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Synthesis of Pyrrol-based Bioconjugates: Perspectives and Applications
by Mariette M. Pereira Sara M.A. Pinto Lucas D. DiasIn recent years, the use of bioconjugation as strategy for development of more specific and directed drugs has been widely researched. Tetrapyrrolic macrocycles are one of the most common families of organic compounds applied in medicinal chemistry, specifically for diagnosis and therapy. For optimization of their efficiency as therapeutic molecules, it is relevant to promote their linking to biomolecules capable of targeting altered cells. This work brings a new dimension to the literature by combining structural modification of biomolecules and polymers with pyrrole-based compounds. It will be of great interest to academicians, industrialists, and undergraduate and graduate students of chemistry, biosciences, and pharmacy since, as apart from the theoretical aspects, it discusses experimental components.Features: Discusses methods for protein modification. Useful for academicians, industrialists and undergraduate and graduated students of chemistry, biosciences, and pharmacy. Explains the synthesis of pyrrole-based molecules.
Synthesizers and Subtractive Synthesis, Volume 2: Application and Practice
by Jean-Michel RéveillacSubtractive sound synthesis is one of the most widely used techniques in electronic music and in many analog synthesizers since the early 1960s. It is based on a simple principle, but its operation is complex, involving many parameters. It can be enhanced by a variety of effects that give the sound its authenticity, and does not simply imitate musical instruments, but can also transcribe noises present in natural soundscapes or generate entirely synthetic sounds. Synthesizers and Subtractive Sound Synthesis 2 presents practical exercises, ranging from the fundamentals to advanced functionalities. Most of the sound effects applicable to subtractive synthesis are covered: vibrato, phaser, reverb, etc. The final chapters deal with polyphony and arpeggiator-sequences.
System Dependability - Theory and Applications: Proceedings of the Nineteenth International Conference on Dependability of Computer Systems DepCoS-RELCOMEX. July 1–5, 2024, Brunów, Poland (Lecture Notes in Networks and Systems #1026)
by Janusz Kacprzyk Wojciech Zamojski Jacek Mazurkiewicz Jarosław Sugier Tomasz WalkowiakThis book presents a selection of papers about problems which arise in dependability studies of contemporary computer systems and networks. Their collection should be an interesting and inspiring source material for scientists, researchers, engineers, and students who must consider diverse dependability characteristics in design, analysis, or maintenance of computer systems and networks. The papers were presented during the 19th DepCoS-RELCOMEX conference which was the next event in a series organized annually since 2006. Originating as a scientific platform for discussions of reliability aspects in computer engineering, the topical scope of the conference has been constantly expanded to incorporate new dependability challenges brought by recent advances in systems and information technologies. Currently, dependable operation in the context of computer processing means obtaining reliable (true and timely) results in the conditions of processing both quantitative and qualitative data, using precise or fuzzy (often: imitating) models and algorithms. With increasing use of artificial intelligence algorithms and tools, dependability in contemporary information technology and computer engineering calls for methods based on cognitive systems and deep learning techniques. Topical variety of the papers included in these proceedings proves that almost all applications of modern computer systems and networks must take into account the aspect of dependability and also illustrates a wide diversity of multidisciplinary subjects which needs to be considered in this context.
System Theory -- A Modern Approach, Volume 1: Linear Ordinary and Functional Differential Equations
by Henri BourlèsThe theory of dynamic systems is addressed in this book in accordance with the "modern" approach, heir to algebraic analysis, which has been implemented since the last decade of the 20th century. After a reminder of the evolution of the representation of systems based on transfer functions or matrices, the duality of controllability and observability is revisited, and new results are produced concerning time-varying discrete-time systems. To complete and improve the existing analyses, the poles and zeros of linear systems and their interconnections are presented in a new way, as well as the problem of systems governed by functional differential equations (of retarded or neutral type) and their stabilization. This book also proposes known and original mathematical complements.
