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Liver Immunology: Principles and Practice
by M. Eric Gershwin John M. Vierling Michael P. MannsLiver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.
Liver Immunology: Principles and Practice
by M. Eric Gershwin John M. Vierling Michael P. MannsImmunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. This volume is a must-read for novice and expert alike. In an easy-to-read and thorough format, it covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation.
Liver Immunology: Principles and Practice
by M. Eric Gershwin John M. Vierling Atsushi Tanaka Michael P. MannsThe third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver’s role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation. The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs. A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students.
The Liver in Systemic Disease: A Clinician's Guide to Abnormal Liver Tests
by Gideon M. Hirschfield Paramjit Gill James NeubergerThe Liver in Systemic Disease A practical guide for non-hepatologists who encounter abnormal liver test results in patients The Liver in Systemic Disease is an easy-to-use and authoritative guide for non-hepatologist health care professionals who need guidance on the management of patients with abnormal liver tests. The book provides definitive advice for when further investigation, or changes in management, are indicated. With a practical focus throughout the text, the editors explore when and how to investigate and manage patients whose primary disease is non-hepatic, but whose liver tests are unexpectedly abnormal. The Liver in Systemic Disease provides substantial flow diagrams and advice on the process, together with updates on the liver diseases non-hepatologists are most likely to encounter. Take-home primers included in the book shine a light on best practice and recommended procedures when dealing with abnormal liver test results. The book also provides: A thorough introduction to evaluate the liver, including serum liver tests, liver imaging, and liver biopsy Comprehensive discussions of practical issues in patients with liver abnormalities, including the diagnosis of drug induced liver injury, prescribing in patients with abnormal liver tests, and more Practical discussions of the management of patients with unexplained abnormal liver tests in primary care In-depth examinations of secondary care management of patients with unexplained abnormal liver tests, including intensive care, and the care of infectious and immunosuppressed patients The Liver in Systemic Disease is an indispensable resource for non-hepatologist medical practitioners seeking to understand the implications of abnormal liver tests and who wish to know when further investigation or alteration of management is indicated.
The Liver in Systemic Disease: A Clinician's Guide to Abnormal Liver Tests
by Gideon M. Hirschfield Paramjit Gill James NeubergerThe Liver in Systemic Disease A practical guide for non-hepatologists who encounter abnormal liver test results in patients The Liver in Systemic Disease is an easy-to-use and authoritative guide for non-hepatologist health care professionals who need guidance on the management of patients with abnormal liver tests. The book provides definitive advice for when further investigation, or changes in management, are indicated. With a practical focus throughout the text, the editors explore when and how to investigate and manage patients whose primary disease is non-hepatic, but whose liver tests are unexpectedly abnormal. The Liver in Systemic Disease provides substantial flow diagrams and advice on the process, together with updates on the liver diseases non-hepatologists are most likely to encounter. Take-home primers included in the book shine a light on best practice and recommended procedures when dealing with abnormal liver test results. The book also provides: A thorough introduction to evaluate the liver, including serum liver tests, liver imaging, and liver biopsy Comprehensive discussions of practical issues in patients with liver abnormalities, including the diagnosis of drug induced liver injury, prescribing in patients with abnormal liver tests, and more Practical discussions of the management of patients with unexplained abnormal liver tests in primary care In-depth examinations of secondary care management of patients with unexplained abnormal liver tests, including intensive care, and the care of infectious and immunosuppressed patients The Liver in Systemic Disease is an indispensable resource for non-hepatologist medical practitioners seeking to understand the implications of abnormal liver tests and who wish to know when further investigation or alteration of management is indicated.
The Liver in Systemic Diseases
by Hiromasa OhiraBased on the results of studies on autoimmunity, the endocrine system, nutrients, metal metabolism and intestinal bacterial flora, this volume thoroughly covers studies on functional correlation of the liver with the spleen, visceral fat, intestinal tract, and central nervous system. Including associations with dysbiosis, nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma, it offers comprehensive data on correlations of organs with the liver from basic and clinical viewpoints. The Liver in Systemic Diseases will especially be of interest to researchers, clinical residents and medical students with an interest in hepatology and gastroenterology. Furthermore, the book has interdisciplinary appeal and provides a foundation that will help physicians to consider clinical conditions of diseases from a broader perspective.
