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Multiple Criteria Decision Making and Risk Analysis Using Microcomputers (NATO ASI Subseries F: #56)

Roughly nine years ago, the two editors met for the first time in Amsterdam, the Netherlands at the EURO III meeting (organized by the Association of European Operational Research Societies) there. As a result of our initial meeting, the two of us planned and carried out a number of activities in the multiple criteria decision making area, much of it supported by the North Atlantic Treaty Organization (NATO). The latest of these activities was a NATO Advanced Study Institute (ASI) on multiple criteria. decision making and risk analysis using microcomputers. The institute was held in Tarabya, Istanbul, TURKEY, on June 28 - July 8, 1987. We received over 100 applications from professors (and a few graduate students) in 13 countries. Roughly half of them were able to participate. The ASI was a great success! Substantial knowledge transfer and learning took place. In addition to the planned presentations, we had several panels and round table discussions. Though we had planned these in advance, we implemented them to fit the occasion, and also organized a few special sessions on site to respond to participants' interests.

Multiple Dimensions of Caregiving and Disability: Research, Practice, Policy (Caregiving: Research • Practice • Policy)

Caring for people with disabilities often becomes an all-encompassing responsibility for one or more family members. To manage the multifaceted demands, caregivers must possess strong multitasking skills, including the ability to assist with daily life tasks; provide emotional support; help with financial affairs; mediate and advocate with health care providers. Maintaining balance within their own lives can become incredibly challenging for caregivers. More often than not, providing care for family members or loved ones occurs at the expense of the caregivers’ well-being. And for caregivers who themselves have disabilities, it further complicates matters.Multiple Dimensions of Caregiving and Disability addresses concerns that have been long familiar to the caregiver population and examines the current state of family care for individuals with disabilities. With a lifespan perspective, this concise reference reviews the literature on specific problems of caregivers and explores which care strategies are effective, promising, or lacking in available resources and support interventions. Contributors also explore the more fluid and subjective aspects of caregiving, such as feelings, spirituality, and family roles. Suggestions for future policy improvements, particularly within the public health sector, are discussed as well.Topics covered include:• Family dynamics and caregiving for people with disabilities.• Parent caregiving of children with disabilities.• Race, ethnicity, socioeconomic status, and caregiving.• Educational, training, and support programs for caregivers.• Emerging technologies to aid caregivers.• Developing partnerships between caregivers and health care providers.Multiple Dimensions of Caregiving and Disability is a must-have resource for researchers, scientist-practitioners, policy makers, and graduate students across such disciplines as clinical psychology, nursing, social work, public health, medicine, and social and education policy.

Multiple Drug Resistance in Cancer: Cellular, Molecular and Clinical Approaches

This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.

Multiple Drug Resistance in Cancer 2: Molecular, Cellular and Clinical Aspects

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.

Multiple Hypothesenprüfung / Multiple Hypotheses Testing: Symposium, 6. und 7. November 1987 (Medizinische Informatik, Biometrie und Epidemiologie #70)

Multiple Imputation and its Application (Statistics in Practice)

A practical guide to analysing partially observed data. Collecting, analysing and drawing inferences from data is central to research in the medical and social sciences. Unfortunately, it is rarely possible to collect all the intended data. The literature on inference from the resulting incomplete data is now huge, and continues to grow both as methods are developed for large and complex data structures, and as increasing computer power and suitable software enable researchers to apply these methods. This book focuses on a particular statistical method for analysing and drawing inferences from incomplete data, called Multiple Imputation (MI). MI is attractive because it is both practical and widely applicable. The authors aim is to clarify the issues raised by missing data, describing the rationale for MI, the relationship between the various imputation models and associated algorithms and its application to increasingly complex data structures. Multiple Imputation and its Application: Discusses the issues raised by the analysis of partially observed data, and the assumptions on which analyses rest. Presents a practical guide to the issues to consider when analysing incomplete data from both observational studies and randomized trials. Provides a detailed discussion of the practical use of MI with real-world examples drawn from medical and social statistics. Explores handling non-linear relationships and interactions with multiple imputation, survival analysis, multilevel multiple imputation, sensitivity analysis via multiple imputation, using non-response weights with multiple imputation and doubly robust multiple imputation. Multiple Imputation and its Application is aimed at quantitative researchers and students in the medical and social sciences with the aim of clarifying the issues raised by the analysis of incomplete data data, outlining the rationale for MI and describing how to consider and address the issues that arise in its application.

