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Multi-Detector CT Imaging Handbook, Two Volume Set
by Luca Saba Jasjit S. SuriThis two volume set covers the engineering and clinical benefits in diagnosis of human pathologies, including the protocols and potential of advanced tomography scanning with very high quality CT images. With contributions from world-class experts, the book examines all aspects of CT technologies related to neck-brain, cardiovascular systems, thorax, abdomen and GI system, pelvis and urinary system, and musculoskeletal system. It also provides coverage of CAD applications to CT along with a discussion of the potential dangers of CT in terms of over-radiation, particularly related to children.
Multi-dimensional Vibrational Circular Dichroism
by Hisako Sato Jun Yoshida Akihiko YamagishiThis book provides the reader with the latest research on vibrational circular dichroism (VCD) spectroscopy including its useful features and applications to many fields. The book starts from an unresolved question in gel chemistry of how component molecules are organized in the flexible fibrils of gels. VCD spectroscopy was successful in giving a clear answer to this mystery. The book also describes a key aspect of this technique lay in the fact that VCD signals were remarkably enhanced when chiral molecules formed a stereoregular molecular array over a few hundred nanometers. VCD spectroscopy was also applied to other topics involving chiral molecules such as the chiral discrimination mechanism in heterogeneous asymmetric catalysis and the build-up of supramolecular chirality in molecular crystals. Furthermore, the book covers the recent instrument developments leading to multi-dimensional VCD measurements with the coordinates of wavenumber, space and time. This progress has opened up new biological and medical applications such as the heterogenous distributions of protein domains in insect wings and the quality control of chiral drugs. The last part of the book presents the possibility of medical diagnosis of Alzheimer’s disease through multi-dimensional VCD analyses. This book appeals not only to researchers and students who study spectroscopy but also to ones in catalysis, biology and medicine as users of the VCD methods.
Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies
by Rishabha Malviya Arun Kumar Singh Deepika YadavMULTI-DRUG RESISTANCE IN CANCER The book details the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents. Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are common outcomes of prolonged chemotherapy. Because of the prevalence of drug-resistance mutations, the difficulty of treating tumors increases and the therapeutic efficacy of drugs decreases. Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies contains nine chapters that cover topics such as: studying the mechanics of resistance to drugs by autophagy; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; advances in metallodrug driven combination treatment for cancer; and use of natural agents for the overcoming of cancer drug resistance. The book aims to provide the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment. It provides a better understanding of the mechanisms of MDR and targets of novel chemotherapy agents which should guide future research concerning new effective strategies in cancer treatment. Audience This book is written for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in the mechanisms and strategies for overcoming cancer’s multi-drug resistance.
Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies
by Rishabha Malviya Arun Kumar Singh Deepika YadavMULTI-DRUG RESISTANCE IN CANCER The book details the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents. Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are common outcomes of prolonged chemotherapy. Because of the prevalence of drug-resistance mutations, the difficulty of treating tumors increases and the therapeutic efficacy of drugs decreases. Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies contains nine chapters that cover topics such as: studying the mechanics of resistance to drugs by autophagy; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; advances in metallodrug driven combination treatment for cancer; and use of natural agents for the overcoming of cancer drug resistance. The book aims to provide the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment. It provides a better understanding of the mechanisms of MDR and targets of novel chemotherapy agents which should guide future research concerning new effective strategies in cancer treatment. Audience This book is written for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in the mechanisms and strategies for overcoming cancer’s multi-drug resistance.
Multi-Drug Resistance in Cancer (Methods in Molecular Biology #596)
by Jun ZhouChemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .
Multi-indicator Systems and Modelling in Partial Order
by Rainer Brüggemann Lars Carlsen Jochen Wittmann“Multi-indicator Systems and Modelling in Partial Order” contains the newest theoretical concepts as well as new applications or even applications, where standard multivariate statistics fail. Some of the presentations have their counterpart in the book; however, there are many contributions, which are completely new in the field of applied partial order.