Liver Intra-arterial PRRT with 111In-Octreotide: The Tumoricidal Efficacy of 111In Auger Electron Emission
by Georgios S. LimourisThis book describes in detail a clinical project that reveals the tumoricidal efficacy of Auger and internal conversion electrons, emitted from n.c.a. 111In and implemented in oncology as a treating armamentarium for peptide receptor radionuclide therapy (PRRT), targeting small size (ø ≤ 20 mm) tumors and micro-metastases.The keen interest in n.c.a. 111In began when it was observed that its Auger electron emission could be highly radiotoxic, due to its high LET when it decayed in the vicinity of cellular DNA. The somatostatin analog octreotide, labeled with [111In-diethylenetriaminepentaacetic acid (DTPA0-D-Phe1)] is an established diagnostic agent for the imaging of somatostatin receptor-positive neuro- (or non-neuro) endocrine tumors. It relies on receptor-mediated binding, internalization and installation in the lysosomes in the proximity of the nucleus; administered in large doses, loco-regionally, via the feeding artery of solid tumors, can be highly radiotoxic if they over-express somatostatin receptors, mainly of the sst2 histotype.The book compares the results between i.v. and i.a. implementation in more than 80 patients after over 800 i.a. infusions in neuroendocrine tumors, meningiomas, paragangliomas and colorectal carcinomas in a single Institute (Aretaieion University Hospital) and encourages the i.a. way, leading to “tumor melting”, while minimizing the toxicity to healthy peritumoral liver tissue and critical organs (kidneys and bone marrow).The volume is an invaluable tool for nuclear medicine physicians, interventional radiologists and oncologists dealing with radiopeptide therapies.
Liver, Lung and Heart Regeneration (Stem Cells in Clinical Applications)
by Phuc Van PhamThis invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in liver, lung and heart regeneration. All chapters are contributed by pre-eminent scientists in the field and covers such topics as cell therapy in the treatment of cirrhosis and other liver, heart and lung diseases, characteristics of hepatic progenitor cells, future directions of the discussed therapies and much more. Liver, Lung and Heart Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.
Liver Malignancies: Diagnostic and Interventional Radiology (Medical Radiology)
by A. L. Baert C. Bartolozzi R. LencioniA comprehensive and up-to-date overview of the role of diagnostic and interventional radiology in respect of liver malignancies. Following background chapters on anatomy, epidemiology, and clinicopathologic features, each of the diagnostic imaging techniques is carefully appraised, focusing on new developments in equipment and contrast agents. The interventional therapeutic approaches to primary and secondary hepatic malignancies are then discussed in depth, as well as such special topics as liver tumors in children and hepatic transplantation. Written by leading experts from around the world, this will prove to be an indispensable source of information for both clinicians and researchers.
Liver Metabolism and Fatty Liver Disease
by Oren TiroshNonalcoholic fatty liver disease is one of the most common liver diseases worldwide affecting patients from all ages, races, and ethnic backgrounds. It comprises a spectrum of hepatic pathology ranging from simple steatosis, in which there is an increase of fat accumulation in hepatocytes, to nonalcoholic steatohepatitis and cirrhosis. The signific
Liver Metastases: Biology, Diagnosis and Treatment
by R. A. Audisio H. S. StoldtLiver Metastasis: Biology, Diagnosis and Treatment offers a comprehensive overview of liver metastasis by providing a collection of pivotal contributions from an international faculty. A wide range of topics are presented, with each contributor focusing on his own area of expertise to provide the latest techniques as well as valuable insights based on a wealth of experience. Epidemiological and biological aspects are discussed, diagnostic and staging problems are reported, and all treatment modalities are analysed including gene therapy, immunotherapy and palliative care. The standard approaches to diagnosis and therapy are examined whilst new and future trends are reported on and explored. Of interest to both specialists and postgraduates in the fields of oncology and gastroenterology this book will also be of interest to researchers in internal medicine.
Liver Metastases
by Graeme J. Poston Riccardo A Audisio Paulo M. G. Hoff Jean-Nicolas VautheyThis book addresses the contemporary multidisciplinary management of liver metastases. Throughout the text, experience from the paradigms of colorectal cancer metastases treatment strategies are used to point to new directions in the management of liver metastases from other cancers. The book will be invaluable for surgeons in general surgery, hepatobiliary surgery, upper GI surgery, colorectal surgery, medical and clinical oncologists with an interest in liver tumours, and radiologists with an interest in liver disease.