Multiple Imputation and its Application (Statistics in Practice)

A practical guide to analysing partially observed data. Collecting, analysing and drawing inferences from data is central to research in the medical and social sciences. Unfortunately, it is rarely possible to collect all the intended data. The literature on inference from the resulting incomplete data is now huge, and continues to grow both as methods are developed for large and complex data structures, and as increasing computer power and suitable software enable researchers to apply these methods. This book focuses on a particular statistical method for analysing and drawing inferences from incomplete data, called Multiple Imputation (MI). MI is attractive because it is both practical and widely applicable. The authors aim is to clarify the issues raised by missing data, describing the rationale for MI, the relationship between the various imputation models and associated algorithms and its application to increasingly complex data structures. Multiple Imputation and its Application: Discusses the issues raised by the analysis of partially observed data, and the assumptions on which analyses rest. Presents a practical guide to the issues to consider when analysing incomplete data from both observational studies and randomized trials. Provides a detailed discussion of the practical use of MI with real-world examples drawn from medical and social statistics. Explores handling non-linear relationships and interactions with multiple imputation, survival analysis, multilevel multiple imputation, sensitivity analysis via multiple imputation, using non-response weights with multiple imputation and doubly robust multiple imputation. Multiple Imputation and its Application is aimed at quantitative researchers and students in the medical and social sciences with the aim of clarifying the issues raised by the analysis of incomplete data data, outlining the rationale for MI and describing how to consider and address the issues that arise in its application.

Multiple Imputation and its Application (Statistics in Practice)

Multiple Imputation and its Application The most up-to-date edition of a bestselling guide to analyzing partially observed data In this comprehensively revised Second Edition of Multiple Imputation and its Application, a team of distinguished statisticians delivers an overview of the issues raised by missing data, the rationale for multiple imputation as a solution, and the practicalities of applying it in a multitude of settings. With an accessible and carefully structured presentation aimed at quantitative researchers, Multiple Imputation and its Application is illustrated with a range of examples and offers key mathematical details. The book includes a wide range of theoretical and computer-based exercises, tested in the classroom, which are especially useful for users of R or Stata. Readers will find: A comprehensive overview of one of the most effective and popular methodologies for dealing with incomplete data sets Careful discussion of key concepts A range of examples illustrating the key ideas Practical advice on using multiple imputation Exercises and examples designed for use in the classroom and/or private study Written for applied researchers looking to use multiple imputation with confidence, and for methods researchers seeking an accessible overview of the topic, Multiple Imputation and its Application will also earn a place in the libraries of graduate students undertaking quantitative analyses.

Multiple Imputation and its Application (Statistics in Practice)

Multiple Imputation and its Application The most up-to-date edition of a bestselling guide to analyzing partially observed data In this comprehensively revised Second Edition of Multiple Imputation and its Application, a team of distinguished statisticians delivers an overview of the issues raised by missing data, the rationale for multiple imputation as a solution, and the practicalities of applying it in a multitude of settings. With an accessible and carefully structured presentation aimed at quantitative researchers, Multiple Imputation and its Application is illustrated with a range of examples and offers key mathematical details. The book includes a wide range of theoretical and computer-based exercises, tested in the classroom, which are especially useful for users of R or Stata. Readers will find: A comprehensive overview of one of the most effective and popular methodologies for dealing with incomplete data sets Careful discussion of key concepts A range of examples illustrating the key ideas Practical advice on using multiple imputation Exercises and examples designed for use in the classroom and/or private study Written for applied researchers looking to use multiple imputation with confidence, and for methods researchers seeking an accessible overview of the topic, Multiple Imputation and its Application will also earn a place in the libraries of graduate students undertaking quantitative analyses.

