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Biological Dosimetry: Cytometric Approaches to Mammalian Systems

In October 1982, a small international symposium was held at the Gesellschaft fUr Strahlen- und Umweltforschung mbH (GSF) in Munich as a satellite meeting of the IX International Conference on Analytical Cytology. The symposium focussed on cytometric approaches to biological dosimetry, and was, to the best of our knowledge, the first meeting on this subject ever held. There was strong encouragement from the 75 attendees and from others to publish a proceedings of the symposium. Hence this book, containing 30 of the 36 presentations, has been assembled. Dosimetry, the accurate and systematic determination of doses, usually refers to grams of substance administered or rads of ionization or some such measure of exposure of a patient, a victim or an experimental system. The term also can be used to describe the quantity of an ultimate, active agent as delivered to the appropriate target material within a biological system. Thus, for mutagens, one can speak of DNA dosimetry, meaning the number of adducts produced in the DNA of target cells such as bone-mar­ row stem cells or spermatogonia.

Biological Drug Products: Development and Strategies

Tested and proven solutions to the challenges of biological drug product development Biological drug products play a central role in combating human diseases; however, developing new successful biological drugs presents many challenges, including labor intensive production processes, tighter regulatory controls, and increased market competition. This book reviews the current state of the science, offering readers a single resource that sets forth the fundamentals as well as tested and proven development strategies for biological drugs. Moreover, the book prepares readers for the challenges that typically arise during drug development, offering straightforward solutions to improve their ability to pass through all the regulatory hurdles and deliver new drug products to the market. Biological Drug Products begins with general considerations for the development of any biological drug product and then explores the strategies and challenges involved in the development of specific types of biologics. Divided into five parts, the book examines: Part 1: General Aspects Part 2: Proteins and Peptides Part 3: Vaccines Part 4: Novel Biologics Part 5: Product Administration/Delivery Each chapter has been prepared by one or more leading experts in biological drug development. Contributions are based on a comprehensive review and analysis of the current literature as well as the authors' first-hand experience developing and testing new drugs. References at the end of each chapter serve as a gateway to original research papers and reviews in the field. By incorporating lessons learned and future directions for research, Biological Drug Products enables pharmaceutical scientists and students to improve their success rate in developing new biologics to treat a broad range of human diseases.

Biological Drug Products: Development and Strategies

Tested and proven solutions to the challenges of biological drug product development Biological drug products play a central role in combating human diseases; however, developing new successful biological drugs presents many challenges, including labor intensive production processes, tighter regulatory controls, and increased market competition. This book reviews the current state of the science, offering readers a single resource that sets forth the fundamentals as well as tested and proven development strategies for biological drugs. Moreover, the book prepares readers for the challenges that typically arise during drug development, offering straightforward solutions to improve their ability to pass through all the regulatory hurdles and deliver new drug products to the market. Biological Drug Products begins with general considerations for the development of any biological drug product and then explores the strategies and challenges involved in the development of specific types of biologics. Divided into five parts, the book examines: Part 1: General Aspects Part 2: Proteins and Peptides Part 3: Vaccines Part 4: Novel Biologics Part 5: Product Administration/Delivery Each chapter has been prepared by one or more leading experts in biological drug development. Contributions are based on a comprehensive review and analysis of the current literature as well as the authors' first-hand experience developing and testing new drugs. References at the end of each chapter serve as a gateway to original research papers and reviews in the field. By incorporating lessons learned and future directions for research, Biological Drug Products enables pharmaceutical scientists and students to improve their success rate in developing new biologics to treat a broad range of human diseases.

