Mitochondrial Disorders Caused by Nuclear Genes

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Synopsis

Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells.  In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes.  Since mitochondria are present in every cell, every tissue, mitochondrial disorder usually affects multiple organs.

Book details

Edition:
2013
Author:
Lee-Jun C. Wong
ISBN:
9781461437222
Related ISBNs:
9781461437215
Publisher:
Springer New York
Pages:
N/A
Reading age:
Not specified
Includes images:
Yes
Date of addition:
2020-12-30
Usage restrictions:
Copyright
Copyright date:
2013
Copyright by:
Springer New York, New York, NY 
Adult content:
No
Language:
English
Categories:
Medicine, Nonfiction, Science