The Multiple Inert Gas Elimination Technique (Methods in Physiology)

The Multiple Inert Gas Elimination Technique (MIGET) is a complex methodology involving specialized gas chromatography and sophisticated mathematics developed in the early 1970’s. Essentially, nobody possesses knowledge of all its elements except for its original developers, and while some practical and theoretical aspects have been published over the years, none have included the level of detail that would be necessary for a potential user to adopt and understand the technique easily. This book is unique in providing a highly detailed, comprehensive technical description of the theory and practice underlying the MIGET to help potential users set up the method and solve problems they may encounter. But it is much more than a reference manual – it is a substantial physiological and mathematical treatise in its own right. It also has a wide applicability – there is extensive discussion of the common biological problem of quantitative inference. The authors took measured whole-lung gas exchange variables, and used mathematical procedures to infer the distribution of ventilation and blood flow from this data. In so doing, they developed novel approaches to answer the question: What are the limits to what can be concluded when inferring the inner workings from the “black box” behavior of a system? The book details the approaches developed, which can be generalized to other similar distributed functions within tissues and organs. They involve engineering approaches such as linear and quadratic programming, and uniquely use mathematical tools with biological constraints to obtain as much information as possible about a “black box” system. Lastly, the book summarizes the hundreds of research papers published by a number of groups over the decades in a way never before attempted in order to marshal the world’s literature on the topic and to provide in one place the wealth of important discoveries, both physiological and clinical, enabled by the technique.

The Multiple Ligament Injured Knee: A Practical Guide to Management

The Multiple Ligament Injured Knee: A Practical Guide to Management includes the most developed knowledge needed to successfully diagnose and treat knee ligament injuries. This thorough work presents anterior and posterior cruciate and collateral ligament anatomy and biomechanics along with non-invasive methods for diagnosing the extent of injury, such as radiographic and arthroscopic evaluation. Various injuries are discussed in addition to useful treatment techniques, including arthroscopic reconstruction, posterolateral and posteromedial corner injury and treatment, assessment and treatment of vascular injuries, assessment and treatment of nerve injuries, rehabilitation, and post-operative results. Each of these clearly written chapters is accompanied by a wealth of line drawings and photographs that demonstrate both the surgical and non-surgical approaches to examination and treatment.

The Multiple Ligament Injured Knee: A Practical Guide to Management

The Multiple Ligament Injured Knee: A Practical Guide to Management includes the most developed knowledge needed to successfully diagnose and treat knee ligament injuries. This thorough work presents anterior and posterior cruciate and collateral ligament anatomy and biomechanics along with non-invasive methods for diagnosing the extent of injury, such as radiographic and arthroscopic evaluation. Various injuries are discussed in addition to useful treatment techniques, including arthroscopic reconstruction, posterolateral and posteromedial corner injury and treatment, assessment and treatment of vascular injuries, assessment and treatment of nerve injuries, rehabilitation, and post-operative results. Each of these clearly written chapters is accompanied by a wealth of line drawings and photographs that demonstrate both the surgical and non-surgical approaches to examination and treatment.

The Multiple Ligament Injured Knee: A Practical Guide to Management

This is not just another book on the knee. Dr. Fanelli's book, The Multiple Ligament Injured Knee: A Practical Guide to Management, written with a team of experienced contributors, is about a subject that is pertinent, as well as often underestimated and underappreciated. The surgeon's thorough knowledge of this subject is essential for the care of the patient with multiple ligaments injured in the knee. Such knowledge is indispensable if the patient's well-being and future function are to be restored. Time, technique, judgment, and decisiveness are critical. These are the surgeon's responsibilities. We have all come to be arthroscopic knee surgeons. We cannot, however, let this diminish our judgment or skill in open surgery. Often in the multi­ ply compromised knee, open surgery is a requisite. We must return to the principles that Drs. O'Donoghue, Slocum, Hughston, Trillat, Mueller-the fathers of modern knee surgery-taught us. Open exposure may be essen­ tial in some cases; we must know when it is necessary. This textbook helps resolve the impasse that often occurs in this arena of evolving art and science. Young surgeons who were not there before the arthroscope might not appreciate the awful injury that frequently is associated with the mul­ tiligament knee injury. We all know Dr. O'Donoghue's firm dictum that early diagnosis and anatomic repair is the best and most appropriate method of treatment. Time has not invalidated this advice.

