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Multidisciplinary Management of Chronic Pain: A Practical Guide for Clinicians

by Sridhar Vasudevan

"This book is a 'must have' resource in every physician/clinician practice setting."--Martin Grabois, M.D., Professor of PM&R, Baylor College of Medicine, Houston,TX.Dr. Vasudevan draws upon an accumulated reservoir of clinical expertise to provide readers with an up-to-date and highly readable guide to multidisciplinary pain management. . . . If only this book was available years ago"--Francis J. Keefe, PhD. Professor of Psychology, Psychiatry and Anesthesiology, Duke University, Durham, NC. This practical volume brings multidisciplinary innovations to the treatment of chronic pain. It argues expertly for the benefits of a biopsychosocial approach over current pain treatments more suited to acute care. The author's insights into the complexity of chronic pain and critiques of common but inconsistent unimodality pain management methods underscore the need for targeted multi-disciplinary pain programs. Among a wealth of useful clinical nuggets, readers will find guidance on adding "virtual" support to a pain management team, details on ways patients can take an active role in dealing with their chronic pain, and the original concept of the "back attack."Included in the coverage:Pain theories and factors behind chronic pain—its application in treatment.Cognitive behavioral coping strategies.Treatments that have questionable or controversial evidence.Evaluation of disability in patients with chronic pain.Creating a virtual multidisciplinary team.Common pain problems: low back pain, complex regional pain syndrome, myofascial pain syndrome, fibromyalgia.Multidisciplinary Pain Management will enhance the work of diverse practitioners, including health and clinical psychologists, family and other primary care physicians, psychiatrists, occupational and physical therapists, and rehabilitation specialists.

Multidisciplinary Management of Common Bile Duct Stones

by Jeffrey W. Hazey Darwin L. Conwell Gregory E. Guy

This volume is a single resource highlighting multidisciplinary options available to clinicians for the management of common bile duct stones. The text highlights management, diagnosis, treatment options, and complications from the perspective of surgeons, gastroenterologists, and interventional radiologists, providing a truly multidisciplinary approach to treatment of these patients. By providing the scope of the problem to clinicians, the text increases awareness such that testing or referral to the most appropriate specialist (whether it be a gastroenterologist, surgeon or radiologist) can be initiated. Providing surgeons, gastroenterologists and radiologists alike access to the most current treatment paradigms in their field, Multidisciplinary Management of Common Bile Duct Stones empowers healthcare providers with interdisciplinary knowledge and options available to patients in management of their common bile duct stones.

Multidisciplinary Management of Eating Disorders

by Jane Morris Alastair McKinlay

This Handbook is an indispensable guide for the multidisciplinary management of eating disorders. It discusses a broad range of issues: managing high-risk patients, the challenges of inserting feeding tubes, addressing nutritional aspects and dealing with additional disorders which might complicate matters, such as diabetes, coeliac disease and cystic fibrosis. It discusses fertility, pregnancy, and eating disorders in children and adolescents, as well as addressing the needs of families. Chapters contain key checklists and flow diagrams. Abundant pictures and conversations, coloured diagrams, charts, maps and boxes, support readers’ varying learning styles and assist retention of key points. Vignettes taken from real (but strenuously anonymised) cases appeal to clinicians’ preference for case-based learning. The book also functions as a practical manual of ‘What to do – and what NOT to do’ with practical scenarios. In the acute situation, clinicians will be able to go directly to the relevant chapter to guide the team through the ‘when, where, how, why and with whom’ of assessing and managing patients with eating disorders. The book is primarily aimed at postgraduate physicians managing patients with Eating disorders on Gastrointestinal, Endocrine or general medical wards, and those who seek to deepen their expertise as they sit higher professional examinations. It is of interest to both medical and psychiatric clinicians, as well as useful to nursing and multidisciplinary staff who want to develop a compassionate understanding of the true pain driving their patients’ behaviours.