Biological Effects and Dosimetry of Nonionizing Radiation: Radiofrequency and Microwave Energies (Nato Science Series A: #49)

During the last 35 years, there has been considerable develop­ ment and increase in the number of devices that emit nonionizing radiant energies. These energies such as radiofrequency including microwaves are used in all sectors of our society for military, industrial. telecommunications, medical, and consumer applications. This increase in sources of nonionizing radiant energies has resulted in growing interest on the part of government regulatory agencies, industrial and military physicians, research workers, clinicians, and environmentalists. Although there is information on biologic effects and potential hazards to man from exposure to microwave/radiofrequency energies, considerable confusion and misinformation has permeated not only the public press but also some scientific and technical publications. Because of the complexity of the interactions of nonionizing radiation in biological systems, an inter-disciplinary approach is necessary to assess and elucidate the problems that evolve as this field advances and as the use of these energies expands. It is important to maintain a proper perspective and assess realistically the biomedical effects of these radiant energies so that the worker or general public will not be unduly exposed nor will research, development and beneficial utilization of these energies be hampered or restricted by an undue concern for effects which may be nonexis­ tent or minimal in comparison to other environmental hazards.

Biological Effects and Dosimetry of Static and ELF Electromagnetic Fields: (pdf) (Problems in Practice)

Biological Effects and Health Implications of Radiofrequency Radiation

The study of electromagnetic bioeffects is multidisciplinary; it draws heavily from the disciplines of physics, engineering, mathematics, biol­ ogy, chemistry, medicine, and environmental health. This book is about these disciplines and how they mutually integrate in the study of electromagnetic pathophysiology. Over aperiod of years, the authors have become increasingly aware of the difficulty in locating information concerning interaction of electro­ magnetic energy and biological tissues. There are numerous reports and publications, but no single comprehensive source in the American literature where such information is readily accessible. Regrettably, much of the importantinformation is contained in government documents and reports, some of which are inaccessible, or spread through many diverse journals, making retrieval and analysis of the material difficult. Although this book is primarily clinically oriented, it also focuses on those biophysical, biochemical, and fundamental molecular studies and findings that provide the basis for understanding the presence or absence of pathophysiological manifestations of exposure to radiofrequency, including microwave, energies. Detailed discussion and analysis of the relevant comprehensive physics, engineering, and biophysics are con­ tained in Chapters 2-5. Because the treatment is multidisciplinary, wherever possible analy­ sis is begun with basic background information that may appear elementary to some readers but is essential to understanding for those from a different discipline. Most confusion and controversies that exist in the field today arise from individuals of one discipline not appreciating basic facts or theories from another.

Biological Effects and Physics of Solar and Galactic Cosmic Radiation: Part A (Nato Science Series A: #243A)

Space missions subject human beings or any other target of a spacecraft to a radiation environment of an intensity and composition not available on earth. Whereas for missions in low earth orbit (LEO), such as those using the Space Shuttle or Space Station scenario, radiation exposure guidelines have been developed and have been adopted by spacefaring agencies, for exploratory class missions that will take the space travellers outside the protective confines of the geomagnetic field sufficient guidelines for radiation protection are still outstanding. For a piloted Mars mission, the whole concept of radiation protection needs to be reconsidered. Since there is an increasing interest ci many nations and space agencies in establishing a lunar base and lor exploring Mars by manned missions, it is both, timely and important to develop appropriate risk estimates and radiation protection guidelines which will have an influence on the design and structure of space vehicles and habitation areas of the extraterrestrial settlements. This book is the result of a multidisciplinary effort to assess the state of art in our knowledge on the radiation situation during deep space missions and on the impact of this complex radiation environment on the space traveller. ]t comprises the lectures by the faculty members as well as short contributions by the students given at the NATO Advanced Study Institute "Biological Effects and Physics of Solar and Galactic Cosmic Radiation" held in Armacao de Pera, Portugal, 12-23 October, 1991.

