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Flashes of Creation: George Gamow, Fred Hoyle, and the Great Big Bang Debate
by Paul HalpernA respected physics professor and author breaks down the great debate over the Big Bang and the continuing quest to understand the fate of the universe. Today, the Big Bang is so entrenched in our understanding of the cosmos that to doubt it would seem crazy. But as Paul Halpern shows in Flashes of Creation, just decades ago its mere mention caused sparks to fly. At the center of the debate were Russian American physicist George Gamow and British astrophysicist Fred Hoyle. Gamow insisted that a fiery explosion explained how the elements of the universe were created. Attacking the idea as half-baked, Hoyle countered that the universe was engaged in a never-ending process of creation. The battle was fierce. In the end, Gamow turned out to be right -- mostly -- and Hoyle, along with his many achievements, is remembered for giving the theory the silliest possible name: "The Big Bang." Halpern captures the brilliance of both thinkers and reminds us that even those proved wrong have much to teach us about boldness, imagination, and the universe itself.
Flat Earth: The History of an Infamous Idea
by Christine GarwoodContrary to popular belief, fostered in countless school classrooms the world over, Christopher Columbus did not discover that the world was round. The idea of the world as a sphere had been widely accepted in scientific, philosophical and even religious circles from as early as the fourth century bc. Bizarrely, it was not until the supposedly more rational nineteenth century that the notion that the world might actually be flat really took hold. Even more bizarrely, it persists to this day. Based on a range of original sources, Garwood's history of flat-earth beliefs - from the Babylonians to the present day - raises issues central to the history and philosophy of science, its relationship with religion and the making of human knowledge about the natural world. Flat Earth is the first definitive study of one of history's most notorious and persistent ideas, and evokes all the intellectual, philosophical and spiritual turmoil of the modern age.'Highly entertaining and often hilarious ... an enjoyable romp through the dottier history of scientific and religious eccentricity' Sunday Times 'This entertaining history of the Flat Earth movement is full of crazy characters and fascinating details' Daily Telegraph'Wonderful ... an intriguing chronicle of 150 years of self- delusion' Financial Times
Flat-Panel Displays and CRTs (Van Nostrand Reinhold Electrical/Computer Science and Engineering Series)
by Lawrence E. TannasFlat-Panel Displays and CRTs, a review of electronic information display devices, is the first sys tematic and comprehensive coverage of the subject. It is intended to distill our wealth of knowledge of flat-panel displays and CRTs from their beginnings to the present state of the art. Historical perspective, theory of operation, and specific applications are all thoroughly covered. The field of display engineering is a multidisciplined technical pursuit with the result that its individual disciplines suffer from a lack of communications and limited perspective. Many previ ously developed standards for, and general understanding of, one technology are often inappro priate for another. Care has been taken here to document the old, incorporate the new, and emphasize commonalities. Criteria for performance have been standardized to enable an expert in one display technology, such as liquid crystals, to compare his device performance with that offered by another technology, such as electroluminescence. This book has been written with a second purpose in mind, to wit, to be the vehicle by means of which a new scientist or engineer can be introduced into the display society. It is organized to be tutorial for use in instructional situations. The first chapters begin with first principles and defini tions; the middle chapters set out requirements and criteria; and the last chapters give a complete description of each major technology.
Flatfish Metamorphosis
by Baolong BaoThis book provides a comprehensive discussion of the development and evolution of flatfish metamorphosis. The chapters use the tissue model to explain a series of metamorphic events， including eye migration, front bone deformation, dorsal fin elongation and regression, and body depth change, left/right asymmetrical pigmentation, give a hypothesis on the mechanism of eye migration, and the evolutionary origin of left/right eye asymmetry. The book is written by expert who has worked on flatfish metamorphosis over 20 years. It serves as a valuable reference for graduate students and researchers in related fields
Flatterland: Like Flatland Only More So
by Ian StewartFirst there was Edwin A. Abbott's remarkable Flatland, published in 1884, and one of the all-time classics of popular mathematics. Now, from mathematician and accomplished science writer Ian Stewart, comes what Nature calls "a superb sequel." Through larger-than-life characters and an inspired story line, Flatterland explores our present understanding of the shape and origins of the universe, the nature of space, time, and matter, as well as modern geometries and their applications. The journey begins when our heroine, Victoria Line, comes upon her great-great-grandfather A. Square's diary, hidden in the attic. The writings help her to contact the Space Hopper, who tempts her away from her home and family in Flatland and becomes her guide and mentor through ten dimensions. In the tradition of Alice in Wonderland and The Phantom Toll Booth, this magnificent investigation into the nature of reality is destined to become a modern classic.