A Systematic Approach to Strabismus (The Basic Bookshelf for Eyecare Professionals)
by Virginia KarlssonWritten for the true beginner, the updated and revised second edition of A Systematic Approach to Strabismus examines the basic types of strabismus, ocular motility, ocular examination of pediatric patients, and extraocular muscle anatomy and functions.Unique features inside the Second Edition: Uses practical and easy-to-follow “how to” instructions to offer fundamental education on the four parts of an eye exam: history, vision, sensory testing, and motor testing Includes necessary information to successfully complete pediatric and strabismus eye exams Highlights the order of testing in an effort to gather the most important information prior to a pediatric meltdown and to avoid "exam pollution" Having worked in both private practice and university settings, Virginia Karlsson brings over 30 years of experience with pediatric ophthalmology and adult strabismus to the pages of A Systematic Approach to Strabismus, Second Edition. Ophthalmic technologists, technicians, assistants, residents, and students will welcome this unique book into their education and career.
A Systematic Approach to Strabismus (The Basic Bookshelf for Eyecare Professionals)
by Virginia KarlssonWritten for the true beginner, the updated and revised second edition of A Systematic Approach to Strabismus examines the basic types of strabismus, ocular motility, ocular examination of pediatric patients, and extraocular muscle anatomy and functions.Unique features inside the Second Edition: Uses practical and easy-to-follow “how to” instructions to offer fundamental education on the four parts of an eye exam: history, vision, sensory testing, and motor testing Includes necessary information to successfully complete pediatric and strabismus eye exams Highlights the order of testing in an effort to gather the most important information prior to a pediatric meltdown and to avoid "exam pollution" Having worked in both private practice and university settings, Virginia Karlsson brings over 30 years of experience with pediatric ophthalmology and adult strabismus to the pages of A Systematic Approach to Strabismus, Second Edition. Ophthalmic technologists, technicians, assistants, residents, and students will welcome this unique book into their education and career.
Systematic Strategic Planning: A Comprehensive Framework for Implementation, Control, and Evaluation
by Hakan ButunerThis book provides a complete set of practical strategic planning techniques and tools. Readers are guided in identifying how and in what circumstances they might use particular tools, and in targeting them directly at achieving effective results. Systematic Strategic Planning consists of a framework of phases through which each project passes, a pattern of procedures for straight-forward planning and the fundamentals involved in any strategic planning project. The book is designed to be simple to understand and easy to use.
Systemic: How Racism Is Making Us Ill
by Dr Layal LiverpoolRacism is a public health crisis – and we can do something about it. 'A work of towering importance that will undoubtedly change science and save lives, but it will also change the way you see yourself and the people around you' Chris van Tulleken, author of Ultra-Processed PeopleA ground-breaking investigation into how racism corrodes science and medicine – leading to worse treatment for everyone.What can you do when science and medicine are as biased as the society they treat? Black and Asian patients in the UK wait nearly a week longer for a cancer diagnosis and globally, people of colour are not only more likely to die while giving birth, they are also more likely to die while being born – or soon afterwards. In Systemic, science journalist Layal Liverpool unearths the shocking facts behind the health threat of racism, and when a scientific bias is this pronounced, it results in worse treatment for everyone. We are collectively more ill, medical research is held back and our potential for scientific discoveries is reduced.But there is hope for a cure – practical solutions that we can implement to heal our world. Individuals can learn to advocate for themselves and others with scientifically backed data in the face of structural prejudice. Governments can enact policies aimed at tackling systemic inequities on a national level. Drawing on years of research, interviews and cutting-edge data from across the world, Systemic is a clarion call for a healthier world for us all.'A groundbreaking, brilliantly argued book that debunks the myth that illness is the great equaliser' Siddhartha Mukherjee, Pulitzer Prize winning-author of The Emperor of All Maladies and The Song of the Cell'Liverpool is a wonderful researcher and this shines through in her writing. Systemic provides a powerful examination on racism in healthcare' Annabel Sowemimo, author of Divided
Systemic: How Racism Is Making Us Ill