Biological Effects and Physics of Solar and Galactic Cosmic Radiation Part B (Nato Science Series A: #243B)

Space missions subject human beings or any other target of a spacecraft to a radiation environment of an intensity and composition not available on earth. Whereas for missions in low earth orbit (LEO), such as those using the Space Shuttle or Space Station scenario, radiation exposure guidelines have been developed and have been adopted by spacefaring agencies, for exploratory class missions that will take the space travellers outside the protective confines of the geomagnetic field sufficient guidelines for radiation protection are still outstanding. For a piloted Mars mission, the whole concept of radiation protection needs to be reconsidered. Since there is an increasing interest of many nations and space agencies in establishing a lunar base and lor exploring Mars by manned missions, it is both, timely and important to develop appropriate risk estimates and radiation protection guidelines which will have an influence on the design and structure of space vehicles and habitation areas of the extraterrestrial settlements. This book is the result of a multidisciplinary effort to assess the state of art in our knowledge on the radiation situation during deep space missions and on the impact of this complex radiation environment on the space traveller. It comprises the lectures by the faculty members as well as short contributions by the students given at the NATO Advanced Study Institute "Biological Effects and Physics of Solar and Galactic Cosmic Radiation" held in Armacao de Pera, Portugal, 12-23 October, 1991.

Biological Effects by Organotins

This book provides an overview of the induction mechanism of imposex caused by organotin compounds in gastropods, as well as fundamental information on the physiology and biochemistry of reproduction in mollusks. Are the sex hormones of gastropod mollusks vertebrate-type steroids, or neuropeptides? What about lipid disturbance and membrane toxicity due to organotin compounds? The book also discusses the latest findings on the role of nuclear receptors, such as retinoid X receptor (RXR), retinoic acid receptor (RAR) and peroxisome proliferator-activated receptor (PPAR), in the development of imposex in gastropods. Further, it describes the current state of contamination by organotins in the marine environment and gastropod imposex, with a special focus on Europe and Asia, introduces readers to analytical techniques for organotin compounds, and assesses the contamination and adverse effects of alternatives to organotin-based antifouling paints. Imposex, a superimposition of male genital tracts, such as penis and vas deferens, on female gastropod mollusks, is known as a typical phenomenon or consequence of endocrine disruption in wildlife. Imposex is typically induced by very low concentrations of organotin compounds, such as tributyltin (TBT) and triphenyltin (TPhT) from antifouling paints on ships and fishing nets. Reproductive failure may be brought about in severely affected stages of imposex, resulting in population decline and/or mass extinction. Thus, gastropod imposex has been recognized as a critical environmental pollution issue. Although gastropod imposex is also highly interesting for the biological sciences because of its acquired pseudohermaphroditism and/or sex change by certain chemicals, such as TBT and TPhT, the mechanism that induces the development of imposex remains unclear, possibly due to our limited understanding of the endocrinology of gastropod mollusks. This book offers a useful guide for professionals and students interested in the fields of aquatic biology, invertebrate physiology, ecotoxicology and environmental science.

Biological Effects of Dietary Restriction (ILSI Monographs)

How does dietary restriction affect the physiological and biochemical state of laboratory animals? How will the present conclusions affect further research? What are the implications for human health and safety assessment? These are the main questions asked in this book by leading international researchers. After a first look at feeding regimens and diets of laboratory animals, the book elaborates on a variety of age-associated toxicological and pathological endpoints including tumor development. The following sections detail the underlying mechanisms which may induce the broad spectrum of physiological and biochemical changes. This summary of current multidisciplinary research will enhance understanding of the practical applications and implications of dietary restriction.

Biological Effects of Electromagnetic Fields: Mechanisms, Modeling, Biological Effects, Therapeutic Effects, International Standards, Exposure Criteria

Reporting new results, this book covers the subject of biological effects of EMF in its entirety. Experimental verification of the theoretical results is given when at all possible, and the book is expected to open new areas of research, providing material for university course creation.