Flavins and Flavoproteins: Methods and Protocols (Methods in Molecular Biology #2280)
by Maria BarileThis book of protocols is devoted to the yellow coenzymes derived from riboflavin or vitamin B2 and to the hundreds of enzymes whose functionality depends on them, and represents a compendium of techniques for working with flavoproteins or with the wide spectrum of functions that flavoproteins can drive in the cells. Starting with Rf production in microorganisms and the chemical, optical, and redox properties of these fascinating molecules and moving along to the variety and the peculiarity of some single flavoenzymes, the volume explores the complexity of functions and distribution of these molecules in the cell. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Flavin and Flavoproteins: Methods and Protocols serves as an ideal guide for protein chemists interested in purifying and characterizing flavoproteins, as well as microbiologists, physiologists, and clinicians, who wish to further study problems connected with flavoproteins.
Flavins and Flavoproteins: Methods and Protocols (Methods in Molecular Biology #1146)
by Stefan Weber and Erik SchleicherIn Flavins and Flavoproteins: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study flavins and flavoproteins. These include review style methods and protocols to exemplify the variety, the power and the success of modern techniques and methods in application to flavoproteins. Part I of this Volume covers general properties, syntheses and applications of free flavins as well as its analogs and flavoproteins. Part II covers characterizations of flavins and flavoproteins using modern experimental techniques as well as theoretical methods. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.Thorough and intuitive, Flavins and Flavoproteins: Methods and Protocols aids scientists in continuing to tackle the countless questions that need to be answered to more fully comprehend the vast diversity and specificity of flavin-governed biological processes.
Flavonoid Pharmacokinetics: Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology
by Neal M. Davies Jaime A. Yáñez Basil RoufogalisSETS FORTH A FRAMEWORK FOR THE ANALYSIS AND STUDY OF FLAVONOIDS More and more dietary supplements contain flavonoids. These products are typically viewed as food rather than drug products by regulatory agencies and therefore not subjected to rigorous clinical trials before they are marketed to the general public. As a result, the use of flavonoid-containing supplements presents a potential public health risk. From discovery to therapeutic application, this book is a comprehensive guide to both achiral and chiral flavonoids, enabling researchers to perform essential preclinical and clinical pharmacokinetics studies in order to ensure the efficacy of flavonoids marketed for therapeutic use. Moreover, the book examines the safety and toxicology of flavonoids as well as flavonoid-drug interactions. With contributions from a multidisciplinary team of leading researchers, Flavonoids Pharmacokinetics reviews and synthesizes the most recent research findings and results from preclinical and clinical studies. The book begins with a comprehensive overview of polyphenols and flavonoids. Next, the book covers: Methods of analysis of achiral flavonoids Preclinical pharmacokinetic of flavonoids Toxicology and safety of flavonoids Methods of analysis for chiral flavonoids Clinical pharmacokinetics of flavonoids Flavonoids and drug interactions Throughout the book, the authors provide examples that demonstrate the use of pharmacokinetics concepts during the preclinical and clinical drug development process. Flavonoid Pharmacokinetics is written for pharmaceutical, food, and nutritional scientists and students, offering the tools they need to thoroughly analyze and test flavonoids and flavonoid-containing supplements to ensure their safety and efficacy.