Multidisciplinary Management of Gastroesophageal Reflux Disease

by Sebastian F. Schoppmann Martin Riegler

This book presents a new, multi- and interdisciplinary approach to gastroesophageal reflux disease (GERD) and Barrett’s esophagus that reflects the latest advances in understanding of the disease. The role of each of the available diagnostic techniques, including endoscopy, histopathology, esophageal manometry, reflux monitoring, and EndoFLIP assessment, is carefully explained. The use of endoscopy for the purposes of mucosal ablation (radiofrequency ablation, cryoablation) and mucosal resection is described, and all aspects of anti-reflux surgery are covered, with detailed explanation of indications and techniques for standard fundoplication, endoscopic fundoplication, and surgical procedures using the LINX system and the EndoStim device. To assist the reader further, a novel interdisciplinary algorithm is presented for GERD diagnosis and treatment. In addition, the latest diagnostic and therapeutic approaches (including endoscopic and surgical resection and chemoradiation) are also presented for esophageal cancer and cancer palliation. A key feature of the book is its recognition of the contribution of different specialties in the management of GERD, and it will accordingly appeal to a wide range of practitioners.

Multidisciplinary Management of Head and Neck Cancer: Contemporary Applications and Techniques

by Ravi A. Chandra Ryan J. Li

This book is a multidisciplinary guide to head and neck cancer.Head and neck cancer remains one of the most technically complex cancer subsites to manage. This field involves highly specialized, multidisciplinary management and collaboration amongst surgeons, radiation oncologists, medical oncologists, radiologists, pathologists, and other health disciplines. The clinical and research landscape for head and neck oncology continues to evolve at a rapid pace. This multidisciplinary book provides the latest updates in the contemporary understanding and management of these tumors. The text incorporates updates in surgical techniques (minimally invasive and robotic techniques, reconstructive approaches), radiation medicine (new data on dose and fields, oligometastatic/oligoprogressive disease, retreatment), medical oncology (targeted, immunotherapy and molecular agents), in addition to other overarching topics such as side effects, biomarkers/nanotechnology, and epidemiology. Written by experts in their respective fields, chapters include the most up to date scientific and clinical information with perspectives from each relevant subspeciality. These sections are concise and accessible, yet comprehensive. Palliative medicine, pathologic and imaging principles, and health systems/economics considerations are also described. This book is an ideal resource for clinicians, trainees, and researchers dealing with, and interested in, this challenging malignancy.

Multidisciplinary Management of Liver Metastases in Colorectal Cancer: Early Diagnosis and Treatment

by Xinyu Qin Jianmin Xu Yunshi Zhong

This book focuses on early diagnosis and multidisciplinary treatment, which is the key to preventing the occurrence of the liver metastases in colorectal cancer, and to increasing the resection rate of the liver metastasis foci and the 5-year survival after surgery. This book is divided into five parts: the introduction, basics, diagnosis, treatment and prevention. It has 20 chapters in total, covering the latest advances in colorectal cancer liver metastases epidemiology, pathogenesis, molecular diagnostics, marker screening, imaging technology, surgery, chemotherapy and prevention, etc. It provides professionals with up-to-date and comprehensive information on colorectal liver metastases. This book is relevant for senior surgeons and physicians working in oncology, general surgery, chemotherapy, digestive medicine, liver medicine and hepatic surgery.

Multidisciplinary Management of Pediatric Voice and Swallowing Disorders

by J. Scott McMurray Matthew R. Hoffman Maia N. Braden

This text provides a comprehensive review of the assessment and management of pediatric voice and swallow disorders from the perspectives of both the pediatric laryngologist as well as the speech-language pathologist whose collaboration is critical to effective clinical care. All chapters are written by experts in dual fields and formatted to present a straightforward approach to diagnosing and managing each disorder, including descriptions of relevant operative interventions. Multiple intraoperative photographs and illustrations depicting how to perform each surgical procedure are also included. Multidisciplinary Management of Pediatric Voice and Swallowing Disorders will serve as a useful step-by-step guide and resource not only for otolaryngologists and speech-language pathologists, but all members of the pediatric aerodigestive team and other providers caring for children affected by voice and swallowing disorders.

Multidisciplinary Management of Prostate Cancer: The Role of the Prostate Cancer Unit

by Vincenzo Gentile Valeria Panebianco Alessandro Sciarra

Prostate cancer is the most common neoplasm in men and its management is very complex, in terms of both diagnosis and treatment. In recent years the value of multidisciplinary management within a prostate cancer unit has been increasingly recognized. Such a multidisciplinary approach within a specialized unit involves a variety of specialists, including urologists, oncologists, radiotherapists, radiologists and pathologists. This book describes in detail the advantages of multidisciplinary management of prostate cancer. It opens by explaining the nature of the required multidisciplinary team and the potential benefits of the prostate cancer unit as a structure for the delivery of specialist multidisciplinary care. Epidemiological aspects favoring multidisciplinary management are described and each element of care within the context of the prostate cancer unit is then discussed; also has been described the role of advanced imaging (Multiparametric MRI) in the management of PCa. Early diagnosis, risk classification, treatment decision making, surgery, radiotherapy, medical therapies and health care support are all fully considered. This book will be informative and enlightening for all who are involved in the management of patients with prostate cancer.

