- Table View
- List View
Long Circulating Liposomes: Old Drugs, New Therapeutics (Biotechnology Intelligence Unit)
by GerritStorm Martin C. WoodleThis book provides an up-to-date evaluation of clinical aspects of newly available "long-circulating liposome" formulations. Based on results from numerous clinical studies, the book describes the fundamentals of this new technology, discusses how it may influence the pharmacology of existing well-known agents reformulated in this manner, and elaborates on future expectations. It provides the practicing clinician - in particular, oncologists and critical care infectious disease physicians - with the tools needed to use these new formulations towards the best outcome for the patient.
Long Distance Entanglement Between Quantum Memories (Springer Theses)
by Yong YuThis book highlights novel research work done on cold atom-based quantum networks. Given that one of the main challenges in building the quantum network is the limited entanglement distribution distance, this book presents some state-of-the-art experiments in tackling this challenge and, for the first time, establishes entanglement between quantum memories via metropolitan-scale fiber transmission. This achievement is accomplished by cooperating high-efficiency cold quantum memories, low-loss quantum frequency conversion modules, and long-fiber phase-locking techniques. In the book, the scheme design, experimental setup, data analyses, and numerous technical details are given. Therefore, it suits a broad readership that includes all students, researchers, and technicians who work in quantum information sciences.
Long-Distance Systemic Signaling and Communication in Plants (Signaling and Communication in Plants #19)
by František BaluškaOur view of plants is changing dramatically. Rather than being only slowly responding organisms, their signaling is often very fast and signals, both of endogenous and exogenous origin, spread throughout plant bodies rapidly. Higher plants coordinate and integrate their tissues and organs via sophisticated sensory systems, which sensitively screen both internal and external factors, feeding them information through both chemical and electrical systemic long-distance communication channels. This revolution in our understanding of higher plants started some twenty years ago with the discovery of systemin and rapid advances continue to be made. This volume captures the current ‘state of the art’ of this exciting topic in plant sciences.
The Long Evolution of Brains and Minds
by Gerhard RothThe main topic of the book is a reconstruction of the evolution of nervous systems and brains as well as of mental-cognitive abilities, in short “intelligence” from simplest organisms to humans. It investigates to which extent the two are correlated. One central topic is the alleged uniqueness of the human brain and human intelligence and mind. It is discussed which neural features make certain animals and humans intelligent and creative: Is it absolute or relative brain size or the size of “intelligence centers” inside the brains, the number of nerve cells inside the brain in total or in such “intelligence centers” decisive for the degree of intelligence, of mind and eventually consciousness? And which are the driving forces behind these processes? Finally, it is asked what all this means for the classical problem of mind-brain relationship and for a naturalistic theory of mind.
The Long Forgotten
by David WhitehouseMemories make us who we are – but what if yours belonged to someone else?David Whitehouse's The Long Forgotten is the story of a missing plane, a rare-flower hunter, and a lonely young man who has begun to remember a past that isn’t his. It’s the story of a long-buried mystery, a quest that ended in tragedy, and a love that can never be forgotten.'This is a wonderful book, its different strands weaving around each other and coming together in the most fantastic conclusion. I am so jealous of David Whitehouse’s writing.' Adam Kay'Powerful, eccentric . . . Whitehouse's writing is energetic and pacey, spiked with startling moments of tenderness and superbly controlled' The Times
Long Island Sound: Prospects for the Urban Sea (Springer Series on Environmental Management)
by James S. Latimer Mark A. Tedesco R. Lawrence Swanson Charles Yarish Paul E. Stacey Corey GarzaThe U.S. Ocean Commission Report identified the need for regional ecosystem assessments to support coastal and ocean management. These assessments must provide greater understanding of physical and biological dynamics than assessments at global and national scales can provide but transcend state and local interests. This need and timeliness is apparent for Long Island Sound, where a multi-state regional restoration program is underway for America’s most urbanized estuary. Synthesis of the Long Island Sound ecosystem is needed to integrate knowledge across disciplines and provide insight into understanding and managing pressing issues, such as non-point sources of pollution, coastal development, global climatic change, and invasive species. Currently, there is a need for a comprehensive volume that summarizes the ecological and environmental dynamics and status of Long Island Sound and its myriad ecosystems. It has been 30 years since a comprehensive summary of Long Island Sound was prepared and 50 years since the pioneering work of Gordon Riley. Major advances in estuarine science are providing new insights into these systems, and yet, the condition of many estuaries is in decline in the face of continuing coastal development. There is an opportunity to lay a foundation for integrative coastal observing systems that truly provide the foundation for improved decision-making. This book will provide a key reference of our scientific understanding for work performed over the past three decades and guide future research and monitoring in a dynamic urbanized estuary.