The Biological Effects of Glutamic Acid and Its Derivatives (Developments in Molecular and Cellular Biochemistry #1)

the GABA increase takes place and (2) the area of the brain that may mediate the anticonvulsant Investigation of the physiology, biochemistry, activity. Three compounds that increase brain pharmacology and anatomy of GAB A and GABA­ GABA by distinct mechanisms were used in these containing neural systems, continues to reveal the studies: di-n-propylacetate (DPA, sodium val­ rich complexities associated with this neuroactive proate, Depakene(R)), amino-oxyacetic acid amino acid (see recent symposia 1,2,3). Advances (AOAA) and y-vinyl GABA (GVG). in the pharmacology of GABA-mimetic agents In the next sections, the metabolism of GABA have resulted in the development of compounds and a brief historical account of the relationship that can selectively activate GABA receptors (4,5, between GABA and anticonvulsant activity are 6, 7), inhibit the synthetic and degradative enzymes outlined followed by a discussion ofthe biochemical for GABA (8, 9) or affect the neuronal and glial and pharmacological effects of the three drugs. In uptake processes for GABA (10, 11). This has particular, the literature pertaining to the suppres­ already had a significant impact on our under­ sion of seizures and the correlation between anti­ standing of the role of GABA in convulsions and a convulsant action and increases in brain G ABA will range of other CNS functions including feeding be examined. (12), cardiovascular control (13), motor activity (14) and release of pituitary hormones (15). Before 1.

Biological Effects of Low Level Exposures to Chemical and Radiation (CRC Press Revivals)

This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies.

Biological Effects of Low Level Exposures to Chemical and Radiation (CRC Press Revivals)

This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies.

Biological Effects of Magnetic and Electromagnetic Fields

The International Symposium on Biological Effects of Magnetic and Electrom- netic Fields was held from September 3-4, 1993 at Kyushu University in Fukuoka . Japan . Originally, it was only intended to be an informal gathering of many scientists who had accepted my invitation to visit Kyushu University after the XXIVth General Assembly of the International Union of Radio Science (URSI), held in Kyoto prior to our symposium . However, since so many distinguished scientists were able to come, it was decided that a more formal symposium would be possible . It was a very productive symposium and, as a result, many of the guests consented that it would be a good idea to gather all the information put forth at the meeting and have it published. In addition, although they were unfortunately unable to attend the symposium . many other distinguished scientists had also expressed their wish to contribute to this effort and, in so doing. help to increase understanding in this, as yet, relatively immature field of science . The question of both positive and negative effects of magnetic and electromagnetic fields on biological systems has become more and more important in our world today as they .

Biological Effects of Magnetic Fields: Volume 2

We define biomagnetism broadly as the science of processes and functions in living organisms induced by static magnetic fields. Biomagnetic research has greatly increased since the publication of the first volume of this series. While much of this work has been reported in various international journals, there exists a need for this work to be collected together in one place. This book covers a rather wide area of research, both with respect to the strength of the field, ranging from "zero" to 150,000 oersteds, and with respect to the various specimens and their biological functions. It is designed primarly to help clarify the action of magnetic fields on biological systems with the hope of achieving a better understanding of the fundamental physiological processes occurring in them. In some chapters it is suggested that magnetic fields could ultimately be used in the treatment of disease. I would like to take this occasion to thank the contributors for their generous interest and willing cooperation. M. F. B. June 1969 Chicago, Illinois v CONTRIBUTORS Robert A. Abler, Varian Associates, Palo Alto, California (page 1). M. M. Alexandrovskaya, Institute of Higher Nervous Activity and Neuro­ physiology, Academy of Sciences, Moscow, USSR (page 215). Jena M. Barnothy, Biomagnetic Research Foundation, Evanston, Illinois (page 61). Madeleine F. Barnothy, College of Pharmacy, University of Illinois, Chicago, Illinois (pages xi, 103). Robert O. Becker, State University of New York, Upstate Medical Center, Syracuse; Veterans Administration Hospital, Syracuse, New York (page 207).

