Hereditary Retinopathies Progress in Development of Genetic and Molecular Therapies

You must be logged in to access this title.

Sign up now

Already a member? Log in

Synopsis

The hereditary retinopathy, retinitis pigmentosa (RP), which affects 1 in 3,500 people worldwide, is the most common cause of registered visual handicap among those of the working age in developed countries. RP is a highly variable disorder where patients may develop symptomatic visual loss in early childhood, while others may remain asymptomatic until mid-adulthood. Most cases of RP segregate in autosomal dominant, recessive or X-linked recessive modes, with approximately 41 genes being implicated in disease pathology to date (RetNet). The extensive genetic heterogeneity associated with autosomal dominant RP (adRP) is an undisputed hindrance to the development of genetically based therapeutics.

Book details

Edition:
2012
Series:
SpringerBriefs in Genetics (Book 1)
Author:
Pete Humphries, Marian M. Humphries, Lawrence C. Tam, G. Jane Farrar, Paul F. Kenna, Matthew Campbell, Anna-Sophia Kiang
ISBN:
9781461444992
Related ISBNs:
9781461444985
Publisher:
Springer New York
Pages:
N/A
Reading age:
Not specified
Includes images:
Yes
Date of addition:
2020-12-31
Usage restrictions:
Copyright
Copyright date:
2012
Copyright by:
N/A 
Adult content:
No
Language:
English
Categories:
Medicine, Nonfiction