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Liver Carcinogenesis: Methods and Protocols (Methods in Molecular Biology #2769)
by Guido Kroemer Jonathan Pol Isabelle MartinsThis volume discusses the latest advancements in modern methodologies used to study liver carcinogenesis. The first half of this book describes pertinent preclinical models of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), established either through orthotopic induction of ectopic implantation. The second half of this book covers a diverse array of techniques applied to characterize the biochemical and cellular composition of hepatic malignancies that operate at the single-cell and histological levels. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Liver Carcinogenesis: Methods and Protocols, is a valuable resource for students and scientists who are interested in driving progress in the important field of liver cancer research.
Liver Carcinogenesis: The Molecular Pathways (Nato ASI Subseries H: #88)
by George G. SkouterisDuring the last years much attention has been given to the investigation of the roles of specific growth modulators acting on liver cell populations. HGF functions as a pleotropic factor in the liver as well as in other extrahepatic tissues. The hepatic stem cell compartment is thought to play a major role in liver tissue restoration. Mechanisms of cell growth and cell death of the liver are described in detail, with particular emphasis on apoptosis. The functions of HBV-pX protein and the roles of hepatitis B virus gene expression relation to hepatocellular carcinoma are discussed. Techniques for obtaining human and nonhuman hepatocytes and other liver cell types and for efficient transfer and expression of genes in hepatocytes and liver-derived cell lines are presented.
Liver Cirrhosis
by KiwamuOkitaSince 1998, the Japanese Society of Hepatology has campaigned to fight hepatocellu lar carcinoma (HCC). Because the mortality rate for this disease has reached more than 30 per 100,000 population, the organizing committee chose HCC as the main topic of the 1999 Yamaguchi Symposium on Liver Diseases. Regarding hepatocar cinogenesis, we know that HCC often develops secondary to liver cirrhosis; thus liver cirrhosis must be recognized as a prevalent pathological condition leading to HCC. If we can control liver fibrosis, we can reduce the risk for HCC among patients with chronic hepatitis. To achieve this goal, we must know more about hepatic fibrosis. Professor Michael J. P. Arthur is familiar as a leading scientist in this field. We were fortunate that he accepted our invitation to speak. His lecture titled "Mechanisms of the Progression and Regression of Liver Fibrosis" provided important advice for developing antifibrotic agents. We also invited Professor Mark A. Zern, who has been studying hepatic fibrosis for some time. In the symposium he talked about novel approaches, including gene therapy, to treat acute and chronic hepatic diseases in the 21st century. In addition to the informative talks by those guests from abroad, the lecture by Dr. J. Fujimoto was very impressive. He revealed that gene therapy using hepatocyte growth factor (HGF) could inhibit progression to liver cirrhosis in rats repeatedly injected with dimethylnitrosamine (DMN). Dr. Fujimoto has already pub lished his finding that administration of HGF reduced hepatocarcinogenesis in rats.
Liver Cirrhosis: From Pathophysiology to Disease Management (Falk Symposium #162)
The International Falk Symposium 162 in Dresden is a good example for the promises of history. Sixty years after the misery of the Second World War and the destruction of Dresden and 20 years after a long and threatening Cold War, scientists from more than 50 nations across the world met in a wonderfully reconstructed city to discuss a series of key lectures on the pathophysiology and clinical management of liver cirrhosis. Liver cirrhosis is a leading cause of morbidity and mortality worldwide. It is the fifth most common cause of death between the age of 25 and 45 years. To date, it is still not possible to inhibit or revert progression of cirrhosis in most patients. Accordingly, clinicians primarily deal with the various complications of cirrhosis, while liver transplantation is only available for selected patients. There has been tremendous progress in the understanding of liver fibrosis and cirrhosis since the last Falk Symposium devoted to this topic in 2000.
Liver-Directed Therapy for Primary and Metastatic Liver Tumors (Cancer Treatment and Research #109)
by Mark S. Talamonti Sam G. PappasLiver-Directed Therapy for Primary and Metastatic Liver Tumors is a comprehensive examination of tumors of the liver. It provides a unique multi-modality approach to management of all types of primary and secondary liver tumors. The biology of liver cancers, state of the art radiologic imaging and novel, non-surgical interventional strategies are given. There is an in depth analysis of surgical options including transplantation, resection, interstitial ablation techniques and liver-directed chemotherapy for hepatocellular carcinoma, bile duct cancers, and colorectal and neuroendocrine liver metastases. Because of the unique and comprehensive examination of liver tumors, this work is an excellent resource for surgical, transplant and medical oncologists, surgeons, gastroenterologists, and radiologists.