Multidisciplinary Management of Rectal Cancer: Questions and Answers

by Vincenzo Valentini Hans-Joachim Schmoll Cornelis J. van de Velde

In this book, a distinguished group of clinicians provide straightforward, focused answers to the questions most commonly confronted by a multidisciplinary team when caring for patients with rectal cancer. The format of the book is designed to aid optimal decision making in a multidisciplinary setting with respect to key issues in imaging, radiotherapy, chemotherapy, and surgery, all of which are considered in detail. Helpful guidance is also offered on risk factor identification, pathology procedures and their prognostic value, and multidisciplinary team management. The authors have been carefully selected for their expertise, and most have been involved in the management of the more significant trials published in Europe during the past decade.In an era in which all patients are entitled to access healthcare systems that deliver the highest quality of treatment within a safe environment, together with appropriate advice, support, and long-term follow-up, the multidisciplinary team is of central importance. This successful book, in its revised and updated second edition, is designed to provide all the guidance likely to be required by members of the multidisciplinary team at various stages of the pathway of care for patients with rectal cancer.

Multidisciplinary Management of Rectal Cancer: Questions and Answers

by Vincenzo Valentini, Hans-Joachim Schmoll and Cornelis J. H. Velde

This book seeks to promote an integrated approach among the various specialists involved in the management of rectal cancer with a view to ensuring that treatment is tailored appropriately to the individual patient. For ease of use, a question and answer format is employed. The focus is on those issues typically confronted during daily clinical practice in relation to risk factors, imaging, surgery, radiotherapy, and chemotherapy. The services of an outstanding panel of authors representative of the major European oncological societies have been acquired in order to formulate the questions and provide the answers. All who need assistance in addressing concerns that arise from the need for multidisciplinary management of rectal cancer will find the book to be an ideal source of helpful information.

Multidisciplinary Medico-Legal Death Investigation: Role of Consultants

by Frcp C Fcap, Facp Lakshmanan Md, Frcp C Fcap, Facp Lakshmanan Sathyavagiswaran Christopher B. Rogers

Multidisciplinary Medico-legal Death Investigation: Role of Consultants is the only book in the field that focuses on the role consultants have in medical examiner/coroner offices. The book provides a multidisciplinary view on the topic by including specialized fields, such as anesthesiology, surgery, radiology, including CT scan, pediatrics, cardiology-electrophysiology, cardiac pathology, forensic anthropology and odontology, firearms examination, firearms, eye pathology and psychiatry/psychology. Coverage also includes chapters on specialized topics, including high profile cases, the media, business continuity planning, envenomations, the importance of quality assurance and peer review, and quality assurance in a medico-legal death investigation office. This one-of-a-kind resource is ideal for those in the medico-legal death investigation field and professionals in the criminal and civil justice system. - Covers many fields, including anesthesiology, surgery, and radiology, including CT scan, pediatrics, cardiology-electrophysiology, cardiac pathology, forensic anthropology and odontology, firearms examination, and more - Includes contributions by world-renowned specialists - Presents comprehensive case studies and examples of consultation reports

The Multidisciplinary Pain Center: Organization and Personnel Functions for Pain Management (Current Management of Pain #1)

by Jawahar N. Ghia

The pain center/clinic is in the stage of transition. It has come a long way since chronic pain was a nonexistent entity and patients with difficult pain problems did not receive well-deserved attention or were lost in the busy practices of vari­ ous specialty clinics. Thirty-five years ahead of the rest of us, John]. Bonica was the first physician who had a clear vision of a pain center's potential. Twenty years later, in response to loud public demands for relief of chronic pain, this idea was put into practice by a number of others on a somewhat larger scale. A team of specialists from various disciplines, trained in the management of chronic pain, now offer approaches ranging from simple outpatient care to inpatient hospital­ ization for comprehensive care including drug detoxification, behavior modi­ fication, and total rehabilitation of these patients. Hospitals have entered this arena with renewed enthusiasm. The pain center/clinic is now an established, ac­ cepted, and expanding method of providing care for chronic pain patients. The chapters in this book are based on examples of multidisciplinary projects that deal comprehensively with management of chronic pain. Aimed primarily at the pain center/clinic in the university hospital setting, this book ranges from his­ torical perspectives to current pain centers with their less orthodox methods of re­ lieving chronic pain to the future of algology as a specialty.