Flavonoid Pharmacokinetics: Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology
by Neal M. Davies Jaime A. Yanez Basil Roufogalis Jaime A. Y EzSETS FORTH A FRAMEWORK FOR THE ANALYSIS AND STUDY OF FLAVONOIDS More and more dietary supplements contain flavonoids. These products are typically viewed as food rather than drug products by regulatory agencies and therefore not subjected to rigorous clinical trials before they are marketed to the general public. As a result, the use of flavonoid-containing supplements presents a potential public health risk. From discovery to therapeutic application, this book is a comprehensive guide to both achiral and chiral flavonoids, enabling researchers to perform essential preclinical and clinical pharmacokinetics studies in order to ensure the efficacy of flavonoids marketed for therapeutic use. Moreover, the book examines the safety and toxicology of flavonoids as well as flavonoid-drug interactions. With contributions from a multidisciplinary team of leading researchers, Flavonoids Pharmacokinetics reviews and synthesizes the most recent research findings and results from preclinical and clinical studies. The book begins with a comprehensive overview of polyphenols and flavonoids. Next, the book covers: Methods of analysis of achiral flavonoids Preclinical pharmacokinetic of flavonoids Toxicology and safety of flavonoids Methods of analysis for chiral flavonoids Clinical pharmacokinetics of flavonoids Flavonoids and drug interactions Throughout the book, the authors provide examples that demonstrate the use of pharmacokinetics concepts during the preclinical and clinical drug development process. Flavonoid Pharmacokinetics is written for pharmaceutical, food, and nutritional scientists and students, offering the tools they need to thoroughly analyze and test flavonoids and flavonoid-containing supplements to ensure their safety and efficacy.
The Flavonoids: Advances in Research
by J. B. Harborne T. J. MabryThe ftavonoid pigments, one of the most numerous and widespread groups of natural constituents, are ofimportance and interest to a wide variety ofphysical and biological scientists and work on their chemistry, occurrence, natural distribution and biological function continues unabated. In 1975, a mono graph covering their chemistry and biochemistry was published by Chapman and Hall under our editors hip entitled The Flavonoids. The considerable success of this publication indicated that it filled an important place in the scientific literature with its comprehensive coverage of these fascinating and versatile plant substances. The present volume is intended to update that earlier work and provide a detailed review of progress in the ftavonoid field during the years 1975 to 1980. Although cross references are made to The Flavonoids, this supplement is entirely self-contained and where necessary, tabular da ta from the earlier volume are incJuded and expanded here. The choice oftopics in Recent Advances has been dictated by the developments that have occurred in ftavonoid research since 1975, so that not all subjects covered in The Flavonoids are reviewed again here. A major advance in ftavonoid separation has been the app1ication ofhigh performance liquid chromatography (HPLC) and this is reviewed inter alia in the opening chapter on separation techniques. An equally important development in the spectral analysis of ftavonoids has been the measurement of carbon-13 NMR spectra and this subject is authoritatively discussed in Chapter 2 and is also illustrated with the spectra of 125 representative ftavonoids.
The Flavonoids
by Jeffrey B. Harborne Helga Marby T. J. MarbyThe flavonoids, one of the most numerous and widespread groups of natural constituents, are important to man not only because they contribute to plant colour but also because many members (e.g. coumestrol, phloridzin, rotenone) are physiologically active. Nearly two thousand substances have been described and as a group they are universally distributed among vascular plants. Although the anthocyanins have an undisputed function as plant pigments, the raison d'etre for the more widely distributed colourless flavones and flavonols still remains a mystery. It is perhaps the challenge of discovering these yet undisc10sed functions which has caused the considerable resurgence of interest in flavonoids during the last decade. This book attempts to summarize progress that has been made in the study of these constituents since the first comprehensive monograph on the chemistry of the flavonoid compounds was published, under the editorship of T. A. Geissman, in 1962. The present volume is divided into three parts. The first section (Chapters 1-4) deals with advances in chemistry, the main emphasis being on spectral techniques to take into account the re cent successful applications of NMR and mass spectral measurements to structural identifications. Recent developments in isolation techniques and in synthesis are also covered in this section. Advances in chemical knowledge of individual c1asses of flavonoid are mentioned inter aha in later chapters of the book.