Multi-Modal EEG Monitoring of Severely Neurologically Ill Patients
by Xuefeng Wang Feng Li Suyue PanThis book provides practical information on applications of multi-modal EEG monitoring in patients with severely neurologically diseases. The First part systematically introduces the modern EEG techniques, and multi-modal EEG monitoring system for severe neurological illness. In the second part, identification of EEG artifacts and interpretation of common abnormal EEG patterns is presented. Accompanying more than 50 typical cases and 200 EEG records, the following chapters discusses EEG’s changes and clinical significance in coma, ischemic-hypoxic encephalopathy, status epilepsy, Creutzfeldt-Jakob disease, traumatic brain injury, and other diseases in details. In addition, application of multi-modal EEG in monitoring intracranial pressure and predicting suicide risk is also included. It will be a valuable reference for professionals in neurology, neurosurgery, emergency care, psychiatry, technology specialists of EEG and senior nurses with basic EEG monitoring knowledge.
Multi-Modality Atherosclerosis Imaging and Diagnosis
by Luca Saba João Miguel Sanches Luís Mendes Pedro Jasjit S. SuriStroke is one of the leading causes of death in the world, resulting mostly from the sudden ruptures of atherosclerosis carotid plaques. Understanding why and how plaque develops and ruptures requires a multi-disciplinary approach such as radiology, biomedical engineering, medical physics, software engineering, hardware engineering, pathological and histological imaging. Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment presents a new dimension of understanding Atherosclerosis in 2D and 3D. This book presents work on plaque stress analysis in order to provide a general framework of computational modeling with atherosclerosis plaques. New algorithms based on 3D and 4D Ultrasound are presented to assess the atherosclerotic disease as well as very recent advances in plaque multimodality image fusion analysis.The goal of Multi-Modality Atherosclerosis Imaging, Diagnosis and Treatment is to fuse information obtained from different 3D medical image modalities, such as 3D US, CT and MRI, providing the medical doctor with some sort of augmented reality information about the atherosclerotic plaque in order to improve the accuracy of the diagnosis. Analysis of the plaque dynamics along the cardiac cycle is also a valuable indicator for plaque instability assessment and therefore for risk stratification. 4D Ultrasound, a sequence of 3D reconstructions of the region of interest along the time, can be used for this dynamic analysis. Multimodality Image Fusion is a very appealing approach because it puts together the best characteristics of each modality, such as, the high temporal resolution of US and the high spatial resolutions of MRI and CT.
Multi-Modality Imaging: Applications And Computational Techniques
by Mauren Abreu de Souza Humberto Remigio Gamba Helio PedriniThis book presents different approaches on multi-modality imaging with a focus on biomedical applications. Medical imaging can be divided into two categories: functional (related to physiological body measurements) and anatomical (structural) imaging modalities.In particular, this book covers imaging combinations coming from the usual popular modalities (such as the anatomical modalities, e.g. X-ray, CT and MRI), and it also includes some promising and new imaging modalities that are still being developed and improved (such as infrared thermography (IRT) and photoplethysmography imaging (PPGI)), implying potential approaches for innovative biomedical applications.Moreover, this book includes a variety of tools on computer vision, imaging processing, and computer graphics, which led to the generation and visualization of 3D models, making the most recent advances in this area possible. This is an ideal book for students and biomedical engineering researchers covering the biomedical imaging field.
Multi-Modality Neuroimaging Study on Neurobiological Mechanisms of Acupuncture
by Jie TianThis book introduces essential advances in acupuncture studies using multi-modality neuroimaging, which provides insights into how specific brain networks are involved in acupuncture effects in humans. Stimulating different acupoints to treat various clinical conditions is usually accompanied by multi-dimensional physiological as well as psychological responses, which are regulated by the central nervous system. The book addresses disease-specific neural correlates and acupuncture-targeted regulatory encoding in the brain, and explains the temporal-spatial encoding in brain networks to clarify the acupuncture mechanisms. By highlighting the targeting mechanisms of typical indications of acupuncture, this book provides a scientific explanation for acupuncture therapy.
Multi Modality State-of-the-Art Medical Image Segmentation and Registration Methodologies: Volume II
by Ayman S. El-Baz Rajendra Acharya U Andrew F. Laine Jasjit S. SuriWith the advances in image guided surgery for cancer treatment, the role of image segmentation and registration has become very critical. The central engine of any image guided surgery product is its ability to quantify the organ or segment the organ whether it is a magnetic resonance imaging (MRI) and computed tomography (CT), X-ray, PET, SPECT, Ultrasound, and Molecular imaging modality. Sophisticated segmentation algorithms can help the physicians delineate better the anatomical structures present in the input images, enhance the accuracy of medical diagnosis and facilitate the best treatment planning system designs. The focus of this book in towards the state of the art techniques in the area of image segmentation and registration.
