardThis book provides a comprehensive overview on the long-term care systems in 12 EU member states and Norway. Focusing on the legal background and its main principles, it includes a comparative analysis which highlights the principal dissimilarities between European long term care benefits, but at the same time also a variety of features in common. It also discusses the increasingly transnational dimension of long-term as a result of migrants returning to their country of origin in old age, and the still-unsolved legal problem of entitlement to long-term care benefits in another EU-member state.
Long-Term Care in the 21st Century: Perspectives from Around the Asia-Pacific Rim
by Iris ChiWho pays for long-term care? Discover the unique approaches of seven countries around the Pacific Rim!Long-Term Care in the Twenty-First Century discusses policies and programs for long-term care in seven countries around the Asia-Pacific Rim: the United States, Canada, Japan, Australia, Singapore, Hong Kong, and Taiwan. Each country is covered in two chapters, one to examine the philosophy and values that underlie its approaches to long-term care, the second to discuss its systems of service delivery. These thoughtful analyses, backed up with facts and figures, explain program successes and failures in the context of demographic and social trends and with reference to the differing political systems across the region. Its breadth of perspective and insightful examination of cultural differences make Long-Term Care in the Twenty-First Century an important contribution to the international comparative study of aging. The programs in the United States, Australia, and Canada offer a fascinating contrast with the longer-established and very different programs in the Asian countries, including Japan, the world&’s oldest country.Long-Term Care in the Twenty-First Century provides practical information on essential gerontological issues for each country, including: financing arrangements development of client classification systems case management in both residential and community-based systems key source documents, references, and Web sites political and cultural influences home-based and family caregivingThis valuable book provides a critical record of developments in the current transition period. This multicultural perspective contributes a chance for all countries to learn from the experience of others in dealing with a problem that is increasingly important as the world population ages. Long-Term Care in the Twenty-First Century is an essential resource for scholars, service providers, policymakers, and anyone concerned with care of the aged, not only in Pacific Rim countries but around the world.
Long-Term Care in the 21st Century: Perspectives from Around the Asia-Pacific Rim
by Iris ChiWho pays for long-term care? Discover the unique approaches of seven countries around the Pacific Rim!Long-Term Care in the Twenty-First Century discusses policies and programs for long-term care in seven countries around the Asia-Pacific Rim: the United States, Canada, Japan, Australia, Singapore, Hong Kong, and Taiwan. Each country is covered in two chapters, one to examine the philosophy and values that underlie its approaches to long-term care, the second to discuss its systems of service delivery. These thoughtful analyses, backed up with facts and figures, explain program successes and failures in the context of demographic and social trends and with reference to the differing political systems across the region. Its breadth of perspective and insightful examination of cultural differences make Long-Term Care in the Twenty-First Century an important contribution to the international comparative study of aging. The programs in the United States, Australia, and Canada offer a fascinating contrast with the longer-established and very different programs in the Asian countries, including Japan, the world&’s oldest country.Long-Term Care in the Twenty-First Century provides practical information on essential gerontological issues for each country, including: financing arrangements development of client classification systems case management in both residential and community-based systems key source documents, references, and Web sites political and cultural influences home-based and family caregivingThis valuable book provides a critical record of developments in the current transition period. This multicultural perspective contributes a chance for all countries to learn from the experience of others in dealing with a problem that is increasingly important as the world population ages. Long-Term Care in the Twenty-First Century is an essential resource for scholars, service providers, policymakers, and anyone concerned with care of the aged, not only in Pacific Rim countries but around the world.
Long-Term Care Medicine: A Pocket Guide (Current Clinical Practice)
by Pamela Ann Fenstemacher and Peter WinnLong-Term Care Medicine: A Pocket Guide lessens the uncertainty involved in caring for patients in a long-term care facility. This practical pocket guide is divided into four sections: Introduction, Common Clinical Conditions, Psychosocial Aspects, and Special Issues in Long-Term Care. The chapters address all the varied components of the LTC system as well as how to take care of the patients and residents living within it. The contributors to this easy-to-read guide are passionate about LTC and many have worked within the American Medical Directors Association to create and disseminate a knowledge base for practitioners. Long-Term Care Medicine: A Pocket Guide is an invaluable resource for clinicians, practitioners, and educators who are seeking to optimize the care and living experience of residents in LTC by providing resident-centered care as well as resident choice, well-being, dignity, and an improved quality of life.