The Flavonoids Advances in Research Since 1986
by J.B. HarborneFlavonoids are a group of natural products isolated from a wide variety of plants, and are responsible for much of the coloring found in vascular plants. They exhibit a wide range of biological activities and are of particular interest as potential anti-cancer agents, as insect antifeedants, and as natural insecticides. The Flavonoids: Advances in Research Since 1986 is a self-contained account of this important group of plant products.
The Flavonoids Advances in Research Since 1986: Advances In Research Since 1980
by J.B. HarborneFlavonoids are a group of natural products isolated from a wide variety of plants, and are responsible for much of the coloring found in vascular plants. They exhibit a wide range of biological activities and are of particular interest as potential anti-cancer agents, as insect antifeedants, and as natural insecticides. The Flavonoids: Advances in Research Since 1986 is a self-contained account of this important group of plant products.
Flavonoids in Cell Function (Advances in Experimental Medicine and Biology #505)
by John A. Manthey Béla S. BusligThe discovery of biological activity associated with flavonoid contaminants in vitamin C preparations from bell peppers and lemons by Szent-Gyorgyi and his associates opened a floodgate of research into the biological functions of this ubiquitous and diverse group of compounds. Since then, a broad range of physiological and biochemical activities were discovered in living systems including most plants and animals. With the continued discovery, isolation and identification of new natural and synthetic compounds exhibiting biological activities, entire research programs are devoted to wide ranging investigations to nearly every conceivable area, from microbial and plant interaction, growth regulation and development to physiological, genetical, medicinal actions and uses in animals. This volume is based on presentations made at a Symposium, titled Flavonoids in Cell Function, held during the 219'h National Meeting of the American Chemical Society held in San Francisco, California on March 29-30, 2000. The book is not intended to be a comprehensive treatise on flavonoid research, only a sampling of recent results. The papers cover a range of topics discussing various approaches to flavonoid study, starting at plant microbe communication through analytical methods to medicinal and systemic implications of these compounds in animal cells and systems. The organizers would like to express their thanks to Cargill Foods, Inc., Minneapolis, Minnesota and the Division of Agricultural and Food Chemistry of the American Chemical Society for financial support. A great deal of thanks is also due to the authors without whose cooperation and patience this volume would not be realized.
Flavonoids in the Living System (Advances in Experimental Medicine and Biology #439)
by John Manthey Béla S. BusligThe presence of contaminant flavonoids in vitamin C preparations from citrus fruits initially led Szent-Gyorgyi and his collaborators to suggest that a flavonoid compound, with biological activity for the prevention of capillary fragility, was vitamin P. Later re search, although not disproving biological activity, discontinued the use of the vitamin classification for these compounds. However, the ubiquitous distribution of flavonoids in living organisms, and the continued discovery of various activity in biological systems makes these compounds targets of wide ranging investigation. This volume is primarily based on a Symposium on Flavonoids and related com pounds held during the 212th National Meeting of the American Chemical Society held in Orlando, Florida on August 28-29, 1996 under the sponsorship of the Division of Agricul tural and Food Chemistry. While the book is not intended to be a comprehensive volume on flavonoid research, the papers provide various approaches to exploring the biological functions of flavonoids in plants and animals, their chemical modifications for enhanced activity, some analytical techniques, as well as their use in food classification. A signifi cant portion is devoted to medicinal implications of these compounds. The organizers would like to express their appreciation to Tropicana Products, Inc., Bradenton, Florida, Coca-Cola Foods Division, Plymouth, Florida and the American Chemical Society's Division of Agricultural and Food Chemistry for financial support. Of course, the book could not be produced without the authors, whose cooperation and pa tience is greatly appreciated.