Multiple Muscle Systems: Biomechanics and Movement Organization

The picture on the front cover of this book depicts a young man pulling a fishnet, a task of practical relevance for many centuries. It is a complex task, involving load transmission throughout the body, intricate balance, and eye­ head-hand coordination. The quest toward understanding how we perform such tasks with skill and grace, often in the presence of unpredictable pertur­ bations, has a long history. However, despite a history of magnificent sculptures and drawings of the human body which vividly depict muscle ac­ tivity and interaction, until more recent times our state of knowledge of human movement was rather primitive. During the past century this has changed; we now have developed a considerable database regarding the com­ position and basic properties of muscle and nerve tissue and the basic causal relations between neural function and biomechanical movement. Over the last few decades we have also seen an increased appreciation of the impor­ tance of musculoskeletal biomechanics: the neuromotor system must control movement within a world governed by mechanical laws. We have now col­ lected quantitative data for a wealth of human movements. Our capacity to understand the data we collect has been enhanced by our continually evolving modeling capabilities and by the availability of computational power. What have we learned? This book is designed to help synthesize our current knowledge regarding the role of muscles in human movement. The study of human movement is not a mature discipline.

Multiple Myeloma: Diagnosis and Treatment (Hematologic Malignancies Ser.)

This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care.Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.

Multiple Myeloma: Methods and Protocols (Methods in Molecular Biology #1792)

This volume provides a thorough guide of the study of multiple myeloma (MM)—from sample acquisition to the performance of molecular tests, and also discusses difficulties that arise during quality control and interpretation of results. The chapters in this book cover topics, such as next-generation-flow-based methods for detection of minimal residual disease and circulating tumor cells; Cytometry by Time-of-Flights (CyTOF); a droplet digital PCR approach for finding contamination in patients’ samples; genome-wide investigation of the methylation and hydroxymethylation status of cytosines; and a microfluidic approach for creating nanoparticles. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Multiple Myeloma: Methods and Protocols is a valuable resource for molecular scientists and laboratory supervisors working with MM samples, and any investigator conducting studies in this field.

Multiple Myeloma: Methods and Protocols (Methods in Molecular Medicine #113)

A comprehensive collection of classic and innovative methodologies used in many laboratories for the investigation of multiple myeloma. These readily reproducible techniques range from the standard Plasma Cell Labeling Index methodology to a final chapter on making sense of microarrays, and include the full spectrum of cytogenetic and molecular diagnostic methods. The protocols follow the successful Methods in Molecular Medicine™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. These proven techniques are ideal for studying the pathogenesis of multiple myeloma and identifying new therapeutic targets.

Multiple Myeloma (Recent Results in Cancer Research #183)

Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.

Multiple Myeloma and Other Plasma Cell Neoplasms (Hematologic Malignancies #0)

This book is a comprehensive source of up-to-date information on plasma cell neoplasms. Key features include the provision of new criteria for the diagnosis of symptomatic multiple myeloma requiring treatment and the description of novel therapies for myeloma and other plasma cell neoplasms that have only very recently been licensed by the U.S. Food and Drug Administration. Examples include lenalidomide as first-line therapy, panobinostat in combination with bortezomib plus dexamethasone for relapsed/refractory myeloma, ibrutinib for Waldenström’s macroglobulinemia, and new therapeutic regimens for systemic amyloidosis and POEMS syndrome. Information is also provided on drug combinations that have shown encouraging results and are very near to approval. Other important aspects covered in the book are the role of different imaging modalities in workup and the significance of newly acquired data relating to prognosis and minimal residual disease. Readers will find Multiple Myeloma and Other Plasma Cell Neoplasms to be a rich source of knowledge that will be invaluable in improving patient management.