Long-term Care of Kidney Transplant Patients
by Sundaram HariharanLong-Term Care of Kidney Transplant Patients provides details on topics relevant to kidney transplant including current survival rates, phases following kidney transplantation, transplant wellness, current immunosuppressive management, and alloimmune injuries such as early and late T-cell- and antibody-mediated rejections. Various nonalloimmune factors such as post-transplant infections, cardiovascular diseases, and cancers are discussed in special chapters. Chapters are dedicated to psychological and social factors influencing kidney transplant, followed by special chapters on pediatric kidney transplantation and multiorgan transplantation. The final chapter addresses transplant tolerance, and the conclusion summarizes all chapters and highlights potential novel advances that might become game changers in the kidney transplant field. This comprehensive book is a valuable resource for clinical transplant physicians and surgeons, nephrologists, primary care physicians, as well as other healthcare specialists involved in the care of kidney transplant patients such as cardiologists and critical care physicians. It also benefits other healthcare providers such as pharmacists, psychologists, advanced nurse practitioners, pharmaceutical and diagnostic companies, and agencies involved in kidney transplantation.
Long-term Care of Kidney Transplant Patients
by Sundaram HariharanLong-Term Care of Kidney Transplant Patients provides details on topics relevant to kidney transplant including current survival rates, phases following kidney transplantation, transplant wellness, current immunosuppressive management, and alloimmune injuries such as early and late T-cell- and antibody-mediated rejections. Various nonalloimmune factors such as post-transplant infections, cardiovascular diseases, and cancers are discussed in special chapters. Chapters are dedicated to psychological and social factors influencing kidney transplant, followed by special chapters on pediatric kidney transplantation and multiorgan transplantation. The final chapter addresses transplant tolerance, and the conclusion summarizes all chapters and highlights potential novel advances that might become game changers in the kidney transplant field. This comprehensive book is a valuable resource for clinical transplant physicians and surgeons, nephrologists, primary care physicians, as well as other healthcare specialists involved in the care of kidney transplant patients such as cardiologists and critical care physicians. It also benefits other healthcare providers such as pharmacists, psychologists, advanced nurse practitioners, pharmaceutical and diagnostic companies, and agencies involved in kidney transplantation.
Long-Term Caring: Residential, Home and Community Aged Care
by Karen Scott Margaret Webb Clare KostelnickLong-Term Caring
Long-Term Caring: Residential, home and community aged care
by Karen Scott Margaret Webb Clare KostelnickAligned to the Community Services Training Package CHC33015 Certificate III Individual Support and CHC43015 Certificate IV Ageing Support Step-by-step instructions on day-to-day carer activities to develop skills and techniques Person-centred support reinforced throughout. Evolve resources for Lecturers: Case Studies Testbank PowerPoints Image collection. Revised to align with CHC33015 Certificate III Individual Support Now meets requirements of CHC43015 Certificate IV Ageing Support Features 3 streams of carers: aged care, disability and home and community care Increased focus on disability and NDIS, mental health and dementia An eBook included with print purchase.
Long-Term Caring: Residential, home and community aged care
by Karen Scott Margaret Webb Sheila A. SorrentinoThe definitive resource for carers working in aged care in Australia and New Zealand Fully revised and updated, this new edition of Long Term Caring addresses all requirements of the recently endorsed national Training Package CHC30208 Certificate 111 in Aged Care. Long Term Caring, 2nd Edition: Residential, home and community aged care is written in a clear, uncomplicated style, ideal for students with English as a second language. The second edition incorporates New Zealand aged care content throughout. It also boasts a stronger practical focus with more interactive exercises for aged care and nursing students to apply in clinical settings. Both helpful and timely this carer’s resource includes dedicated sections on working in the long term care environment, protecting the person being cared for, and assisting with daily living and with specific care needs such as dementia and mental health issues. This excellent health textbook is supported by an impressive and highly-competitive Evolve package with an eBook and suite of resources for both instructor and student. • pullout boxes providing increased focus on cultural dimensions• boxes highlighting considerations for caring for people with dementia• informational boxes focusing on promoting quality of life • safety alerts outlining safety issues in aged care• procedures boxes listing step-by-step methods • delegation guidelines describing information required before performing and reporting a procedure• summary review questions at the end of each chapter• addresses the new national Aged Care Training package requirements• a cross-referenced grid aligning chapters to key competencies• New Zealand content integrated throughout• updated chapters on anatomy and physiology, wound care and practical components of care according to evidence-based practice• Evolve package featuring an eBook, case studies, videos, web links and more
Long-Term Caring - e-Book: Residential, home and community aged care