by Dr Layal LiverpoolRacism is a public health crisis – and we can do something about it. 'A work of towering importance that will undoubtedly change science and save lives, but it will also change the way you see yourself and the people around you' Chris van Tulleken, author of Ultra-Processed PeopleA ground-breaking investigation into how racism corrodes science and medicine – leading to worse treatment for everyone.What can you do when science and medicine are as biased as the society they treat? Black and Asian patients in the UK wait nearly a week longer for a cancer diagnosis and globally, people of colour are not only more likely to die while giving birth, they are also more likely to die while being born – or soon afterwards. In Systemic, science journalist Layal Liverpool unearths the shocking facts behind the health threat of racism, and when a scientific bias is this pronounced, it results in worse treatment for everyone. We are collectively more ill, medical research is held back and our potential for scientific discoveries is reduced.But there is hope for a cure – practical solutions that we can implement to heal our world. Individuals can learn to advocate for themselves and others with scientifically backed data in the face of structural prejudice. Governments can enact policies aimed at tackling systemic inequities on a national level. Drawing on years of research, interviews and cutting-edge data from across the world, Systemic is a clarion call for a healthier world for us all.'A groundbreaking, brilliantly argued book that debunks the myth that illness is the great equaliser' Siddhartha Mukherjee, Pulitzer Prize winning-author of The Emperor of All Maladies and The Song of the Cell'Liverpool is a wonderful researcher and this shines through in her writing. Systemic provides a powerful examination on racism in healthcare' Annabel Sowemimo, author of Divided
Systemic and Narrative Work with Unaccompanied Asylum-Seeking Children: Stories of Relocation (The Systemic Thinking and Practice Series)
by Ana Draper Elisa Marcellino Samantha ThomsonSystemic and Narrative Work with Unaccompanied Asylum-Seeking Children: Stories of Relocation provides a contextualised, research-based understanding of how to enhance and support the emotional health and well-being of unaccompanied asylum-seeking children.The framework presented in this book is an innovative intervention that enhances the well-being of children who have experienced trauma by improving the therapeutic abilities for all who support and care for them. This book presents the evidence base for this new systemic and narrative trauma-informed framework of care, creates a wider understanding of working with trauma responses in unaccompanied asylum-seeking children and offers coherence for practitioners wanting to use this approach. The authors provide a physiological view, as well as identify embodied aspects of trauma experience, and describe a narrative approach developed from a clinical understanding of trauma, as well as presenting the words of children who took part in the project. Creating a common multi-disciplinary language, this approach can be used to improve coherence, coordination, and excellence within the whole system.This book is essential reading for all practitioners working with unaccompanied asylum-seeking children. It will also be of interest to students and trainees of social work and other mental health disciplines, as well as other professionals seeking to understand the needs of this group.
Systemic and Narrative Work with Unaccompanied Asylum-Seeking Children: Stories of Relocation (The Systemic Thinking and Practice Series)
by Ana Draper Elisa Marcellino Samantha ThomsonSystemic and Narrative Work with Unaccompanied Asylum-Seeking Children: Stories of Relocation provides a contextualised, research-based understanding of how to enhance and support the emotional health and well-being of unaccompanied asylum-seeking children.The framework presented in this book is an innovative intervention that enhances the well-being of children who have experienced trauma by improving the therapeutic abilities for all who support and care for them. This book presents the evidence base for this new systemic and narrative trauma-informed framework of care, creates a wider understanding of working with trauma responses in unaccompanied asylum-seeking children and offers coherence for practitioners wanting to use this approach. The authors provide a physiological view, as well as identify embodied aspects of trauma experience, and describe a narrative approach developed from a clinical understanding of trauma, as well as presenting the words of children who took part in the project. Creating a common multi-disciplinary language, this approach can be used to improve coherence, coordination, and excellence within the whole system.This book is essential reading for all practitioners working with unaccompanied asylum-seeking children. It will also be of interest to students and trainees of social work and other mental health disciplines, as well as other professionals seeking to understand the needs of this group.