Liver Disease: A Clinical Casebook
by Stanley Martin Cohen Perica DavitkovThis clinical casebook provides a concise yet comprehensive state-of-the-art review of liver disease. Presented in a case-based format, each case features a scenario centered on a different variant of liver disease, with sections on case history, diagnosis/assessment, treatment, outcomes, alternative approaches, and clinical pearls. Diseases covered include drug-induced liver injury, acute hepatitis, chronic hepatitis, NAFLD, and cholangitis. Scenarios such as liver disease in pregnancy, elevated liver function tests, and liver transplants are also presented in the casebook.Written by experts in the field, Liver Disease: A Clinical Casebook is a valuable resource for clinicians and practitioners who treat patients with liver disease.
Liver Disease (Novartis Foundation Symposia #823)
by Shiela Sherlock G. E. W. WolstenholmeThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Liver Disease in Adolescence (In Clinical Practice)
by Nedim Hadžić Marianne SamynThis book discusses the clinical management of adolescents with liver disease bridging the gap between pediatric and adult hepatology patient management. Expert views on liver disease in adolescence are discussed and specific differences for this patient subset are highlighted and examined in depth. The reader will gain the specific knowledge required on pathophysiology and treatment, but also about additional aspects such as psychological difficulties and cultural differences including use of social media.Information is presented in a manner relevant to clinical practice, and is fully up-to-date in terms of development and integration of new communication technologies in the society. This book offers a fresh insight to this transitional period which will be a great benefit to hepatologists both in pediatric and adult setting. Edited by two experts in the field and authored by international experts in the area using a multidisciplinary approach, this book is a helpful tool in managing these complex patients and will help minimise their complication rates and improve outcomes by the end of their transition periods.
Liver Disease in Children: An Atlas of Angiography and Cholangiography
by Francis Brunelle Daniele Pariente Pierre ChaumontIn recent years, developments in ultrasound, computed tomography and magnetic resonance imaging have made important changes in the practice of diagnostic radio logy. Concomitantly, invasive radiology for both diagnostic and therapeutic purposes has grown into a rapidly evolving subspecialty. This text represents a landmark in paediatric radiology. The three authors are distinguished radiologists who, over the past two decades, have greatly contributed to paediatric hepatology. Their pioneering work in the area of splanchnic angiography and diagnostic as well as therapeutic cholangiography was facilitated by their close day-to-day interaction with the Paediatric Liver Disease Unit at Höpital Bicetre. The contents and the format of this "atlas" are testimony to their knowledge of clinical hepatology and to their wide experience in invasive paediatric radiology. The out standing quality of the images is enhanced by appropriate clinical descriptions which will help the reader understand the indications for these procedures, their accuracy and limitations.
Liver Disease in Clinical Practice (In Clinical Practice)
by Tim CrossThis pocket guide covers the common manifestations of liver disease, how to treat them and when to refer patients on to specialist centers. The book outlines the common clinical liver diseases such as fatty liver disease and hepatitis, among others, and their current up to date management. Written by experts in the field and containing figures and tables, as well as case histories and questions, this is an enjoyable and reader-friendly book for the busy physician. With its authoritative, didactic style and short chapters, it covers the common presentations and complications of liver disease, and how to deal with them. Given the increasing prevalence of liver disease in the UK and throughout Western Europe, this is an ideal reference book for primary care physicians, doctors in specialist training, clinical nurse specialists and for gastroenterologists, who see patients with liver disease in their working lives.