Long-Life Design and Test Technology of Typical Aircraft Structures
by Jun Liu Zhufeng Yue Xiaoliang Geng Shifeng Wen Wuzhu YanThis book addresses anti-fatigue manufacturing, analysis and test verification technologies for typical aircraft structures, including fastening holes, shot peening plates, different types of joints and wing boxes. Offering concrete solutions to practical problems in aircraft engineering, it will benefit researchers and engineers in the fields of Aerospace Technology and Astronautics.
Long-lived Proteins in Human Aging and Disease
by Roger TruscottThis authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.
Long-lived Proteins in Human Aging and Disease
by Roger J. W. TruscottThis authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.
Long Non-Coding RNAs (Progress in Molecular and Subcellular Biology #51)
by Durdica UgarkovicLong non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.
Long Non Coding RNA Biology (Advances in Experimental Medicine and Biology #1008)
by M.R.S. RaoThis contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
Long Noncoding RNA: Mechanistic Insights and Roles in Inflammation (Advances in Experimental Medicine and Biology #1363)
by Susan CarpenterThis book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.
Long Noncoding RNAs: Structures and Functions
by Riki KurokawaThis book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests.
Long 'on' the Tooth: Dental Evidence of Diet
by Christopher W. SchmidtLong 'on' the Tooth: Dental Evidence of Diet addresses human dental macroscopic and microscopic wear, as well as dental disease, as indicators of diet. The book focuses primarily on 350 pre-contact humans from North America dating from approximately 5,500 to 600 years ago. These populations had subsistence strategies ranging from terrestrial foraging to intensive maize agriculture. The study makes intra- and intergroup comparisons to elucidate dietary nuances that are largely beyond the reach of other means of dietary reconstruction. Finally, the book discusses the importance of using multiple dietary indicators in unison in order to provide paleodietary insights.Includes state-of-the-art dental microwear texture data Focuses on populations largely overlooked in archaeological and dental anthropology volumes Offers the first dental anthropology book to integrate dental pathology and dental microwear texture analysis
The Long-Range Atmospheric Transport of Natural and Contaminant Substances (Nato Science Series C: #297)
by Mary-Scott KaiserProceedings of the NATO Advanced Research Workshop on The Long-Range Atmospheric Transport of Natural and Contaminant Substances from Continent to Ocean and Continent to Continent, St. Georges, Bermuda, January 10-17, 1988
Long-Range Casimir Forces: Theory and Recent Experiments on Atomic Systems (Finite Systems and Multiparticle Dynamics)
by Frank S. Levin David A. MichaThis series, Finite Systems and Multiparticle Dynamics, is intended to provide timely reviews of current research topics, written in a style sufficiently pedagogic so as to allow a nonexpert to grasp the underlying ideas as well as understand technical details. The series is an outgrowth of our involvement with three interdis ciplinary activities, namely, those arising from the American Physical Society's Topical Group on Few Body Systems and Multiparticle Dynam ics, the series of Gordon Research Conferences first known by the title "Few Body Problems in Chemistry and Physics" and later renamed "Dynamics of Simple Systems in Chemistry and Physics," and the series of Sanibel Symposia, sponsored in part by the University of Florida. The vitality of these activities and the enthusiastic response to them by researchers in various subfields of physics and chemistry have convinced us that there is a place--even a need-for a series of timely reviews on topics of interest not only to a narrow band of experts but also to a broader, interdisciplinary readership. It is our hope that the emphasis on pedagogy will permit at least some of the books in the series to be useful in graduate-level courses. Rather than use the adjective "Few-Body" or "Simple" to modify the word "Systems" in the title, we have chosen "Finite. " It better expresses the wide range of systems with which the reviews of the series may deal.