Flavonoids of the Sunflower Family (Asteraceae)
by Bruce A. Bohm Tod F. StuessyFlavonoids are secondary plant products that have previously been shown to be helpful in determining relationships among plant groups. This work presents comprehensively the occurrence, patterns of variation, and systematic and evolutionary importance of flavonoids in the sunflower family (Asteraceae), the largest family of flowering plants (23,000 species). It gathers together the more than 2500 reports of flavonoids in Asteraceae published between 1950 to the present and interprets these data in context of new taxonomic (especially generic) alignments. The authors discuss flavonoid patterns with reference to modern phylogenetic studies based on morphology and DNA data. This book provides, therefore, the most exhaustive synthesis and evaluation of the systematic and evolutionary import of flavonoids ever accomplished for any large family of angiosperms.
Flavoprotein Protocols (Methods in Molecular Biology #131)
by Stephen K. Chapman and Graeme A. ReidAs a scientist with an interest in proteins you will, at some time in your career, isolate an enzyme that turns out to be yellow—or perhaps you already have. Alternatively, you may identify a polypeptide sequence that is related to known flavin-containing proteins. This may, or may not, be your first encounter with flavoproteins. However, even if you are an old hand in the field, you may not have exploited the full range of experimental approaches applicable to the study of flavoproteins. We hope that Flavoprotein Protocols will encourage you to do so. In this volume we have sought to bring together a range of experimental methods of value to researchers with an interest in flavoproteins, whether or not these researchers have experience in this area. A broad range of techniques, from the everyday to the more specialized, is described by scientists who are experts in their fields and who have ext- sive practical experience with flavoproteins. The wide range of approaches, from wet chemistry to dry computation, has, as a consequence, demanded a range of formats. Where appropriate (particularly for analytical methods) the protocol described is laid out in easy-to-follow steps. In other cases (e. g. , the more advanced spectroscopies and computational methods) it is far more apt to describe the general approach and relevance of the methods. We hope this wide-ranging approach will sow the seeds of many future collaborations - tween laboratories and further our knowledge and understanding of how f- voproteins work.
Flavor Chemistry: Thirty Years of Progress
by Roy Teranishi Emily L. Wick Irwin HornsteinCelebrating the founding of the Flavor Subdivision of the Agriculture and Food Chemistry Division of the American Chemical Society, this book provides an overview of progress made during the past 30-40 years in various aspects of flavor chemistry as seen by internationally renowned scientists in the forefront of their respective fields. In addition, it presents up-to-date findings in the areas of flavor chemistry, analytical methods, thermally produced flavors and precursors, enzymatically produced flavors and precursors, and sensory methods and results.
Flavor, Fragrance, and Odor Analysis
by Ray MarsiliThere are many advantages to stir bar sorptive extraction (SBSE) for isolating and concentrating flavor-active chemicals from foods, including its simplicity and wide application appeal. Written from a practical, problem-solving perspective, the second edition of Flavor, Fragrance, and Odor Analysis highlights this powerful technique and emphasizes
Flavor, Fragrance, and Odor Analysis
by Ray MarsiliThere are many advantages to stir bar sorptive extraction (SBSE) for isolating and concentrating flavor-active chemicals from foods, including its simplicity and wide application appeal. Written from a practical, problem-solving perspective, the second edition of Flavor, Fragrance, and Odor Analysis highlights this powerful technique and emphasizes
Flavor in the Era of the LHC: Reports of the CERN Working Groups (Advances in the Physics of Particles and Nuclei #29)
a R. Fleischer, T. Hurth, M. L. Mangano Physics Department, CERN, 1211 Geneva, Switzerland In the history of quantum and particle physics, discrete system. In this past decade, the key player has been the B-meson system, and we also witnessed the appearance on symmetries and their violation have played an outstanding + ? rôle. First, the assumption of the conservation of P (parity), stage of the top quark. Thanks to thee e B factories with C (charge conjugation), CP and CPT (T denotes time rever- their detectors BaBar (SLAC) and Belle (KEK), CP vio- tion is now also rmly seen in B-meson decays, where the sal) helped theorists to restrict theoretical predictions, such 0 “golden” decay B ?J/?K shows CP-violating effects as in Fermi’s 1934 seminal paper on weak interactions. In S d at the level of 70%. These effects can be translated into the 1957, the observation of P (and C) violation in weak int- angle? of the “unitarity triangle” (UT), which characterizes actions gave a new impact and led to the conjecture that CP the Kobayashi–Maskawa mechanism of CP violation. S- was still a conserved symmetry. In 1963, one year before + ? eral strategies to determine the other angles of the triangle, the surprising observation of CP violation in K ?? ? L ? and ?, have been proposed and successfully applied to decays, the concept of quark- avour mixing was introduced theB-factory data.