Systemic Financial Risk: An Emerging Market Perspective
by Alexander Karminsky Mikhail StolbovThis book provides an analysis of various sources and forms of systemic financial risk. It focuses on the most pressing research questions for both advanced and emerging market economies, including green finance, ESG agenda and related risks, international financial connectivity across countries and financial institutions, and catastrophic risks modeling. Part 1 considers emerging research issues in risk assessment and management, including new approaches to measuring financial development, trends and prospects of green finance, and cross-country financial spillovers. Part 2 casts a more nuanced look at the quantitative models and methods adopted in risk assessment and risk management, putting such issues as measuring catastrophic risks, liquidity mismatches as well as modeling probabilities of default and the impact of macroeconomic fundamentals on capital adequacy ratios in the Russian banking sector in the spotlight. Finally, Part 3 discusses the new regulatory challenges dealingwith risk assessment and risk management, such as macroprudential policies which have proved efficient to mitigate systemic risk are investigated. The book offers a comprehensive picture of the challenges which emerging market economies are facing in the field of financial risk assessment and management. Specifically, the challenges are discussed in the context of elaborated models and policy responses, which are based on the up-to-date theoretical contributions and empirical evidence from various fields, making the book relevant to professors, researchers, graduate students, and practitioners of risk management, international finance, and financial services.
Systems Engineering: Analysis, Modeling and Simulation of Systems
by Emmanuel HygounencThis book is intended for students, teachers, researchers, engineers and project managers wishing to understand and implement systems engineering into their work. Based on numerous bibliographical sources, it provides coherent and accessible information, complemented with numerous illustrations. Systems Engineering will enable the reader to not only understand but also master the development cycle of a system, as well as gain an in-depth understanding of the associated terminology. An introduction to systems theory is presented first, clarifying what is meant by a complex system. The book then outlines systems engineering and one of its components: requirements engineering. A detailed presentation of the downhill activities of the development cycle follows the definition of requirements and the design of systems. Finally, the book explores the upstream activities of the development cycle with the virtual and concrete integration of the system.
Systems Engineering: Analysis, Modeling and Simulation of Systems
by Emmanuel HygounencThis book is intended for students, teachers, researchers, engineers and project managers wishing to understand and implement systems engineering into their work. Based on numerous bibliographical sources, it provides coherent and accessible information, complemented with numerous illustrations. Systems Engineering will enable the reader to not only understand but also master the development cycle of a system, as well as gain an in-depth understanding of the associated terminology. An introduction to systems theory is presented first, clarifying what is meant by a complex system. The book then outlines systems engineering and one of its components: requirements engineering. A detailed presentation of the downhill activities of the development cycle follows the definition of requirements and the design of systems. Finally, the book explores the upstream activities of the development cycle with the virtual and concrete integration of the system.
Systems Theory and Agile Brand Management: The Educative View of Branding (Systems Thinking)
by Jan LiesBrands started out as communication tools to influence the image of companies or products (inside-out thinking) but have developed into channels of social forces. Powerful brands impact not just customer decisions but also markets and social institutions, such as fashion trends, city life, or even social movements. This book explores the implications of Niklas Luhmann’s theory of social systems for the theory and practice of agile brand management, in particular highlighting the central role of brand aesthetics and of brands as channels for mutual education between companies and consumers.Since the rise of social media, “perfect” brands have become the mirror of community values as the communities themselves develop brand content. Brands themselves become “living systems” and evolve like systems do. The author introduces systems theory to provide a conceptual framework that integrates the different views of branding: inside-out and outside-in thinking. This Luhmannian theory of branding is discussed against the current background of (Western) societies, which are undergoing a broad shift from hard to soft selling in marketing, influenced by social media. The book is not about whether closed systems analysis and discussion can or should replace traditional management; moreover, it emphasizes the fruitful insights and demonstrates that the power of management is limited and should be extended by looking at the means of closed systems.This book will be of primary value to scholars with an interest in systems theory and thinking, brand theory, and management. The interdisciplinary approach also makes the book a valuable resource for those researching change management, agile management, and sociology.
Systems Theory and Agile Brand Management: The Educative View of Branding (Systems Thinking)
by Jan LiesBrands started out as communication tools to influence the image of companies or products (inside-out thinking) but have developed into channels of social forces. Powerful brands impact not just customer decisions but also markets and social institutions, such as fashion trends, city life, or even social movements. This book explores the implications of Niklas Luhmann’s theory of social systems for the theory and practice of agile brand management, in particular highlighting the central role of brand aesthetics and of brands as channels for mutual education between companies and consumers.Since the rise of social media, “perfect” brands have become the mirror of community values as the communities themselves develop brand content. Brands themselves become “living systems” and evolve like systems do. The author introduces systems theory to provide a conceptual framework that integrates the different views of branding: inside-out and outside-in thinking. This Luhmannian theory of branding is discussed against the current background of (Western) societies, which are undergoing a broad shift from hard to soft selling in marketing, influenced by social media. The book is not about whether closed systems analysis and discussion can or should replace traditional management; moreover, it emphasizes the fruitful insights and demonstrates that the power of management is limited and should be extended by looking at the means of closed systems.This book will be of primary value to scholars with an interest in systems theory and thinking, brand theory, and management. The interdisciplinary approach also makes the book a valuable resource for those researching change management, agile management, and sociology.