Multi Modality State-of-the-Art Medical Image Segmentation and Registration Methodologies: Volume 1
by Ayman S. S. El-Baz, Rajendra Rajendra Acharya U, Majid Mirmehdi and Jasjit S. S. SuriWith the advances in image guided surgery for cancer treatment, the role of image segmentation and registration has become very critical. The central engine of any image guided surgery product is its ability to quantify the organ or segment the organ whether it is a magnetic resonance imaging (MRI) and computed tomography (CT), X-ray, PET, SPECT, Ultrasound, and Molecular imaging modality. Sophisticated segmentation algorithms can help the physicians delineate better the anatomical structures present in the input images, enhance the accuracy of medical diagnosis and facilitate the best treatment planning system designs. The focus of this book in towards the state of the art techniques in the area of image segmentation and registration.
Multi-Omics Analysis of the Human Microbiome: From Technology to Clinical Applications
by Vijai Singh Indra ManiThis book introduces the rapidly evolving field of multi-omics in understanding the human microbiome. The book focuses on the technology used to generate multi-omics data, including advances in next-generation sequencing and other high-throughput methods. It also covers the application of artificial intelligence and machine learning algorithms to the analysis of multi-omics data, providing readers with an overview of the powerful computational tools that are driving innovation in this field. The chapter also explores the various bioinformatics databases and tools available for the analysis of multi-omics data. The book also delves into the application of multi-omics technology to the study of microbial diversity, including metagenomics, metatranscriptomics, and metaproteomics. The book also explores the use of these techniques to identify and characterize microbial communities in different environments, from the gut and oral microbiome to the skin microbiome and beyond. Towards theend, it focuses on the use of multi-omics in the study of microbial consortia, including mycology and the viral microbiome. The book also explores the potential of multi-omics to identify genes of biotechnological importance, providing readers with an understanding of the role that this technology could play in advancing biotech research. Finally, the book concludes with a discussion of the clinical applications of multi-omics technology, including its potential to identify disease biomarkers and develop personalized medicine approaches. Overall, this book provides readers with a comprehensive overview of this exciting field, highlighting the potential for multi-omics to transform our understanding of the microbial world.
Multi-parameter Mueller Matrix Microscopy for the Expert Assessment of Acute Myocardium Ischemia (SpringerBriefs in Applied Sciences and Technology)
by Victor Bachinsky Oleh Ya Vanchulyak Alexander G. Ushenko Yurii A. Ushenko Alexander V. Dubolazov Alexander Bykov Benjamin Hogan Igor MeglinskiThis book provides an essential overview of the basic principles of imaging modalities, accompanied by examples of their applications in modern clinical and associated pre-clinical studies. The monograph is based on the original results of investigation of the efficiency use of laser light and Mueller-matrix polarimetry approach for assessment of myocardial tissues towards confirmation the cause of death. A morphological analysis of necrotic changes in the myocardial tissue of patients that died due to heart attack, coronary heart disease and acute coronary insufficiency was carried out and the data and histological sections of the myocardium inspected utilizing Mueller-matrix mapping of tissue samples with polarized light. A unified optical model of polycrystalline structure of the myocardium is proposed, and the principles and regulations of Mueller-matrix description of its polarization manifestations are explored and developed. The book also provides a statistical and scale-selective wavelet analysis of polarization and Mueller-matrix maps. Finally, the key forensic medical criteria for the differential diagnosis of the cause of death due to necrotic and pathological changes in the morphological structure of the myocardium have been established
Multi-Parametric Live Cell Microscopy of 3D Tissue Models (Advances in Experimental Medicine and Biology #1035)
by Ruslan I. DmitrievThis book provides an essential overview of existing state-of-the-art quantitative imaging methodologies and protocols (intensity-based ratiometric and FLIM/ PLIM). A variety of applications are covered, including multi-parametric quantitative imaging in intestinal organoid culture, autofluorescence imaging in cancer and stem cell biology, Ca2+ imaging in neural ex vivo tissue models, as well as multi-parametric imaging of pH and viscosity in cancer biology. The current state-of-the-art of 3D tissue models and their compatibility with live cell imaging is also covered. This is an ideal book for specialists working in tissue engineering and designing novel biomaterial.