Multiple Myeloma and Related Disorders

During the past decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals. Much of this has come about as new technologies have made it possible to refine studies on chromosomes and genes and to gain information abo

Multiple Objective Treatment Aspects of Bank Filtration

Bank filtration (BF) is a natural water treatment process which induces surface water to flow in response to a hydraulic gradient through soil/sediment and into a vertical or horizontal well. It is a relatively cost-effective, robust and sustainable technology. From a historical perspective, BF is first mentioned in the bible, and the process has been recognized as a proven method for drinking water treatment in Europe for more than 100 years. However, the mechanisms of removal of different contaminants during BF are not fully understood. This study showed that BF is an effective multiple objective barrier for removal of different contaminants present in surface water sources including bulk organic matter and organic micropollutants (OMPs) like pharmaceutically active compounds and endocrine disrupting compounds. It was found that biodegradation and adsorption play primary and secondary roles, respectively, in the removal of OMPs during soil passage. Furthermore, using field data from BF sites and chemical properties of OMPs, models were developed to estimate the removal of OMPs during soil passage. It can be concluded that the removal efficiencies of BF for these contaminants can be maximised by proper design and operation of recovery wells taking into consideration source water quality characteristics and local hydrogeological conditions.

Multiple Objective Treatment Aspects of Bank Filtration: Unesco-ihe Phd Thesis

Bank filtration (BF) is a natural water treatment process which induces surface water to flow in response to a hydraulic gradient through soil/sediment and into a vertical or horizontal well. It is a relatively cost-effective, robust and sustainable technology. From a historical perspective, BF is first mentioned in the bible, and the process has been recognized as a proven method for drinking water treatment in Europe for more than 100 years. However, the mechanisms of removal of different contaminants during BF are not fully understood. This study showed that BF is an effective multiple objective barrier for removal of different contaminants present in surface water sources including bulk organic matter and organic micropollutants (OMPs) like pharmaceutically active compounds and endocrine disrupting compounds. It was found that biodegradation and adsorption play primary and secondary roles, respectively, in the removal of OMPs during soil passage. Furthermore, using field data from BF sites and chemical properties of OMPs, models were developed to estimate the removal of OMPs during soil passage. It can be concluded that the removal efficiencies of BF for these contaminants can be maximised by proper design and operation of recovery wells taking into consideration source water quality characteristics and local hydrogeological conditions.

Multiple Organ Failure: Pathophysiology, Prevention, and Therapy

Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.

Multiple Origins of Sex Differences in Brain: Neuroendocrine Functions and their Pathologies (Research and Perspectives in Endocrine Interactions)

In theoretical terms, sex differences in brains and behaviors of laboratory animals offer the possibility of fascinating scientific studies on a range of molecular phenomena such as genomic imprinting, DNA methylation, chromatin protein modification, non-coding DNA, potentially resulting in important neuroanatomical and neurochemical sex differences in the brain. Such sex differences could arise consequent to exposures to testosterone early in development, or to other effects deriving from the Y chromosome. However, this general subject has been treated with much hyperbole. Historically, sex differences were assumed to be present where they did not really exist, e.g. with respect to mathematics, executive leadership, etc. etc. Under what circumstances do we really care about sex differences in brain and behavior? These circumstances concern human maladies whose diagnoses are much different between boys and girls, or between women and men. Prominent examples discussed in this volume include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia. In fact, infant boys are more susceptible than infant girls to a variety of disorders that arise early in development. This volume then ends with a consideration of effects of estrogenic hormones on the injured brain, and their roles as protective agents.

Multiple Pathways of Cognitive Aging: Motivational and Contextual Influences

The study of aging and cognition has grown exponentially over the past 50 years, developing from a field dominated by experimentally based information-processing traditions to one represented by a more mature approach both conceptually and methodologically. In the past 10 years there has been growth in integrative approaches that incorporate behavioral, neuropsychological, and social information. In addition, there has been a growing recognition of the limitations associated with simple cross-sectional age-group comparisons, along with an increased use of more complex methods. This has resulted in the development of increasingly sophisticated research designs and analytic tools focused on understanding a multitude of potential mediators and moderators of cognitive change. The result has been a move away from negative-views of cognitive aging to one that is more nuanced and sensitive to contextual factors. Multiple Pathways of Cognitive Aging explores the factors associated with adaptive functioning in later life. Its emphasis is on understanding both the factors underlying individual differences in change in cognitive functioning in later life and the nature of the compensatory mechanisms developed by most successful and active middle-aged and older adults. This includes a consideration of motivational factors as a driver of both cognitive change and adaptive functioning. For students and researchers, Multiple Pathways of Cognitive Aging offers valuable insights into the field of cognitive development, along with innovative methodological approaches to help them in their own research.