Liver Disease in Clinical Practice (In Clinical Practice)
by Tim CrossThe new edition of this pocket guide has been fully updated to cover the common manifestations of liver disease, how to treat them and when to refer patients on to specialist centers. New chapters on Acute Liver Failure, Nutrition and Congenital Heart Disease have been added to reflect the key issues in management of liver diseases. The book outlines the common clinical liver diseases such as fatty liver disease and viral hepatitis, among others, and their current up to date management. Written by experts in the field and containing figures and tables, as well as case histories and questions, this is an enjoyable and reader-friendly book for the busy physician. With its authoritative, didactic style and short chapters, it covers the common presentations and complications of liver disease, and how to deal with them. Given the increasing prevalence of liver disease in the UK and Worldwide, this is an ideal reference book for primary care physicians, doctors in specialist training, clinical nurse specialists and for gastroenterologists, who see patients with liver disease in their working lives.
Liver Diseases: A Multidisciplinary Textbook (The\clinics: Internal Medicine Ser. #22-2)
by Florentina Radu-Ionita Nikolaos T. Pyrsopoulos Mariana Jinga Ion C. Tintoiu Zhonghua Sun Ecaterina BontasThis book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation. The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation. This is an invaluable book for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation.
Liver Diseases: An Essential Guide for Nurses and Health Care Professionals
by Suzanne SargentLiver disease is a rapidly growing speciality, and nurses and health care professionals need to have the relevant knowledge and skills to care for patients with liver problems in a safe and effective way. Liver Diseases is a comprehensive, evidence-based, practical guide to the nursing care and management of patients with liver disease. Liver Diseases explores a range of liver conditions, including cirrhosis, portal hypertension, alcoholic liver disease, viral hepatitis, autoimmune hepatitis, Wilson’s disease and acute liver failure. It looks at the anatomy & physiology of the liver, assessment of liver function and diagnostic studies, acute and chronic liver disease, pregnancy related liver disease, liver transplantation and infectious liver diseases. For each condition the epidemiology, complications and nursing management are provided, along with illustrative case studies and further reading. Liver Diseases is an invaluable tool for all nurses and health care professionals working with people with liver disease. SPECIAL FEATURES The first UK book on care of the liver from a nursing and healthcare perspective Written by a well-respected and renowned author in the field Covers a wide spectrum of liver diseases, with relevant nursing management guidelines With case studies, further reading and illustrations throughout
Liver Diseases and Hepatic Sinusoidal Cells
by TakatoUeno KyuichiTanikawaHepatic sinusoidal cells such as sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, and pit cells play an important role in hemodynamic and metabolic function and are involved in various liver diseases. The frequent involvement of sinusoidal cells in pathologic conditions is explained by the diverse actions of those cells, an understanding of which is essential to clinicians. Generously illustrated, this volume presents results of recent studies on hepatic sinusoidal cells in liver diseases, with an introduction to the structure and function of the various types of sinusoidal cells. The in-depth focus of the book is on the role of hepatic sinusoidal cells in relation to liver injury and regeneration, hepatic sinusoidal microcirculation, alcoholic liver diseases, hepatic fibrosis, liver tumor, liver transplantation, cholestasis, and congenital lipidosis, thus providing a valuable reference source for practitioners and researchers.
Liver Diseases in Infancy and Childhood
by Samuel R. BerenbergFor almost four decades the Josiah Macy, Jr. Foundation has been con vening conferences relating to medicine, medical education, and health care in their broadest contexts. During the 1940s and 1950s the conferences focused on biomedical research, which was at that time in its golden age in the United States. As medical care and medical education ascended in importance, since the mid-1960s the conferences have been largely con centrated on topics in these fields. The Macy Foundation also fosters international conferences, and a major effort in recent years has been a rewarding collaboration with France's most distinguished medical statesman, Professor Robert Debre, and the Inter national Children's Centre in Paris, which he founded and directs. Nineteen seventy-five was an especially busy year for this Franco-American alliance: in April there was a seminar on 'The Family Doctor: France and the United States'; and, in June, a conference on 'Diseases of the Liver in Infancy and Childhood'. Earlier Franco-American conferences have been on 'Brain Development' (1972) and on 'Puberty' (1974). As with the others the participants in this conference on Liver Disease in Infancy and Childhood were drawn from the United States and Europe. We were especially pleased to have as three of the participants men who hold sabbatical awards as Macy Foundation Faculty Scholars, Ivan Dia mond, M.D., Ph.D., Thomas Starzl, M.D., Ph.D. and M. Michael Thaler, M.D.