Systems Thinking for Sustainability Education in Business Schools (SpringerBriefs in Complexity)
by Hassan Qudrat-UllahThis book delves into the current state and future prospects of systems thinking and sustainability education within business schools. It meticulously examines the trends and drivers shaping the demand and supply of such education, along with the implications and challenges it presents for various stakeholders and society at large. Strategic recommendations and suggestions are provided to elevate and propel systems thinking and sustainability education in business schools, outlining a visionary roadmap for the future. Furthermore, the book explores the intersectionality of sustainability and diversity in business education, offering examples and cases of visionary and innovative initiatives and projects in the field. Distinguished by special features such as illustrations, the book offers a comprehensive and integrative overview of the current landscape and future trajectories of systems thinking and sustainability education in business schools. The primary benefit for readers lies in gaining a deeper and broader understanding of systems thinking and sustainability education in business schools. It equips them with the knowledge to apply systems thinking and sustainability principles and tools to tackle the complex and wicked problems of the twenty-first century. Additionally, the book aims to inspire and inform business schools and their stakeholders to embrace and enhance systems thinking and sustainability education in their curricula and pedagogy, contributing to the advancement of sustainability and systems thinking in both business and society.
Table For Two: The instant Sunday Times bestseller
by Amor TowlesTHE INSTANT SUNDAY TIMES and NEW YORK TIMES BESTSELLERFROM THE AUTHOR OF A GENTLEMAN IN MOSCOW, THE LINCOLN HIGHWAY AND RULES OF CIVILITY'A knockout . . . Table for Two is a winner'NEW YORK TIMES'There is no better writer working today'CHRIS CLEAVE'He makes it all seem effortless'TANA FRENCH'A gem of a book that springs delights and surprises on every page'JEFFREY ARCHER'There is a great deal to relish in Table for Two . . . If you take only one book on holiday this summer, you couldn’t ask for a better literary capsule wardrobe'THE TIMESMillions of Amor Towles fans are in for a treat as he shares some of his shorter fiction: six stories based in New York City and a novella set in Golden Age Hollywood.The New York stories, most of which take place around the year 2000, consider the fateful consequences that can spring from brief encounters and the delicate mechanics of compromise that operate at the heart of modern marriages.In Towles’s novel Rules of Civility, the indomitable Evelyn Ross leaves New York City in September 1938 with the intention of returning home to Indiana. But as her train pulls into Chicago, where her parents are waiting, she instead extends her ticket to Los Angeles. Told from seven points of view, “Eve in Hollywood” describes how Eve crafts a new future for herself—and others—in a noirish tale that takes us through the movie sets, bungalows, and dive bars of Los Angeles.Written with his signature wit, humor, and sophistication, Table for Two is another glittering addition to Towles’s canon of stylish and transporting fiction.Praise for The Lincoln Highway:"A rollicking cross-country adventure, rife with unforgettable characters, vivid scenery and suspensethat will keep readers flying through the pages." Time"Elegantly constructed and compulsively readable . . . hitch onto this delightful tour de force and you'll be pulled straight through to the end, helpless against the inventive exuberance of Towles' storytelling." NPR"Wise and wildly entertaining . . . Towles goes all in on the kind of episodic, exuberant narrativehaywire found in myth or Homeric epic." The New York Times Book ReviewInstant New York Times bestseller, May 2024
Tackling Addiction: Pathways to Recovery
by George De Leon Brian Kidd Betsy Thom Albert Zandvoort Alex Stevens David Best Mark Gilman Wendy Dawson Tim McSweeney KuladhariniThis edited collection brings together the thoughts and experiences of researchers, practitioners and service users from the fields of health, addiction and criminal justice and centres on current developments in addiction policy and practice. Tackling Addiction examines what recovery, addiction and dependence really mean.
