The Ontology of Physics for Biology Semantic Modeling of Multiscale, Multidomain Physiological Systems

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Synopsis

This book introduces semantic representations of multiscale, multidomain physiological systems that link to qualitative reasoning and to quantitative analysis of biophysical processes in health and disease. Two major public health problems, diabetes and hypertension, serve as use-cases to illustrate the depth and rigor of such representations for logical inference and quantitative analysis. Central to this approach is the Ontology of Physics for Biology (OPB) that formally represents the foundations of classical physics and engineering system dynamics that are the basis for our understanding of biomedical entities, processes, and functional relationships.
Furthermore, we introduce OPB-based software for annotating and abstracting available biosimulation models for reuse, recombination, and for archiving of physics-based biomedical knowledge. We have formalized and leveraged physics-based biological knowledge as a working view of physiology and biophysics from three distinct perspectives: (1) biologists and biomedical investigators, (2) biophysicists and bioengineers, and (3) biomedical ontologists and informaticists. We present a logical and intuitive semantics of classical physics as a tool for mediating and translating biophysical knowledge among biomedical domains.
Daniel L. Cook, MD, PhD
John H. Gennari, PhD
Maxwell L. Neal, PhD

Book details

Author:
Daniel L. Cook, John H. Gennari, Maxwell L. Neal
ISBN:
9780429892325
Related ISBNs:
9781138598058, 9780429469961, 9781032533100
Publisher:
CRC Press
Pages:
N/A
Reading age:
Not specified
Includes images:
Yes
Date of addition:
2023-12-15
Usage restrictions:
Copyright
Copyright date:
2024
Copyright by:
Taylor & Francis Group, LLC 
Adult content:
No
Language:
English
Categories:
Nonfiction, Science