Liver Diseases in the Pediatric Intensive Care Unit: A Clinical Guide
by Philippe Jouvet Fernando AlvarezIn recent years, substantial progress has been made in the approaches to diagnosis and treatment of severe liver diseases in the pediatric ICU, from various forms of liver failure and hepatitis to acute and chronic liver disease. New techniques and tools are being utilized to prevent patients from experiencing complications and for patients in recovery from operations on the native or donor liver. This book describes the clinical presentation and management of liver diseases in the intensive care unit with the pediatric patient in mind. In addition, advances in bone marrow transplantation, cardiac-generated liver disorders and new therapeutic approaches, such as artificial liver support, are discussed in detail. Presenting the current available knowledge in a compelling form, Liver Diseases in the Pediatric Intensive Care Unit is a valuable resource for pediatric gastroenterologists and hepatologists, pediatricians and intensivists.
Liver Disorders: A Point of Care Clinical Guide
by Kia Saeian Reza ShakerThis book is a comprehensive and easy-to-access guide not only in the diagnosis of the various types of liver disease but in the management of specific disorders, including the particular nuances of the care of the patient with liver disease. It provides a resource to the practitioner caring for patients with liver disease for addressing everyday questions posed by patients and their families, as well as referring physicians, in a manner that can easily be conveyed. The spectrum covered includes appropriate testing and disease monitoring of patients, use of medications, supplements, alternative therapies and alcohol, operative risk assessment, implementation of health maintenance for patients with chronic liver disease and cirrhosis, identification and management of particular complications of cirrhosis, and appropriate referral for liver transplantation, as well as management of special populations.Written by experts in the field, Liver Disorders: A Point of Care Clinical Guide is a valuable resource for clinicians who treat patients with a variety of liver disorders.
Liver Elastography: Clinical Use and Interpretation
by Sebastian MuellerThis is the first comprehensive book on the new elastographic techniques discussing the early assessment of liver fibrosis. The book covers all aspects of measuring liver stiffness starting from the methodology, the molecular basis of liver stiffness elevation up to current clinical algorithms and interpretation. Future directions and novel implications that go beyond diagnosis but are relevant for understanding of liver cirrhosis per se are also discussed in detail. Liver Elastography, is an essential companion for hepatologists and gastroenterologists that provides an overview of its basic principles and gives a detailed account of how to use elastrography in clinical practice.
Liver Failure: Acute and Acute on Chronic (The\clinics: Internal Medicine Ser. #22-2)
by Nikolaos PyrsopoulosThis book offers a comprehensive overview of liver failure including Epidemiology, mechanism of the disease, and its clinical manifestations. The diagnosis of numerous types of liver disease leading to liver failure; with specific emphasis on the current and future treatment modalities including up-to-date and extensive information on liver transplantation. It provides the most up-to-date information on liver failure for clinicians, practitioners including GPs, scientists/researchers, postgraduates and allied health professionals. It features an overview of the relevant classification and epidemiologic aspects of acute liver failure along with a thorough review of the mechanisms associated with acute liver failure and multisystemic involvement. Detailed guidance is also provided on the latest treatment techniques including those available for liver transplantation and potential future approaches, enabling the reader to develop a detailed understanding of the topic. Liver Failure: Acute and Acute on Chronic provides a practically applicable guide to the epidemiology and management of liver failure. It features contributions from an outstanding panel of experts in hepatology, gastroenterology and surgery making it a vital up-to-date reference for trainee and practicing medical professionals in a variety of disciplines who encounter these patients.
Liver Fluke, Opisthorchis viverrini Related Cholangiocarcinoma: Liver Fluke Related Cholangiocarcinoma (Recent Results in Cancer Research #219)
by Narong Khuntikeo Ross H. Andrews Trevor N. Petney Shahid A. KhanThis volume discusses new developments in the etiology, diagnosis, and treatment of cholangiocarcinoma induced by the liver fluke Opisthorchis viverrini. Although cholangiocarcinoma is rare in the Western world, it has a very high incidence in continental Southeast Asian countries, where it is linked to infection with O. viverrini. In Southeast Asia this cancer causes thousands of deaths every year and places a severe socioeconomic burden on the affected families. Diagnosis is usually at a late disease stage, and in the past palliative surgery and care have been the major therapeutic options. Recently, however, techniques have become available for early-stage diagnosis that offer the possibility of curative surgery, and novel chemotherapeutic options are also under development. In Thailand alone, more than 2 million individuals have now been registered for screening for this cancer. The aim of this book is to highlight the latest research in the field and to explain how the newly available techniques can be applied to reduce the risk of developing cholangiocarcinoma and increase the likelihood of survival.