Long-Range Dependence and Sea Level Forecasting (SpringerBriefs in Statistics)
by Ali Ercan M. Levent Kavvas Rovshan K. AbbasovThis study shows that the Caspian Sea level time series possess long range dependence even after removing linear trends, based on analyses of the Hurst statistic, the sample autocorrelation functions, and the periodogram of the series. Forecasting performance of ARMA, ARIMA, ARFIMA and Trend Line-ARFIMA (TL-ARFIMA) combination models are investigated. The forecast confidence bands and the forecast updating methodology, provided for ARIMA models in the literature, are modified for the ARFIMA models. Sample autocorrelation functions are utilized to estimate the differencing lengths of the ARFIMA models. The confidence bands of the forecasts are estimated using the probability densities of the residuals without assuming a known distribution.There are no long-term sea level records for the region of Peninsular Malaysia and Malaysia’s Sabah-Sarawak northern region of Borneo Island. In such cases the Global Climate Model (GCM) projections for the 21st century can be downscaled to the Malaysia region by means of regression techniques, utilizing the short records of satellite altimeters in this region against the GCM projections during a mutual observation period.This book will be useful for engineers and researchers working in the areas of applied statistics, climate change, sea level change, time series analysis, applied earth sciences, and nonlinear dynamics.
Long-range Interactions, Stochasticity and Fractional Dynamics: Dedicated to George M. Zaslavsky (1935—2008) (Nonlinear Physical Science)
by Albert C. J. Luo Valentin AfraimovichIn memory of Dr. George Zaslavsky, "Long-range Interactions, Stochasticity and Fractional Dynamics" covers the recent developments of long-range interaction, fractional dynamics, brain dynamics and stochastic theory of turbulence, each chapter was written by established scientists in the field. The book is dedicated to Dr. George Zaslavsky, who was one of three founders of the theory of Hamiltonian chaos. The book discusses self-similarity and stochasticity and fractionality for discrete and continuous dynamical systems, as well as long-range interactions and diluted networks. A comprehensive theory for brain dynamics is also presented. In addition, the complexity and stochasticity for soliton chains and turbulence are addressed. The book is intended for researchers in the field of nonlinear dynamics in mathematics, physics and engineering. Dr. Albert C.J. Luo is a Professor at Southern Illinois University Edwardsville, USA. Dr. Valentin Afraimovich is a Professor at San Luis Potosi University, Mexico.
Long-Range Transport of Airborne Pollutants
by H. C. MartinLong-Range Transport of Airborne Pollutants and Acid Rain Conference This issue of Water, Air, and Soil Pollution is devoted to the collection of papers presented at the Long-Range Transport of Airborne Pollutants and Acid Rain Con ference held at Albany, N.Y., April 27-30, 1981. The issue includes most of the invited papers as well as a good number of the poster papers. The conference consisted of seven plenary sessions at which the invited papers were presented. After each session the participants discussed the session topic in the poster area where the subject was further explored and expanded. The seven technical sessions were: (1) Networks. (2) Models of Delivery. (3) Interactions with Soils and Ground Water. (4) Calibrated Water Sheds. (5) Effects on Aquatic Biota. (6) Effects on Terrestrial Biota. (7) Health implications. The closing session was devoted to the topic 'The Application of Scientific and Technical Data to the Development of Government Policy; Acid Rain - A Case Study'. The four papers given are not included here.
The Long Road to Stockholm: The Story of Magnetic Resonance Imaging - An Autobiography
by Peter MansfieldIn this autobiography, Sir Peter Mansfield describes his life from war time childhood that initially sparked his interest in physics to his work in magnetic resonance imaging (MRI) that eventually led to the award of the Nobel Prize in 2003. Peter Mansfield grew up in London, but was evacuated to Devon during the blitz and following the V1 and V2 attacks on London. At the end of hostilities, he worked briefly in the printing industry before deciding to pursue his real interests in science by joining the Rocket Propulsion Department at Westcott near Aylesbury. Following a period of National Service and his studies at Queen Mary College, University of London, he married and moved to the USA for two years, returning in 1964 as a Lecturer in Physics at the University of Nottingham. In 1972 he spent a sabbatical period in Heidelberg, and during this period corresponded with his student, Peter Grannell, in Nottingham on the novel idea of magnetic resonance imaging. This led to his first paper on MRI which was presented at the first Specialised Colloque Ampère in 1973. During this period, he demonstrated how the MRI radio signals can be analysed and turned into images of the body. In 2003 the Nobel Prize in Physiology or Medicine was awarded jointly to Sir Peter and Paul Lauterbur for their crucial achievements in the development of MRI.