by Karen Scott Margaret Webb Sheila A. SorrentinoThis third edition of Long-term Caring: Residential, Home and Community Aged Care has been updated to cover components of the National Aged Care Training Package for students undertaking the Certificate III in Aged Care and Certificate III in Home and Community Care. Written by leading specialists in aged care from both Australia and New Zealand, Long Term Caring: Residential, Home and Community Aged Care 3e continues to prepare students thoroughly for all aspects of personal care in a variety of aged care settings, within the home, community and in dedicated centres. The focus of the new edition is on how to deliver longterm care to meet an individual’s needs and to enhance their quality of life.• Aligned to the most current Aged Care Training Package requirements • A focus on cultural considerations in aged care • Safety Alerts focusing on the key safety aspects of care giving • Procedure boxes providing step-by-step instructions for performing care-giving tasks • Quality of Life boxes focusing on how to promote quality of life • Updated Review Questions at the end of each chapter, reinforcing learning and understanding of key concepts• New chapter on the context of provision of care for older Maori • New chapter structure linking like topics together • Updated to reflect current manual handling procedures • Additional information on normal ageing • Wellness approach to ageing and aged care integrated throughout
Long-Term Conditions: Nursing Care and Management
by Liz Meerabeau Kerri WrightThis book is a very welcome tool, which will enable health professionals to understand the complexity, challenge and rewards of proactively managing long-term conditions. Putting this knowledge into skilled practice, in partnership with patients, will transform the lives of many individuals and their families, and thus fulfil the fundamental purpose of nursing. —From the Foreword by Professor Rosemary Cook CBE, Director, the Queen’s Nursing Institute and Visiting Professor of Enterprise, University of Northumbria Long-Term Conditions is a comprehensive, practical guide for nurses and healthcare professionals on the care and management of people with chronic illness. It explores case management, individual care and management, the role of the ‘expert patient’, quality-of-life issues, counselling skills, self-management, and optimum self-care. Long-Term Conditions discusses the three main long-term conditions currently resulting in most hospital admissions: diabetes, respiratory, and coronary heart disease, with a focus on empowering the patient to self-manage. Key Features: A comprehensive guide to the care and management of long-term conditions Focuses on the management of the conditions from the patients’ perspective Practical and accessible in style
Long-Term Conditions: Nursing Care and Management
by Liz Meerabeau Kerri WrightThis book is a very welcome tool, which will enable health professionals to understand the complexity, challenge and rewards of proactively managing long-term conditions. Putting this knowledge into skilled practice, in partnership with patients, will transform the lives of many individuals and their families, and thus fulfil the fundamental purpose of nursing. —From the Foreword by Professor Rosemary Cook CBE, Director, the Queen’s Nursing Institute and Visiting Professor of Enterprise, University of Northumbria Long-Term Conditions is a comprehensive, practical guide for nurses and healthcare professionals on the care and management of people with chronic illness. It explores case management, individual care and management, the role of the ‘expert patient’, quality-of-life issues, counselling skills, self-management, and optimum self-care. Long-Term Conditions discusses the three main long-term conditions currently resulting in most hospital admissions: diabetes, respiratory, and coronary heart disease, with a focus on empowering the patient to self-manage. Key Features: A comprehensive guide to the care and management of long-term conditions Focuses on the management of the conditions from the patients’ perspective Practical and accessible in style
Long-Term Conditions: A Guide for Nurses and Healthcare Professionals
by Sue Randall Helen FordLong Term Conditions is a comprehensive textbook for all nursing and healthcare students and practitioners that explores the key issues surrounding caring for patients with chronic diseases or long-term conditions. Divided into three sections, this book explores living with a long-term condition, empowerment, and care management. Rather than being disease-focused, it looks at key issues and concepts which unify many different long-term conditions, including psychological and social issues that make up a considerable part of living with a long-term condition. Within each of the chapters, issues of policy, culture and ethics are intertwined, and case studies are used throughout, linking the concepts to specific diseases. Key features: A comprehensive textbook on the principles and practice of caring for people with long-term conditions User-friendly in style with learning outcomes, further reading, useful websites, and case studies throughout linking to specific conditions Moves away from a disease-focused medical model, and takes a needs-led approach Uniquely explores the overarching issues of living with one or more long-term conditions Focuses on the importance of multi-disciplinary team work and collaborative teamwork in the management of long-term conditions
Long-Term Conditions: A Guide for Nurses and Healthcare Professionals
by Sue Randall Helen FordLong Term Conditions is a comprehensive textbook for all nursing and healthcare students and practitioners that explores the key issues surrounding caring for patients with chronic diseases or long-term conditions. Divided into three sections, this book explores living with a long-term condition, empowerment, and care management. Rather than being disease-focused, it looks at key issues and concepts which unify many different long-term conditions, including psychological and social issues that make up a considerable part of living with a long-term condition. Within each of the chapters, issues of policy, culture and ethics are intertwined, and case studies are used throughout, linking the concepts to specific diseases. Key features: A comprehensive textbook on the principles and practice of caring for people with long-term conditions User-friendly in style with learning outcomes, further reading, useful websites, and case studies throughout linking to specific conditions Moves away from a disease-focused medical model, and takes a needs-led approach Uniquely explores the overarching issues of living with one or more long-term conditions Focuses on the importance of multi-disciplinary team work and collaborative teamwork in the management of long-term conditions