Liver, Gall Bladder, and Bile Ducts (Gastrointestinal Surgery Library)
by Mohamed Rela, Pierre-Alain ClavienOver the last two decades, there have been major advances in imaging, endoscopy, and laparoscopy in the field of gastrointestinal (GI) surgery. GI surgery is the newest sub-specialty branch of general surgery, where enhanced expertise and high-volume centres have made a difference to the outcomes of complex operations. Surgeons can now do difficult procedures with low morbidity and mortality rates, and greatly improved overall results. This volume provides detailed and up-to-date knowledge on diseases of the liver, gall bladder, and bile ducts. Split into two sections, it covers anatomy and physiology, approaches to specific conditions and traumas, a thorough analysis of current knowledge and future advances in the field, and a review of the relevant literature. Written and edited by world-renowned experts in the field, this book will be a valuable resource for hepatobiliary surgeons and trainees, general surgeons, researchers, and medical students.
Liver, Gall Bladder, and Bile Ducts (Gastrointestinal Surgery Library)
Over the last two decades, there have been major advances in imaging, endoscopy, and laparoscopy in the field of gastrointestinal (GI) surgery. GI surgery is the newest sub-specialty branch of general surgery, where enhanced expertise and high-volume centres have made a difference to the outcomes of complex operations. Surgeons can now do difficult procedures with low morbidity and mortality rates, and greatly improved overall results. This volume provides detailed and up-to-date knowledge on diseases of the liver, gall bladder, and bile ducts. Split into two sections, it covers anatomy and physiology, approaches to specific conditions and traumas, a thorough analysis of current knowledge and future advances in the field, and a review of the relevant literature. Written and edited by world-renowned experts in the field, this book will be a valuable resource for hepatobiliary surgeons and trainees, general surgeons, researchers, and medical students.
Liver Growth and Repair
by A. Strain A. M. DiehlNelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.
Liver Imaging: MRI with CT Correlation (Current Clinical Imaging #1)
by Ersan Altun Mohamed El-Azzazi Richard C. SemelkaThe first single source work to deal with the two primary radiologic modalities in diagnosing and treating benign and malignant diseases of the liver, presented with clearly laid out MRI and CT correlations. Developed by an editor team led by one of the world’s leading authorities in abdominal imaging, Richard C. Semelka MD. User-friendly, atlas-style presentation, with over 1500 MRI and CT images in over 320 figures featuring state-of-the-art MR and CT imaging sequences, multidetector row CT images, 3D reformatted images, breath-hold MRI sequences, and cutting-edge MR 3T images Highly practical approach for imaging of focal and diffuse liver lesions, complete relevant and systematic (differential) diagnostic information, the latest references to primary literature and clinical evidence, and patient management possibilities Reflects a pattern-recognition approach to MRI and CT imaging, assisting with efficient scanning of images and assessment and diagnosis of disorders
Liver Imaging: MRI with CT Correlation (Current Clinical Imaging)
by Ersan Altun Mohamed El-Azzazi Richard C. SemelkaThe first single source work to deal with the two primary radiologic modalities in diagnosing and treating benign and malignant diseases of the liver, presented with clearly laid out MRI and CT correlations. Developed by an editor team led by one of the world’s leading authorities in abdominal imaging, Richard C. Semelka MD. User-friendly, atlas-style presentation, with over 1500 MRI and CT images in over 320 figures featuring state-of-the-art MR and CT imaging sequences, multidetector row CT images, 3D reformatted images, breath-hold MRI sequences, and cutting-edge MR 3T images Highly practical approach for imaging of focal and diffuse liver lesions, complete relevant and systematic (differential) diagnostic information, the latest references to primary literature and clinical evidence, and patient management possibilities Reflects a pattern-recognition approach to MRI and CT imaging, assisting with efficient scanning of images and assessment and diagnosis of disorders