Flavor Mixing in Weak Interactions (Ettore Majorana International Science Series #20)
by Ling-Lie ChauThe 50-year history of weak interaction since Fermi's pro posal of this coupling has been marked with striking direct inter plays between experimental results and theoretical understanding, e.g. the discoveries of neutrinos, parity violation, and CP vio lation. The recent discoveries of the quark hierarchy, the charm and the beauty, and the intermediate vector bosons W± and ZO have truly made a splendid page in the history of particle physics. It is the purpose of this conference to discuss the questions of quark and lepton generations and mixing, their relations to CP violation, and to ask the questions about what are inside the quarks and the leptons in view of the present and future exper imental situation. Dr. Ling-Lie Chau Brookhaven National Laboratory Upton, New York vii ACKNOWLEDGMENTS I would like to thank all the Advisory and Organizing Committee members for their advice and suggestions during the organization of the conference. The running of the conference could not have gone so smoothly without the help of many participants, I sincerely thank: L. Becker, F.J. Botella, S. Gentile, P. Le Comte, M.E. Machacek, L. Lanceri, W.M. Morse, F.J. Olness, Y.-X. Pham, G. Poulard, K.J. Sliwa, and J.N. Webb.
Flavor Physics and the TeV Scale (Springer Tracts in Modern Physics #233)
by George W. HouThe second edition of this monograph discusses the usefulness of heavy flavor as a probe of TeV-scale physics, exploring a number of recently-uncovered “flavor anomalies” that are suggestive of possible TeV-scale phenomena.The large human endeavor at the Large Hadron Collider has not turned up any New Physics, except the last particle of the Standard Model, the Higgs boson. Revised and updated throughout, this book puts the first results from the LHC into perspective and provides an outlook for a new era of flavor physics. The author readdresses many questions raised in the first edition and poses new ones. As before, the experimental perspective is taken, with a focus on processes, rather than theories or models, as a basis for exploration, and two-thirds of the book is concerned with b -^ s or bs sb transitions. In the face of the advent of Belle II and other flavor experiments, this book becomes a part of a dialogue between the energy/collider and intensity/flavor frontiers that will continue over the coming decade. Researchers with an interest in modern particle physics will find this book particularly valuable.
Flavor Physics and the TeV Scale (Springer Tracts in Modern Physics #233)
by George W. HouThe ?avor sector carries the largest number of parameters in the Standard Model of particle physics. With no evident symmetry principle behind its existence, it is not as well understood as the SU(3)×SU(2)×U(1) gauge interactions. Yet it tends to be underrated, sometimes even ignored, by the erudite. This is especially so on the verge of the LHC era, where the exploration of the physics of electroweak symmetry breaking at the high energy frontier would soon be the main thrust of the ?eld. Yet, the question of “Who ordered the muon?” by I. I. Rabi lingers. We do not understand why there is “family” (or generation) replication. That three generations are needed to have CP violation is a partial answer. We do not understand why there are only three generations, but Nature insists on (just about) only three active neutrinos. But then the CP violation with three generations fall far short of what is needed to generate the baryon asymmetry of the Universe. We do not understand why most fermions are so light on the weak symmetry breaking scale (v. e. v. ), yet the third-generation top quark is a v. e. v. scale particle. We do not understand why quarks and leptons look so different, in particular, why neutrinos are rather close to being massless, but then have (at least two) near maximal mixing angles. We shall not, however, concern ourselves with the neutrino sector. It has a life of its own.