Multidisciplinary Perspectives on Genocide and Memory

by Jutta Lindert Armen T. Marsoobian

This book explores the memory and representation of genocide as they affect individuals, communities and families, and artistic representations. It brings together a variety of disciplines from public health to philosophy, anthropology to architecture, offering readers interdisciplinary and international insights into one of the most important challenges in the 21st century. The book begins by describing the definitions and concepts of genocide from historical and philosophical perspectives. Next, it reviews memories of genocide in bodies and in societies as well as genocide in memory through lives, mental health and transgenerational effects. The book also examines the ways genocide has affected artistic works. From poetry to film, photography to theatre, it explores a range of artistic approaches to help demonstrate the heterogeneity of representations. This book provides a comprehensive and wide-ranging assessment of the many ways genocide has been remembered and represented. It presents an ideal foundation for understanding genocide and possibly preventing it from occurring again.

Multidisciplinary public health: Understanding the development of the modern workforce

by Jenny Wright Fiona Sim

Including the voices of key protagonists in the development of the public health workforce, this book is an important addition to the history of public health in England. It charts events leading to the unique achievement, from 2003, of specialist status, equivalent to public health medical consultants, for those from non-medical backgrounds. Setting these changes in context it discusses implications for practitioners and the wider UK public health workforce. A lively and comprehensive review of policy change, Multidisciplinary public health: Understanding the development of the modern workforce concludes with a reflection on the new public health system under way in England, making useful comparisons with the rest of the UK. This is an invaluable resource for anyone with an interest in public health, including public health academics and relevant postgraduate students.

Multidisciplinary public health: Understanding the development of the modern workforce

by Jenny Wright Fiona Sim

Including the voices of key protagonists in the development of the public health workforce, this book is an important addition to the history of public health in England. It charts events leading to the unique achievement, from 2003, of specialist status, equivalent to public health medical consultants, for those from non-medical backgrounds. Setting these changes in context it discusses implications for practitioners and the wider UK public health workforce. A lively and comprehensive review of policy change, Multidisciplinary public health: Understanding the development of the modern workforce concludes with a reflection on the new public health system under way in England, making useful comparisons with the rest of the UK. This is an invaluable resource for anyone with an interest in public health, including public health academics and relevant postgraduate students.

Multidisciplinary Spine Care

by Carl E. Noe

This book presents multiple aspects of spine care from the perspective of different disciplines. It's organized by sections focused on non-operative care, spine injections and procedures, perioperative care, operative care, pediatric care, and special topics. Each chapter has been written by a clinician whose active practice involves the topic of their chapter. Practical and clinically relevant, this book educates any practitioner who cares for patients with back and neck pain and other spine conditions about implementing a multidisciplinary team to treat the spine.

Multidisciplinary Teaching Atlas of the Pancreas: Radiological, Surgical, and Pathological Correlations

by Javier Casillas Joe U. Levi Alexander O. Quiroz Roberto Ruiz-Cordero Monica T. Garcia-Buitrago Danny Sleeman

This innovative teaching atlas provides the reader with a practical approach to the diagnosis and management of the common and uncommon diseases that may involve the pancreatic gland. Its perspective is multidisciplinary, the authors being radiologists, surgeons, pathologists, and gastroenterologists who have worked together for the past 25 years. Very concise descriptions of clinical presentation, pathology, imaging, and management are provided for a great variety of pathologic conditions, and a wealth of illustrative material displays intraoperative appearances, gross specimens, histology, and radiological findings. Pancreatic surgery, including transplantation, is also discussed, and the final chapter presents a gallery of challenging and diverse cases. Specialists and residents in a range of specialties will find this atlas to be an invaluable aid, and it will also serve as an excellent reference for medical students.