Biological Effects of Magnetic Fields: Volume 2

Study of the biological effect of magnetic fields is both a very old and a very recent area of investigation. A connection between health and the mysterious force of the lodestone has been suspected since the dawn of human culture. Nevertheless, only during the last decades has reliable evidence of biological effects of the magnetic field been dis­ covered. The purpose of this book is to bring together in one volume the present-day knowledge in all the active fields of biomagnetic research and at the same time to provide a theoretical and practical background to all scientists who wish to engage in investigations in this new disci­ pline. The need for such a comprehensive survey of current informa­ tion became evident to the editor from the interest manifested in the biomagnetic symposia and from the extended correspondence maintained by the Biomagnetic Research Foundation. It is hoped that the book will aid in attracting the interest of specialists and may thus serve as a catalyst for interdisciplinary exchange of ideas.

Biological Effects of Magnetic Fields: Volume 2 (pdf)

Biological Effects of Metal Nanoparticles

This book offers a comprehensive overview of recent studies conducted on the biological effects of metal nanoparticles. It also provides a solid theoretical foundation and various metal nanoparticle synthesis methods.Part I reviews the main chemical methods used for synthesizing metal nanoparticles in a solution and describes original method of biochemical synthesis, as well as some special procedures developed specifically for studying the biological activity of nanoparticles.Part II analyzes current literature on the effects of metal nanoparticles observed in microorganisms and addresses the influence of silver nanoparticles obtained by biochemical synthesis on biological objects on various organization levels, namely on microorganisms, acellular slim mold, unicellular alga, plant seeds and mammalian cells.The last section explains the central problems common in studies on the biological effects of metal nanoparticles and outlines potential uses of this trend in bio-nanotechnologies.This book is aimed at specialists, professors and students aspiring to expand their knowledge about the biological activities of metal nanoparticles and nanoparticle-containing materials.

Biological Effects of Polynucleotides: Proceedings of the Symposium on Molecular Biology, Held in New York, June 4–5, 1970 Sponsored by Miles Laboratories, Inc.

In recent years our horizons regarding the role of nucleic acids in biological systems have been expanded vastly by the finding that these molecules not only carry and transmit specific infOImation but also can act as less specific triggers of antiviral factors and of immunological responses. The latter properties are of particular interest in terms of possible utilization in human and veterinary medicine and consequently led, in the last few years, to the development of a new research area that combines both fundamental and applied problems in a uniquely attractive way. Furthermore, the importance and the complexity of the problems has attracted investigators from many fields, including molecular biologists, virologists, immunologists, chemists, biophysicists, oncologists, pharmacologists, and clinicians. A discussion of new developments in this area of biological effects of polynucleotides, with particular emphasis on interferon induction and modification of immune responses, therefore, seemed a logical topic for one of the annual symposia that Miles Laboratories, Inc. , has sponsored in recent years. The manage­ ment of Miles accepted the suggestion with enthusiasm and thus once again earned the gratitude of the scientific community for sponsoring a catalytic meeting that was principally concerned with basic research problems and only tangentially with immediate applications. Springer-Verlag agreed to publish the proceedings of the meeting which was held at the Americana Hotel in New York City, June 4-5, 1970 and attracted an unusually large audience.

Biological Effects of Static Magnetic Fields

The book summarizes the emerging topic about the effects of SMF on biological samples ranging from single molecules, subcellular compartments, and cells to whole organisms, as well as the potential application of SMF in clinical treatment of cancer and other diseases. With the development and growing popularity of modern appliances, including MRI in the hospitals, the potential impact of magnetic fields on human health is invoking increasing concerns. At the same time, SMF has been used in the clinical treatment of tumors and other diseases for decades. However, there are still some reservations and uncertainties about these treatments, which are largely due to the differential biological effects reported in the literature. These experimental inconsistencies are mainly caused by variations such as different magnetic field types, intensities, treatment time as well as biological samples examined. This volume will help clarify some dilemmas in this field and encourage further investigations in order to achieve a better understanding of the biological effects of SMF, aiming for a rational application of SMF in clinical therapy in the near future. The book is useful for scientists doctors, and students who are interested in magnetic fields and life sciences.