Liver Metastasis: Basic aspects, detection and management (Developments in Oncology #24)
by Cornelis J. H. Velde and Paul H. SugarbakerB. CADY Hepatic met,,'~tasl~S present one of the major therapeutic challenges of cancer patien: management, for it is the destruction of vital organ function that makes cancer fatal, not local tumor growth. The process of tumor cell dislodgement from the primary cancer, their spread through the lymphatic and hematogenous channels, their lodgement in distant sites, and their subsequent progressive growth tax our comprehension a'ld i. -ustrate our therapies. The proceedings of this International Con,t ss on Hepatic Metastasis address these aspects of metastases to t:'. >2 _ . ver, and predominatly focus on metastatic colon cancer because of t ~. s frequency, its prominent hepatic only pattern of spread, and enticing preliminary data about prevention and control of small sub . '(ts of the afflicted population. Predictably, the "false technologies" of Dr. Lewis Thomas that involve surgical, radiotherapeutic and chemo therapeutic attack on these metastases after elaborate diagnostic studies take precedence because of the clinical imperatives of sick patients. This is displayed in the preponderance of papers and in terest in various diagnostic scanning techniques by means of radio isotopes, radiographically useful dyes, biochemical markers, interest in developing accurate staging systems to categorize patients for therapeutic comparisons, and interest in elaborate, and expensive, technology to increase the effectiveness of chemotherap~utic agents that are of limited benefit with simple intravenous administration. Behind this clinical enthusiasm, however, lies the research to develop the "true technology," in Thomas' words, that will prevent such clinical catastrophies as hepatic metastases.
Liver Metastasis: Biology and Clinical Management (Cancer Metastasis - Biology and Treatment #16)
by Pnina BrodtLiver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.
Liver MRI: Correlation with other Imaging Modalities and Histopathology
by Shahid M. HussainThis book provides a practical approach for MR imaging of the focal and diffuse liver lesions. Its unique layout is based on state-of-the-art MR imaging sequences, computer-generated drawings, concise figure captions, relevant and systematic (differential) diagnostic information, recent literature references, and patient management possibilities. MR imaging findings are correlated to ultrasound, computed tomography, and pathology when appropriate. This book will greatly benefit all professionals interested and involved in imaging, diagnosis, and treatment of focal and diffuse liver lesions.
Liver MRI: Correlation with Other Imaging Modalities and Histopathology
by Shahid M. Hussain Michael F. SorrellThe second edition of this very successful book provides a practical approach to liver MRI, with coverage of the most up-to-date MR imaging sequences, normal and variant anatomy and diverse pathologic conditions. It features computer-generated drawings relating clinical concepts to the MRI findings, 2D and 3D reconstructions, systematic (differential) diagnostic information and descriptions of patient management options. MRI findings are correlated to ultrasound, computed tomography, nuclear medicine exams, laboratory findings and histopathology when appropriate. New information is presented on a wide range of topics and more than 50 extra figure pages are included. This book will greatly benefit all professionals interested and involved in imaging, diagnosis and treatment of focal and diffuse liver lesions, including radiologists, gastroenterologists, hepatologists, surgeons, pathologists, MR physicists, radiology and other residents, MR technologists and medical students.p>
Liver Pathology and Alcohol: Drug & Alcohol Abuse Reviews (Drug and Alcohol Abuse Reviews #2)
by Ronald WatsonAlcohol and other drugs of abuse are major contributing factors to liver disease and its pathology. Alcoholic cirrhosis causes thousands of deaths each year in the United States, and encourages liver replacement. A better understanding of the mechanisms of liver pathology will significantly aid basic researchers and physicians in treating and preventing liver damage. This book is designed especially for those researchers wishing to understand alcoholic liver disease. Therefore the role of alcohol in changing nutrition and its nutritional effects on liver disease are reviewed. The generation of free radicals during alcohol use has been found to be an important cause of membrane changes, of cancer development, and of lipid alterations-and thus of liver pathology. In addition to alcohol, other drugs of abuse, including morphine, cocaine, marijuana, and caffeine have also been shown to be significant contributors to liver pathology. The prevalence of drug and alcohol use and abuse today means that liver disease will continue as a major social and medical problem. The explanation of its biological origins cannot fail to help us better understand and treat the disease in the years to come.
Liver Pathology for Clinicians (Pathology for Clinicians)
by Maura O'Neil Ivan Damjanov Ryan M. TaylorThis is the first volume in a new Springer series, Pathology for Clinicians, which aims to assist clinicians in their daily decision making by providing reliable, clearly presented information on current techniques in pathology, their uses and indications, clinical–pathologic correlations, and the significance of pathologic diagnoses. Liver Pathology for Clinicians first discusses key technical aspects of liver biopsy, including the use of special stains and immunohistochemistry. Detailed guidance is provided on both common and uncommon indications for liver biopsy, including repeat or serial biopsies, and on the choice of procedure. The role of liver biopsy in the contexts of transplantation and systemic disease is also clearly explained. Clinical-pathologic correlations are presented with the aid of high-quality illustrations.
Liver Radioembolization with 90Y Microspheres (Medical Radiology)
by José Ignacio Bilbao Maximilian F. ReiserThis is the second edition of a very well received book devoted specifically to the treatment of liver tumors by radioembolization with 90Y microspheres. The success of the first edition was based on the provision of all the fundamental information required for successful use of this therapeutic modality in clinical practice. The new edition has been fully updated to cover the most recent advances and includes additional chapters on regulations and emerging trends. Detailed information is provided on the full range of relevant topics, including hepatic vascular anatomy (including variants), dosimetry, assessment of tumor response, and the results achieved using radioembolization alone and in combination with other treatments in patients with primary or metastatic disease. Complications and side-effects are also fully discussed. This book will prove immensely valuable for both beginners and practitioners.