Multidisciplinary Teleconsultation in Developing Countries (TELe-Health)

by Michelangelo Bartolo Fabio Ferrari

This book presents a replicable model of multidisciplinary teleconsultation, designed and set up by Global Health Telemedicine, that offers very significant health benefits in remote and rural areas of developing countries. The model is based on experiences gained in sub-Saharan Africa while training and cooperating with local health professionals within the DREAM program, managed by the Community of Sant’Egidio. This program has to date treated almost 300,000 patients across many countries and has provided health education and disease prevention training to tens of millions. It originated in the context of the fight against AIDS but has been extended to encompass other pathologies and to exploit the capabilities of new telemedicine technologies that allow multispecialist teleconsultation (hence the acronym now represents “Disease Relief through Excellent and Advanced Means”). In addition to thorough description of the program, readers will find reflections and analysis on logistical, technical, sociological, and epidemiological issues. The book is divided into thematic chapters with easy-to-understand graphics. It will be a readily accessible source of information for professionals in international cooperation and global health students and professionals.

Multidisciplinary Tools for Investigating Synaptic Plasticity (Neuromethods #81)

by Peter Nguyen

Investigations involving incisive mechanistic dissection of various types of synaptic plasticity have revealed that it plays key roles in neural development, sensory information processing, cortical remapping following brain injury, perception, and behavioral learning and memory. Disruptions of synaptic plasticity may underlie neurological and behavioral disorders such as Alzheimer disease, Fragile-X syndrome, autism, and drug addiction. Multidisciplinary Tools for Investigating Synaptic Plasticity, therefore, assembles expert contributions that highlight techniques and strategies used in probing the cellular and molecular mechanisms of synaptic plasticity in the nervous systems of vertebrate and invertebrate species. Divided into three sections, this meticulous volume describes biochemical and genetic strategies for studying synaptic plasticity, behavior, neural development, and synaptogenesis, and also includes cellular electrophysiological and optical methods for interrogating a diverse array of mechanistic issues. As part of the Neuromethods series, this book contains the kind of detail and key implementation advice that maximizes successful results. Authoritative and invaluable, Multidisciplinary Tools for Investigating Synaptic Plasticity serves as an ideal primer for introducing researchers to specific techniques that will enhance their success at addressing novel questions in synaptic plasticity at the lab bench.

Multidisciplinary Treatment of Colorectal Cancer: Staging – Treatment – Pathology – Palliation

by Gunnar Baatrup

This book is intended as the equivalent of the Swiss Army knife for all members of colorectal cancer (CRC) multidisciplinary teams and those training in the fields of CRC management. It describes how to organize the team and explains the basic principles within the different disciplines involved in the treatment and care of CRC patients. Important, up-to-date knowledge is provided on visualization techniques, surgery, oncological treatment, palliation, and pathology, with special focus on controversies and aspects of interest to all team members. Care has been taken to ensure that each specialty-specific chapter will be approachable for team members from other specialties or professions, thereby facilitating an effective interdisciplinary approach to teamwork. The authors include leading European doctors and scientists who have influenced the development of the multidisciplinary team concept as well as other aspects of high-quality, individualized treatment of CRC patients.

Multidisciplinary Treatment of Colorectal Cancer: Staging – Treatment – Pathology – Palliation

by Gunnar Baatrup

This book is a comprehensive reference work on the multidisciplinary team (MDT) management of colorectal cancer (CRC) patients that will meet the needs of all members of CRC MDTs and those training in the field. Important, up-to-date knowledge is provided on organization of MDTs, early intervention, surgery, oncology, imaging, pathology, and palliation, with special focus on controversies. This second edition has been thoroughly revised. It includes an entirely new section on the principles of treatment of significant polyps and early cancers and a total of 14 new chapters, including one on the early integration of palliative care. Every effort has been made to ensure that each specialty-specific chapter will be approachable for all team members, thereby facilitating an effective interdisciplinary approach to teamwork. The authors are leading European doctors and scientists who have influenced the development of the MDT concept as well as other aspects of individualized treatment of CRC patients.