The Long Space Age: The Economic Origins of Space Exploration from Colonial America to the Cold War
by Alexander MacDonaldAn economic historian argues that privately funded space exploration is not a new development, but a trend beginning with the astronomical observatories of the nineteenth century Over the last half-century there has been a rapid expansion in commerce off the surface of our planet. Nations and corporations have placed hundreds of satellites that provide billions of dollars’ worth of communications, scientific, global positioning, and commercial services, while construction has been completed on humanity’s ninth and largest space station. On the planet itself, government agencies, corporations, and individuals plan for the expansion of economic development to the lunar surface, asteroids, and Mars. The future of space exploration seems likely to include a mix of large government funded missions as well as independent private-sector missions. The Long Space Age examines the economic history of American space exploration and spaceflight, from early astronomical observatories to the International Space Station, and argues that the contemporary rise of private-sector efforts is the re-emergence of a long-run trend not a new phenomenon.
The Long Spring: Tracking the Arrival of Spring Through Europe
by Laurence RoseExploring Europe's remarkable heritage of exceptional places and the wildlife, traditions and people associated with them, in February 2016 Laurence Rose crossed the Mediterranean from North Africa and set off on a series of journeys northwards towards the Arctic coast of Norway, all the while keeping pace with the arrival of spring.Like a modern-day pilgrimage, he is accompanied by fellow wayfarers, migrating swallows and cranes and later, wild swans and eagles. He witnesses the awakening of a continent from its winter slumber and encounters new behaviours, such as storks that no longer migrate, exploring how they link to climate change. From Spain, Laurence headed north through France and Britain. Crossing over to Sweden, Finland and Norway, he ended his travels four months later as the long Arctic days stretched into continuous daylight. In The Long Spring, Laurence evokes the landscapes, sounds and colours of the continent at its most vibrant. And as a lifelong naturalist, his journeys tracking the world's most significant and beautiful phenomenon – spring – were a chance to explore the past, present and future of our connections to nature, reflecting on three decades of work and travel in Europe and his own long relationship with wildlife.
The Long Spring: Tracking the Arrival of Spring Through Europe
by Laurence RoseExploring Europe's remarkable heritage of exceptional places and the wildlife, traditions and people associated with them, in February 2016 Laurence Rose crossed the Mediterranean from North Africa and set off on a series of journeys northwards towards the Arctic coast of Norway, all the while keeping pace with the arrival of spring.Like a modern-day pilgrimage, he is accompanied by fellow wayfarers, migrating swallows and cranes and later, wild swans and eagles. He witnesses the awakening of a continent from its winter slumber and encounters new behaviours, such as storks that no longer migrate, exploring how they link to climate change. From Spain, Laurence headed north through France and Britain. Crossing over to Sweden, Finland and Norway, he ended his travels four months later as the long Arctic days stretched into continuous daylight. In The Long Spring, Laurence evokes the landscapes, sounds and colours of the continent at its most vibrant. And as a lifelong naturalist, his journeys tracking the world's most significant and beautiful phenomenon – spring – were a chance to explore the past, present and future of our connections to nature, reflecting on three decades of work and travel in Europe and his own long relationship with wildlife.
Long-Term Changes in Coastal Benthic Communities: Proceedings of a Symposium, held in Brussels, Belgium, December 9–12,1985 (Developments in Hydrobiology #38)
by C. H. R. Heip B. F. Keegan J. R. LewisThis volume contains the papers and abstracts of the posters given at the symposium on Long-term Changes in Coastal Benthic Communities organized by the Commission of the European Communities in Brussels, Belgium from 9 till 12 December 1985. The organization of this symposium came to conclude five years of activities in the COST 647 project on Coastal Benthic Ecology, the rationale of which is explained in the foreword by B. F. Keegan. The importance of this volume is that for the first time special attention is given to long-term data series of relevant biological variables collected in different marine benthic habitats. Many of the data presented here are the result of years of careful data collection by some of the leading scientists in the field of benthic ecology. Some of the series, such as the Macoma balthica data from the Wadden Sea or the macrofauna data from Loch Linnhe, to name just those two, are already classics in the marine biological literature. Other data were collected in the framework of a monitoring programme and are now analyzed for the first time in the different perspective of the COST 647 project. Several papers are from related fields where they represent well known case studies; they were chosen in order to see how problems have been tackled elsewhere.