Liver Radioembolization with 90Y Microspheres (Medical Radiology)
by Maximilian F. Reiser José Ignacio Bilbao S. NagThis vital text for oncologists and radiotherapists provides an in-depth account of all aspects of radioembolization, a relatively novel technique based on the efficacy of radiotherapy for the treatment of liver tumors. Radioembolization combines embolization (intravascular deployment of particles – microspheres loaded with yttrium-90) and brachytherapy (local administration of radiotherapy), thereby allowing delivery of high doses of beta-radiation specifically to the tumoral area.
Liver Transplantation: Challenging Controversies and Topics (Clinical Gastroenterology)
by Gregory T. Everson James F. TrotterLiver Transplantation: Challenging Controversies and Topics grew out of a need I perceived within the fields of transplant hepatology and liver transplantation. Liver transplantation has rightly gained recognition as an established therapy for end-stage liver disease. Few would argue that liver transplantation is one of the few truly lifesaving and life-altering treatments within medicine and surgery. Not many realize that 20 years passed from the time of the first human liver transplantation in 1963 to its acceptance as therapy by the 1983 NIH Consensus Conference on Liver Transplantation. In 2008, 25 years will have passed since the 1983 NIH conference—a mere 25 years for a field that has provided patients hope, doctors options, and to some the “gift of life. ” Many issues in liver transplantation involve indications, patient selection, and outcomes after transplantation—these are standard topics, covered by textbooks of hepatology and transplantation. In contrast, the field of liver tra- plantation is young, evolving, dynamic, and issues and decisions are often controversial. Thus, Dr. Trotter and I, as well as our colleagues at the University of Colorado, felt that a text with a different focus was required, one that highlighted controversy and challenged dogma. Out of this perceived need emerged Liver Transplantation: Challenging Controversies and Topics. To meet the transplant community’s need for emerging information about liver transplantation, Dr. Larry Chan, Dr. Igal Kam, and I initiated the Controversies in Transplantation Conference.
Liver Transplantation: Clinical Assessment and Management (Vademecum Ser.)
by James Neuberger James Ferguson Philip N. NewsomeLiver Transplantation: Clinical Assessment and Management is the perfect tool for all gastroenterologists, hepatologists and transplant surgeons managing patients with liver disease awaiting and undergoing transplantation. Led by James Neuberger, world experts in hepatology and transplantation provide a chronological, step-by-step approach to best clinical management and patient care. Evidence-based throughout and with reference to the very latest practice guidelines from major societies such as EASL and AASLD, the book covers: When to refer a patient for liver transplantation Selection, assessment and management on the list Transplantation for acute liver failure Donation and allocation Care of the liver transplant recipient 80 high definition videos of transplant surgery allow you to watch the experts in action and provide an outstanding visual and teaching element. In addition, key points, potential pitfalls, management algorithms, and useful weblinks all help ensure rapid reference browsing. If you're managing patients requiring a liver transplant, this multimedia resource will save you time and effort by putting essential information within easy reach.
Liver Transplantation: Clinical Assessment and Management
by James Neuberger James Ferguson Philip N. NewsomeLiver Transplantation: Clinical Assessment and Management is the perfect tool for all gastroenterologists, hepatologists and transplant surgeons managing patients with liver disease awaiting and undergoing transplantation. Led by James Neuberger, world experts in hepatology and transplantation provide a chronological, step-by-step approach to best clinical management and patient care. Evidence-based throughout and with reference to the very latest practice guidelines from major societies such as EASL and AASLD, the book covers: When to refer a patient for liver transplantation Selection, assessment and management on the list Transplantation for acute liver failure Donation and allocation Care of the liver transplant recipient 80 high definition videos of transplant surgery allow you to watch the experts in action and provide an outstanding visual and teaching element. In addition, key points, potential pitfalls, management algorithms, and useful weblinks all help ensure rapid reference browsing. If you're managing patients requiring a liver transplant, this multimedia resource will save you time and effort by putting essential information within easy reach.
Liver Transplantation: Clinical Assessment and Management
by James Neuberger James Ferguson Philip N. Newsome Michael R. LuceyExplore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care. Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management. Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy: A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list A discussion of care of the liver transplant recipient after the procedure in the short and long term Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.
Liver Transplantation: Clinical Assessment and Management
by James Neuberger James Ferguson Philip N. Newsome Michael Ronan LuceyExplore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care. Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management. Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy: A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list A discussion of care of the liver transplant recipient after the procedure in the short and long term Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.