Multi-Professional Learning for Nurses: Breaking the Boundaries (Nurse Education in Practice)
by Tony Leiba Sally GlenDelivering effective health and social care, enhancing effective interprofessional collaboration and adopting effective teaching and learning strategies in the education of health and social care professionals, have become subjects of intense scrutiny and debate in recent years. This book is a timely response to an increasing number of initiatives being launched to enable collaboration between the various professions in health and social care.Multi-Professional Learning for Nurses argues that opportunities for interprofessional experiences, teaching and learning should be consciously and deliberately built into educational programmes available to practitioners as they move along numerous pathways from education and training to work. This expertly written and carefully edited book explores key questions such as:· Do we need multi-professional and inter-professional education and training?· Will joint training programmes between health and social care prepare practitioners for the new integrated context in which health and social care are likely to be delivered?· What are the constraints that are present in the planning and delivery of multi-professional and inter-professional education and training? Written by experienced health and social care educators with leading roles in planning, implementing, and evaluating multi-professional education, this text is a valuable resource. It offers critiques, ideas and practical guidance to those developing multi-professional, intra-professional and inter-professional curricula in the changing climate of health and social care.
Multi-Pronged Omics Technologies to Understand COVID-19
by Sanjeeva Srivastava"COVID-19 and Omics Technologies" is a comprehensive, integrative assessment of recent information and knowledge collected on SARS-CoV-2 and COVID-19 during the pandemic based on omics technologies. It demonstrates how omics technologies could better investigate the infectious disease and propose solutions to the current concerns. The value of multi-omics technologies in understanding disease etiology and host response, discovering infection biomarkers and illness prediction, identifying vaccine candidates, discovering therapeutic targets, and tracing pathogen evolution is discussed in this book. These factors combine to make it a valuable resource to enhance understanding of both "Omics technology" and "COVID-19" as a disease. The book covers the most recent understanding of COVID-19 and the applications of cutting-edge studies, making it accessible to a large multidisciplinary readership. The book explains how high-throughput technologies and systems biology might assist to solve the pandemic’s challenges and deconstruct and appreciate the substantial contributions that omics technologies have made in predicting the path of this unforeseeable pandemic. Features: In-depth summary of clinical presentation, epidemiological impact, and long-term sequelae of COVID-19 pandemic. A systematic overview of omics-based approaches to the study of COVID-19 biology. Recent research results and some pointers to future advancements in methodologies used. Detailed examples from recent studies on COVID-19 encompassing different omics methodologies. A detailed description of methodologies and notes on the applications of state-of-the-art technologies. This book is intended for scientists who need to understand the biology of COVID-19 from the perspective of omics investigations, as well as researchers who want to employ omics-based technologies in disease biology.
Multi-Pronged Omics Technologies to Understand COVID-19
by Sanjeeva Srivastava"COVID-19 and Omics Technologies" is a comprehensive, integrative assessment of recent information and knowledge collected on SARS-CoV-2 and COVID-19 during the pandemic based on omics technologies. It demonstrates how omics technologies could better investigate the infectious disease and propose solutions to the current concerns. The value of multi-omics technologies in understanding disease etiology and host response, discovering infection biomarkers and illness prediction, identifying vaccine candidates, discovering therapeutic targets, and tracing pathogen evolution is discussed in this book. These factors combine to make it a valuable resource to enhance understanding of both "Omics technology" and "COVID-19" as a disease. The book covers the most recent understanding of COVID-19 and the applications of cutting-edge studies, making it accessible to a large multidisciplinary readership. The book explains how high-throughput technologies and systems biology might assist to solve the pandemic’s challenges and deconstruct and appreciate the substantial contributions that omics technologies have made in predicting the path of this unforeseeable pandemic. Features: In-depth summary of clinical presentation, epidemiological impact, and long-term sequelae of COVID-19 pandemic. A systematic overview of omics-based approaches to the study of COVID-19 biology. Recent research results and some pointers to future advancements in methodologies used. Detailed examples from recent studies on COVID-19 encompassing different omics methodologies. A detailed description of methodologies and notes on the applications of state-of-the-art technologies. This book is intended for scientists who need to understand the biology of COVID-19 from the perspective of omics investigations, as well as researchers who want to employ omics-based technologies in disease biology.