Multidisciplinary Treatment of Hepatocellular Carcinoma (Recent Results in Cancer Research #190)

by Jean-Nicolas Vauthey and Antoine Brouquet

It is now widely accepted that multidisciplinary collaboration and multimodality treatment approaches are important in improving the survival of patients with hepatocellular carcinoma. In this comprehensive textbook, internationally renowned experts in the field present and discuss the various strategies employed in the treatment of the disease. Up-to-date information is provided on the indications for and outcome of a range of treatment options, including surgical resection, liver transplantation, radiofrequency ablation, transarterial chemoembolization, yttrium-90 transarterial radioembolization, and systemic therapy. In addition, important background information is included on biology, pathology, staging, and imaging. This book will be particularly helpful to all professionals and trainees worldwide who have an interest in the diagnosis and treatment of hepatocellular carcinoma.

Multidisciplinary Treatment of Soft Tissue Sarcomas (Cancer Treatment and Research #67)

by Jaap Verweij Herbert M. Pinedo Herman D. Suit

The previous volume of this series on soft tissue sarcomas highlighted the importance of the multidisciplinary approach to treatment, the focus of which is continued in the present edition. Proper diagnosis and staging remain the cornerstone of the treatment strategy. Sophisticated histopathology techniques and growing consensus on grading systems have further increased the importance of the histopathologist in providing estimates of the prognosis of the patient as well as providing data for the planning of treatment strategy. The use of cytogenetics is relatively new in this field. This might enable the distinction of subgroups in specific histological tumor types. Furthermore, molecular biological studies not only help to reveal inherited predispositions and details in oncogenesis in tumor development, but they may also provide additional predictive factors for tumor behavior. Further data on treatment strategy will be provided by diagnostic imaging, a field in which the role of magnetic resonance imaging is rapidly developing. As far as actual treatment is concerned, surgery still provides the major chance for cure. In view of the endeavor to be as sparing as possible, the addition of radiotherapy to surgery is of utmost importance. Usually radiotherapy is given after surgery, but the optimal sequence of the two modalities still needs to be defined. The combined use of surgery with radiotherapy and/or chemotherapy does have an impact on wound healing.

Multidisziplinäre Perspektiven auf Körper und Gesundheit

by Michael Wendler Stefan Schache Klaus Fischer

Die Begriffe Körper und Gesundheit sind (nicht erst) seit dem sogenannten body-, corporeal- oder somatic-turn Gegenstand sehr unterschiedlicher Disziplinen und Perspektiven: Die Komplexität der Zusammenhänge, Verschränkungen, Bedingungen des Gegenstandspaares Körper-Gesundheit bis hin zur Identifikation macht es erforderlich, multidisziplinär und multiperspektivisch vorzugehen. In diesem Band sind unterschiedliche Disziplinen und Perspektiven versammelt, die sich aus ihrer Fachgenese und wissenschaftlichen Position heraus mit Körper, Leib und Gesundheit beschäftigen, um v.a. Forschungsfelder zu erschließen und praxeologische Konsequenzen zu benennen.

Multidrug-resistant Tuberculosis (Resurgent and Emerging Infectious Diseases #1)

by Ivan Bastian and Françoise Portaels

Multidrug-resistant tuberculosis: past, present and future Ivan Bastian and Franyoise Portaels Mycobacteriology Unit. Institute of Tropical Medicine. Antwerp. Belgium The Lord hath created medicines out of the earth and he that is wise will not abhor them. Ecclesiasticus 38:4, quoted by Selman Waksman when accepting the 1952 Nobel Prize for Medicine that was awarded for the discovery of the first effective antituberculosis drug. streptomycin. which was derived from the soil bacterium, Streptomyces grisells. 1. HISTORICAL PERSPECTIVE This book has been published at the close of the twentieth century when the medical profession and the general community are increasingly concerned about the threat of multidrug-resistant tuberculosis (MDRTB)[1. 2]. However, at this epoch, it is enlightening to move back from our immediate concerns about MDRTB 'hot spots' in Asia, South America, and the former Soviet Union [3], and to place our current predicament in an historical context. If the results of the global survey of antituberculosis drug resistance conducted by the World Health Organisation (WHO) and the International Union against Tuberculosis and Lung Disease (IUATLD) can be extrapolated, only 2. 2% of TB cases worldwide are due to multi drug­ resistant strains [3]. At the beginning of the 20th century, all TB cases were refractory to all available therapies. Great advances had been made during the 19th century in the understanding of the epidemiology and pathogenesis of TB, and in the diagnosis of the disease (reviewed in references 4-7).

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