Biological Electron Microscopy: Theory, Techniques, and Troubleshooting

In this practical text, the author covers the fundamentals of biological electron microscopy - including fixation, instrumentation, and darkroom work - to provide an excellent introduction to the subject for the advanced undergraduate or graduate student.

Biological Electron Microscopy: Theory, Techniques, and Troubleshooting

Electron microscopy is frequently portrayed as a discipline that stands alone, separated from molecular biology, light microscopy, physiology, and biochemistry, among other disciplines. It is also presented as a technically demanding discipline operating largely in the sphere of "black boxes" and governed by many absolute laws of procedure. At the introductory level, this portrayal does the discipline and the student a disservice. The instrumentation we use is complex, but ultimately understandable and, more importantly, repairable. The procedures we employ for preparing tissues and cells are not totally understood, but enough information is available to allow investigators to make reasonable choices concerning the best techniques to apply to their parti­ cular problems. There are countless specialized techniques in the field of electron and light microscopy that require the acquisition of specialized knowledge, particularly for interpretation of results (electron tomography and energy dispersive spectroscopy immediately come to mind), but most laboratories possessing the equipment to effect these approaches have specialists to help the casual user. The advent of computer operated electron microscopes has also broadened access to these instruments, allowing users with little technical knowledge about electron microscope design to quickly become operators. This has been a welcome advance, because earlier instru­ ments required a level of knowledge about electron optics and vacuum systems to produce optimal photographs and to avoid "crashing" the instruments that typically made it difficult for beginners.

Biological Electron Transfer Chains: Genetics, Composition and Mode of Operation (Nato Science Series C: #512)

From May 3-7,1997, the NATO Advanced Research Workshop on 'Biological Electron Transfer Chains' was organized in Tomar, Portugal. In the application for support the choice of the topic was justified as follows: "[Until recently efforts] have concentrated on the study of the structure and function of individual redox enzymes and proteins. Enough information is now available to make a start with the study of biological electron transfer (E1) at the next higher level of organization, that of the complete ET chain." The interest in the workshop was high: the majority of participants had registered before the workshop was formally announced, which illustrates the popularity of the topic within the biochemical and biophysical communities. The present volume contains a number of reports based on the lectures presented by the key speakers during the meeting. The workshop dealt with the following three themes: a) Electron transfer, which is the subject of Chapter 1. The analysis of ET at the molecular level is still fundamental for an understanding of how ET chains operate in vivo. After 40 years of research the contours of the subject are becoming clear now. b) Bacterial redox chains. This is the subject of Chapter 2. Its contents show how complicated these chains can be, often involving a number of gene clusters. Our understanding of the regulatory aspects and control mechanisms of these chains is only in its beginning.

Biological Energy Conservation: Oxidative Phosphorylation (Outline Studies in Biology)

The student of biological science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the frontiers of his discipline. New research work is published in a perplexing diversity of publications and is inevitably concerned with the minutiae of the subject. The sheer number of research journals and papers also causes confusion and difficulties of assimilation. Review articles usually presuppose a background know­ ledge of the field and are inevitably rather restricted in scope. There is thus a need for short but authoritative introductions to those areas of modern biological research which are either not dealt with in standard introductory textbooks or are not dealt with in sufficient detail to enable the student to go on from them to read scholarly reviews with profit. This series of books is designed to satisfy this need. The authors have been asked to produce a brief outline of their subject assuming that their readers will have read and remembered much of a standard introductory textbook on biology. This outline then sets out to provide by building on this basis, the conceptual framework within which modern research work is progressing and aims to give the reader an indication of the problems, both conceptual and practical, which must be overcome if progress is to be maintained.