The Multi-Sensory Reminiscence Activity Book: 52 Weekly Group Session Plans for Working with Older Adults
by Sophie Jopling Sarah MousleyThese multi-sensory group sessions, one for each week of the year, are ideal for working with older adults. Focusing on reminiscence to stimulate memory and sensory functioning, and enhance wellbeing, these activities bring a fresh approach to group sessions. Supporting colour photographs and cards are available to download.
Multi-slice and Dual-source CT in Cardiac Imaging: Principles - Protocols - Indications - Outlook
by Bernd M. Ohnesorge Thomas G. Flohr Christoph R. Becker Andreas Knez Maximilian F ReiserThis book discusses the state-of-the-art developments in multi-slice CT for cardiac imaging as well as those that can be anticipated in the future. It is a comprehensive work covering all aspects of this technology from the technical fundamentals to clinical indications and protocol recommendations. This second edition draws on the most recent clinical experience obtained with 16- and 64-slice CT scanners by world-leading experts. The book also has chapters on area-detector CT and the brand new dual-source CT.
Multi-slice CT in Cardiac Imaging: Technical Principles, Imaging Protocols, Clinical Indications and Future Perspective
by Bernd M. Ohnesorge Thomas G. Flohr Christoph R. Becker Maximilian F ReiserCardiac diseases and in particular coronary artery disease are the leading cause of death and morbidity in the industrialized countries. The development of reliable cardiac imaging techniques is considered a key issue in improving patient care. This book presents and discusses the technical concepts, the potential spectrum of applications and the future perspectives of multi-slice CT in cardiac imaging. The discussion is based on the experience of internationally leading clinical institutions. It shows that this new modality has the potential to become an important and robust tool for non-invasive and early diagnosis of cardiac diseases.
Multi-System Endocrine Disruption (Research and Perspectives in Endocrine Interactions)
by Jean-Pierre Bourguignon, Bernard Jégou, Bernard Kerdelhué, Jorma Toppari and Yves ChristenEndocrine disruption is an expanding field due to the numerous chemicals involved and, as evidenced more recently, the variety of homeostatic systems that they can alter throughout life. The gathering of experts from all over the world should help to identify health disorders that are possibly or likely related to exposure to endocrine disrupters. The research needs have been discussed as well as recommendations prioritizing target groups and following the precautionary principle.
Multi-Target Drug Design Using Chem-Bioinformatic Approaches (Methods in Pharmacology and Toxicology)
by Kunal RoyThis detailed book showcases recent advances in computational design of multi-target drug candidates involving various ligand and structure-based strategies. Different chem-bioinformatic modeling strategies that can be applied for design of multi-target drugs as well as important databases and web servers in connection with multi-target drug design are also featured in this collection. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of key implementation advice that will aid researchers greatly in their laboratory pursuits. Authoritative and practical, Multi-Target Drug Design Using Chem-Bioinformatic Approaches seeks to aid all scientists working in the field of drug discovery research.
Multi-Targeted Approach to Treatment of Cancer
by Varsha Gandhi Kapil Mehta Rajesh Grover Sen Pathak Bharat B. AggarwalIn this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pathways. Genomics, proteomics, and metabolomics have revealed that dysregulation of dozens of genes and their products occur in any given cell type that ultimately leads to cancer. These discoveries are providing unprecedented opportunities to tackle cancer by multi-faceted approaches that target these underpinnings. This book emphasizes a multi-targeted approach to treating cancer, the focus of the 5th International Conference on Translational Cancer Research that was held in Vigyan Bhawan, Delhi (India) from Feb 6-9, 2014.
Multi-Treatment Modalities of Liver Tumours
by Nagy A. HabibCancer is one of the major health problems of our time and liver cancer is responsible for over one million deaths per year world-wide, making it the fourth most common cause of death from cancer. Surgical resection of the tumour(s) is the treatment of choice and offers the only chance of prolonged survival. Yet the best attempts are often frustrated by either advanced or co-existent disease that renders the patient non-resectable. This book tackles the many options available to doctors and patients in an attempt to combat this desperate disease.