Tackling Child Neglect: Research, Policy and Evidence-Based Practice
by Wendy Lee Andrew Turnell Leigh Taylor Sarah Gorin Hilary Kennedy Jane Barlow Jenny Woodman Amanda Bunn Debra Allnock Jan Horwath Katelyn M. Guastaferro Whitney R. Rostad John R. Lutzker Maeve Macdonald Paul Whalley Marian Brandon Dan Koziolek Pippa Belderson Jan McAllisterWith contributions from internationally recognized experts, this edited volume presents original thinking on the theory, research and practice surrounding child neglect.Comprehensive and current, the book takes an expansive look at how we can better address this prevalent issue. It explores the effects of neglect on the developing child and makes recommendations on how to identify neglect at the earliest opportunity. It considers common causal and contributing factors in neglect cases and the impact of these on children. The book details effective intervention techniques alongside case vignettes and shows how change can be achieved. It highlights the importance of supporting parental care and developing parental responsibility in families where children are neglected. Chapters provide in-depth descriptive examples and include a summary of learning points. Including practical suggestions for combating child neglect, this is an essential guide to best practice for students and practitioners working with children and families. The book also contains useful insights relevant to researchers and policy makers.
Tackling Disability Discrimination and Disability Hate Crime: A Multidisciplinary Guide
by David Cain Mike Smith Melanie Giannasi Kathryn Stone Catherine White Mark Brookes Paul Frederick Matt Houghton Bob Munn Nathan Hall Phillipa Russell Jemma Tyson Sylvia Lancaster Syed Mohammed Naqvi Nigel CrispA powerful and comprehensive look at disability discrimination and disability hate crimes, offering recommendations for a cross-government response to ensure disabled people are seen and treated as equal citizens.
Tackling Selective Mutism: A Guide for Professionals and Parents
by Tony Cline Alison Wintgens Maggie Johnson Jenny Packer Nitza Katz-Bernstein Geoffrey Gibson David Bramble Johnston Susan Lindsay Whittington Victoria Roe Denise Lanes Charlotte Firth Kate Jones Keiko Kakuta Jane Kay Rosemary Sage Miriam Jemmett Jyoti Sharma Carl Sutton Hilary M CleatorIn this definitive guide to selective mutism the latest research and understanding are consolidated in chapters from experts in the fields of speech therapy, psychology, music therapy and education and communication. It includes helpful information on the various treatment and therapeutic options with illustrative case studies.
Tai Chi Chuan and the Code of Life: Revealing the Deeper Mysteries of China's Ancient Art for Health and Harmony (Revised Edition)
by Graham HorwoodIn this book Graham Horwood describes the various styles of Tai Chi Chuan, exploring its roots in the Chinese philosophy of Taoism as well as elaborating on the evolution it has undergone over millennia. He highlights parallels between its source, The I Ching, and archetypal principles from both Eastern and Western philosophy and medicine.
A Tai Chi Imagery Workbook: Spirit, Intent, and Motion
by Martin MellishThis innovative book makes the benefits of Tai Chi directly available to Westerners by communicating its essence in poetic, evocative, and humorous images that apply to movement practices of all kinds and to daily life. The book contains hundreds of photos and drawings, and detailed explanations of the biomechanical realities that underlie them.
Taiji As Moving Meditation: Fundamental Principles and Practices
by Paul FendosA clear introduction to Taiji, a slow and rhythmical martial art, this visual guide shows how it can be used as a 'moving meditation' that bestows strength, vigour and longevity.The book focuses on helping people apply the principles of the Taiji practice by offering a short introduction to its history and philosophy, as well as a primer on its general practices as established by the International Wushu Federation. Divided into five chapters, it includes an easy-to-learn warm-up, stances, hand techniques, steps, breathing, basic moves and the four Forms that are usually learned to receive a black belt in the art.With a growing focus on alternative ways of improving general health and well-being, Taiji as Moving Meditation is the perfect guide for those wanting to enhance focus and peace of mind.