Tumour Necrosis Factor and Related Cytotoxins

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Synopsis

The number of factors implicated in the regulation of cell proliferation and differentiation is already considerable and more are continually being identified. This book concentrates on tumor necrosis factor (cachectin) and lymphotoxin, but includes observations of their interactions with other cytokines, especially the interferons and interleukins. TNF can be either cytostatic or cytotoxic to cultured cell lines, and a variety of mechanisms are proposed, ranging from DNA fragmentation to activation of phospholiopases. TNF is also reported to stimulate the growth of normal fibroblasts in vivo. The in vivo actions of TNF described here include haemorrhagic necrosis of tumors, cachexia, effects on the vasculature, and antiparasitic and antiviral activities. Also presented is some interesting data from the first stages of clinical trials of TNF as an anticancer agent.

Book details

Series:
Novartis Foundation Symposia (Book 131)
Author:
Gregory R. Bock, Joan Marsh
ISBN:
9780470513538
Related ISBNs:
9780470513521, 9780471910978
Publisher:
Wiley
Pages:
252
Reading age:
Not specified
Includes images:
No
Date of addition:
2020-01-04
Usage restrictions:
Copyright
Copyright date:
1987
Copyright by:
N/A 
Adult content:
No
Language:
English
Categories:
Medicine, Nonfiction